Chemical modifications of resveratrol for improved protein kinase C alpha activity

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 18, 2011, Pages 5321-5333

  Das, Joydip ^a   Pany, Satyabrata ^a   Majhi, Anjoy ^a  

^a UNIVERSITY OF HOUSTON   (United States)

Author keywords

Activation; Fluorescence; Membrane translocation; Molecular docking; Protein kinase C; Resveratrol

Indexed keywords

1 (BROMOMETHYL) 3,5 BIS(HEXADECYLOXY)BENZENE; 1 (BROMOMETHYL) 3,5 BIS(OCTYLOXY)BENZENE; 1,2 BIS(3,4,5 TRIMETHOXYPHENYL)ETHENE; 1,3 DIMETHOXY 5 (4 METHOXYSTYRYL)BENZENE; 2 (HEXADECYLOXY) 1,3 DIMETHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)BENZENE; 4 (HEXADECYLOXY) 3,5 DIMETHOXYBENZALDEHYDE; 4 [(TERT BUTYLDIMETHYLSILYL)OXY]BENZALDEHYDE; 4 [3,5 BIS(HEXADECYLOXY)STYRYL]PHENOL; 4 [3,5 BIS(OCTYLOXY)STYRYL]PHENOL; 5 (BROMOMETHYL) 1,2,3 TRIMETHOXYBENZENE; 5 [3,5 DIHYDROXY 4 (OCTYLOXY)STYRYL]BENZENE 1,2,3 TRIOL; 5 [4 (HEXADECYLOXY)STYRYL]BENZENE 1,3 DIOL; 5 [4 (OCTYLOXY)STYRYL]BENZENE 1,3 DIOL; 5,5' (ETHENE 1,2 DIYL)BIS(BENZENE 1,2,3 TRIOL); [3,5 BIS(HEXADECYLOXY)PHENYL]METHANOL; [3,5 BIS(OCTYLOXY)PHENYL]METHANOL; CYTOTOXIC AGENT; DIETHYL (3,4,5 TRIMETHOXYBENZYL)PHOSPHINE OXIDE; DIETHYL 3,5 BIS(HEXADECYLOXY)BENZYLPHOSPHONATE; DIETHYL 3,5 BIS(OCTYLOXY)BENZYLPHOSPHONATE; PROTEIN KINASE C ALPHA; RESVERATROL; RESVERATROL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ABSORPTION; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; HYDROGEN BOND; IMMUNOREGULATION; MOLECULAR DOCKING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MOLECULAR STRUCTURE; PROTEIN KINASE C-ALPHA; STEREOISOMERISM; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRADECANOYLPHORBOL ACETATE;

EID: 80052584689     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.008     Document Type: Article

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