Identification of a novel pharmacophore for peptide toxins interacting with K+ channels

Journal of Biological Chemistry

Volumn 280, Issue 22, 2005, Pages 21246-21255

  Verdier, Laurent ^a   Al Sabi, Ahmed ^b   Rivier, Jean E F ^c   Olivera, Baldomero M ^d   Terlau, Heinrich ^b   Carlomagno, Teresa ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; IONS; MOLECULAR DYNAMICS; MUTAGENESIS; PHARMACODYNAMICS; POTASSIUM; TOXIC MATERIALS;

BINDING MODES; ION CHANNELS; PEPTIDES; TOXINS;

POLYPEPTIDES;

DNA; KAPPA M CONOTOXIN RIIIK; OMEGA CONOTOXIN; POTASSIUM CHANNEL; POTASSIUM ION; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; OOCYTE; PHARMACOPHORE; POINT MUTATION; PRIORITY JOURNAL; RAINBOW TROUT; TOXIN ANALYSIS; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; CLUSTER ANALYSIS; CONOTOXINS; DNA MUTATIONAL ANALYSIS; ELECTROPHYSIOLOGY; ELECTROSTATICS; INHIBITORY CONCENTRATION 50; IONS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OOCYTES; PEPTIDES; POINT MUTATION; POTASSIUM; POTASSIUM CHANNELS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SOFTWARE; THERMODYNAMICS; TROUT; XENOPUS;

SALMONIDAE;

EID: 20444387572     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M502376200     Document Type: Article

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