-
1
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-[kappa]B by Toll-like receptor 3
-
Alexopoulou, L., Holt, A. C., Medzhitov, R. and Flavell, R. A. (2001). Recognition of double-stranded RNA and activation of NF-[kappa]B by Toll-like receptor 3. Nature 413, 732-738.
-
(2001)
Nature
, vol.413
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
2
-
-
33646044395
-
WHISCY: What information does surface conservation yield? Application to data-driven docking
-
de Vries, S. J., van Dijk, A. D. and Bonvin, A. M. (2006). WHISCY: what information does surface conservation yield? Application to data-driven docking. Proteins 63, 479-489.
-
(2006)
Proteins
, vol.63
, pp. 479-489
-
-
de Vries, S.J.1
van Dijk, A.D.2
Bonvin, A.M.3
-
3
-
-
0035199166
-
Design and application of a cytokine-receptor-based interaction trap
-
Eyckerman, S., Verhee, A., der Heyden, J. V., Lemmens, I., Ostade, X. V., Vandekerckhove, J. and Tavernier, J. (2001). Design and application of a cytokine-receptor-based interaction trap. Nat. Cell Biol. 3, 1114-1119.
-
(2001)
Nat. Cell Biol
, vol.3
, pp. 1114-1119
-
-
Eyckerman, S.1
Verhee, A.2
der Heyden, J.V.3
Lemmens, I.4
Ostade, X.V.5
Vandekerckhove, J.6
Tavernier, J.7
-
4
-
-
0035817925
-
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
-
Fitzgerald, K. A., Palsson-McDermott, E. M., Bowie, A. G., Jefferies, C. A., Mansell, A. S., Brady, G., Brint, E., Dunne, A., Gray, P., Harte, M. T. et al. (2001). Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413, 78-83.
-
(2001)
Nature
, vol.413
, pp. 78-83
-
-
Fitzgerald, K.A.1
Palsson-McDermott, E.M.2
Bowie, A.G.3
Jefferies, C.A.4
Mansell, A.S.5
Brady, G.6
Brint, E.7
Dunne, A.8
Gray, P.9
Harte, M.T.10
-
5
-
-
0141959224
-
LPS-TLR4 signaling to IRF-3/7 and NF-{kappa}B involves the toll adapters TRAM and TRIF
-
Fitzgerald, K. A., Rowe, D. C., Barnes, B. J., Caffrey, D. R., Visintin, A., Latz, E., Monks, B., Pitha, P. M. and Golenbock, D. T. (2003). LPS-TLR4 signaling to IRF-3/7 and NF-{kappa}B involves the toll adapters TRAM and TRIF. J. Exp. Med. 198, 1043-1055.
-
(2003)
J. Exp. Med
, vol.198
, pp. 1043-1055
-
-
Fitzgerald, K.A.1
Rowe, D.C.2
Barnes, B.J.3
Caffrey, D.R.4
Visintin, A.5
Latz, E.6
Monks, B.7
Pitha, P.M.8
Golenbock, D.T.9
-
6
-
-
33744543517
-
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
-
Gray, P., Dunne, A., Brikos, C., Jefferies, C. A., Doyle, S. L. and O'Neill, L. A. (2006). MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J. Biol. Chem. 281, 10489-10495.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 10489-10495
-
-
Gray, P.1
Dunne, A.2
Brikos, C.3
Jefferies, C.A.4
Doyle, S.L.5
O'Neill, L.A.6
-
7
-
-
0035555301
-
TIRAP: An adapter molecule in the Toll signaling pathway
-
Horng, T., Barton, G. M. and Medzhitov, R. (2001). TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2, 835-841.
-
(2001)
Nat. Immunol
, vol.2
, pp. 835-841
-
-
Horng, T.1
Barton, G.M.2
Medzhitov, R.3
-
8
-
-
0037153130
-
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
-
Horng, T., Barton, G. M., Flavell, R. A. and Medzhitov, R. (2002). The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420, 329-333.
-
(2002)
Nature
, vol.420
, pp. 329-333
-
-
Horng, T.1
Barton, G.M.2
Flavell, R.A.3
Medzhitov, R.4
-
9
-
-
33746631265
-
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis
-
Jiang, Z., Georgel, P., Li, C., Choe, J., Crozat, K., Rutschmann, S., Du, X., Bigby, T., Mudd, S., Sovath, S. et al. (2006). Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. PNAS 103, 10961-10966.
-
(2006)
PNAS
, vol.103
, pp. 10961-10966
-
-
Jiang, Z.1
Georgel, P.2
Li, C.3
Choe, J.4
Crozat, K.5
Rutschmann, S.6
Du, X.7
Bigby, T.8
Mudd, S.9
Sovath, S.10
-
10
-
-
33646908228
-
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
-
Kagan, J. C. and Medzhitov, R. (2006). Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125, 943-955.
-
(2006)
Cell
, vol.125
, pp. 943-955
-
-
Kagan, J.C.1
Medzhitov, R.2
-
11
-
-
40949134086
-
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
-
Kagan, J. C., Su, T., Horng, T., Chow, A., Akira, S. and Medzhitov, R. (2008). TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat. Immunol. 9, 361-368.
-
(2008)
Nat. Immunol
, vol.9
, pp. 361-368
-
-
Kagan, J.C.1
Su, T.2
Horng, T.3
Chow, A.4
Akira, S.5
Medzhitov, R.6
-
13
-
-
3843055773
-
Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL
-
Khan, J. A., Brint, E. K., O'Neill, L. A. and Tong, L. (2004). Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. J. Biol. Chem. 279, 31664-31670.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 31664-31670
-
-
Khan, J.A.1
Brint, E.K.2
O'Neill, L.A.3
Tong, L.4
-
14
-
-
34047098731
-
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
-
Khor, C. C., Chapman, S. J., Vannberg, F. O., Dunne, A., Murphy, C., Ling, E. Y., Frodsham, A. J., Walley, A. J., Kyrieleis, O., Khan, A. et al. (2007). A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat. Genet. 39, 523-528.
-
(2007)
Nat. Genet
, vol.39
, pp. 523-528
-
-
Khor, C.C.1
Chapman, S.J.2
Vannberg, F.O.3
Dunne, A.4
Murphy, C.5
Ling, E.Y.6
Frodsham, A.J.7
Walley, A.J.8
Kyrieleis, O.9
Khan, A.10
-
15
-
-
0037075551
-
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
-
Kobayashi, K., Inohara, N., Hernandez, L. D., Galan, J. E., Núñez, G., Janeway, C. A., Medzhitov, R. and Flavell, R. A. (2002). RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416, 194-199.
-
(2002)
Nature
, vol.416
, pp. 194-199
-
-
Kobayashi, K.1
Inohara, N.2
Hernandez, L.D.3
Galan, J.E.4
Núñez, G.5
Janeway, C.A.6
Medzhitov, R.7
Flavell, R.A.8
-
16
-
-
2642517305
-
Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity
-
Lamkanfi, M., Kalai, M., Saelens, X., Declercq, W. and Vandenabeele, P. (2004). Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity. J. Biol. Chem. 279, 24785-24793.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 24785-24793
-
-
Lamkanfi, M.1
Kalai, M.2
Saelens, X.3
Declercq, W.4
Vandenabeele, P.5
-
17
-
-
34548436187
-
The negative regulation of Toll-like receptor and associated pathways
-
Lang, T. and Mansell, A. (2007). The negative regulation of Toll-like receptor and associated pathways. Immunol. Cell Biol. 85, 425-434.
-
(2007)
Immunol. Cell Biol
, vol.85
, pp. 425-434
-
-
Lang, T.1
Mansell, A.2
-
18
-
-
0242317457
-
Heteromeric MAPPIT: A novel strategy to study modification-dependent protein-protein interactions in mammalian cells
-
Lemmens, I., Eyckerman, S., Zabeau, L., Catteeuw, D., Vertenten, E., Verschueren, K., Huylebroeck, D., Vandekerckhove, J. and Tavernier, J. (2003). Heteromeric MAPPIT: a novel strategy to study modification-dependent protein-protein interactions in mammalian cells. Nucleic Acids Res. 31, e75.
-
(2003)
Nucleic Acids Res
, vol.31
-
-
Lemmens, I.1
Eyckerman, S.2
Zabeau, L.3
Catteeuw, D.4
Vertenten, E.5
Verschueren, K.6
Huylebroeck, D.7
Vandekerckhove, J.8
Tavernier, J.9
-
19
-
-
22544484235
-
Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway
-
Li, C., Zienkiewicz, J. and Hawiger, J. (2005). Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway. J. Biol. Chem. 280, 26152-26159.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 26152-26159
-
-
Li, C.1
Zienkiewicz, J.2
Hawiger, J.3
-
20
-
-
4444258208
-
Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4
-
Mansell, A., Brint, E., Gould, J. A., O'Neill, L. A. and Hertzog, P. J. (2004). Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4. J. Biol. Chem. 279, 37227-37230.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 37227-37230
-
-
Mansell, A.1
Brint, E.2
Gould, J.A.3
O'Neill, L.A.4
Hertzog, P.J.5
-
21
-
-
33847672241
-
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
-
Miggin, S. M., Palsson-McDermott, E., Dunne, A., Jefferies, C., Pinteaux, E., Banahan, K., Murphy, C., Moynagh, P., Yamamoto, M., Akira, S. et al. (2007). NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc. Natl. Acad. Sci. USA 104, 3372-3377.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 3372-3377
-
-
Miggin, S.M.1
Palsson-McDermott, E.2
Dunne, A.3
Jefferies, C.4
Pinteaux, E.5
Banahan, K.6
Murphy, C.7
Moynagh, P.8
Yamamoto, M.9
Akira, S.10
-
22
-
-
70350026642
-
A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling
-
Nagpal, K., Plantinga, T. S., Wong, J., Monks, B. G., Gay, N. J., Netea, M. G., Fitzgerald, K. A. and Golenbock, D. T. (2009). A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. J. Biol. Chem. 284, 25742-25748.
-
(2009)
J. Biol. Chem
, vol.284
, pp. 25742-25748
-
-
Nagpal, K.1
Plantinga, T.S.2
Wong, J.3
Monks, B.G.4
Gay, N.J.5
Netea, M.G.6
Fitzgerald, K.A.7
Golenbock, D.T.8
-
23
-
-
40749097627
-
A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
-
Núñez, M. R., Wong, J., Westoll, J. F., Brooks, H. J., O'Neill, L. A., Gay, N. J., Bryant, C. E. and Monie, T. P. (2007). A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLoS ONE. 2, e788.
-
(2007)
PLoS ONE
, vol.2
-
-
Núñez, M.R.1
Wong, J.2
Westoll, J.F.3
Brooks, H.J.4
O'Neill, L.A.5
Gay, N.J.6
Bryant, C.E.7
Monie, T.P.8
-
24
-
-
45549086115
-
The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer
-
Nyman, T., Stenmark, P., Flodin, S., Johansson, I., Hammarstrom, M. and Nordlund, P. (2008). The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer. J. Biol. Chem. 283, 11861-11865.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 11861-11865
-
-
Nyman, T.1
Stenmark, P.2
Flodin, S.3
Johansson, I.4
Hammarstrom, M.5
Nordlund, P.6
-
25
-
-
67649865588
-
Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling
-
Ohnishi, H., Tochio, H., Kato, Z., Orii, K. E., Li, A., Kimura, T., Hiroaki, H., Kondo, N. and Shirakawa, M. (2009). Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. Proc. Natl. Acad. Sci. USA 106, 10260-10265.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 10260-10265
-
-
Ohnishi, H.1
Tochio, H.2
Kato, Z.3
Orii, K.E.4
Li, A.5
Kimura, T.6
Hiroaki, H.7
Kondo, N.8
Shirakawa, M.9
-
26
-
-
0037320451
-
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-[beta] induction
-
Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T. and Seya, T. (2003a). TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-[beta] induction. Nat. Immunol. 4, 161-167.
-
(2003)
Nat. Immunol
, vol.4
, pp. 161-167
-
-
Oshiumi, H.1
Matsumoto, M.2
Funami, K.3
Akazawa, T.4
Seya, T.5
-
27
-
-
0345991221
-
TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-β
-
Oshiumi, H., Sasai, M., Shida, K., Fujita, T., Matsumoto, M. and Seya, T. (2003b). TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-β. J. Biol. Chem. 278, 49751-49762.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 49751-49762
-
-
Oshiumi, H.1
Sasai, M.2
Shida, K.3
Fujita, T.4
Matsumoto, M.5
Seya, T.6
-
28
-
-
4444221565
-
UCSF Chimera-a visualization system for exploratory research and analysis
-
Pettersen, E. F., Goddard, T. D., Huang, C. C., Couch, G. S., Greenblatt, D. M., Meng, E. C. and Ferrin, T. E. (2004). UCSF Chimera-a visualization system for exploratory research and analysis. J. Comput. Chem. 25, 1605-1612.
-
(2004)
J. Comput. Chem
, vol.25
, pp. 1605-1612
-
-
Pettersen, E.F.1
Goddard, T.D.2
Huang, C.C.3
Couch, G.S.4
Greenblatt, D.M.5
Meng, E.C.6
Ferrin, T.E.7
-
29
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
-
Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C. et al. (1998). Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088.
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
He, X.2
Smirnova, I.3
Liu, M.Y.4
Huffel, C.V.5
Du, X.6
Birdwell, D.7
Alejos, E.8
Silva, M.9
Galanos, C.10
-
30
-
-
54049126870
-
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases
-
Rebsamen, M., Meylan, E., Curran, J. and Tschopp, J. (2008). The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases. Cell Death. Differ. 15, 1804-1811.
-
(2008)
Cell Death. Differ
, vol.15
, pp. 1804-1811
-
-
Rebsamen, M.1
Meylan, E.2
Curran, J.3
Tschopp, J.4
-
31
-
-
0037379201
-
Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets
-
Ronni, T., Agarwal, V., Haykinson, M., Haberland, M. E., Cheng, G. and Smale, S. T. (2003). Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets. Mol. Cell. Biol. 23, 2543-2555.
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 2543-2555
-
-
Ronni, T.1
Agarwal, V.2
Haykinson, M.3
Haberland, M.E.4
Cheng, G.5
Smale, S.T.6
-
32
-
-
33645757512
-
ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions
-
Sarkar, A., Duncan, M., Hart, J., Hertlein, E., Guttridge, D. C. and Wewers, M. D. (2006). ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J. Immunol. 176, 4979-4986.
-
(2006)
J. Immunol
, vol.176
, pp. 4979-4986
-
-
Sarkar, A.1
Duncan, M.2
Hart, J.3
Hertlein, E.4
Guttridge, D.C.5
Wewers, M.D.6
-
33
-
-
0034283578
-
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
-
Stennicke, H. R., Renatus, M., Meldal, M. and Salvesen, G. S. (2000). Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8. Biochem. J. 350, 563-568.
-
(2000)
Biochem. J
, vol.350
, pp. 563-568
-
-
Stennicke, H.R.1
Renatus, M.2
Meldal, M.3
Salvesen, G.S.4
-
34
-
-
40149083727
-
MAPPIT analysis of early Toll-like receptor signalling events
-
Ulrichts, P. and Tavernier, J. (2008). MAPPIT analysis of early Toll-like receptor signalling events. Immunol. Lett. 116, 141-148.
-
(2008)
Immunol. Lett
, vol.116
, pp. 141-148
-
-
Ulrichts, P.1
Tavernier, J.2
-
35
-
-
33846785260
-
MAPPIT analysis of TLR adaptor complexes
-
Ulrichts, P., Peelman, F., Beyaert, R. and Tavernier, J. (2007). MAPPIT analysis of TLR adaptor complexes. FEBS Lett. 581, 629-636.
-
(2007)
FEBS Lett
, vol.581
, pp. 629-636
-
-
Ulrichts, P.1
Peelman, F.2
Beyaert, R.3
Tavernier, J.4
-
36
-
-
0031423761
-
MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
-
Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. and Cao, Z. (1997). MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7, 837-847.
-
(1997)
Immunity
, vol.7
, pp. 837-847
-
-
Wesche, H.1
Henzel, W.J.2
Shillinglaw, W.3
Li, S.4
Cao, Z.5
-
37
-
-
0034597766
-
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
-
Xu, Y., Tao, X., Shen, B., Horng, T., Medzhitov, R., Manley, J. L. and Tong, L. (2000). Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408, 111-115.
-
(2000)
Nature
, vol.408
, pp. 111-115
-
-
Xu, Y.1
Tao, X.2
Shen, B.3
Horng, T.4
Medzhitov, R.5
Manley, J.L.6
Tong, L.7
-
38
-
-
0037153191
-
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
-
Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T. et al. (2002). Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420, 324-329.
-
(2002)
Nature
, vol.420
, pp. 324-329
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
Sanjo, H.4
Uematsu, S.5
Kaisho, T.6
Hoshino, K.7
Takeuchi, O.8
Kobayashi, M.9
Fujita, T.10
-
39
-
-
0033168728
-
Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
-
Yoshimura, A., Lien, E., Ingalls, R. R., Tuomanen, E., Dziarski, R. and Golenbock, D. (1999). Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 163, 1-5.
-
(1999)
J. Immunol
, vol.163
, pp. 1-5
-
-
Yoshimura, A.1
Lien, E.2
Ingalls, R.R.3
Tuomanen, E.4
Dziarski, R.5
Golenbock, D.6
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