Stromal cell-derived factor-1/CXC receptor 4 and β1 integrin interaction regulates urokinase-type plasminogen activator expression in human colorectal cancer cells

Journal of Cellular Physiology

Volumn 227, Issue 3, 2012, Pages 1114-1122

  Huang, Wen Shih ^a,b   Chin, Chih Chien ^a,b   Chen, Cheng Nan ^c   Kuo, Yi Hung ^a,b   Chen, Te Chuan ^a   Yu, Hong Ren ^a   Tung, Shui Yi ^b   Shen, Chien Heng ^a,b   Hsieh, Yung Yu ^b   Guo, Su Er ^d   Shi, Chung Sheng ^a   Liu, Ta Ju ^e   Kuo, Hsing Chun ^d  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^d CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^e Department of Aesthetics and Dermatology   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CHEMOKINE RECEPTOR CXCR4; DNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PLASMINOGEN ACTIVATOR; PROTEIN KINASE B; SMALL INTERFERING RNA; STROMAL CELL DERIVED FACTOR 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1; UROKINASE;

ARTICLE; CANCER CELL; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; COLORECTAL CANCER; DNA BINDING; DOWN REGULATION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANTIGENS, CD29; CELL LINE, TUMOR; CHEMOKINE CXCL12; COLORECTAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN INTERACTION MAPPING; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CXCR4; SP1 TRANSCRIPTION FACTOR; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84155178005     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22831     Document Type: Article

References (41)

1. Benasciutti E, Pagès G, Kenzior O, Folk W, Blasi F, Crippa MP. 2004. MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription. Blood 104: 256-262.
2. Burger JA, Kipps TJ. 2006. CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107: 1761-1767.
3. Chiang JK, Sung ML, Yu HR, Chang HI, Kuo HC, Tsai TC, Yen CK, Chen CN. 2011. Homocysteine induces smooth muscle cell proliferation through differential regulation of cyclins A and D1 expression. J Cell Physiol 226: 1017-1026.
4. Danø K, Behrendt N, Høyer-Hansen G, Johnsen M, Lund LR, Ploug M, Rømer J. 2005. Plasminogen activation and cancer. Thromb Haemost 93: 676-681.
5. Duffy MJ, McGowan PM, Gallagher WM. 2008. Cancer invasion and metastasis: Changing views. J Pathol 214: 283-293.
6. Gallagher DJ, Kemeny N. 2010. Metastatic colorectal cancer: From improved survival to potential cure. Oncology 78: 237-248.
7. Gulubova MV, Vlaykova TI. 2006. Significance of tenascin-C, fibronectin, laminin, collagen IV, α5β1 and α9β1 integrins and fibrotic capsule formation around liver metastases originating from cancers of the digestive tract. Neoplasma 53: 372-383.
8. Hartmann TN, Burger JA, Glodek A, Fujii N, Burger M. 2005. CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells. Oncogene 24: 4462-4471.
9. Huang YC, Hsiao YC, Chen YJ, Wei YY, Lai TH, Tang CH. 2007. Stromal cell-derived factor-1 enhances motility and integrin up-regulation through CXCR4, ERK and NF-κB-dependent pathway in human lung cancer cells. Biochem Pharmacol 74: 1702-1712.
10. Hynes RO. 2002. Integrins: Bidirectional, allosteric signaling machines. Cell 110: 673-687.
11. Jones J, Marian D, Weich E, Engl T, Wedel S, Relja B, Jonas D, Blaheta RA. 2007. CXCR4 chemokine receptor engagement modifies integrin dependent adhesion of renal carcinoma cells. Exp Cell Res 313: 4051-4065.
12. Joo EK, Broxmeyer HE, Kwon HJ, Kang HB, Kim JS, Lim JS, Choe YK, Choe IS, Myung PK, Lee Y. 2004. Enhancement of cell survival by stromal cell-derived factor-1/CXCL12 involves activation of CREB and induction of Mcl-1 and c-Fos in factor-dependent human cell line MO7e. Stem Cells Dev 13: 563-570.
13. Kwaan HC, McMahon B. 2009. The role of plasminogen-plasmin system in cancer. Cancer Treat Res 148: 43-66.
14. Kessenbrock K, Plaks V, Werb Z. 2010. Matrix metalloproteinases: Regulators of the tumor microenvironment. Cell 141: 52-67.
15. Kim M, Murakami A, Kawabata K, Ohigashi H. 2005. (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells. Carcinogenesis 26: 1553-1562.
16. Kirkland SC, Ying H. 2008. α2β1 integrin regulates lineage commitment in multipotent human colorectal cancer cells. J Biol Chem 283: 27612-27619.
17. Kollmar O, Rupertus K, Scheuer C, Junker B, Tilton B, Schilling MK, Menger MD. 2007. Stromal cell-derived factor-1 promotes cell migration and tumor growth of colorectal metastasis. Neoplasia 9: 862-870.
18. Koshikawa N, Hayashi J, Nakagawara A, Takenaga K. 2009. Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1α gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway. J Biol Chem 284: 33185-33194.
19. Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska-Wieczorek A, Ratajczak J, Ratajczak MZ. 2005. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: Pivotal role of the SDF-1-CXCR4 axis. Stem Cells 23: 879-894.
20. Kuo HC, Kuo WH, Lee YJ, Wang CJ, Tseng TH. 2006. Enhancement of caffeic acid phenethyl ester on all-trans retinoic acid-induced differentiation in human leukemia HL-60cells. Toxicol Appl Pharmacol 216: 80-88.
21. Liu Y, Bodmer WF. 2006. Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines. Proc Natl Acad Sci U S A 103: 976-981.
22. Mantovani A, Savino B, Locati M, Zammataro L, Allavena P, Bonecchi R. 2010. The chemokine system in cancer biology and therapy. Cytokine Growth Factor Rev 21: 27-39.
23. Maurer GD, Leupold JH, Schewe DM, Biller T, Kates RE, Hornung HM, Lau-Werner U, Post S, Allgayer H. 2007. Analysis of specific transcriptional regulators as early predictors of independent prognostic relevance in resected colorectal cancer. Clin Cancer Res 13: 1123-1132.
24. Meier F, Schittek B, Busch S, Garbe C, Smalley K, Satyamoorthy K, Li G, Herlyn M. 2005. The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma. Front Biosci 10: 2986-3001.
25. Miura K, Uniyal S, Leabu M, Oravecz T, Chakrabarti S, Morris VL, Chan BM. 2005. Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. Biochem Cell Biol 83: 36-48.
26. Monje P, Marinissen MJ, Gutkind JS. 2003. Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor. Mol Cell Biol 23: 7030-7043.
27. Murphy LO, Smith S, Chen RH, Fingar DC, Blenis J. 2002. Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol 4: 556-564.
28. Nagamine Y, Medcalf RL, Muñoz-Cánoves P. 2005. Transcriptional and posttranscriptional regulation of the plasminogen activator system. Thromb Haemost 93: 661-675.
29. Ratajczak MZ, Zuba-Surma E, Kucia M, Reca R, Wojakowski W, Ratajczak J. 2006. The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis. Leukemia 20: 1915-1924.
30. Saigusa S, Toiyama Y, Tanaka K, Yokoe T, Okugawa Y, Kawamoto A, Yasuda H, Inoue Y, Miki C, Kusunoki M. 2010. Stromal CXCR4 and CXCL12 expression is associated with distant recurrence and poor prognosis in rectal cancer after chemoradiotherapy. Ann Surg Oncol 17: 2051-2058.
31. Seetoo DQ, Crowe PJ, Russell PJ, Yang JL. 2003. Quantitative expression of protein markers of plasminogen activation system in prognosis of colorectal cancer. J Surg Oncol 82: 184-193.
32. Shao J, Evers BM, Sheng H. 2004. Prostaglandin E2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells. J Biol Chem 279: 14287-14293.
33. Sung ML, Wu CC, Chang HI, Yen CK, Chen HJ, Cheng JC, Chien S, Chen CN. 2009. Shear stress inhibits homocysteine-induced stromal cell-derived factor-1 expression in endothelial cells. Circ Res 105: 755-763.
34. Tang CH, Wei Y. 2008. The urokinase receptor and integrins in cancer progression. Cell Mol Life Sci 65: 1916-1932.
35. Tanos T, Marinissen MJ, Leskow FC, Hochbaum D, Martinetto H, Gutkind JS, Coso OA. 2005. Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light. J Biol Chem 280: 18842-18852.
36. Teicher BA, Fricker SP. 2010. CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 16: 2927-2931.
37. Thamilselvan V, Craig DH, Basson MD. 2007. FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. FASEB J 21: 1730-1741.
38. Vial E, Sahai E, Marshall CJ. 2003. ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. Cancer Cell 4: 67-79.
39. Yang JL, Seetoo D, Wang Y, Ranson M, Berney CR, Ham JM, Russell PJ, Crowe PJ. 2000. Urokinase-type plasminogen activator and its receptor in colorectal cancer: Independent prognostic factors of metastasis and cancer-specific survival and potential therapeutic targets. Int J Cancer 89: 431-439.
40. Yeh CC, Chang HI, Chiang JK, Tsai WT, Chen LM, Wu CP, Chien S, Chen CN. 2009. Regulation of plasminogen activator inhibitor 1 expression in human osteoarthritic chondrocytes by fluid shear stress: Role of protein kinase Cα. Arthritis Rheum 60: 2350-2361.
41. Yoshitake N, Fukui H, Yamagishi H, Sekikawa A, Fujii S, Tomita S, Ichikawa K, Imura J, Hiraishi H, Fujimori T. 2008. Expression of SDF-1α and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer. Br J Cancer 98: 1682-1689.