-
1
-
-
0028018223
-
Non-small-cell lung cancer. Toward the next plateau
-
Vokes EE, Bitran JD. Non-small-cell lung cancer. Toward the next plateau. Chest 1994; 106:659-61.
-
(1994)
Chest
, vol.106
, pp. 659-661
-
-
Vokes, E.E.1
Bitran, J.D.2
-
2
-
-
0022640642
-
A randomized trial of the four most active regimens for metastatic non-small-cell lung cancer
-
Ruckdeschel JC, Finkelstein DM, Ettinger DS, et al. A randomized trial of the four most active regimens for metastatic non-small-cell lung cancer. J Clin Oncol 1986; 4:14-22.
-
(1986)
J Clin Oncol
, vol.4
, pp. 14-22
-
-
Ruckdeschel, J.C.1
Finkelstein, D.M.2
Ettinger, D.S.3
-
3
-
-
84971581087
-
Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials
-
Non-small Cell Lung Cancer Collaborative Group
-
Non-small Cell Lung Cancer Collaborative Group. Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ 1995; 311:899-909.
-
(1995)
BMJ
, vol.311
, pp. 899-909
-
-
-
4
-
-
0023922084
-
Chemotherapy can prolong survival in patients with advanced non-small-cell lung cancer - report of a Canadian multicenter randomized trial
-
Rapp E, Pater JL, Willan A, et al. Chemotherapy can prolong survival in patients with advanced non-small-cell lung cancer - report of a Canadian multicenter randomized trial. J Clin Oncol 1988; 6:633-41.
-
(1988)
J Clin Oncol
, vol.6
, pp. 633-641
-
-
Rapp, E.1
Pater, J.L.2
Willan, A.3
-
5
-
-
0032887573
-
Mitomycin, ifosfamide, and cisplatin in unresectable non-small-cell lung cancer: Effects on survival and quality of life
-
Cullen MH, Billingham LJ, Woodroffe CM, et al. Mitomycin, ifosfamide, and cisplatin in unresectable non-small-cell lung cancer: effects on survival and quality of life. J Clin Oncol 1999; 17:3188-94.
-
(1999)
J Clin Oncol
, vol.17
, pp. 3188-3194
-
-
Cullen, M.H.1
Billingham, L.J.2
Woodroffe, C.M.3
-
6
-
-
0025787507
-
A randomized trial of alternating chemotherapy versus best supportive care in advanced non-small-cell lung cancer
-
Cellerino R, Tummarello D, Guidi F, et al. A randomized trial of alternating chemotherapy versus best supportive care in advanced non-small-cell lung cancer. J Clin Oncol 1991; 9:1453-61.
-
(1991)
J Clin Oncol
, vol.9
, pp. 1453-1461
-
-
Cellerino, R.1
Tummarello, D.2
Guidi, F.3
-
7
-
-
0027159808
-
Cisplatin-cyclophosphamide- mitomycin combination chemotherapy with supportive care versus supportive care alone for treatment of metastatic non-small-cell lung cancer
-
Cartei G, Cartei F, Cantone A, et al. Cisplatin-cyclophosphamide- mitomycin combination chemotherapy with supportive care versus supportive care alone for treatment of metastatic non-small-cell lung cancer. J Natl Cancer Inst 1993; 85:794-800.
-
(1993)
J Natl Cancer Inst
, vol.85
, pp. 794-800
-
-
Cartei, G.1
Cartei, F.2
Cantone, A.3
-
8
-
-
6344254442
-
Chemotherapy versus supportive care in advanced non-small cell lung cancer: Improved survival without detriment to quality of life
-
Spiro SG, Rudd RM, Souhami RL, et al. Chemotherapy versus supportive care in advanced non-small cell lung cancer: improved survival without detriment to quality of life. Thorax 2004; 59:828-36.
-
(2004)
Thorax
, vol.59
, pp. 828-836
-
-
Spiro, S.G.1
Rudd, R.M.2
Souhami, R.L.3
-
9
-
-
3042741125
-
Are chemotherapy response rates related to treatment-induced survival prolongations in patients with advanced cancer?
-
Shanafelt TD, Loprinzi C, Marks R, et al. Are chemotherapy response rates related to treatment-induced survival prolongations in patients with advanced cancer? J Clin Oncol 2004; 22:1966-74.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1966-1974
-
-
Shanafelt, T.D.1
Loprinzi, C.2
Marks, R.3
-
10
-
-
33144474858
-
Should chemotherapy combinations for advanced non-small cell lung cancer be platinum-based? A meta-analysis of phase III randomized trials
-
Pujol JL, Barlesi F, Daures JP. Should chemotherapy combinations for advanced non-small cell lung cancer be platinum-based? A meta-analysis of phase III randomized trials. Lung Cancer 2006; 51:335-45.
-
(2006)
Lung Cancer
, vol.51
, pp. 335-345
-
-
Pujol, J.L.1
Barlesi, F.2
Daures, J.P.3
-
11
-
-
17344384668
-
Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patients with locally advanced or metastatic non-small-cell lung cancer
-
Sandler AB, Nemunaitis J, Denham C, et al. Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patients with locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2000; 18:122-30.
-
(2000)
J Clin Oncol
, vol.18
, pp. 122-130
-
-
Sandler, A.B.1
Nemunaitis, J.2
Denham, C.3
-
12
-
-
33644684204
-
Phase III trial of gemcitabine plus carboplatin versus single-agent gemcitabine in the treatment of locally advanced or metastatic non-small-cell lung cancer: The Swedish Lung Cancer Study Group
-
Sederholm C, Hillerdal G, Lamberg K, et al. Phase III trial of gemcitabine plus carboplatin versus single-agent gemcitabine in the treatment of locally advanced or metastatic non-small-cell lung cancer: the Swedish Lung Cancer Study Group. J Clin Oncol 2005; 23:8380-8.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8380-8388
-
-
Sederholm, C.1
Hillerdal, G.2
Lamberg, K.3
-
13
-
-
4344683671
-
Docetaxel versus docetaxel plus cisplatin as front-line treatment of patients with advanced non-small-cell lung cancer: A randomized, multicenter phase III trial
-
Georgoulias V, Ardavanis A, Agelidou A, et al. Docetaxel versus docetaxel plus cisplatin as front-line treatment of patients with advanced non-small-cell lung cancer: a randomized, multicenter phase III trial. J Clin Oncol 2004; 22:2602-9.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2602-2609
-
-
Georgoulias, V.1
Ardavanis, A.2
Agelidou, A.3
-
14
-
-
0028154069
-
Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: Results of a European multicenter trial including 612 patients
-
Le Chevalier T, Brisgand D, Douillard JY, et al. Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: results of a European multicenter trial including 612 patients. J Clin Oncol 1994; 12:360-7.
-
(1994)
J Clin Oncol
, vol.12
, pp. 360-367
-
-
Le Chevalier, T.1
Brisgand, D.2
Douillard, J.Y.3
-
15
-
-
0037050352
-
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
-
Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 2002; 346:92-8.
-
(2002)
N Engl J Med
, vol.346
, pp. 92-98
-
-
Schiller, J.H.1
Harrington, D.2
Belani, C.P.3
-
16
-
-
16644396077
-
Single-agent versus combination chemotherapy in advanced non-small-cell lung cancer: The Cancer and Leukemia Group B (study 9730)
-
Lilenbaum RC, Herndon JE II, List MA, et al. Single-agent versus combination chemotherapy in advanced non-small-cell lung cancer: the Cancer and Leukemia Group B (study 9730). J Clin Oncol 2005; 23:190-6.
-
(2005)
J Clin Oncol
, vol.23
, pp. 190-196
-
-
Lilenbaum, R.C.1
Herndon II, J.E.2
List, M.A.3
-
17
-
-
0346560025
-
Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: A phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group - EORTC 08975
-
Smit EF, van Meerbeeck JP, Lianes P, et al. Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: a phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group - EORTC 08975. J Clin Oncol 2003; 21:3909-17.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3909-3917
-
-
Smit, E.F.1
van Meerbeeck, J.P.2
Lianes, P.3
-
18
-
-
33846906016
-
Matrix metalloproteinases (MMPs): Chemical-biological functions and (Q)SARs
-
Verma RP, Hansch C. Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs. Bioorg Med Chem 2007; 15:2223-68.
-
(2007)
Bioorg Med Chem
, vol.15
, pp. 2223-2268
-
-
Verma, R.P.1
Hansch, C.2
-
19
-
-
34249309574
-
Matrix metalloproteinase-induced epithelial-mesenchymal transition: Tumor progression at snail's pace
-
Przybylo JA, Radisky DC. Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at snail's pace. Int J Biochem Cell Biol 2007; 39:1082-8.
-
(2007)
Int J Biochem Cell Biol
, vol.39
, pp. 1082-1088
-
-
Przybylo, J.A.1
Radisky, D.C.2
-
20
-
-
21044453902
-
Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18
-
Leighl NB, Paz-Ares L, Douillard JY, et al. Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18. J Clin Oncol 2005; 23:2831-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2831-2839
-
-
Leighl, N.B.1
Paz-Ares, L.2
Douillard, J.Y.3
-
21
-
-
20044388325
-
Phase III study of matrix metalloproteinase inhibitor prinomastat in non-small-cell lung cancer
-
Bissett D, O'Byrne KJ, von Pawel J, et al. Phase III study of matrix metalloproteinase inhibitor prinomastat in non-small-cell lung cancer. J Clin Oncol 2005; 23:842-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 842-849
-
-
Bissett, D.1
O'Byrne, K.J.2
von Pawel, J.3
-
22
-
-
0001185393
-
Phase III study of the matrix metalloprotease (MMP) inhibitor prinomastat in patients having advanced non-small cell lung cancer (NSCLC)
-
Smylie M, Mercier R, Aboulafia D, et al. Phase III study of the matrix metalloprotease (MMP) inhibitor prinomastat in patients having advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2001; 20:307a.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Smylie, M.1
Mercier, R.2
Aboulafia, D.3
-
23
-
-
0032791421
-
Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: Single agent and combination chemotherapy studies
-
Shalinsky DR, Brekken J, Zou H, et al. Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies. Clin Cancer Res 1999; 5:1905-17.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 1905-1917
-
-
Shalinsky, D.R.1
Brekken, J.2
Zou, H.3
-
24
-
-
0032837028
-
Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials
-
Shalinsky DR, Brekken J, Zou H, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. Ann N Y Acad Sci 1999; 878:236-70.
-
(1999)
Ann N Y Acad Sci
, vol.878
, pp. 236-270
-
-
Shalinsky, D.R.1
Brekken, J.2
Zou, H.3
-
25
-
-
0036118399
-
Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer
-
Bonomi P. Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer. Semin Oncol 2002; 29:78-86.
-
(2002)
Semin Oncol
, vol.29
, pp. 78-86
-
-
Bonomi, P.1
-
26
-
-
10744222424
-
Phase I and pharmacokinetic study of prinomastat, a matrix metalloprotease inhibitor
-
Hande KR, Collier M, Paradiso L, et al. Phase I and pharmacokinetic study of prinomastat, a matrix metalloprotease inhibitor. Clin Cancer Res 2004; 10:909-15.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 909-915
-
-
Hande, K.R.1
Collier, M.2
Paradiso, L.3
-
27
-
-
0242455819
-
Randomized phase III trial of chemotherapy and antisense oligonucleotide LY900003 (ISIS 3521) in patients with advanced NSCLC: Initial report
-
Abstract 2504
-
Lynch TJ, Raju R, Lind M, et al. Randomized phase III trial of chemotherapy and antisense oligonucleotide LY900003 (ISIS 3521) in patients with advanced NSCLC: initial report. Proc Am Soc Clin Oncol 2003; 22 (Abstract 2504).
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Lynch, T.J.1
Raju, R.2
Lind, M.3
-
28
-
-
33750615794
-
Randomized phase III trial of gemcitabine/cisplatin (GC) and protein kinase C a (PKCa) antisense oligonucleotide aprinocarsen in patients (pts) with advanced stage non-small cell lung cancer (NSCLC)
-
Abstract 7053
-
Paz-Ares L, Douillard J, Koralewski P, et al. Randomized phase III trial of gemcitabine/cisplatin (GC) and protein kinase C a (PKCa) antisense oligonucleotide aprinocarsen in patients (pts) with advanced stage non-small cell lung cancer (NSCLC). J Clin Oncol 2005; 23 (Abstract 7053).
-
(2005)
J Clin Oncol
, pp. 23
-
-
Paz-Ares, L.1
Douillard, J.2
Koralewski, P.3
-
29
-
-
85031355074
-
-
Jassem J, Zatloukal P, Ramlau R, et al. A randomized phase III trial comparing bexarotene/cisplatin/vinorelbine versus cisplatin/vinorelbine in chemotherapy-naive patients with advanced or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 2005; 23(16 suppl):627s (Abstract 7024).
-
Jassem J, Zatloukal P, Ramlau R, et al. A randomized phase III trial comparing bexarotene/cisplatin/vinorelbine versus cisplatin/vinorelbine in chemotherapy-naive patients with advanced or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 2005; 23(16 suppl):627s (Abstract 7024).
-
-
-
-
30
-
-
85031365662
-
-
Blumenschein GR, Khuri F, Gatzemeier U, et al. A randomized phase III trial comparing bexarotene/carboplatin/paclitaxel versus carboplatin/paclitaxel in chemotherapy-naive patients with advanced or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 2005; 23(16 suppl):621s (Abstract 7001).
-
Blumenschein GR, Khuri F, Gatzemeier U, et al. A randomized phase III trial comparing bexarotene/carboplatin/paclitaxel versus carboplatin/paclitaxel in chemotherapy-naive patients with advanced or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 2005; 23(16 suppl):621s (Abstract 7001).
-
-
-
-
31
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006; 355:2542-50.
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
32
-
-
85031368159
-
-
Manegold C, von Pawel J, Zatloukal P, et al. Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naïve patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704. J Clin Oncol 2007; 25(18 suppl):388s (Abstract LBA7514).
-
Manegold C, von Pawel J, Zatloukal P, et al. Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naïve patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704. J Clin Oncol 2007; 25(18 suppl):388s (Abstract LBA7514).
-
-
-
-
33
-
-
39049152256
-
A randomized multicenter phase III study of cetuximab (Erbitux) in combination with taxane/carboplatin versus taxane/carboplatin alone as first-line treatment for patients with advanced/metastatic non-small cell lung cancer (NSCLC)(B3-03)
-
Presented at: September 2-6, Seoul, Korea
-
Lynch T, Patel T, Dreisbach L, et al. A randomized multicenter phase III study of cetuximab (Erbitux) in combination with taxane/carboplatin versus taxane/carboplatin alone as first-line treatment for patients with advanced/metastatic non-small cell lung cancer (NSCLC)(B3-03). Presented at: the 12th World Conference on Lung Cancer; September 2-6, 2007; Seoul, Korea.
-
(2007)
the 12th World Conference on Lung Cancer
-
-
Lynch, T.1
Patel, T.2
Dreisbach, L.3
-
34
-
-
4444238981
-
Results of a phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer (NSCLC)
-
Abstract 7010
-
Gatzemeier U, Pluzanska A, Szczesna A, et al. Results of a phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer (NSCLC). Proc Amer Soc Clin Oncol 2004; 23:617 (Abstract 7010).
-
(2004)
Proc Amer Soc Clin Oncol
, vol.23
, pp. 617
-
-
Gatzemeier, U.1
Pluzanska, A.2
Szczesna, A.3
-
35
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1
-
Giaccone G, Herbst RS, Manegold C, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 1. J Clin Oncol 2004; 22:777-84.
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
-
36
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
-
Herbst RS, Giaccone G, Schiller JH, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 2. J Clin Oncol 2004; 22:785-94.
-
(2004)
J Clin Oncol
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
-
37
-
-
24944440830
-
TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
-
Herbst RS, Prager D, Hermann R, et al. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2005; 23:5892-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5892-5899
-
-
Herbst, R.S.1
Prager, D.2
Hermann, R.3
-
39
-
-
62349107301
-
A phase III randomised study of first-line bevacizumab combined with cisplatin/gemcitabine (CG) in patients with advanced or recurrent non-squamous, non-small cell lung cancer (NSCLC)
-
Presented at: September 12-16, Stockholm, Sweden. Abstract
-
Manegold C, von Pawel J, Zatloukal P, et al. A phase III randomised study of first-line bevacizumab combined with cisplatin/gemcitabine (CG) in patients with advanced or recurrent non-squamous, non-small cell lung cancer (NSCLC). Presented at: 2008 European Society for Medical Oncology conference; September 12-16, 2008; Stockholm, Sweden. Abstract LBA1.
-
(2008)
2008 European Society for Medical Oncology conference
-
-
Manegold, C.1
von Pawel, J.2
Zatloukal, P.3
-
40
-
-
85031347764
-
-
Pirker R, Szczesna A, von Pawel J, et al. FLEX: a randomized, multicenter, phase III study of cetuximab in combination with cisplatin/vinorelbine (CV) versus CV alone in the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2008; 26(15 suppl):6s (Abstract 3).
-
Pirker R, Szczesna A, von Pawel J, et al. FLEX: a randomized, multicenter, phase III study of cetuximab in combination with cisplatin/vinorelbine (CV) versus CV alone in the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2008; 26(15 suppl):6s (Abstract 3).
-
-
-
-
41
-
-
85031352574
-
-
Bristol-Myers Squibb Pharmaceutical Research Institute Investigator Brochure, Matrix metalloproteinase inhibitor BMS-275291, version 4. Wallingford CT, Bristol-Myers Squibb; 2002
-
Bristol-Myers Squibb Pharmaceutical Research Institute Investigator Brochure - Matrix metalloproteinase inhibitor BMS-275291, version 4. Wallingford (CT): Bristol-Myers Squibb; 2002.
-
-
-
-
42
-
-
8444248227
-
Randomized phase II feasibility study of combining the matrix metalloproteinase inhibitor BMS-275291 with paclitaxel plus carboplatin in advanced non-small cell lung cancer
-
Douillard JY, Peschel C, Shepherd F, et al. Randomized phase II feasibility study of combining the matrix metalloproteinase inhibitor BMS-275291 with paclitaxel plus carboplatin in advanced non-small cell lung cancer. Lung Cancer 2004; 46:361-8.
-
(2004)
Lung Cancer
, vol.46
, pp. 361-368
-
-
Douillard, J.Y.1
Peschel, C.2
Shepherd, F.3
-
43
-
-
0042466484
-
Antisense strategies targeting protein kinase C: Preclinical and clinical development
-
Tortora G, Ciardiello F. Antisense strategies targeting protein kinase C: preclinical and clinical development. Semin Oncol 2003; 30:26-31.
-
(2003)
Semin Oncol
, vol.30
, pp. 26-31
-
-
Tortora, G.1
Ciardiello, F.2
-
44
-
-
10244267435
-
Expression levels of protein kinase C-alpha in non-small-cell lung cancer
-
Lahn M, Su C, Li S, et al. Expression levels of protein kinase C-alpha in non-small-cell lung cancer. Clin Lung Cancer 2004; 6:184-9.
-
(2004)
Clin Lung Cancer
, vol.6
, pp. 184-189
-
-
Lahn, M.1
Su, C.2
Li, S.3
-
45
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
Bos JL. Ras oncogenes in human cancer: a review. Cancer Res 1989; 49:4682-9.
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
47
-
-
0033729718
-
The farnesyl protein transferase inhibitor SCH66336 synergizes with taxanes in vitro and enhances their antitumor activity in vivo
-
Shi B, Yaremko B, Hajian G, et al. The farnesyl protein transferase inhibitor SCH66336 synergizes with taxanes in vitro and enhances their antitumor activity in vivo. Cancer Chemother Pharmacol 2000; 46:387-93.
-
(2000)
Cancer Chemother Pharmacol
, vol.46
, pp. 387-393
-
-
Shi, B.1
Yaremko, B.2
Hajian, G.3
-
48
-
-
0034905234
-
Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines
-
Adjei AA, Davis JN, Bruzek LM, et al. Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines. Clin Cancer Res 2001; 7:1438-45.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1438-1445
-
-
Adjei, A.A.1
Davis, J.N.2
Bruzek, L.M.3
-
49
-
-
1842471336
-
Signaling through the epidermal growth factor receptor during the development of malignancy
-
Grandis JR, Sok JC. Signaling through the epidermal growth factor receptor during the development of malignancy. Pharmacol Ther 2004; 102:37-46.
-
(2004)
Pharmacol Ther
, vol.102
, pp. 37-46
-
-
Grandis, J.R.1
Sok, J.C.2
-
50
-
-
33750627160
-
Integrating new targeted agents into the treatment of non-small-cell lung cancer
-
Thatcher N. Integrating new targeted agents into the treatment of non-small-cell lung cancer. Lung Cancer 2006; 54(suppl 2):S25-S31.
-
(2006)
Lung Cancer
, vol.54
, Issue.SUPPL. 2
-
-
Thatcher, N.1
-
51
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 trial) [corrected]
-
Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 trial) [corrected]. J Clin Oncol 2003; 21:2237-46.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
-
52
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
-
Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003; 290:2149-58.
-
(2003)
JAMA
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
-
53
-
-
85031351595
-
-
Tarceva [package insert, South San Francisco CA, Genentech, Inc; 2007
-
Tarceva [package insert]. South San Francisco (CA): Genentech, Inc; 2007.
-
-
-
-
54
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005; 353:123-32.
-
(2005)
N Engl J Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
-
55
-
-
85031365706
-
-
Erbitux [package insert, Princeton NJ, Bristol-Myers Squibb Company; 2007
-
Erbitux [package insert]. Princeton (NJ): Bristol-Myers Squibb Company; 2007.
-
-
-
-
56
-
-
85031357824
-
-
Butts CA, Bodkin D, Middleman EL, et al. Gemcitabine/platinum alone or in combination with cetuximab as first-line treatment for advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007; 25(18 suppl):394s (Abstract 7539).
-
Butts CA, Bodkin D, Middleman EL, et al. Gemcitabine/platinum alone or in combination with cetuximab as first-line treatment for advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007; 25(18 suppl):394s (Abstract 7539).
-
-
-
-
57
-
-
85031352891
-
-
Herbst RS, Chansky K, Kelly K, et al. A phase II randomized selection trial evaluating concurrent chemotherapy plus cetuximab or chemotherapy followed by cetuximab in patients with advanced non-small cell lung cancer (NSCLC): final report of SWOG 0342. J Clin Oncol 2007; 25(18 suppl):395s (Abstract 7545).
-
Herbst RS, Chansky K, Kelly K, et al. A phase II randomized selection trial evaluating concurrent chemotherapy plus cetuximab or chemotherapy followed by cetuximab in patients with advanced non-small cell lung cancer (NSCLC): final report of SWOG 0342. J Clin Oncol 2007; 25(18 suppl):395s (Abstract 7545).
-
-
-
-
58
-
-
85031365211
-
-
Von Pawel J, Park K, Pereira JR, et al. Phase III study comparing cisplatin/vinorelbine plus cetuximab versus cisplatin/vinorelbine as first-line treatment for patients with epidermal growth factor (EGFR)-expressing advanced non-small cell lung cancer (NSCLC) (FLEX). J Clin Oncol 2006; 24(18 suppl):391s (Abstract 7109).
-
Von Pawel J, Park K, Pereira JR, et al. Phase III study comparing cisplatin/vinorelbine plus cetuximab versus cisplatin/vinorelbine as first-line treatment for patients with epidermal growth factor (EGFR)-expressing advanced non-small cell lung cancer (NSCLC) (FLEX). J Clin Oncol 2006; 24(18 suppl):391s (Abstract 7109).
-
-
-
-
59
-
-
12844273744
-
Emerging role of rexinoids in non-small cell lung cancer: Focus on bexarotene
-
Rigas JR, Dragnev KH. Emerging role of rexinoids in non-small cell lung cancer: focus on bexarotene. Oncologist 2005; 10:22-33.
-
(2005)
Oncologist
, vol.10
, pp. 22-33
-
-
Rigas, J.R.1
Dragnev, K.H.2
-
60
-
-
0032736668
-
Retinoids in lung cancer chemoprevention and treatment
-
Toma S, Raffo P, Isnardi L, et al. Retinoids in lung cancer chemoprevention and treatment. Ann Oncol 1999; 10(suppl):S95-S102.
-
(1999)
Ann Oncol
, vol.10
, Issue.SUPPL.
-
-
Toma, S.1
Raffo, P.2
Isnardi, L.3
-
61
-
-
0036184660
-
The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer
-
Brabender J, Danenberg KD, Metzger R, et al. The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer. Clin Cancer Res 2002; 8:438-43.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 438-443
-
-
Brabender, J.1
Danenberg, K.D.2
Metzger, R.3
-
62
-
-
0030997822
-
Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: Implications for lung cancer development
-
Xu XC, Sozzi G, Lee JS, et al. Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development. J Natl Cancer Inst 1997; 89:624-9.
-
(1997)
J Natl Cancer Inst
, vol.89
, pp. 624-629
-
-
Xu, X.C.1
Sozzi, G.2
Lee, J.S.3
-
63
-
-
0028087742
-
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids
-
Boehm MF, Zhang L, Badea BA, et al. Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. J Med Chem 1994; 37:2930-41.
-
(1994)
J Med Chem
, vol.37
, pp. 2930-2941
-
-
Boehm, M.F.1
Zhang, L.2
Badea, B.A.3
-
64
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285:1182-6.
-
(1971)
N Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
66
-
-
0035187771
-
Vascular endothelial growth factor: Its prognostic, predictive, and therapeutic implications
-
Toi M, Matsumoto T, Bando H. Vascular endothelial growth factor: its prognostic, predictive, and therapeutic implications. Lancet Oncol 2001; 2:667-73.
-
(2001)
Lancet Oncol
, vol.2
, pp. 667-673
-
-
Toi, M.1
Matsumoto, T.2
Bando, H.3
-
67
-
-
13444278498
-
Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
-
Gerber HP, Ferrara N. Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res 2005; 65:671-80.
-
(2005)
Cancer Res
, vol.65
, pp. 671-680
-
-
Gerber, H.P.1
Ferrara, N.2
-
68
-
-
0029949160
-
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
-
Yuan F, Chen Y, Dellian M, et al. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci U S A 1996; 93:14765-70.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 14765-14770
-
-
Yuan, F.1
Chen, Y.2
Dellian, M.3
-
69
-
-
0036189478
-
Dynamic contrast-enhanced magnetic resonance imaging as a surrogate marker of tumor response to anti-angiogenic therapy in a xenograft model of glioblastoma multiforme
-
Gossmann A, Helbich TH, Kuriyama N, et al. Dynamic contrast-enhanced magnetic resonance imaging as a surrogate marker of tumor response to anti-angiogenic therapy in a xenograft model of glioblastoma multiforme. J Magn Reson Imaging 2002; 15:233-40.
-
(2002)
J Magn Reson Imaging
, vol.15
, pp. 233-240
-
-
Gossmann, A.1
Helbich, T.H.2
Kuriyama, N.3
-
70
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307:58-62.
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
71
-
-
0038235987
-
Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11
-
Wildiers H, Guetens G, De Boeck G, et al. Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11. Br J Cancer 2003; 88:1979-86.
-
(2003)
Br J Cancer
, vol.88
, pp. 1979-1986
-
-
Wildiers, H.1
Guetens, G.2
De Boeck, G.3
-
72
-
-
2942657615
-
Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
-
Johnson DH, Fehrenbacher L, Novotny WF, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004; 22:2184-91.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2184-2191
-
-
Johnson, D.H.1
Fehrenbacher, L.2
Novotny, W.F.3
-
73
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356:125-34.
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
74
-
-
34247857540
-
Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: A review of four phase I trials in patients with advanced refractory solid tumors
-
Strumberg D, Clark JW, Awada A, et al. Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: a review of four phase I trials in patients with advanced refractory solid tumors. Oncologist 2007; 12:426-37.
-
(2007)
Oncologist
, vol.12
, pp. 426-437
-
-
Strumberg, D.1
Clark, J.W.2
Awada, A.3
-
75
-
-
33747874091
-
A phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration
-
Nguyen QD, Shah SM, Hafiz G, et al. A phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration. Ophthalmology 2006; 113:1522.
-
(2006)
Ophthalmology
, vol.113
, pp. 1522
-
-
Nguyen, Q.D.1
Shah, S.M.2
Hafiz, G.3
-
76
-
-
33744954585
-
Sunitinib in patients with metastatic renal cell carcinoma
-
Motzer RJ, Rini BI, Bukowski RM, et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006; 295:2516-24.
-
(2006)
JAMA
, vol.295
, pp. 2516-2524
-
-
Motzer, R.J.1
Rini, B.I.2
Bukowski, R.M.3
-
77
-
-
33846850223
-
Vandetanib (ZD6474): An orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis
-
Herbst RS, Heymach JV, O'Reilly MS, et al. Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis. Expert Opin Investig Drugs 2007; 16:239-49.
-
(2007)
Expert Opin Investig Drugs
, vol.16
, pp. 239-249
-
-
Herbst, R.S.1
Heymach, J.V.2
O'Reilly, M.S.3
-
78
-
-
35948978403
-
Randomized phase II study of vandetanib (VAN) alone or in combination with carboplatin and paclitaxel (CP) as first-line treatment for advanced non-small cell lung cancer (NSCLC)
-
Abstract 7544
-
Heymach J, Paz-Ares L, De Braud F, et al. Randomized phase II study of vandetanib (VAN) alone or in combination with carboplatin and paclitaxel (CP) as first-line treatment for advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007; 25 (Abstract 7544).
-
(2007)
J Clin Oncol
, pp. 25
-
-
Heymach, J.1
Paz-Ares, L.2
De Braud, F.3
-
79
-
-
85031363901
-
-
Tykerb [package insert, Research Triangle Park NC, GlaxoSmithKline; 2007
-
Tykerb [package insert]. Research Triangle Park (NC): GlaxoSmithKline; 2007.
-
-
-
-
80
-
-
85031358295
-
-
Smylie M, Blumenschein GR, Dowlati A, et al. A phase II multicenter trial comparing two schedules of lapatinib (LAP) as first or second line monotherapy in subjects with advanced or metastatic non-small cell lung cancer (NSCLC) with either bronchioloalveolar carcinoma (BAC) or no smoking history. J Clin Oncol 2007; 25(18 suppl):412s (Abstract 7611).
-
Smylie M, Blumenschein GR, Dowlati A, et al. A phase II multicenter trial comparing two schedules of lapatinib (LAP) as first or second line monotherapy in subjects with advanced or metastatic non-small cell lung cancer (NSCLC) with either bronchioloalveolar carcinoma (BAC) or no smoking history. J Clin Oncol 2007; 25(18 suppl):412s (Abstract 7611).
-
-
-
-
81
-
-
0032909952
-
Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: In vitro studies
-
Jackson WT, Froelich LL, Boyd RJ, et al. Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: in vitro studies. J Pharmacol Exp Ther 1999; 288:286-94.
-
(1999)
J Pharmacol Exp Ther
, vol.288
, pp. 286-294
-
-
Jackson, W.T.1
Froelich, L.L.2
Boyd, R.J.3
-
82
-
-
85031358108
-
-
Janne PA, Paz-Ares RL, Gottfried M, et al. Randomized phase II trial of cisplatin/gemcitabine with or without LY293111, a multiple eicosanoid pathway modulator, in patients with chemotherapy naïve advanced non-small cell lung carcinoma. J Clin Oncol 2006; 24(18 suppl):370s (Abstract 7024).
-
Janne PA, Paz-Ares RL, Gottfried M, et al. Randomized phase II trial of cisplatin/gemcitabine with or without LY293111, a multiple eicosanoid pathway modulator, in patients with chemotherapy naïve advanced non-small cell lung carcinoma. J Clin Oncol 2006; 24(18 suppl):370s (Abstract 7024).
-
-
-
-
83
-
-
20144387947
-
Predictors of the response to gefitinib in refractory non-small cell lung cancer
-
Kim KS, Jeong JY, Kim YC, et al. Predictors of the response to gefitinib in refractory non-small cell lung cancer. Clin Cancer Res 2005; 11:2244-51.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2244-2251
-
-
Kim, K.S.1
Jeong, J.Y.2
Kim, Y.C.3
-
84
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 2004; 304:1497-500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
85
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350:2129-39.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
86
-
-
32944481596
-
Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib
-
Riely GJ, Pao W, Pham D, et al. Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res 2006; 12:839-44.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 839-844
-
-
Riely, G.J.1
Pao, W.2
Pham, D.3
-
87
-
-
33746034167
-
Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib
-
Jackman DM, Yeap BY, Sequist LV, et al. Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res 2006; 12:3908-14.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3908-3914
-
-
Jackman, D.M.1
Yeap, B.Y.2
Sequist, L.V.3
-
88
-
-
33947732977
-
Angiogenesis: An organizing principle for drug discovery?
-
Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007; 6:273-86.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 273-286
-
-
Folkman, J.1
-
89
-
-
33747844588
-
Response rate or time to progression as predictors of survival in trials of metastatic colorectal cancer or non-small-cell lung cancer: A meta-analysis
-
Johnson KR, Ringland C, Stokes BJ, et al. Response rate or time to progression as predictors of survival in trials of metastatic colorectal cancer or non-small-cell lung cancer: a meta-analysis. Lancet Oncol 2006; 7:741-6.
-
(2006)
Lancet Oncol
, vol.7
, pp. 741-746
-
-
Johnson, K.R.1
Ringland, C.2
Stokes, B.J.3
-
90
-
-
0029973785
-
A rationale for expanding the endpoints for clinical trials in advanced pancreatic carcinoma
-
Rothenberg ML, Abbruzzese JL, Moore M, et al. A rationale for expanding the endpoints for clinical trials in advanced pancreatic carcinoma. Cancer 1996; 78:627-32.
-
(1996)
Cancer
, vol.78
, pp. 627-632
-
-
Rothenberg, M.L.1
Abbruzzese, J.L.2
Moore, M.3
-
91
-
-
85031357552
-
-
Avastin [package insert, South San Francisco CA, Genentech, Inc; 2007
-
Avastin [package insert]. South San Francisco (CA): Genentech, Inc; 2007.
-
-
-
|