메뉴 건너뛰기




Volumn 49, Issue 6, 2009, Pages 2021-2030

Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor β actions in hepatocytes - But without modulating bone morphogenetic protein 7 signaling

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ADENOVIRUS VECTOR; CONNECTIVE TISSUE GROWTH FACTOR; OSTEOGENIC PROTEIN 1; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

EID: 68949101788     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22850     Document Type: Article
Times cited : (51)

References (55)
  • 1
    • 34848865661 scopus 로고    scopus 로고
    • Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes
    • Gressner OA, Lahme B, Demirci I, Gressner AM, Weiskirchen R. Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes. J Hepatol 2007;47:699-710.
    • (2007) J Hepatol , vol.47 , pp. 699-710
    • Gressner, O.A.1    Lahme, B.2    Demirci, I.3    Gressner, A.M.4    Weiskirchen, R.5
  • 2
    • 36348932917 scopus 로고    scopus 로고
    • Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes
    • Weng HL, Ciuclan L, Liu Y, Hamzavi J, Godoy P, Gaitantzi H, et al. Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes. HEPATOLOGY 2007;46:1257-1270.
    • (2007) HEPATOLOGY , vol.46 , pp. 1257-1270
    • Weng, H.L.1    Ciuclan, L.2    Liu, Y.3    Hamzavi, J.4    Godoy, P.5    Gaitantzi, H.6
  • 3
    • 0026055366 scopus 로고
    • Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10
    • Bradham DM, Igarashi A, Potter RL, Grotendorst GR. Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol 1991;114:1285-1294.
    • (1991) J Cell Biol , vol.114 , pp. 1285-1294
    • Bradham, D.M.1    Igarashi, A.2    Potter, R.L.3    Grotendorst, G.R.4
  • 4
    • 0042092032 scopus 로고    scopus 로고
    • Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis
    • Rachfal AW, Brigstock DR. Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis. Hepatol Res 2003;26:1-9.
    • (2003) Hepatol Res , vol.26 , pp. 1-9
    • Rachfal, A.W.1    Brigstock, D.R.2
  • 5
    • 33845906843 scopus 로고    scopus 로고
    • Leask A, Abraham DJ. All in the CCN family: Essential matricellular signaling modulators emerge from the bunker. J Cell Sci 2006;119:4803-4810.
    • Leask A, Abraham DJ. All in the CCN family: Essential matricellular signaling modulators emerge from the bunker. J Cell Sci 2006;119:4803-4810.
  • 6
    • 0027219381 scopus 로고
    • The modular architecture of a new family of growth regulators related to connective tissue growth factor
    • Bork P. The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett 1993;327:125-130.
    • (1993) FEBS Lett , vol.327 , pp. 125-130
    • Bork, P.1
  • 7
    • 0033541389 scopus 로고    scopus 로고
    • The CCN family of angiogenic regulators: The integrin connection
    • Lau LF, Lam SC. The CCN family of angiogenic regulators: The integrin connection. Exp Cell Res 1999;248:44-57.
    • (1999) Exp Cell Res , vol.248 , pp. 44-57
    • Lau, L.F.1    Lam, S.C.2
  • 8
  • 9
    • 2142646426 scopus 로고    scopus 로고
    • TGF-beta signaling and the fibrotic response
    • Leask A, Abraham DJ. TGF-beta signaling and the fibrotic response. FASEB J 2004;18:816-827.
    • (2004) FASEB J , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 11
    • 0032862910 scopus 로고    scopus 로고
    • Expression of connective tissue growth factor in experimental rat and human liver fibrosis
    • Paradis V, Dargere D, Vidaud M, De Gouville AC, Huet S, Martinez V, et al. Expression of connective tissue growth factor in experimental rat and human liver fibrosis. HEPATOLOGY 1999;30:968-976.
    • (1999) HEPATOLOGY , vol.30 , pp. 968-976
    • Paradis, V.1    Dargere, D.2    Vidaud, M.3    De Gouville, A.C.4    Huet, S.5    Martinez, V.6
  • 12
    • 34248179500 scopus 로고    scopus 로고
    • siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats
    • George J, Tsutsumi M. siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats. Gene Ther 2007;14:790-803.
    • (2007) Gene Ther , vol.14 , pp. 790-803
    • George, J.1    Tsutsumi, M.2
  • 13
    • 33746265975 scopus 로고    scopus 로고
    • Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats
    • Li G, Xie Q, Shi Y, Li D, Zhang M, Jiang S, et al. Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats. J Gene Med 2006;8:889-900.
    • (2006) J Gene Med , vol.8 , pp. 889-900
    • Li, G.1    Xie, Q.2    Shi, Y.3    Li, D.4    Zhang, M.5    Jiang, S.6
  • 14
    • 0029808645 scopus 로고    scopus 로고
    • A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene
    • Grotendorst GR, Okochi H, Hayashi N. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ 1996;7:469-480.
    • (1996) Cell Growth Differ , vol.7 , pp. 469-480
    • Grotendorst, G.R.1    Okochi, H.2    Hayashi, N.3
  • 15
    • 34247539528 scopus 로고    scopus 로고
    • A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling
    • Brown KA, Pietenpol JA, Moses HL. A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. J Cell Biochem 2007;101:9-33.
    • (2007) J Cell Biochem , vol.101 , pp. 9-33
    • Brown, K.A.1    Pietenpol, J.A.2    Moses, H.L.3
  • 16
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, et al. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003;9:964-968.
    • (2003) Nat Med , vol.9 , pp. 964-968
    • Zeisberg, M.1    Hanai, J.2    Sugimoto, H.3    Mammoto, T.4    Charytan, D.5    Strutz, F.6
  • 17
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, e al. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 2007;282:23337-23347.
    • (2007) J Biol Chem , vol.282 , pp. 23337-23347
    • Zeisberg, M.1    Yang, C.2    Martino, M.3    Duncan, M.B.4    Rieder, F.5    Tanjore, H.6
  • 18
    • 1842524153 scopus 로고    scopus 로고
    • Integration of TGFbeta/ Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
    • Zavadil J, Cermak L, Soto-Nieves N, Bottinger EP. Integration of TGFbeta/ Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J 2004;23:1155-1165.
    • (2004) EMBO J , vol.23 , pp. 1155-1165
    • Zavadil, J.1    Cermak, L.2    Soto-Nieves, N.3    Bottinger, E.P.4
  • 20
    • 0036051343 scopus 로고    scopus 로고
    • Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta
    • Abreu JG, Ketpura NI, Reversade B, De Robertis EM. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 2002;4:599-604.
    • (2002) Nat Cell Biol , vol.4 , pp. 599-604
    • Abreu, J.G.1    Ketpura, N.I.2    Reversade, B.3    De Robertis, E.M.4
  • 21
    • 48949084865 scopus 로고    scopus 로고
    • Connective tissue growth factor: A fibrogenic master switch in fibrotic liver diseases
    • Gressner OA, Gressner AM. Connective tissue growth factor: A fibrogenic master switch in fibrotic liver diseases. Liver Int 2008;28:1065-1079.
    • (2008) Liver Int , vol.28 , pp. 1065-1079
    • Gressner, O.A.1    Gressner, A.M.2
  • 22
    • 49549122634 scopus 로고    scopus 로고
    • Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells
    • Karger A, Fitzner B, Brock P, Sparmann G, Emmrich J, Liebe S, et al. Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells. Cell Signal 2008;20:1865-1872.
    • (2008) Cell Signal , vol.20 , pp. 1865-1872
    • Karger, A.1    Fitzner, B.2    Brock, P.3    Sparmann, G.4    Emmrich, J.5    Liebe, S.6
  • 23
    • 44049097094 scopus 로고    scopus 로고
    • Focal adhesion kinase/Src suppresses early chondrogenesis: Central role of CCN2
    • Pala D, Kapoor M, Woods A, Kennedy L, Liu S, Chen S, et al. Focal adhesion kinase/Src suppresses early chondrogenesis: Central role of CCN2. J Biol Chem 2008;283:9239-9247.
    • (2008) J Biol Chem , vol.283 , pp. 9239-9247
    • Pala, D.1    Kapoor, M.2    Woods, A.3    Kennedy, L.4    Liu, S.5    Chen, S.6
  • 24
    • 0017101039 scopus 로고
    • Preparation of isolated rat liver cells
    • Prescott DM, ed, New York: Academic
    • Seglen P. Preparation of isolated rat liver cells. In: Prescott DM, ed. Methods in Cell Biology. Volume 8. New York: Academic, 1987:29-83.
    • (1987) Methods in Cell Biology , vol.8 , pp. 29-83
    • Seglen, P.1
  • 25
    • 84945737937 scopus 로고
    • Preventive effects of acute inflammation on liver cell necrosis and inhibition of heparan sulphate synthesis in hepatocytes
    • Gressner AM, Pfeiffer T. Preventive effects of acute inflammation on liver cell necrosis and inhibition of heparan sulphate synthesis in hepatocytes. J Clin Chem Clin Biochem 1986;24:821-829.
    • (1986) J Clin Chem Clin Biochem , vol.24 , pp. 821-829
    • Gressner, A.M.1    Pfeiffer, T.2
  • 26
    • 24344500807 scopus 로고    scopus 로고
    • Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization
    • Uemura M, Swenson ES, Gaca MD, Giordano FJ, Reiss M, Wells RG. Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Mol Biol Cell 2005;16: 4214-4224.
    • (2005) Mol Biol Cell , vol.16 , pp. 4214-4224
    • Uemura, M.1    Swenson, E.S.2    Gaca, M.D.3    Giordano, F.J.4    Reiss, M.5    Wells, R.G.6
  • 27
    • 0038644847 scopus 로고    scopus 로고
    • Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts
    • Leask A, Holmes A, Black CM, Abraham DJ. Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts. J Biol Chem 2003;278:13008-13015.
    • (2003) J Biol Chem , vol.278 , pp. 13008-13015
    • Leask, A.1    Holmes, A.2    Black, C.M.3    Abraham, D.J.4
  • 28
    • 0034971702 scopus 로고    scopus 로고
    • The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts
    • Leask A, Sa S, Holmes A, Shiwen X, Black CM, Abraham DJ. The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts. Mol Pathol 2001;54:180-183.
    • (2001) Mol Pathol , vol.54 , pp. 180-183
    • Leask, A.1    Sa, S.2    Holmes, A.3    Shiwen, X.4    Black, C.M.5    Abraham, D.J.6
  • 30
    • 0028559768 scopus 로고
    • An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3
    • Bett AJ, Haddara W, Prevec L, Graham FL. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc Natl Acad Sci U S A 1994;91:8802-8806.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8802-8806
    • Bett, A.J.1    Haddara, W.2    Prevec, L.3    Graham, F.L.4
  • 31
    • 0023883716 scopus 로고
    • A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5
    • McGrory WJ, Bautista DS, Graham FL. A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology 1988;163:614-617.
    • (1988) Virology , vol.163 , pp. 614-617
    • McGrory, W.J.1    Bautista, D.S.2    Graham, F.L.3
  • 32
    • 1642403011 scopus 로고    scopus 로고
    • Weiskirchen R, Kneifel J, Weiskirchen S, van de Leur E, Kunz D, Gressner AM. Comparative evaluation of gene delivery devices in primary cultures of rat hepatic stellate cells and rat myofibroblasts.BMCCell Biol 2000;1:4.
    • Weiskirchen R, Kneifel J, Weiskirchen S, van de Leur E, Kunz D, Gressner AM. Comparative evaluation of gene delivery devices in primary cultures of rat hepatic stellate cells and rat myofibroblasts.BMCCell Biol 2000;1:4.
  • 33
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
    • Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, Gauthier JM. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 1998;17:3091-3100.
    • (1998) EMBO J , vol.17 , pp. 3091-3100
    • Dennler, S.1    Itoh, S.2    Vivien, D.3    ten Dijke, P.4    Huet, S.5    Gauthier, J.M.6
  • 34
    • 0037085441 scopus 로고    scopus 로고
    • Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
    • Korchynskyi O, ten Dijke P. Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J Biol Chem 2002;277:4883-4891.
    • (2002) J Biol Chem , vol.277 , pp. 4883-4891
    • Korchynskyi, O.1    ten Dijke, P.2
  • 35
    • 0036479133 scopus 로고    scopus 로고
    • Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene
    • Lopez-Rovira T, Chalaux E, Massague J, Rosa JL, Ventura F. Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene. J Biol Chem 2002;277:3176-3185.
    • (2002) J Biol Chem , vol.277 , pp. 3176-3185
    • Lopez-Rovira, T.1    Chalaux, E.2    Massague, J.3    Rosa, J.L.4    Ventura, F.5
  • 36
    • 34347230515 scopus 로고    scopus 로고
    • Endoglin differentially modulates antagonistic transforming growth factor-beta1 and BMP-7 signaling
    • Scherner O, Meurer SK, Tihaa L, Gressner AM, Weiskirchen R. Endoglin differentially modulates antagonistic transforming growth factor-beta1 and BMP-7 signaling. J Biol Chem 2007;282:13934-13943.
    • (2007) J Biol Chem , vol.282 , pp. 13934-13943
    • Scherner, O.1    Meurer, S.K.2    Tihaa, L.3    Gressner, A.M.4    Weiskirchen, R.5
  • 37
    • 33646691720 scopus 로고    scopus 로고
    • Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells
    • Wiercinska E, Wickert L, Denecke B, Said HM, Hamzavi J, Gressner AM, et al. Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells. HEPATOLOGY 2006;43:1032-1041.
    • (2006) HEPATOLOGY , vol.43 , pp. 1032-1041
    • Wiercinska, E.1    Wickert, L.2    Denecke, B.3    Said, H.M.4    Hamzavi, J.5    Gressner, A.M.6
  • 38
    • 0036085920 scopus 로고    scopus 로고
    • SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    • Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 2002;62:65-74.
    • (2002) Mol Pharmacol , vol.62 , pp. 65-74
    • Inman, G.J.1    Nicolas, F.J.2    Callahan, J.F.3    Harling, J.D.4    Gaster, L.M.5    Reith, A.D.6
  • 39
    • 31044448265 scopus 로고    scopus 로고
    • Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induce dextracellular matrix expression
    • Jinnin M, Ihn H, Tamaki K. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induce dextracellular matrix expression. Mol Pharmacol 2006;69: 597-607.
    • (2006) Mol Pharmacol , vol.69 , pp. 597-607
    • Jinnin, M.1    Ihn, H.2    Tamaki, K.3
  • 40
    • 49149123259 scopus 로고    scopus 로고
    • Smad signaling pathway is a pivotal component of tissue inhibitor of metalloproteinases-3 regulation by transforming growth factor beta in human chondrocytes
    • Qureshi HY, Ricci G, Zafarullah M. Smad signaling pathway is a pivotal component of tissue inhibitor of metalloproteinases-3 regulation by transforming growth factor beta in human chondrocytes. Biochim Biophys Acta 2008;1783:1605-1612.
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 1605-1612
    • Qureshi, H.Y.1    Ricci, G.2    Zafarullah, M.3
  • 41
    • 53249097208 scopus 로고    scopus 로고
    • Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor
    • Gressner OA, Lahme B, Siluschek M, Rehbein K, Herrmann J, Weiskirchen R, et al. Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor. J Cell Mol Med 2008;12:2717-2730.
    • (2008) J Cell Mol Med , vol.12 , pp. 2717-2730
    • Gressner, O.A.1    Lahme, B.2    Siluschek, M.3    Rehbein, K.4    Herrmann, J.5    Weiskirchen, R.6
  • 42
    • 53249092406 scopus 로고    scopus 로고
    • Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPAR-gamma and Smad2/3-dependent pathways
    • Gressner OA, Lahme B, Rehbein K, Siluschek M, Weiskirchen R, Gressner AM. Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPAR-gamma and Smad2/3-dependent pathways. J Hepatol 2008;49:758-767.
    • (2008) J Hepatol , vol.49 , pp. 758-767
    • Gressner, O.A.1    Lahme, B.2    Rehbein, K.3    Siluschek, M.4    Weiskirchen, R.5    Gressner, A.M.6
  • 43
    • 51649091208 scopus 로고    scopus 로고
    • Intracrine signalling of activin A in hepatocytes upregulates connective tissue growth factor (CTGF/CCN2) expression
    • Gressner OA, Lahme B, Siluschek M, Rehbein K, Weiskirchen R, Gressner AM. Intracrine signalling of activin A in hepatocytes upregulates connective tissue growth factor (CTGF/CCN2) expression. Liver Int 2008;28: 1207-1216.
    • (2008) Liver Int , vol.28 , pp. 1207-1216
    • Gressner, O.A.1    Lahme, B.2    Siluschek, M.3    Rehbein, K.4    Weiskirchen, R.5    Gressner, A.M.6
  • 45
    • 2542609844 scopus 로고    scopus 로고
    • Flanders KC. Smad3 as a mediator of the fibrotic response. Int J Exp Pathol 2004;85:47-64.
    • Flanders KC. Smad3 as a mediator of the fibrotic response. Int J Exp Pathol 2004;85:47-64.
  • 46
    • 0037837754 scopus 로고    scopus 로고
    • Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent
    • Liu C, Gaca MD, Swenson ES, Vellucci VF, Reiss M, Wells RG. Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent. J Biol Chem 2003;278:11721-11728.
    • (2003) J Biol Chem , vol.278 , pp. 11721-11728
    • Liu, C.1    Gaca, M.D.2    Swenson, E.S.3    Vellucci, V.F.4    Reiss, M.5    Wells, R.G.6
  • 48
    • 35848951385 scopus 로고    scopus 로고
    • Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling
    • Bujak M, Ren G, Kweon HJ, Dobaczewski M, Reddy A, Taffet G, et al. Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation 2007;116:2127-2138.
    • (2007) Circulation , vol.116 , pp. 2127-2138
    • Bujak, M.1    Ren, G.2    Kweon, H.J.3    Dobaczewski, M.4    Reddy, A.5    Taffet, G.6
  • 50
    • 33646794060 scopus 로고    scopus 로고
    • Essential role of Smad3 in angiotensin II-induced vascular fibrosis
    • Wang W, Huang XR, Canlas E, Oka K, Truong LD, Deng C, et al. Essential role of Smad3 in angiotensin II-induced vascular fibrosis. Circ Res 2006;98:1032-1039.
    • (2006) Circ Res , vol.98 , pp. 1032-1039
    • Wang, W.1    Huang, X.R.2    Canlas, E.3    Oka, K.4    Truong, L.D.5    Deng, C.6
  • 51
    • 3242799550 scopus 로고    scopus 로고
    • Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis
    • Bonniaud P, Kolb M, Galt T, Robertson J, Robbins C, Stampfli M, et al. Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis. J Immunol 2004;173:2099-2108.
    • (2004) J Immunol , vol.173 , pp. 2099-2108
    • Bonniaud, P.1    Kolb, M.2    Galt, T.3    Robertson, J.4    Robbins, C.5    Stampfli, M.6
  • 52
    • 0142211305 scopus 로고    scopus 로고
    • Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1
    • Holmes A, Abraham DJ, Chen Y, Denton C, Shi-wen X, Black CM, et al. Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1. J Biol Chem 2003;278:41728-41733.
    • (2003) J Biol Chem , vol.278 , pp. 41728-41733
    • Holmes, A.1    Abraham, D.J.2    Chen, Y.3    Denton, C.4    Shi-wen, X.5    Black, C.M.6
  • 54
    • 33744950568 scopus 로고    scopus 로고
    • CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts
    • Shi-wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, et al. CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem 2006;281:10715-10726.
    • (2006) J Biol Chem , vol.281 , pp. 10715-10726
    • Shi-wen, X.1    Stanton, L.A.2    Kennedy, L.3    Pala, D.4    Chen, Y.5    Howat, S.L.6
  • 55
    • 0032794692 scopus 로고    scopus 로고
    • Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model
    • Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, et al. Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model. J Cell Physiol 1999;181:153-159.
    • (1999) J Cell Physiol , vol.181 , pp. 153-159
    • Mori, T.1    Kawara, S.2    Shinozaki, M.3    Hayashi, N.4    Kakinuma, T.5    Igarashi, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.