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Volumn , Issue 16, 2008, Pages 2759-2766

Guanidine-catalyzed asymmetric synthesis of 2,2-disubstituted chromane skeletons by intramolecular oxa-Michael addition

Author keywords

Asymmetric synthesis; Chromane; Guanidine; Michael addition; Organocatalysis

Indexed keywords


EID: 53749089571     PISSN: 1434193X     EISSN: 10990690     Source Type: Journal    
DOI: 10.1002/ejoc.200800089     Document Type: Article
Times cited : (73)

References (42)
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    • and references cited therein
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  • 17
    • 2442661261 scopus 로고    scopus 로고
    • For the synthesis of 2-monosubstituted chromane, see: a
    • For the synthesis of 2-monosubstituted chromane, see: a) A. Merschaert, P. Delbeke, D. Daloze, G. Dive, Tetrahedron Lett. 2004, 45, 4697-4701;
    • (2004) Tetrahedron Lett , vol.45 , pp. 4697-4701
    • Merschaert, A.1    Delbeke, P.2    Daloze, D.3    Dive, G.4
  • 20
    • 34247167637 scopus 로고    scopus 로고
    • for 2-monosubstituted chromanones, see: d
    • for 2-monosubstituted chromanones, see: d) M. M. Biddle, M. Lin, K. A. Scheidt, J. Am. Chem. Soc. 2007, 129, 3830-3831;
    • (2007) J. Am. Chem. Soc , vol.129 , pp. 3830-3831
    • Biddle, M.M.1    Lin, M.2    Scheidt, K.A.3
  • 40
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    • 24 = -2.10 (see Supporting Information).
    • 24 = -2.10 (see Supporting Information).
  • 41
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    • The relative energy of the transition state that leads to (R)-5a was estimated to be 31.5 kcal/mol, which is 5.5 kcal/mol lower than that of (S)-5a. The theoretical calculation was performed by PM3 using the CAChe MOPAC2002 program. The results of these calculations will be published in the near future.
    • The relative energy of the transition state that leads to (R)-5a was estimated to be 31.5 kcal/mol, which is 5.5 kcal/mol lower than that of (S)-5a. The theoretical calculation was performed by PM3 using the CAChe MOPAC2002 program. The results of these calculations will be published in the near future.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.