20(S)-Protopanaxadiol, a metabolite of ginsenosides, induced cell apoptosis through endoplasmic reticulum stress in human hepatocarcinoma HepG2 cells

European Journal of Pharmacology

Volumn 668, Issue 1-2, 2011, Pages 88-98

  Zhu, Guo Yuan ^a   Li, Ying Wei ^a   Tse, Anfernee Kai Wing ^a   Hau, Desmond Kwok Po ^a   Leung, Chung Hang ^a   Yu, Zhi Ling ^a   Fong, Wang Fun ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

20(S) Protopanaxadiol; Apoptosis; CHOP; Endoplasmic reticulum stress; Ginseng; Human hepatocarcinoma

Indexed keywords

20 PROTOPANAXADIOL; ACTIVATING TRANSCRIPTION FACTOR 6; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; DEATH RECEPTOR 5; GINSENOSIDE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN BCL XL; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; CELL ULTRASTRUCTURE; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; DRUG TARGETING; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE SILENCING; GENETIC REGULATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; RNA SPLICING; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING;

APOPTOSIS; ENDOPLASMIC RETICULUM STRESS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GINSENOSIDES; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SAPOGENINS; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE; UP-REGULATION; VACUOLES;

EID: 80052064898     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.06.008     Document Type: Article

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