Actions of two GABAA receptor benzodiazepine-site ligands that are mediated via non-γ2-dependent modulation

European Journal of Pharmacology

Volumn 666, Issue 1-3, 2011, Pages 111-121

  Leppä, Elli ^a   Linden, Anni Maija ^a   Rabe, Holger ^b   Vekovischeva, Olga Yu ^a   Wulff, Peer ^c   Lüddens, Hartmut ^b   Wisden, William ^d   Korpi, Esa R ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

2 subunit; Benzodiazepine; DMCM (methyl 6,7 dimethoxy 4 ethyl carboline 3 carboxylate); GABAA receptor; Mouse model; Zolpidem

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR BETA3; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; BENZODIAZEPINE; RECOMBINANT PROTEIN; ZOLPIDEM TARTRATE; 4 AMINOBUTYRIC ACID A RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; AZIDE; BENZODIAZEPINE DERIVATIVE; CARBOLINE DERIVATIVE; CONVULSANT AGENT; HYPNOTIC SEDATIVE AGENT; LIGAND; METHYL 6,7-DIMETHOXY-4-ETHYL-BETA-CARBOLINE-3-CARBOXYLATE; PROTEIN SUBUNIT; PYRIDINE DERIVATIVE; ZOLPIDEM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN TISSUE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG MEGADOSE; DRUG RECEPTOR BINDING; FEAR; FEMALE; FOREBRAIN; HUMAN; HUMAN CELL; LEARNING; LIGAND BINDING; MALE; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOUSE; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEUROMODULATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SEDATION; WILD TYPE; ANIMAL; ANIMAL BEHAVIOR; AUTORADIOGRAPHY; BRAIN; C57BL MOUSE; CELL STRAIN HEK293; CHEMISTRY; DRUG EFFECT; METABOLISM; PROTEIN BINDING;

ANIMALS; AUTORADIOGRAPHY; AZIDES; BEHAVIOR, ANIMAL; BENZODIAZEPINES; BINDING SITES; BRAIN; CARBOLINES; CONVULSANTS; FEMALE; HEK293 CELLS; HUMANS; HYPNOTICS AND SEDATIVES; LIGANDS; MALE; MICE; MICE, INBRED C57BL; PROTEIN BINDING; PROTEIN SUBUNITS; PYRIDINES; RECEPTORS, GABA-A;

EID: 80052424153     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.05.011     Document Type: Article

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