Antitumor agents. 261. 20(S)-protopanaxadiol and 20(S)-protopanaxatriol as antiangiogenic agents and total assignment of 1H NMR spectra

Journal of Natural Products

Volumn 71, Issue 3, 2008, Pages 478-481

  Usami, Yoshihide ^a,b   Liu, Yi Nan ^a   Lin, An Shen ^a,c   Shibano, Makro ^a,b   Akiyama, Toshiyuki ^a   Itokawa, Hideji ^a   Morris Natschke, Susan L ^a   Bastow, Kenneth ^a   Kasai, Ryoji ^d   Lee, Kuo Hsiung ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b OSAKA MEDICAL COLLEGE   (Japan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

20 PROTOPANAXADIOL; 20 PROTOPANAXATRIOL; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; GROWTH INHIBITION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HUMAN CELL; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR GROWTH; VASCULAR ENDOTHELIUM;

ANGIOGENESIS INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SAPOGENINS; STEREOISOMERISM; TRITERPENES; UMBILICAL VEINS;

PANAX GINSENG;

EID: 42249110033     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np070613q     Document Type: Article

References (35)

1. Melnick, S. J. J. Pediatr. Hematol. Oncol. 2006, 28, 221-230.
2. Melnick, S. J. J. Pediatr. Hematol. Oncol. 2006, 28, 271-285.
3. Zhao, S.; Dai, X. Guangdong Yaoxue 2005, 15, 63-65.
4. Chung, A-S.; Cho, K.-J.; Park, J. D. Oxidative Stress Dis. 2004, 14, 517-536.
5. Shibata, S. Gendai Toyo Igaku 1982, 3, 62-69.
6. Tanaka, O.; Kasai, R.; Matsuura, H.; Yamaguchi, T. Pharm. Tech. Japon 1986, 2, 475-481.
7. Tanaka, O.; Kasai, R. Progr. Chem. Org. Nat. Prod. 1984, 46, 1-76.
8. Hasegawa, H. J. Pharmacol. Sci. 2004, 95, 153-157.
9. Tachikawa, E.; Kudo, K. J. Pharmacol. Sci. 2004, 95, 140-144.
10. Shibata, S.; Ando, T.; Tanaka, O. Chem. Pharm. Bull. 1966, 14, 1157-1161.
11. Nagai, M.; Tanaka, O.; Shibata, S. Tetrahedron 1971, 27, 881-892.
12. Nagai, M.; Ando, T.; Tanaka, N.; Tanaka, O.; Shibata, S. Chem. Pharm. Bull. 1972, 20, 1212-1216.
13. Sanada, S.; Kondo, N.; Shoji, J.; Tanaka, O.; Shibata, S. Chem. Pharm. Bull. 1974, 22, 2407-2412.
14. Sanada, S.; Kondo, N.; Shoji, J.; Tanaka, O.; Shibata, S. Chem. Pharm. Bull. 1974, 22, 421-428.
15. Tanaka, O.; Nagai, M.; Shibata, S. Tetrahedron Lett. 1964, 2291, 2297.
16. Shibata, S.; Tanaka, O.; Ando, T.; Sado, M.; Tsushima, S.; Ohsawa, T. Chem. Pharm. Bull. 1966, 14, 595-600.
17. Tanaka, O.; Nagai, M.; Shibata, S. Chem. Pharm. Bull. 1966, 14, 1150-1156.
18. Tanaka, K.; Kubota, M.; Zhu, S.; Sankawa, U.; Komatsu, K. Nat. Prod. Commun. 2007, 652-632, and references therein.
19. Bae, E. A.; Han, M. J.; Choo, M. K.; Oark, S. Y.; Kim, D. H. Biol. Pharm. Bull. 2002, 25, 58-63, and references therein.
20. Yu, Y.; Zhou, Q.; Hang, Y.; Bu, X.; Jia, W. Cancer 2007, 109, 2374-2382.
21. Asakawa, J.; Kasai, R.; Yamasaki, K.; Tanaka, O. Tetrahedron 1977, 33, 1935-1939.
22. Baek, N.-I.; Kim, D. S.; Lee, Y. H.; Park, J.; Dae, J.; So, Y.; Lee, C. B.; Kim, S. I. Koryo Insam Hakhoechi 1995, 19, 45-50.
23. Ma, S. G.; Jiang, Y. T.; Song, S. J.; Wang, Z. H.; Bai, J.; Xu, S. X.; Liu, K. Yaoxue Xuebao 2005, 40, 924-930.
24. Fan, T.-P.; Yeh, J.-C.; Leung, K. W.; Yue, P. Y. K.; Wong, R. N. S. Trends Pharmacol. Sci. 2006, 27, 297-309.
25. Bergers, G.; Benjamin, L. E. Nat. Rev., Cancer 2003, 3, 401-410.
26. Sato, K.; Mochizuki, M.; Saiki, I.; Yoo, Y. C.; Samukawa, K.; Azuma, I. Biol. Pharm. Bull. 1994, 17, 635-639.
27. Yue, P. Y. K.; Mak, N. K.; Cheng, Y. K.; Leung, K. W.; Ng, T. B.; Fan, D. T. P.; Yeung, H. W.; Wong, R. N. S. Chin. Med. 2007, 2, 42-62.
28. Mochizuki, M.; Yoo, Y. C.; Matsuzaka, K.; Sato, K.; Saiki, I.; Tanooka, S.; Samukawa, K.; Azuma, I. Biol. Pharm. Bull. 1995, 18, 1197-1202.
29. Sengupta, S.; Toh, S.-A.; Sellers, L. A.; Skepper, J. N.; Koolwijk, P.; Leung, H. W.; Yeung, H.-W.; Wong, L. N. S.; Sasisekharan, R.; Fan, T.-P. D. Circulation 2004, 110, 1219-1225.
30. Liu, G. Y.; Bu, X.; Yan, H.; Jia, W. W. G. J. Nat. Prod. 2007, 70, 259-264.
31. Chen, Y. J.; Nose, M.; Ogihara, Y. Chem. Pharm. Bull. 1987, 35, 1653-1655.
32. Ligor, T.; Ludwiczuk, A.; Tolski, T.; Buszewski, B. Anal. Bioanal. Chem. 2005, 383, 1098-1105.
33. Sun, J.; Wang, G.; Haitang, X.; Hao, L.; Guoyu, P.; Tucker, I. J. Pharm. Biomed. Anal. 2005, 18, 126-132.
34. Ye, J.; Yuan, L. Biosci. Biotechnol. Biochem. 2007, 71, 1162-1169.
35. Hoang, T. H.; Huang, S. H.; Armstrong, E.; Eickhoff, J. C.; Harari, P. M. Int. J. Radiat. Oncol. Biol. Phys. 2006, 64, 1458-1465.