Different effects of L-type and T-type calcium channel blockers on the hypnotic potency of triazolam and zolpidem in rats

European Neuropsychopharmacology

Volumn 9, Issue 4, 1999, Pages 317-321

  Takahashi, Hitoshi ^a   Yoshimoto, Masaki ^a   Higuchi, Hisashi ^a   Shimizu, Tetuo ^a   Hishikawa, Yasuo ^a  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Benzodiazepine hypnotic; Calcium channel blocker; Non benzodiazepine hypnotic; Rat; Sleep

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; FLUNARIZINE; NILVADIPINE; TRIAZOLAM; ZOLPIDEM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; HYPNOSIS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; NONREM SLEEP; POLYSOMNOGRAPHY; PRIORITY JOURNAL; RAT; REM SLEEP; SLEEP; SLEEP TIME;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, T-TYPE; DRUG INTERACTIONS; FLUNARIZINE; HYPNOTICS AND SEDATIVES; MALE; NIFEDIPINE; PYRIDINES; RATS; RATS, WISTAR; SLEEP, REM; TRIAZOLAM;

EID: 0033152529     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(98)00051-0     Document Type: Article

References (21)

1. Akaike N., Kostyuk P.G., Osipchuk Y.V. Dihydropyridine-sensitive low-threshold calcium channels in isolated rat hypothalamic neurons. J. Physiol. 412:1989;181-195.
2. Backman J.T., Olkkola K.T., Aranko K., Himberg J.J., Neuvonen P.J. Dose of midazolam should be reduced during diltiazem and verapamil treatments. Br. J. Clin. Pharmacol. 37:1994;221-225.
3. Czuczwar S.J., Malek U., Kleinrok Z. Influence of calcium channel inhibitors upon the anticonvulsant efficacy of common antiepileptics against pentylenetetrazol-induced convulsions in mice. Neuropharmacology. 29:1990;943-948.
4. Dolin S.J., Little H.J. Augmentation by calcium channel antagonists of general anaesthetic potency in mice. Br. J. Pharmacol. 88:1986;909-914.
5. Dolin S.J., Patch T.L., Rabbani M., Taberner P.V., Little H.J. Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644. Neuropharmacology. 30:1991;217-224.
6. Dubovsky S.L., Franks R.D., Lifschitz M., Coen P. Effectiveness of verapamil in the treatment of a manic patient. Am. J. Psychiatry. 139:1982;502-504.
7. Gasior M., Kleinrok Z., Czuczwar S.J. Influence of BAY k-8644, a calcium channel agonist, on the anticonvulsant activity of conventional anti-epileptics against electroconvulsions in mice. Neuropharmacology. 34:1995;433-438.
8. 2+ channels in rat CNS neurons. Neuroreport. 8:1997;853-857.
9. Leslie S.W., Barr E., Chandler J., Farrar R.P. Inhibition of fast- and slow-phase depolarization-dependent synaptosomal calcium uptake by ethanol. J. Pharmacol. Exp. Ther. 225:1983;571-575.
10. Leslie S.W., Chandler L.J., Chweh A.Y., Swinyard E.A. Correlation of the hypnotic potency of benzodiazepines with inhibition of voltage-dependent calcium uptake into mouse brain synaptosomes. Eur. J. Pharmacol. 126:1986;129-134.
11. Mendelson W.B., Monti D. Effects of triazolam and nifedipine injections into the medial preoptic area on sleep. Neuropsychopharmacology. 8:1993;227-232.
12. Mendelson W.B., Owen C., Skolnick P.et al. Nifedipine blocks sleep induction by flurazepam in the rat. Sleep. 7:1984;64-68.
13. Morrow A.L., Suzdak P.D., Paul S.M. Benzodiazepine, barbiturate, ethanol and hypnotic steroid hormone modulation of GABA-mediated chloride ion transport in rat brain synaptosomes. Adv. Biochem. Psychopharmacol. 45:1988;247-261.
14. Pichard L., Gillet G., Bonfils J., Domergue J., Thenot J.P., Maurel P. Oxidative metabolism of zolpidem by human liver cytochrome P450S. Drug. Metab. Dispos. 23:1995;1253-1262.
15. Rogawski M.A., Porter R.J. Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol. Rev. 42:1990;223-286.
16. 2+ channel blockers; multiple sites of action. Folia Pharmacol. 100:1992;239-247.
17. Soubrie P. Neuropsychological profiles of calcium antagonists. Fundam. Clin. Pharmacol. 3(Suppl):1989;71s-78s.
18. Taft W.C., DeLorenzo R.J. Micromolar-affinity benzodiazepine receptors regulate voltage-sensitive calcium channels in nerve terminal preparations. Proc. Natl. Acad. Sci. USA. 81:1984;3118-3122.
19. Takakura S., Furuichi Y., Yamamoto T., Ogawa T., Satoh H., Mori J. Effect of nilvadipine on the development of neurological deficits in stroke-prone spontaneously hypertensive rats. Stroke. 25:1994;677-682.
20. Varhe A., Olkkola K.T., Neuvonen P.J. Diltiazem enhances the effects of triazolam by inhibiting its metabolism. Clin. Pharmacol. Ther. 59:1996;369-375.
21. Yoshimoto, M., Higuchi, H., Kamata, M., Yoshida, K., Shimizu, T., Hishikawa, Y., 1999. The effects of benzodiazepine (triazolam), cyclopyrrolone (zolpidem) hypnotics on the frequency of hippocampal theta activity and sleep structure in rats. Eur. Neuropsychopharmacol., in press.