Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats

Pharmaceutical Research

Volumn 22, Issue 12, 2005, Pages 2007-2015

  Tian, Hui ^a   Ou, Junhai ^a   Strom, Stephen C ^b   Venkataramanan, Raman ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Hepatic regeneration; Microsome; Real time PCR; Regulation; UGT

Indexed keywords

ANDROSTERONE; BORNEOL; DRUG METABOLIZING ENZYME; ESTRADIOL; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; ISOENZYME; MESSENGER RNA; MORPHINE; PARACETAMOL; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SUBSTRATE; LIVER FUNCTION; LIVER MICROSOME; LIVER REGENERATION; LIVER TRANSPLANTATION; LIVING DONOR; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARTIAL HEPATECTOMY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; BIOLOGICAL MARKERS; DNA PRIMERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; HEPATECTOMY; INTERLEUKIN-6; ISOENZYMES; LIVER; LIVER REGENERATION; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 29244460592     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-8111-1     Document Type: Article

References (39)

1. D. S. Seaman 2001 Adult living donor liver transplantation: current status J. Clin. Gastroenterol. 33 97 106
2. M. E. Wachs T. E. Bak F. M. Karrer G. T. Everson R. Shrestha T. E. Trouillot M. S. Mandell T. G. Steinberg I. Kam 1998 Adult living donor liver transplantation using a right hepatic lobe Transplantation 66 1313 1316
3. P. H. Hayashi J. F. Trotter 2002 Review article: adult-to-adult right hepatic lobe living donor liver transplantation Aliment. Pharmacol. Ther. 16 1833 1841
4. G. K. Michalopoulos M. C. DeFrances 1997 Liver regeneration Science 276 60 66
5. P. M. Lindroos R. Zarnegar G. K. Michalopoulos 1991 Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration Hepatology 13 743 750
6. J. E. Mead N. Fausto 1989 Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism Proc. Natl. Acad. Sci. USA 86 1558 1562
7. A. M. Diehl M. Yin J. Fleckenstein S. Q. Yang H. Z. Lin D. A. Brenner J. Westwick G. Bagby S. Nelson 1994 Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury Am. J. Physiol. 267 G552 G561
8. H. Matsunami S. Kawasaki S. Ishizone Y. Hashikura T. Ikegami M. Makuuchi H. Kawarasaki T. Iwanaka A. Nose M. Takemura 1992 Serial changes of h-HGF and IL-6 in living-related donor liver transplantation with special reference to their relationship to intra operative portal blood flow Transplant. Proc. 24 1971 1972
9. C. Favre J. A. Monti C. Scapini J. Pellegrino C. E. Carnovale M. C. Carrillo 1998 Putrescine decreases cytochrome P450 3A4 levels during liver regeneration in the rat J. Hepatol. 28 700 708
10. M. Ishizuka S. Yoshino Y. Yamamoto H. Yamamoto S. Imaoka Y. Funae M. Masuda H. Iwata A. Kazusaka S. Fujita 1997 Isozyme selective alterations of the expression of cytochrome P450 during regeneration of male rat liver following partial hepatectomy Xenobiotica 27 923 931
11. V. Tamasi A. Kiss O. Dobozy A. Falus L. Vereczkey K. Monostory 2001 The effect of dexamethasone on P450 activities in regenerating rat liver Biochem. Biophys. Res. Commun. 286 239 242
12. V. A. Catania M. G. Luquita E. J. Sanchez Pozzi A. D. Mottino 1998 Enhancement of intestinal UDP-glucuronosyltransferase activity in partially hepatectomized rats Biochim. Biophys. Acta 1380 345 353
13. P. L. Iversen Z. Liu M. R. Franklin 1985 Selective changes in cytochrome P-450 and UDP-glucuronosyltransferase subpopulations following partial hepatectomy in rats Toxicol. Appl. Pharmacol. 78 10 18
14. A. M. Pellizzer S. A. Smid S. I. Strasser C. S. Lee M. L. Mashford P. V. Desmond 1996 UDP-glucuronosyltransferase in the regenerating rat liver J. Gastroenterol. Hepatol. 11 1130 1136
15. W. F. Zakko R. M. Green J. L. Gollan C. L. Berg 1996 Hepatic regeneration is associated with preservation of microsomal glucuronidation Hepatology 24 1250 1255
16. G. M. Higgins R. M. Anderson 1931 Experimental pathology of the liver Arch. Pathol. 12 186 202
17. H. Tian J. Ou S. C. Strom R. Venkataramanan 2005 Pharmacokinetics of tacrolimus and mycophenolic acid are altered but recover at different times during hepatic regeneration in rats Drug Metab. Dispos. 33 329 335
18. O. H. Lowry N. J. Rosenbrough A. L. Farr R. J. Randall 1951 Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 265 275
19. S. B. Senafi D. J. Clarke B. Burchell 1994 Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation Biochem. J. 303 233 240
20. C. D. King M. D. Green G. R. Rios B. L. Coffman I. S. Owens W. P. Bishop T. R. Tephly 1996 The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1 Arch. Biochem. Biophys. 332 92 100
21. F. K. Kessler M. R. Kessler D. J. Auyeung J. K. Ritter 2002 Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases Drug Metab. Dispos. 30 324 330
22. C. D. King G. R. Rios M. D. Green P. I. [tmp] MacKenzie T. R. Tephly 1997 Comparison of stably expressed rat UGT1.1 and UGT2B1 in the glucuronidation of opioid compounds Drug Metab. Dispos. 25 251 255
23. P. I. Mackenzie B. Mojarrabi R. Meech A. Hansen 1996 Steroid UDP glucuronosyltransferases: characterization and regulation J. Endocrinol. 150 S79 S86
24. B. Burchell 1999 Transformation reactions: glucuronidation T. F. Woolf Handbook of Drug Metabolism Marcel Dekker New York 164
25. K. M. Alkharfy R. F. Frye 2002 Sensitive liquid chromatographic method using fluorescence detection for the determination of estradiol 3- and 17-glucuronides in rat and human liver microsomal incubations: formation kinetics J. Chromatogr., B Analyt. Technol. Biomed. Life Sci. 774 33 38
26. M. B. Fisher K. Campanale B. L. Ackermann M. VandenBranden S. A. Wrighton 2000 In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin Drug Metab. Dispos. 28 560 566
27. R. Narayanan B. LeDuc D. A. Williams 2000 Determination of the kinetics of rat UDP-glucuronosyltransferases (UGTs) in liver and intestine using HPLC J. Pharm. Biomed. Anal. 22 527 540
28. R. S. Rittmaster C. A. Leopold D. L. Thompson 1989 Androgen glucuronyl transferase activity in rat liver, evidence for the importance of hepatic tissue in 5 alpha-reduced androgen metabolism J. Steroid Biochem. 33 1207 1212
29. M. D. Green D. J. Clarke E. M. Oturu P. B. Styczynski M. R. Jackson B. Burchell T. R. Tephly 1995 Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols Arch. Biochem. Biophys. 322 460 468
30. B. J. Komoroski S. Zhang H. Cai J. M. Hutzler R. Frye T. S. Tracy S. C. Strom T. Lehmann C. Y. Ang Y. Y. Cui R. Venkataramanan 2004 Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures Drug Metab. Dispos. 32 512 518
31. S. I. Strasser M. L. Mashford P. V. Desmond 1998 Regulation of uridine diphosphate glucuronosyltransferase during the acute-phase response J. Gastroenterol. Hepatol. 13 88 94
32. M. Monshouwer R. F. Witkamp S. M. Nujmeijer J. G. Van Amsterdam A. S. Van Miert 1996 Suppression of cytochrome P450- and UDP glucuronosyl transferase-dependent enzyme activities by proinflammatory cytokines and possible role of nitric oxide in primary cultures of pig hepatocytes Toxicol. Appl. Pharmacol. 137 237 244
33. A. K. Fulop E. Pocsik M. Brozik C. Karabelyos A. Kiss I. Novak C. Szalai O. Dobozy A. Falus 2001 Hepatic regeneration induces transient acute phase reaction: systemic elevation of acute phase reactants and soluble cytokine receptors Cell Biol. Int. 25 585 592
34. M. Iwai T. X. Cui H. Kitamura M. Saito T. Shimazu 2001 Increased secretion of tumour necrosis factor and interleukin 6 from isolated, perfused liver of rats after partial hepatectomy Cytokine 13 60 64
35. A. P. Beigneux A. H. Moser J. K. Shigenaga C. Grunfeld K. R. Feingold 2002 Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response Biochem. Biophys. Res. Commun. 293 145 149
36. P. I. Mackenzie P. A. Gregory D. A. Gardner-Stephen R. H. Lewinsky B. R. Jorgensen T. Nishiyama W. Xie A. Radominska-Pandya 2003 Regulation of UDP glucuronosyltransferase genes Curr. Drug Metab. 4 249 257
37. Y. H. Lee B. Sauer P. F. Johnson F. J. Gonzalez 1997 Disruption of the c/ebp alpha gene in adult mouse liver Mol. Cell. Biol. 17 6014 6022
38. Y. Ishii A. J. Hansen P. I. Mackenzie 2000 Octamer transcription factor-1 enhances hepatic nuclear factor-1alpha-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter Mol. Pharmacol. 57 940 947
39. P. Flodby P. Antonson C. Barlow A. Blanck I. Porsch-Hallstrom K. G. Xanthopoulos 1993 Differential patterns of expression of three C/EBP isoforms, HNF-1, and HNF-4 after partial hepatectomy in rats Exp. Cell Res. 208 248 256