Neurotrophic effects of Cerebrolysin® in animal models of excitotoxicity

Journal of Neural Transmission, Supplement

Volumn , Issue 59, 2000, Pages 273-280

  Veinbergs, I ^a   Mante, M ^a   Mallory, M ^a   Masliah, E ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEREBROLYSIN; KAINIC ACID; NOOTROPIC AGENT; AMINO ACID; AMINO ACID RECEPTOR STIMULATING AGENT; NEUROPROTECTIVE AGENT;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CELL STRUCTURE; CONTROLLED STUDY; DEGENERATIVE DISEASE; EXCITOTOXICITY; LASER MICROSCOPY; MAZE TEST; NERVE CELL; NEUROPROTECTION; NEUROTROPISM; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; RAT; ANIMAL; BRAIN; C57BL MOUSE; CONFOCAL MICROSCOPY; DRUG ADMINISTRATION; DRUG ANTAGONISM; DRUG EFFECT; MOUSE; PATHOLOGY; SWIMMING;

AMINO ACIDS; ANIMALS; BRAIN; DRUG ADMINISTRATION SCHEDULE; EXCITATORY AMINO ACID AGONISTS; KAINIC ACID; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; NEUROPROTECTIVE AGENTS; SWIMMING;

EID: 0033624431     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6781-6_29     Document Type: Article

References (20)

1. Boado RJ (1996) Brain-derived peptides increase the expression of a blood-brain barrier GLUT1 glucose transporter reporter gene. Neurosci Lett 220: 53-56
2. Chen KS, Masliah E, Mallory M, Gage FH (1995) Synaptic loss in cognitively impaired rats is ameliorated by chronic NGF infusion. Neuroscience 68: 19-27
3. Choi DW (1987) Ionic dependence of glutamate neurotoxicity. J Neurosci 7: 369-379
4. Drejer J, Benveniste H, Diemer NH, Schousbue A (1985) Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro. J Neurochem 45: 145-151
5. Francis-Turner L, Valouskova V (1996) Nerve growth factor and nootropic drug Cerebrolysin but not fibroblast growth factor can reduce spatial memory impairment elicited by fimbria-fornix transection: short-term study. Neurosci Lett 202: 1-4
6. Gray CW, Patel AJ (1995) Neurodegeneration mediated by glutamate and β-amyloid peptide: a comparison and possible interaction. Brain Res 691: 169-179
7. Greenamyre JT, Porter RHP (1994) Anatomy and physiology of glutamate in the CNS. Neurology 44: S7-S13
8. Kofler B, Erhard C, Erhard P, Harrer G (1990) A multidementional approach in testing nootropic drug effects (cerebrolysin). Arch Gerontol Geriatr 10: 129-140
9. Masliah E, Fagan AM, Terry RD, DeTeresa R, Mallory M, Gage FH (1991) Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat. Exp Neurol 113: 131-142
10. Masliah E, Achim CL, Ge N, DeTeresa R, Terry RD, Wiley CA (1992a) Spectrum of human immunodeficiency virus-associated neocortical damage. Ann Neurol 32: 321-329
11. Masliah E, Ellisman M, Carragher B, Mallory M, Young S, Hansen L, DeTeresa R, Terry RD (1992b) Three-dimensional analysis of the relationship between synaptic pathology and neuropil threads in Alzheimer disease. J Neuropathol Exp Neurol 51: 404-414
12. Masliah E, Mallory M, Ge N, Alford M, Veinbergs I, Roses AD (1995) Neurodegeneration in the CNS of apoE-deficient mice. Exp Neurol 136: 107-122
13. Masliah E, Alford M, Salmon D, DeTeresa R, Mallory M, Hansen L (1996) Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease. Ann Neurol 40: 759-766
14. Masliah E, Westland CE, Abraham CR, Mallory M, Veinbergs I, Rockenstein EM, Mucke L (1997) Amyloid precursor protein protects neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience 78: 135-141
15. Masliah E, Amorsolo F, Veinbergs I, Mallory M, Samuel W (1999) Cerebrolysin ameliorates performance deficits and neuronal damage in apolipoprotein E-deficient mice. Pharmacol Biochem Beh 62: 239-245
16. Paier B, Windisch M, Eggenreich U (1992) Postnatal administration of two peptide solutions affects passive avoidance behaviour of young rats. Brain Res 51: 23-28
17. Ruther E, Ritter R, Apecechea M, Freytag S, Windisch M (1994) Efficacy of the peptidergic nootropic drug cerebrolysin in patients with senile dementia of the Alzheimer's type (SDAT). Pharmacopsychiatry 27: 32-40
18. Schwab M, Schaller R, Bauer R, Zwiener U (1997) Morphofunctional effects of moderate forebrain ischemia combined with short-term hypoxia in rats - protective effects of Cerebrolysin. Exp Toxicol Pathol 49: 29-37
19. Strain SM, Tasker RAR (1991) Hippocampal damage produced by systemic injections of domoic acid in mice. Neuroscience 44: 343-352
20. Whetsell WO Jr (1996) Current concepts of excitotoxicity. J Neuropathol Exp Neurol 55: 1-13