Enhanced specificity of the viral suppressor of RNA silencing protein p19 toward sequestering of human microRNA-122

Biochemistry

Volumn 50, Issue 36, 2011, Pages 7745-7755

  Cheng, Jenny ^a   Danielson, Dana C ^a,c   Nasheri, Neda ^a,c   Singaravelu, Ragunath ^a,c   Pezacki, John Paul ^a,b,c  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SURFACE; DIMERIC PROTEINS; HUMAN HEPATOMA CELL LINES; HUMAN LIVER; HYDROGEN BONDING INTERACTIONS; MICRORNAS; MUTATIONAL ANALYSIS; POST-TRANSCRIPTIONAL; RNA SILENCING; RNA-INDUCED SILENCING COMPLEXES; SIDE-CHAINS; SINGLE RESIDUE; SITE DIRECTED MUTAGENESIS; SIZE SELECTIVITY; SMALL RNA; WILD TYPES;

CELL CULTURE; GENES; HYDROGEN BONDS; PROTEINS;

RNA;

HYDROGEN; MICRORNA 122; MUTANT PROTEIN; PROTEIN P19; RNA; RNA INDUCED SILENCING COMPLEX; SIRNA 027; UNCLASSIFIED DRUG;

ARTICLE; BASE MISPAIRING; ENZYME SPECIFICITY; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENE SILENCING; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROGEN BOND; MUTATIONAL ANALYSIS; PLASMID; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

BINDING SITES; CELL LINE, TUMOR; CIRCULAR DICHROISM; GENOME, VIRAL; HUMANS; HYDROGEN BONDING; MICRORNAS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; RNA INTERFERENCE; TOBACCO; TOMBUSVIRUS; TRANSFECTION; VIRAL PROTEINS;

EUKARYOTA;

EID: 80052467119     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2008273     Document Type: Article

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