Hydropathic interaction analyses of small organic activators binding to antithrombin

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 3, 2004, Pages 633-640

  Gunnarsson, Gunnar T ^a   Desai, Umesh R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Antithrombin; HINT; Molecular modeling; Sulfated flavanoids; Sulfated flavonoids

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; CATECHIN; FLAVANOID; FLAVONOID; HEPARIN; PENTASACCHARIDE; SULFATE;

ARTICLE; BINDING SITE; BLOOD CLOTTING; CORRELATION ANALYSIS; DRUG ACTIVATION; ENERGY; MOLECULE; PROTEIN BINDING; SULFATION;

EID: 0346500727     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.10.034     Document Type: Article

References (36)

1. Björk I., Olson S.T. Adv. Exp. Med. Biol. 425:1997;17.
2. Rosenberg R.D., Damus P.S. J. Biol. Chem. 248:1973;6490.
3. Björk I., Lindahl U. Mol. Cell. Biochem. 48:1982;161.
4. Gunay N.S., Linhardt R.J. Planta Med. 65:1999;301.
5. Linhardt R.J., Loganathan D. Heparin, heparinoids and heparin oligosaccharides: Structure and biological activities. Gebelein C.G. Biomimetic Polymers. 1990;135 Plenum Press, New York.
6. Choay J., Lormeau J.C., Petitou M., Sinäy P., Fareed J. Ann. N. Y. Acad. Sci. 370:1981;640.
7. Thunberg L., Bäckström G., Lindahl U. Carbohydr. Res. 100:1982;393.
8. Choay J., Petitou M., Lormeau J.C., Sinäy P., Casu B., Gatti G. Biochem. Biophys. Res. Commun. 116:1983;492.
9. Atha D.H., Stephens A.W., Rosenberg R.D. Proc. Natl. Acad. Sci. U.S.A. 81:1984;1030.
10. Nordenman B., Danielsson Å., Björk I. Eur. J. Biochem. 90:1987;1.
11. Jordan R.E., Oosta G.M., Gardner W.T., Rosenberg R.D. J. Biol. Chem. 255:1980;10081.
12. Olson S.T., Srinivasan K.R., Björk I., Shore J.D. J. Biol. Chem. 256:1981;11073.
13. Olson S.T., Björk I., Sheffer R., Craig P.A., Shore J.D., Choay J. J. Biol. Chem. 267:1992;12528.
14. Jin L., Abrahams J.P., Skinner R., Petitou M., Pike R.N., Carrell R.W. Proc. Natl. Acad. Sci. U.S.A. 94:1997;14683.
15. Ersdal-Badju E., Lu A., Zuo Y., Picard V., Bock S.C. J. Biol. Chem. 272:1997;19393.
16. Desai U.R., Swanson R.S., Bock S.C., Björk I., Olson S.T. J. Biol. Chem. 275:2000;18976.
17. Arocas V., Bock S.C., Raja S., Olson S.T., Björk I. J. Biol. Chem. 276:2001;43809.
18. Schedin-Weiss S., Desai U.R., Bock S.C., Gettins P.G.W., Olson S.T., Björk I. Biochemistry. 41:2002;4779.
19. Arocas V., Turk B., Bock S.C., Olson S.T., Björk I. Biochemistry. 39:2000;8512.
20. Meagher J., Olson S., Gettins P. J. Biol. Chem. 275:2000;2698.
21. Gunnarsson G.T., Desai U.R. J. Med. Chem. 45:2002;1233.
22. Kellogg G.E., Semus S.F., Abraham D.J. J. Comput. Aided Mol. Des. 5:1991;545.
23. Kellogg G.E., Joshi G.J., Abraham D.J. Med. Chem. Res. 1:1992;444.
24. Abraham D.J., Kellogg G.E., Holt J.M., Ackers G.K. J. Mol. Biol. 272:1997;613.
25. Cozzini P., Fornabaio M., Marabotti A., Abraham D.J., Kellogg G.E., Mozzarelli A. J. Med. Chem. 45:2002;2469.
26. Gunnarsson G.T., Desai U.R. Bioorg. Med. Chem. Lett. 13:2003;579.
27. Gunnarsson G.T., Desai U.R. J. Med. Chem. 45:2002;4460.
28. Skinner R., Abrahams J.-P., Whisstock J.C., Lesk A.M., Carrell R.W., Wardell M.R. J. Mol. Biol. 266:1997;601.
29. Gettins P.G.W., Patston P.A., Olson S.T. Serpins: Structure, Function and Biology. 1996;RG Landes, Austin, TX.
30. Desai U.R., Gunnarsson G.T. Med. Chem. Res. 9:1999;643.
31. Desai U.R., Petitou M., Björk I., Olson S.T. J. Biol. Chem. 273:1998;7478.
32. Desai U.R., Petitou M., Björk I., Olson S.T. Biochemistry. 37:1998;13033.
33. Fitton H.L., Skinner R., Dafforn T.R., Lin J., Pike R.N. Protein Sci. 7:1998;782.
34. Whisstock J., Pike R., Jin L., Skinner R., Pei X.Y., Carrell R.W., Lesk A.M. J. Mol. Biol. 301:2000;1287.
35. Skinner R., Abrahams J.-P., Whisstock J.C., Lesk A.M., Carrell R.W., Wardell M.R. J. Mol. Biol. 266:1997;601.
36. Schedin-Weiss S., Arocas V., Bock S.C., Olson S.T., Björk I. Biochemistry. 41:2002;12369.