Application of a double aza-Michael reaction in a click, click, cy-click strategy: From bench to flow

Synthesis

Volumn , Issue 17, 2011, Pages 2743-2750

  Zang, Qin ^a   Javed, Salim ^a   Ullah, Farman ^b   Zhou, Aihua ^a   Knudtson, Christopher A ^a   Bi, Danse ^a   Basha, Fatima Z ^c   Organ, Michael G ^b   Hanson, Paul R ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b YORK UNIVERSITY   (Canada)

^c UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

1,2,5 thiadiazepane 1,1 dioxides; click; double aza Michael; flow; MACOS

Indexed keywords

1,2,5-THIADIAZEPANE 1,1-DIOXIDES; CLICK; DOUBLE-AZA-MICHAEL; FLOW; MACOS;

ADDITION REACTIONS;

SYNTHESIS (CHEMICAL);

1,2,5 THIADIAZEPANE 1,1 DIOXIDE; CYCLOPENTYLAMINE; METHYL 2 (4 CHLOROBENZYL) 5 (4 METHOXYBENZYL) 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 2 (4 CHLOROBENZYL) 5 PHENETHYL 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 2 (4 FLUOROBENZYL) 5 ISOBUTYL 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 2 (4 METHOXYBENZYL) 5 OCTYL 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 2 [[1 (2 BROMOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5 (2 HYDROXYETHYL) 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 2 [[1 (2 BROMOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5 BUTYL 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 2 [[1 (3 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 2 BENZYL 5 (4 FLUOROBENZYL) 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 2 BENZYL 5 BUTYL 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 5 (2 HYDROXYETHYL) 2 [[1 (4 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 5 BENZYL 2 [4 (TRIFLUOROMETHYL)BENZYL] 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 5 BENZYL 2 [[1 (2 BROMOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 5 BENZYL 2 [[1 (3 BROMOBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 5 BENZYL 2 [[1 (3 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 5 BENZYL 2 [[1 (4 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 5 BUTYL 2 [[1 (3 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 5 BUTYL 2 [[1 (4 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL 5 CYCLOPENTYL 2 (4 METHYLBENZYL) 1,2,5 THIADIAZEPANE 3 CARBOXYLATE 1,1 DIOXIDE; OXIDE; PENTYLAMINE; SULFONAMIDE; TETRAHYDROFURAN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CLICK CHEMISTRY; CYCLIZATION; CYCLOADDITION; DOUBLE AZA MICHAEL ADDITION; MICHAEL ADDITION; MICROWAVE ASSISTED CONTINUOUS FLOW ORGANIC SYNTHESIS PLATFORM; REACTION OPTIMIZATION;

EID: 80052052860     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1260112     Document Type: Article

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