Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis

Biochemistry

Volumn 46, Issue 28, 2007, Pages 8379-8391

  Doan, Lanxuan T ^a   Martucci, W Edward ^a   Vargo, Melissa A ^a   Atreya, Chloé E ^a   Anderson, Karen S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTOSPORIDIUM HOMINIS; FOLATE-BINDING HELIX; MUTANT ENZYME; PHENYLALANINE;

AMINO ACIDS; CATALYSIS; CONFORMATIONS; CRYSTAL STRUCTURE; MUTAGENESIS; REACTION KINETICS;

BIOCHEMISTRY;

ALANINE; FOLIC ACID; GLYCINE; METHYLENETETRAHYDROFOLIC ACID; PHENYLALANINE; SERINE;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; COVALENT BOND; CRYPTOSPORIDIUM HOMINIS; CRYSTAL STRUCTURE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYPTOSPORIDIUM; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; QUINAZOLINES; SERINE; TETRAHYDROFOLATE DEHYDROGENASE; TETRAHYDROFOLATES; THYMIDINE MONOPHOSPHATE; THYMIDYLATE SYNTHASE;

CRYPTOSPORIDIUM HOMINIS;

EID: 34447566115     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700531r     Document Type: Article

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