메뉴 건너뛰기




Volumn 89, Issue 11, 2011, Pages 1812-1821

Beneficial effects of a neurotrophic peptidergic mixture persist for a prolonged period following treatment interruption in a transgenic model of Alzheimer's disease

Author keywords

Amyloid precursor protein; Cerebrolysin; Neurodegeneration; Synapses; Water maze

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CEREBROLYSIN; NEUROTROPHIC FACTOR;

EID: 80052638741     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22712     Document Type: Article
Times cited : (28)

References (67)
  • 5
    • 78650121248 scopus 로고    scopus 로고
    • Efficacy and safety of Cerebrolysin in moderate to moderately severe Alzheimer's disease: results of a randomized, double-blind, controlled trial investigating three dosages of Cerebrolysin
    • Alvarez XA, Cacabelos R, Sampedro C, Aleixandre M, Linares C, Granizo E, Doppler E, Moessler H. 2011. Efficacy and safety of Cerebrolysin in moderate to moderately severe Alzheimer's disease: results of a randomized, double-blind, controlled trial investigating three dosages of Cerebrolysin. Eur J Neurol 18: 59-68.
    • (2011) Eur J Neurol , vol.18 , pp. 59-68
    • Alvarez, X.A.1    Cacabelos, R.2    Sampedro, C.3    Aleixandre, M.4    Linares, C.5    Granizo, E.6    Doppler, E.7    Moessler, H.8
  • 6
    • 0038516240 scopus 로고    scopus 로고
    • Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density
    • Chana G, Landau S, Beasley C, Everall IP, Cotter D. 2003. Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density. Biol Psychiatry 53: 1086-1098.
    • (2003) Biol Psychiatry , vol.53 , pp. 1086-1098
    • Chana, G.1    Landau, S.2    Beasley, C.3    Everall, I.P.4    Cotter, D.5
  • 8
    • 34249336353 scopus 로고    scopus 로고
    • Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis
    • Chen H, Tung YC, Li B, Iqbal K, Grundke-Iqbal I. 2007. Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis. Neurobiol Aging 28: 1148-1162.
    • (2007) Neurobiol Aging , vol.28 , pp. 1148-1162
    • Chen, H.1    Tung, Y.C.2    Li, B.3    Iqbal, K.4    Grundke-Iqbal, I.5
  • 9
    • 0028965223 scopus 로고
    • Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration
    • Chen KS, Gage FH. 1995. Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration. J Neurosci 15: 2819-2825.
    • (1995) J Neurosci , vol.15 , pp. 2819-2825
    • Chen, K.S.1    Gage, F.H.2
  • 10
    • 0034023010 scopus 로고    scopus 로고
    • Apoptosis modulators in the therapy of neurodegenerative diseases
    • Deigner HP, Haberkorn U, Kinscherf R. 2000. Apoptosis modulators in the therapy of neurodegenerative diseases. Expert Opin Invest Drugs 9: 747-764.
    • (2000) Expert Opin Invest Drugs , vol.9 , pp. 747-764
    • Deigner, H.P.1    Haberkorn, U.2    Kinscherf, R.3
  • 11
    • 0030513943 scopus 로고    scopus 로고
    • Structural correlates of cognition in dementia: quantification and assessment of synapse change
    • DeKosky ST, Scheff SW, Styren SD. 1996. Structural correlates of cognition in dementia: quantification and assessment of synapse change. Neurodegeneration 5: 417-421.
    • (1996) Neurodegeneration , vol.5 , pp. 417-421
    • DeKosky, S.T.1    Scheff, S.W.2    Styren, S.D.3
  • 12
    • 84856579022 scopus 로고    scopus 로고
    • EBEWENeuroPharmaGmbH. Cerebrolysin® solution for injection: summary of product characteristics.
    • EBEWENeuroPharmaGmbH. 2009. Cerebrolysin® solution for injection: summary of product characteristics.
    • (2009)
  • 13
    • 0023643241 scopus 로고
    • Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
    • Fischer W, Wictorin K, Bjorklund A, Williams LR, Varon S, Gage FH. 1987. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329: 65-68.
    • (1987) Nature , vol.329 , pp. 65-68
    • Fischer, W.1    Wictorin, K.2    Bjorklund, A.3    Williams, L.R.4    Varon, S.5    Gage, F.H.6
  • 14
    • 17044458021 scopus 로고    scopus 로고
    • Nerve growth factor and nootropic drug Cerebrolysin but not fibroblast growth factor can reduce spatial memory impairment elicited by fimbria-fornix transection: short-term study
    • Francis-Turner L, Valouskova V. 1996. Nerve growth factor and nootropic drug Cerebrolysin but not fibroblast growth factor can reduce spatial memory impairment elicited by fimbria-fornix transection: short-term study. Neurosci Lett 202: 193-196.
    • (1996) Neurosci Lett , vol.202 , pp. 193-196
    • Francis-Turner, L.1    Valouskova, V.2
  • 15
    • 0029839736 scopus 로고    scopus 로고
    • The long-term effect of NGF, b-FGF and Cerebrolysin on the spatial memory after fimbria-fornix lesion in rats
    • Francis-Turner L, Valouskova V, Mokry J. 1996. The long-term effect of NGF, b-FGF and Cerebrolysin on the spatial memory after fimbria-fornix lesion in rats. J Neural Transm Suppl 47: 277.
    • (1996) J Neural Transm Suppl , vol.47 , pp. 277
    • Francis-Turner, L.1    Valouskova, V.2    Mokry, J.3
  • 16
    • 0031596289 scopus 로고    scopus 로고
    • Dose-dependent effects of Cerebrolysin on EEG and short-term memory of healthy volunteers during control and hyperventilation induced cerebral ischemia
    • Funke M, Fiehler J, Mewes I, Eiselt M, Rother I, Windisch M. 1998. Dose-dependent effects of Cerebrolysin on EEG and short-term memory of healthy volunteers during control and hyperventilation induced cerebral ischemia. J Neural Transm Suppl 53: 385-398.
    • (1998) J Neural Transm Suppl , vol.53 , pp. 385-398
    • Funke, M.1    Fiehler, J.2    Mewes, I.3    Eiselt, M.4    Rother, I.5    Windisch, M.6
  • 17
    • 0022486717 scopus 로고
    • Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
    • Hefti F. 1986. Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. J Neurosci 6: 2155-2162.
    • (1986) J Neurosci , vol.6 , pp. 2155-2162
    • Hefti, F.1
  • 18
    • 0023067115 scopus 로고
    • Nerve growth factor treatment after brain injury prevents neuronal death
    • Kromer LF. 1987. Nerve growth factor treatment after brain injury prevents neuronal death. Science 235: 214-216.
    • (1987) Science , vol.235 , pp. 214-216
    • Kromer, L.F.1
  • 19
    • 76549235314 scopus 로고
    • Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo
    • Levi-Montalcini R, Hamburger V. 1951. Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. J Exp Zool 116: 321-361.
    • (1951) J Exp Zool , vol.116 , pp. 321-361
    • Levi-Montalcini, R.1    Hamburger, V.2
  • 22
    • 0029902122 scopus 로고    scopus 로고
    • Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain
    • Martinez-Serrano A, Fischer W, Soderstrom S, Ebendal T, Bjorklund A. 1996. Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain. Proc Natl Acad Sci U S A 93: 6355-6360.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 6355-6360
    • Martinez-Serrano, A.1    Fischer, W.2    Soderstrom, S.3    Ebendal, T.4    Bjorklund, A.5
  • 23
    • 0028898888 scopus 로고
    • Mechanisms of synaptic dysfunction in Alzheimer's disease
    • Masliah E. 1995. Mechanisms of synaptic dysfunction in Alzheimer's disease. Histol Histopathol 10: 509-519.
    • (1995) Histol Histopathol , vol.10 , pp. 509-519
    • Masliah, E.1
  • 24
    • 0032932837 scopus 로고    scopus 로고
    • Cerebrolysin ameliorates performance deficits, and neuronal damage in apolipoprotein E-deficient mice
    • Masliah E, Armasolo F, Veinbergs I, Mallory M, Samuel W. 1999. Cerebrolysin ameliorates performance deficits, and neuronal damage in apolipoprotein E-deficient mice. Pharmacol Biochem Behav 62: 239-245.
    • (1999) Pharmacol Biochem Behav , vol.62 , pp. 239-245
    • Masliah, E.1    Armasolo, F.2    Veinbergs, I.3    Mallory, M.4    Samuel, W.5
  • 26
    • 33747391594 scopus 로고    scopus 로고
    • Synaptic remodeling during aging and in Alzheimer's disease
    • Masliah E, Crews L, Hansen L. 2006. Synaptic remodeling during aging and in Alzheimer's disease. J Alzheimers Dis 9( Suppl 3): 91-99.
    • (2006) J Alzheimers Dis , vol.9 , Issue.SUPPL. 3 , pp. 91-99
    • Masliah, E.1    Crews, L.2    Hansen, L.3
  • 27
    • 77949336151 scopus 로고    scopus 로고
    • 2010 Alzheimer's disease facts and figures
    • Maslow K. 2010. 2010 Alzheimer's disease facts and figures. Alzheimers Dement 6: 158-194.
    • (2010) Alzheimers Dement , vol.6 , pp. 158-194
    • Maslow, K.1
  • 29
    • 0029039162 scopus 로고
    • Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis
    • Mufson EJ, Conner JM, Kordower JH. 1995. Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis. Neuroreport 6: 1063-1066.
    • (1995) Neuroreport , vol.6 , pp. 1063-1066
    • Mufson, E.J.1    Conner, J.M.2    Kordower, J.H.3
  • 30
    • 39149133958 scopus 로고    scopus 로고
    • A pilot study to evaluate the effects of Cerebrolysin on cognition and qEEG in vascular dementia: cognitive improvement correlates with qEEG acceleration
    • Muresanu DF, Alvarez XA, Moessler H, Buia M, Stan A, Pintea D, Moldovan F, Popescu BO. 2008. A pilot study to evaluate the effects of Cerebrolysin on cognition and qEEG in vascular dementia: cognitive improvement correlates with qEEG acceleration. J Neurol Sci 267: 112-119.
    • (2008) J Neurol Sci , vol.267 , pp. 112-119
    • Muresanu, D.F.1    Alvarez, X.A.2    Moessler, H.3    Buia, M.4    Stan, A.5    Pintea, D.6    Moldovan, F.7    Popescu, B.O.8
  • 33
    • 77954358003 scopus 로고    scopus 로고
    • Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins
    • Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E. 2010. Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. FEBS J 277: 3051-3067.
    • (2010) FEBS J , vol.277 , pp. 3051-3067
    • Pham, E.1    Crews, L.2    Ubhi, K.3    Hansen, L.4    Adame, A.5    Cartier, A.6    Salmon, D.7    Galasko, D.8    Michael, S.9    Savas, J.N.10    Yates, J.R.11    Glabe, C.12    Masliah, E.13
  • 34
    • 70350475310 scopus 로고    scopus 로고
    • Cerebrolysin: a review of its use in dementia
    • Plosker GL, Gauthier S. 2009. Cerebrolysin: a review of its use in dementia. Drugs Aging 26: 893-915.
    • (2009) Drugs Aging , vol.26 , pp. 893-915
    • Plosker, G.L.1    Gauthier, S.2
  • 35
    • 76949085182 scopus 로고    scopus 로고
    • Spotlight on cerebrolysin in dementia
    • Plosker GL, Gauthier S. 2010. Spotlight on cerebrolysin in dementia. CNS Drugs 24: 263-266.
    • (2010) CNS Drugs , vol.24 , pp. 263-266
    • Plosker, G.L.1    Gauthier, S.2
  • 36
    • 0032774942 scopus 로고    scopus 로고
    • Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 24-month-old rats
    • Reinprecht I, Gschanes A, Windisch M, Fachbach G. 1999. Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 24-month-old rats. Histochem J 31: 395-401.
    • (1999) Histochem J , vol.31 , pp. 395-401
    • Reinprecht, I.1    Gschanes, A.2    Windisch, M.3    Fachbach, G.4
  • 37
    • 0028875687 scopus 로고
    • Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease
    • Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L. 1995. Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. J Biol Chem 270: 28257-28267.
    • (1995) J Biol Chem , vol.270 , pp. 28257-28267
    • Rockenstein, E.M.1    McConlogue, L.2    Tan, H.3    Power, M.4    Masliah, E.5    Mucke, L.6
  • 38
    • 0035889404 scopus 로고    scopus 로고
    • Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42)
    • Rockenstein E, Mallory M, Mante M, Sisk A, Masliaha E. 2001. Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42). J Neurosci Res 66: 573-582.
    • (2001) J Neurosci Res , vol.66 , pp. 573-582
    • Rockenstein, E.1    Mallory, M.2    Mante, M.3    Sisk, A.4    Masliaha, E.5
  • 40
    • 0345059236 scopus 로고    scopus 로고
    • The neuroprotective effects of Cerebrolysin in a transgenic model of Alzheimer's disease are associated with improved behavioral performance
    • Rockenstein E, Adame A, Mante M, Moessler H, Windisch M, Masliah E. 2003a. The neuroprotective effects of Cerebrolysin in a transgenic model of Alzheimer's disease are associated with improved behavioral performance. J Neural Transm 110: 1313-1327.
    • (2003) J Neural Transm , vol.110 , pp. 1313-1327
    • Rockenstein, E.1    Adame, A.2    Mante, M.3    Moessler, H.4    Windisch, M.5    Masliah, E.6
  • 41
    • 0345059236 scopus 로고    scopus 로고
    • The neuroprotective effects of Cerebrolysin trade mark in a transgenic model of Alzheimer's disease are associated with improved behavioral performance
    • Rockenstein E, Adame A, Mante M, Moessler H, Windisch M, Masliah E. 2003b. The neuroprotective effects of Cerebrolysin trade mark in a transgenic model of Alzheimer's disease are associated with improved behavioral performance. J Neural Transm 110: 1313-1327.
    • (2003) J Neural Transm , vol.110 , pp. 1313-1327
    • Rockenstein, E.1    Adame, A.2    Mante, M.3    Moessler, H.4    Windisch, M.5    Masliah, E.6
  • 42
    • 13144258773 scopus 로고    scopus 로고
    • Amelioration of the cerebrovascular amyloidosis in a transgenic model of Alzheimer's disease with the neurotrophic compound cerebrolysin
    • Rockenstein E, Adame A, Mante M, Larrea G, Crews L, Windisch M, Moessler H, Masliah E. 2005a. Amelioration of the cerebrovascular amyloidosis in a transgenic model of Alzheimer's disease with the neurotrophic compound cerebrolysin. J Neural Transm 112: 269-282.
    • (2005) J Neural Transm , vol.112 , pp. 269-282
    • Rockenstein, E.1    Adame, A.2    Mante, M.3    Larrea, G.4    Crews, L.5    Windisch, M.6    Moessler, H.7    Masliah, E.8
  • 43
    • 25444479179 scopus 로고    scopus 로고
    • High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease
    • Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E. 2005b. High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease. J Biol Chem 280: 32957-32967.
    • (2005) J Biol Chem , vol.280 , pp. 32957-32967
    • Rockenstein, E.1    Mante, M.2    Alford, M.3    Adame, A.4    Crews, L.5    Hashimoto, M.6    Esposito, L.7    Mucke, L.8    Masliah, E.9
  • 44
    • 33646364811 scopus 로고    scopus 로고
    • Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease
    • Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E. 2006. Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease. J Neurosci Res 83: 1252-1261.
    • (2006) J Neurosci Res , vol.83 , pp. 1252-1261
    • Rockenstein, E.1    Torrance, M.2    Mante, M.3    Adame, A.4    Paulino, A.5    Rose, J.B.6    Crews, L.7    Moessler, H.8    Masliah, E.9
  • 45
    • 35348932113 scopus 로고    scopus 로고
    • Transgenic animal models of neurodegenerative diseases and their application to treatment development
    • Rockenstein E, Crews L, Masliah E. 2007a. Transgenic animal models of neurodegenerative diseases and their application to treatment development. Adv Drug Deliv Rev 59: 1093-1102.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 1093-1102
    • Rockenstein, E.1    Crews, L.2    Masliah, E.3
  • 46
    • 33947389569 scopus 로고    scopus 로고
    • Effects of Cerebrolysin on neurogenesis in an APP transgenic model of Alzheimer's disease
    • Rockenstein E, Mante M, Adame A, Crews L, Moessler H, Masliah E. 2007b. Effects of Cerebrolysin on neurogenesis in an APP transgenic model of Alzheimer's disease. Acta Neuropathol 113: 265-275.
    • (2007) Acta Neuropathol , vol.113 , pp. 265-275
    • Rockenstein, E.1    Mante, M.2    Adame, A.3    Crews, L.4    Moessler, H.5    Masliah, E.6
  • 47
    • 33847214486 scopus 로고    scopus 로고
    • Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation
    • Rockenstein E, Torrance M, Adame A, Mante M, Baron P, Rose JB, Crews L, Masliah E. 2007c. Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J Neurosci 27: 1981-1991.
    • (2007) J Neurosci , vol.27 , pp. 1981-1991
    • Rockenstein, E.1    Torrance, M.2    Adame, A.3    Mante, M.4    Baron, P.5    Rose, J.B.6    Crews, L.7    Masliah, E.8
  • 48
    • 0028217297 scopus 로고
    • Efficacy of the peptidergic nootropic drug cerebrolysin in patients with senile dementia of the Alzheimer type (SDAT)
    • Ruther E, Ritter R, Apecechea M, Freytag S, Windisch M. 1994. Efficacy of the peptidergic nootropic drug cerebrolysin in patients with senile dementia of the Alzheimer type (SDAT). Pharmacopsychiatry 27: 32-40.
    • (1994) Pharmacopsychiatry , vol.27 , pp. 32-40
    • Ruther, E.1    Ritter, R.2    Apecechea, M.3    Freytag, S.4    Windisch, M.5
  • 49
    • 0033911108 scopus 로고    scopus 로고
    • Sustained improvements in patients with dementia of Alzheimer's type (DAT) 6 months after termination of Cerebrolysin therapy
    • Ruther E, Ritter R, Apecechea M, Freytag S, Gmeinbauer R, Windisch M. 2000. Sustained improvements in patients with dementia of Alzheimer's type (DAT) 6 months after termination of Cerebrolysin therapy. J Neural Transm 107: 815-829.
    • (2000) J Neural Transm , vol.107 , pp. 815-829
    • Ruther, E.1    Ritter, R.2    Apecechea, M.3    Freytag, S.4    Gmeinbauer, R.5    Windisch, M.6
  • 50
    • 0033747106 scopus 로고    scopus 로고
    • Neurotrophic effects of FPF-1070 (Cerebrolysin) on cultured neurons from chicken embryo dorsal root ganglia, ciliary ganglia, and sympathetic trunks
    • Satou T, Itoh T, Tamai Y, Ohde H, Anderson AJ, Hashimoto S. 2000. Neurotrophic effects of FPF-1070 (Cerebrolysin) on cultured neurons from chicken embryo dorsal root ganglia, ciliary ganglia, and sympathetic trunks. J Neural Transm 107: 1253-1262.
    • (2000) J Neural Transm , vol.107 , pp. 1253-1262
    • Satou, T.1    Itoh, T.2    Tamai, Y.3    Ohde, H.4    Anderson, A.J.5    Hashimoto, S.6
  • 51
    • 0025217385 scopus 로고
    • Quantitative assessment of cortical synaptic density in Alzheimer's disease
    • Scheff S, DeKosky S, Price D. 1990. Quantitative assessment of cortical synaptic density in Alzheimer's disease. Neurobiol Aging 11: 29-37.
    • (1990) Neurobiol Aging , vol.11 , pp. 29-37
    • Scheff, S.1    DeKosky, S.2    Price, D.3
  • 52
    • 0029022112 scopus 로고
    • Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis
    • Scott SA, Mufson EJ, Weingartner JA, Skau KA, Crutcher KA. 1995. Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. J Neurosci 15: 6213-6221.
    • (1995) J Neurosci , vol.15 , pp. 6213-6221
    • Scott, S.A.1    Mufson, E.J.2    Weingartner, J.A.3    Skau, K.A.4    Crutcher, K.A.5
  • 55
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R. 1991. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30: 572-580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 56
    • 0029010034 scopus 로고
    • Relationship between plaques, tangles, and dystrophic processes in Alzheimer's disease
    • discussion 341-335.
    • Trojanowski JQ, Shin RW, Schmidt ML, Lee VM. 1995. Relationship between plaques, tangles, and dystrophic processes in Alzheimer's disease. Neurobiol Aging 16: 335-340; discussion 341-335.
    • (1995) Neurobiol Aging , vol.16 , pp. 335-340
    • Trojanowski, J.Q.1    Shin, R.W.2    Schmidt, M.L.3    Lee, V.M.4
  • 57
    • 34249941829 scopus 로고    scopus 로고
    • Nerve growth factor gene therapy in Alzheimer disease
    • Tuszynski MH. 2007. Nerve growth factor gene therapy in Alzheimer disease. Alzheimer Dis Assoc Disord 21: 179-189.
    • (2007) Alzheimer Dis Assoc Disord , vol.21 , pp. 179-189
    • Tuszynski, M.H.1
  • 58
    • 0029013323 scopus 로고
    • Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery
    • Tuszynski MH, Gage FH. 1995. Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery. Proc Natl Acad Sci U S A 92: 4621-4625.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 4621-4625
    • Tuszynski, M.H.1    Gage, F.H.2
  • 61
    • 0030337812 scopus 로고    scopus 로고
    • The short-term influence of b-FGF, NGF and Cerebrolysin on the memory impaired after fimbria-fornix lesion
    • Valouskova V, Francis-Turmer L. 1996. The short-term influence of b-FGF, NGF and Cerebrolysin on the memory impaired after fimbria-fornix lesion. J Neural Transm Suppl 47: 280.
    • (1996) J Neural Transm Suppl , vol.47 , pp. 280
    • Valouskova, V.1    Francis-Turmer, L.2
  • 62
    • 0033624431 scopus 로고    scopus 로고
    • Neurotrophic effects of Cerebrolysin in animal models of excitotoxicity
    • Veinbergs I, Mante M, Mallory M, Masliah E. 2000. Neurotrophic effects of Cerebrolysin in animal models of excitotoxicity. J Neural Transm Suppl 59: 273-280.
    • (2000) J Neural Transm Suppl , vol.59 , pp. 273-280
    • Veinbergs, I.1    Mante, M.2    Mallory, M.3    Masliah, E.4
  • 64
    • 0025954742 scopus 로고
    • Exogenous NGF affects cholinergic transmitter function and Y-maze behavior in aged Fischer 344 male rats
    • Williams LR, Rylett RJ, Moises HC, Tang AH. 1991. Exogenous NGF affects cholinergic transmitter function and Y-maze behavior in aged Fischer 344 male rats. Can J Neurol Sci 18( Suppl 3): 403-407.
    • (1991) Can J Neurol Sci , vol.18 , Issue.SUPPL. 3 , pp. 403-407
    • Williams, L.R.1    Rylett, R.J.2    Moises, H.C.3    Tang, A.H.4
  • 65
    • 0031596269 scopus 로고    scopus 로고
    • Neurotrophic activities and therapeutic experience with a brain derived peptide preparation
    • Windisch M, Gschanes A, Hutter-Paier B. 1998. Neurotrophic activities and therapeutic experience with a brain derived peptide preparation. J Neural Transm Suppl 53: 289-298.
    • (1998) J Neural Transm Suppl , vol.53 , pp. 289-298
    • Windisch, M.1    Gschanes, A.2    Hutter-Paier, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.