Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA A receptor γ2 subunit

Biochemical Pharmacology

Volumn 68, Issue 8, 2004, Pages 1621-1629

  Ogris, Waltraud ^a   Pöltl, Angelika ^a   Hauer, Birgit ^a   Ernst, Margot ^a   Oberto, Alessandra ^b   Wulff, Peer ^c   Höger, Harald ^a   Wisden, William ^c   Sieghart, Werner ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

2 Subunit; 3H flunitrazepam; Benzodiazepine binding site ligands; Benzodiazepine binding site property; GABA A receptor; Point mutation 2F77I

Indexed keywords

2 (4 CHLOROPHENYL) 5H PYRAZOLO[4,3 C]QUINOLIN 3 ONE; 2 BENZOYL 6 ETHYL 7 METHOXY 5 METHYLIMIDAZO[1,2 A]PYRIMIDINE; 2 BENZOYL 7 ETHYL 9 METHOXYIMIDAZO[1,2 A]QUINOLINE; 2 PHENYL 4 [2 (3 PIPERIDYL)ETHYL]QUINOLINE; 2,3,5,6,7,8,9,10 OCTAHYDRO 2 (4 METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4 D]PYRIDIN 3 ONE; 3 METHYL 6 (3 TRIFLUOROMETHYLPHENYL) 1,2,4 TRIAZOLO[4,3 B]PYRIDAZINE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; BENZODIAZEPINE DERIVATIVE; BRETAZENIL; CARBOLINE DERIVATIVE; CLOBAZAM; CLOTIAZEPAM; DIAZEPAM; FLUMAZENIL; FLUNITRAZEPAM; FLURAZEPAM; IMIDAZOPYRIDINE DERIVATIVE; L 655708; MIDAZOLAM; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PIPEQUALINE; PROTEIN SUBUNIT; QUINOLINE DERIVATIVE; RU 33203; RU 33356; UNCLASSIFIED DRUG; ZOLPIDEM; ZOPICLONE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL;

ANIMALS; BENZODIAZEPINES; BINDING SITES; FEMALE; FLUNITRAZEPAM; LIGANDS; MALE; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN SUBUNITS; RECEPTORS, GABA-A;

EID: 4644319039     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.07.020     Document Type: Article

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