Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): A new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 12, 1999, Pages 2811-2822

  Arranz, M ^a   Díaz, Juan A ^a   Ingate, Simon T ^a   Witvrouw, Myriam ^b   Pannecouque, Christophe ^b   Balzarini, Jan ^b   De Clercq, Erik ^b   Vega, Salvador ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

1,1,3 trioxo 2H,4H thieno 3,4 e 1,2,4 thiadiazines (TTDs); Antivirals; Enzyme inhibitors; HIV 1 reverse transcriptase

Indexed keywords

DELAVIRDINE; DEOXYGUANOSINE TRIPHOSPHATE; HETEROCYCLIC COMPOUND; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS ENZYME; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RESISTANCE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SIMIAN IMMUNODEFICIENCY VIRUS; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELL LINE; DRUG EVALUATION, PRECLINICAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZINES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0343920864     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00221-7     Document Type: Article

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