Δ12-prostaglandin J2 is a potent inhibitor of influenza A virus replication

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 1, 2000, Pages 200-204

  Pica, Francesca ^a   Palamara, Anna Teresa ^a   Rossi, Antonio ^a,b   De Marco, Alessandra ^a   Amici, Carla ^a   Santoro, M Gabriella ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPENTENONE DERIVATIVE; DELTA12 PROSTAGLANDIN J2; HEAT SHOCK PROTEIN; PROSTAGLANDIN D2; 9-DEOXY-9,10-DIDEHYDRO-12,13-DIDEHYDRO-13,14-DIHYDROPROSTAGLANDIN D2; ANTIVIRUS AGENT; DNA; DRUG DERIVATIVE; HEAT SHOCK PROTEIN 70; RNA; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CELL PROTECTION; CELL STRAIN; CONTROLLED STUDY; DOG; DRUG EFFICACY; DRUG POTENCY; INFLUENZA; INFLUENZA VIRUS A; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; VIRUS INHIBITION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; DRUG EFFECT; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; DNA; HSP70 HEAT-SHOCK PROTEINS; INFLUENZA A VIRUS; MALE; MICE; MICE, INBRED BALB C; PROSTAGLANDIN D2; RNA; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0033621570     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.1.200-204.2000     Document Type: Article

References (18)

1. Basler, C. F., A. García-Sastre, and P. Palese. 1999. Mutation of neuraminidase cysteine residues yields temperature-sensitive influenza viruses. J. Virol. 73:8095-8103.
2. Centers for Disease Control and Prevention. 1996. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices. Morbid. Mortal. Weekly Rep. 45(RR-5):1-24.
3. Conti, C., P. Mastromarino, P. Tomao, A. De Marco, F. Pica, and M. G. Santoro. 1996. Inhibition of poliovirus replication by prostaglandins A and J in human cells. Antimicrob. Agents Chemother. 40:367-372.
4. Couch, R. B. 1997. A new antiviral agent for influenza - is there a clinical niche? N. Engl. J. Med. 337:927-928.
5. Hayden, F. G. 1996. Amantadine and rimantadine - clinical aspects, p. 59-77. In D. D. Richman (ed.), Antiviral drug resistance. John Wiley, Chichester, United Kingdom.
6. 1 on herpes simplex virus and immunodeficiency virus replication. Antimicrob. Agents Chemother. 36:2253-2258.
7. Morimoto, R. I., and M. G. Sanforo. 1998. Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection. Nat. Biotechnol. 16:833-838.
8. 2 is regulated at two separate levels and is associated with induction of stress protein synthesis. Antivir. Res. 20:193-208.
9. Rossi, A., G. Elia, and M. G. Santoro. 1996. 2-Cyclopenten-1-one, a new inducer of heat shock protein 70 with antiviral activity. J. Biol. Chem. 271:32192-32196.
10. 1: an effect associated with heat shock transcription factor activation. Proc. Natl. Acad. Sci. USA 94:746-750.
11. Rozera, C., A. Carattoli, A. De Marco, C. Amici, C. Giorgi, and M. G. Santoro. 1996. Inhibition of HIV-I replication by cyclopentenone prostaglandins in acutely infected human cells: evidence for a transcriptional block. J. Clin. Investig. 97:1795-1803.
12. Santoro, M. G. 1997. Antiviral activity of cyclopentenone prostanoids. Trends Microbiol. 5:276-281.
13. Santoro, M. G., C. Favalli, A. Mastino, B. M. Jaffe, M. Esteban, and E. Garaci. 1988. Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus. Arch. Virol. 99:89-100.
14. Shigeta, S., S. Mori, J. Watanabe, S. Soeda, K. Takahashi, and T. Yamase. 1997. Synergistic anti-influenza virus A (H1N1) activities of PM-523 (polyoxometalate) and ribavirin in vitro and in vivo. Antimicrob. Agents Chemother. 41:1423-1427.
15. Sinclair, S. B., P. D. Greig, L. M. Blendis, et al. 1989. Biochemical and clinical response of fulminant viral hepatitis to administration of prostaglandin E. J. Clin. Investig. 84:1063-1069.
16. Superti, F., C. Amici, A. Tinari, G. Donelli, and M. G. Santoro. 1998. Inhibition of rotavirus replication by prostaglandin A: evidence for a block of virus maturation. J. Infect. Dis. 178:564-568.
17. Vane, J., and J. O'Grady. 1993. Therapeutic applications of prostaglandins, p. 1-288. Edward Arnold, Sevenoaks, United Kingdom.
18. 2. Biochem. Biophys. Res. Commun. 146:1425-1431.