Crystal structure of Rsr, an ortholog of the antigenic Ro protein, links conformational flexibility to RNA binding activity

Journal of Biological Chemistry

Volumn 282, Issue 20, 2007, Pages 14960-14967

  Ramesh, Arati ^a   Savva, Christos G ^a,b   Holzenburg, Andreas ^a,b   Sacchettini, James C ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Texas AandM University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENIC RO PROTEIN; CONFORMATIONAL FLEXIBILITY; DIVALENT METAL; HELICAL DOMAIN; HIGH RESOLUTION STRUCTURE; LUPUS ERYTHEMATOSUS; RHEUMATIC AUTOIMMUNE;

ANTIGENS; BINDING SITES; CONFORMATIONS; CRYSTAL STRUCTURE; DISEASES; RNA; ULTRAVIOLET RADIATION;

PROTEINS;

RIBONUCLEOPROTEIN; RNA; RO RIBONUCLEOPROTEIN; RSR RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; METAL; SS A ANTIGEN; SS-A ANTIGEN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEINOCOCCUS RADIODURANS; EUKARYOTE; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN RNA BINDING; CHEMISTRY; DEINOCOCCUS; GENETICS; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); DEINOCOCCUS RADIODURANS; EUKARYOTA; PROKARYOTA;

BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DEINOCOCCUS; HUMANS; METALS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEOPROTEINS; RNA; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34447538488     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611163200     Document Type: Article

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