Automated synthesis of a 184-member library of thiadiazepan-1,1-dioxide-4- ones

ACS Combinatorial Science

Volumn 13, Issue 3, 2011, Pages 244-250

  Fenster, Erik ^a   Long, Toby R ^a   Zang, Qin ^a   Hill, David ^a   Neuenswander, Benjamin ^a   Lushington, Gerald H ^a   Zhou, Aihua ^a   Santini, Conrad ^a   Hanson, Paul R ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

aza Michael reaction; Huisgen cycloaddition; parallel synthesis platform; Suzuki Miyaura coupling; thiadiazepan 1,1 dioxide 4 ones

Indexed keywords

AZEPINE DERIVATIVE;

ARTICLE; CHEMISTRY; COMBINATORIAL CHEMISTRY;

AZEPINES; COMBINATORIAL CHEMISTRY TECHNIQUES;

EID: 79955844136     PISSN: 21568952     EISSN: None     Source Type: Journal    
DOI: 10.1021/co100060x     Document Type: Article

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50. 2 was removed during the process of concentrating the reaction mixture under reduced pressure.
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52. The standards for compound purity and quantity are based upon those requested for the National Institutes of Health?s Molecular Libraries Small Molecule Repository (http://mlsmr.glpg.com/MLSMR-HomePage/submitcompounds.html). The compound purities were determined by reverse-phase HPLC with peak area (UV) at 214 nm.