Baicalein inhibits the migration and invasive properties of human hepatoma cells

Toxicology and Applied Pharmacology

Volumn 255, Issue 3, 2011, Pages 316-326

  Chiu, Yung Wei ^a,b   Lin, Tseng Hsi ^c   Huang, Wen Shih ^d,e   Teng, Chun Yuh ^f   Liou, Yi Sheng ^g   Kuo, Wu Hsien ^f,h   Lin, Wea Lung ⁱ   Huang, Hai I ^h   Tung, Jai Nien ^a   Huang, Chih Yang ^j,k   Liu, Jer Yuh ^l   Wang, Wen Hung ^c   Hwang, Jin Ming ^b   Kuo, Hsing Chun ^m,n  

^a TUNGS' TAICHUNG METROHARBOR HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^e CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^f TAICHUNG ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^g NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^h CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

ⁱ CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^j CHINA MEDICAL UNIVERSITY   (Taiwan)

^k ASIA UNIVERSITY   (Taiwan)

^l CHINA MEDICAL UNIVERSITY   (Taiwan)

^m CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

ⁿ CGUST   (Taiwan)

more..

Author keywords

Baicalein; Flavonoid; Hepatoma; Invasion; P38; PKC

Indexed keywords

BAICALEIN; BAICALIN; GELATINASE A; GELATINASE B; I KAPPA B BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE C ALPHA; PROTEIN P50; SYNAPTOTAGMIN I;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; TUMOR XENOGRAFT;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MIGRATION INHIBITION; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; FLAVANONES; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; RANDOM ALLOCATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS MUSCULUS;

EID: 80052376690     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.07.008     Document Type: Article

References (47)

1. Arts I.C., Hollman P.C. Polyphenols and disease risk in epidemiologic studies. Am. J. Clin. Nutr. 2005, 81:317S-325S.
2. Bao B.Y., Yeh S.D., Lee Y.F. 1alpha,25-Dihydroxyvitamin D3 inhibits prostate cancer cell invasion via modulation of selective proteases. Carcinogenesis 2006, 27:32-42.
3. Cha H.J., Bae S.K., Lee H.Y., Lee O.H., Sato H., Seiki M. Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells. Cancer Res. 1996, 56:2281-2284.
4. Chakraborti S., Mandal M., Das S., Mandal A., Chakraborti T. Regulation of matrix metalloproteinases: an overview. Mol. Cell. Biochem. 2003, 253:269-285.
5. Chen C.H., Huang L.L., Huang C.C., Lin C.C., Lee Y., Lu F.J. Baicalein, a novel apoptotic agent for hepatoma cell lines: a potential medicine for hepatoma. Nutr. Cancer 2000, 38:287-295.
6. Chen K.S., Hsiao Y.C., Kuo D.Y., Chou M.C., Chu S.C., Hsieh Y.S. Tannic acid-induced apoptosis and -enhanced sensitivity to arsenic trioxide in human leukemia HL-60 cells. Leuk. Res. 2009, 33:297-307.
7. Clark I.M., Swingler T.E., Sampieri C.L., Edwards D.R. The regulation of matrix metalloproteinases and their inhibitors. Int. J. Biochem. Cell Biol. 2008, 40:1362-1378.
8. Echeverry C., Arredondo F., Abin-Carriquiry J.A., Midiwo J.O., Ochieng C., Kerubo L., Dajas F. Pretreatment with natural flavones and neuronal cell survival after oxidative stress: a structure-activity relationship study. J. Agric. Food Chem. 2010, 58:2111-2115.
9. Fernandez-Martinez A., Molla B., Mayoral R., Bosca L. Cyclo-oxygenase 2 expression impairs serum-withdrawal-induced apoptosis in liver cells. Biochem. J. 2006, 398:371-380.
10. Giancotti F.G., Ruoslahti E. Integrin signaling. Science 1999, 285:1028-1032.
11. Havsteen B.H. The biochemistry and medical significance of the flavonoids. Pharmacol. Ther. 2002, 96:67-202.
12. Hsieh Y.H., Wu T.T., Tsai J.H., Huang C.Y., Hsieh Y.S., Liu J.Y. PKC? expression regulated by Elk-1 and MZF-1 in human HCC cells. Biochem. Biophys. Res. Commun. 2006, 339:217-225.
13. Hsieh Y.H., Wu T.T., Huang C.Y., Hsieh Y.S., Hwang J.M., Liu J.Y. p38 mitogen-activated protein kinase pathway is involved in protein kinase Calpha-regulated invasion in human hepatocellular carcinoma cells. Cancer Res. 2007, 67:4320-4327.
14. Huang S.T., Lee Y., Gullen E.A., Cheng Y.C. Impacts of baicalein analogs with modification of the 6th position of A ring on the activity toward NF-kappaB-, AP-1-, or CREB-mediated transcription. Bioorg. Med. Chem. Lett. 2011, 18:5046-5049.
15. Huang W.S., Chin T.C., Chen C.N., Kuo Y.H., Guo S.E., Yu H.R., Wu Y.C., Chou B.M., Kuo H.C. Stromal cell-derived factor-1/CXC receptor 4 and -1 integrin interaction regulates urokinase-type plasminogen activator expression in human colorectal cancer cells. J. Cell. Physiol. 2011, doi:10.1002/jcp.22831.2011.05.12.
16. Humphries M.J., Travis M.A., Clark K., Mould A.P. Mechanisms of integration of cells and extracellular matrices by integrins. Biochem. Soc. Trans. 2004, 32:822-825.
17. Huynh H., Ngo V.C., Koong H.N., Poon D., Choo S.P., Thng C.H. Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J. Cell. Mol. Med. 2009, 13:2673-2683.
18. Hwang J.M., Kuo H.C., Tseng T.H., Liu J.Y., Chu C.Y. Berberine induces apoptosis through a mitochondria/caspases pathway in human hepatoma cells. Arch. Toxicol. 2006, 80:62-73.
19. Karin M. Nuclear factor-κB in cancer development and progression. Nature 2006, 441:431-436.
20. Kim B.W., Lee E.R., Min H.M., Jeong H.S., Ahn J.Y., Kim J.H. Sustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition. Cancer Biol. Ther. 2008, 7:1080-1089.
21. Knekt P., Kumpulainen J., Jarvinen R., Rissanen H., Heliovaara M., Reunanen A. Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr. 2002, 76:560-568.
22. Kuo H.C., Kuo W.H., Lee Y.J., Wang C.J., Tseng T.H. Enhancement of caffeic acid phenethyl ester on all-trans retinoic acid-induced differentiation in human leukemia HL-60 cells. Toxicol. Appl. Pharmacol. 2006, 216:80-88.
23. Kuo H.C., Kuo W.H., Lee Y.J., Lin W.L., Chou F.P., Tseng T.H. Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo. Cancer Lett. 2006, 234:199-208.
24. Kuo H.M., Tsai H.C., Lin Y.L., Yang J.S., Huang A.C., Yang M.D. Mitochondrial-dependent caspase activation pathway is involved in baicalein-induced apoptosis in human hepatoma J5 cells. Int. J. Oncol. 2009, 35:717-724.
25. Kuo H.C., Chiu C.C., Chang W.C., Sheen J.M., Ou C.Y., Kuo H.C., Chen R.F., Hsu T.Y., Chang J.C., Hsaio C.C., Wang F.S., Huang C.C., Huang H.Y., Yang Kuender D. Use of proteomic differential displays to assess functional discrepancies and facilitate adjustments of different human mesenchymal stem cell types. J. Proteome Res. 2011, 10:1305-1315.
26. Larsen M., Artym V.V., Green J.A., Yamada K.M. The matrix reorganized: extracellular matrix remodeling and integrin signaling. Curr. Opin. Cell Biol. 2006, 18:463-471.
27. Li R., Ning Z., Majumdar R., Cui J., Takabe W., Jen N., Sioutas C., Hsiai T. Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses: implication of chemical components and NF-κB signaling. Part. Fibre Toxicol. 2010, 7:6.
28. Lin H.L., Chiou S.H., Wu C.W., Lin W.B., Chen L.H., Yang Y.P. Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. J. Pharmacol. Exp. Ther. 2007, 323:365-373.
29. Lin T.H., Kuo H.C., Chou F.P., Lu F.J. Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide. BMC Cancer 2008, 8:58.
30. Liu T.Z., Hu C.C., Chen Y.H., Stern A., Cheng J.T. Differentiation status modulates transcription factor NF-kappaB activity in unstimulated human hepatocellular carcinoma cell lines. Cancer Lett. 2000, 151:49-56.
31. Li-Weber M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents wogonin, baicalein and baicalin. Cancer Treat. Rev. 2009, 35:57-68.
32. López-Otín C., Hunter T. The regulatory crosstalk between kinases and proteases in cancer. Nat. Rev. Cancer 2010, 10:278-292.
33. Lotito S.B., Frei B. Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism. J. Biol. Chem. 2006, 281:37102-37110.
34. Mantovani A., Allavena P., Sica A., Balkwill F. Cancer-related inflammation. Nature 2008, 454:436-444.
35. Mehlen P., Puisieux A. Metastasis: a question of life or death. Nat. Rev. Cancer 2005, 5:591-602.
36. Pan M.H., Chiou Y.S., Chen W.J., Wang J.M., Badmaev V., Ho C.T. Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. Carcinogenesis 2009, 30:1234-1242.
37. Parkin D.M., Bray F., Ferlay J., Pisani P. Global cancer statistics. CA Cancer J. Clin. 2002, 55:74-108.
38. Po L.S., Chen Z.Y., Tsang D.S., Leung L.K. Baicalein and genistein display differential actions on estrogen receptor (ER) transactivation and apoptosis in MCF-7 cells. Cancer Lett. 2002, 187:33-40.
39. Roskelley C.D., Williams D.E., McHardy L.M., Leong K.G., Troussard A., Karsan A. Inhibition of tumor cell invasion and angiogenesis by motuporamines. Cancer Res. 2001, 61:6788-6794.
40. Sakamoto Y., Mafune K., Mori M., Shiraishi T., Imamura H., Mori M.T. Overexpression of MMP-9 correlates with growth of small hepatocellular carcinoma. Int. J. Oncol. 2000, 17:237-243.
41. Tretiakova M.S., Hart J., Shabani-Rad M.T., Zhang J., Gao Z. Distinction of hepatocellular adenoma from hepatocellular carcinoma with and without cirrhosis using E-cadherin and matrix metalloproteinase immunohistochemistry hepatocellular neoplasm differential diagnosis. Mod. Pathol. 2009, 22:1113-1120.
42. Wagner E.F., Nebreda A.R. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat. Rev. Cancer 2009, 9:537-549.
43. Wan R., Mo Y., Zhang X., Chien S., Tollerud D.J., Zhang Q. Matrix metalloproteinase-2 and -9 are induced differently by metal nanoparticles in human monocytes: the role of oxidative stress and protein tyrosine kinase activation. Toxicol. Appl. Pharmacol. 2008, 233:276-285.
44. Weigelt B., Peterse J.L., van't Veer L.J. Breast cancer metastasis: markers and models. Nat. Rev. Cancer 2005, 5:591-602.
45. Yan C., Boyd D.D. Regulation of matrix metalloproteinase gene expression. Cell Physiol. 2007, 211:19-26.
46. Yoon S.O., Kim M.M., Chung A.S. Inhibitory effect of selenite on invasion of HT1080 tumor cells. J. Biol. Chem. 2001, 276:20085-20092.
47. Zhou L., Rui J.A., Yamamoto M., Kuroda Y., Itoh H. Clinical significance of urokinase type plasminogen activator activity in hepatocellular carcinoma. J. Gastroenterol. Hepatol. 2000, 15:422-430.