Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis

Acta Crystallographica Section F: Structural Biology and Crystallization Communications

Volumn 67, Issue 9, 2011, Pages 1070-1077

  Begley, Darren W ^a,b   Edwards, Thomas E ^a,b   Raymond, Amy C ^a,b   Smith, Eric R ^a,b   Hartley, Robert C ^a,b   Abendroth, Jan ^a,b   Sankaran, Banumathi ^c   Lorimer, Donald D ^a,b   Myler, Peter J ^a,d,e   Staker, Bart L ^a,b   Stewart, Lance J ^a,b  

^a Seattle Structural Genomics Center for Infectious Disease   (United States)

^b Emerald BioStructures Inc   (United States)

^c Berkeley Center for Structural Biology   (United States)

^d Seattle BioMed   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

antifolates; Babesia bovis; dihydrofolate reductase; pemetrexed; raltitrexed; SSGCID; thymidylate synthase

Indexed keywords

APOPROTEIN; DIHYDROFOLATE REDUCTASE; ENZYME INHIBITOR; LIGAND; MULTIENZYME COMPLEX; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE DIHYDROFOLATE REDUCTASE; THYMIDYLATE SYNTHASE-DIHYDROFOLATE REDUCTASE;

ARTICLE; BABESIA BOVIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY;

APOPROTEINS; BABESIA BOVIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; LIGANDS; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

BABESIA; BABESIA BOVIS; BOS; CANIS FAMILIARIS; EQUIDAE; EUKARYOTA; IXODIDA; MAMMALIA; PLASMODIUM (APICOMPLEXA); PLASMODIUM FALCIPARUM; RATTUS;

EID: 80052617984     PISSN: None     EISSN: 17443091     Source Type: Journal    
DOI: 10.1107/S1744309111029009     Document Type: Article

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