Mechanism of heparin activation of antithrombin: Evidence for an induced-fit model of allosteric activation involving two interaction subsites

Biochemistry

Volumn 37, Issue 37, 1998, Pages 13033-13041

  Desai, Umesh R ^a   Petitou, Maurice ^b   Björk, Ingemar ^c   Olson, Steven T ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b SANOFI   (France)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; HEPARIN; PENTASACCHARIDE; SERINE PROTEINASE INHIBITOR;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; HUMAN; HUMAN TISSUE; HYDROGEN BOND; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANTITHROMBIN III; FACTOR XA; GLYCINE; HEPARIN; HUMANS; IDURONIC ACID; IONS; KINETICS; MODELS, CHEMICAL; OLIGOSACCHARIDES; PROTEIN CONFORMATION; SERPINS; SPECTROMETRY, FLUORESCENCE;

EID: 0032530648     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981426h     Document Type: Article

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