-
1
-
-
29244465509
-
Human fat cell lipolysis: Biochemistry, regulation and clinical role
-
Arner P (2005) Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Pract Res Clin Endocrinol Metab 19:471-482.
-
(2005)
Best Pract Res Clin Endocrinol Metab
, vol.19
, pp. 471-482
-
-
Arner, P.1
-
2
-
-
1442352339
-
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: Peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach
-
Bays H, Mandarino L, and DeFronzo RA (2004) Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. J Clin Endocrinol Metab 89:463-478.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 463-478
-
-
Bays, H.1
Mandarino, L.2
DeFronzo, R.A.3
-
4
-
-
0014480714
-
Effect of adrenergic receptor blockade on nicotinic acid-induced plasma FFA rebound
-
Blackard WG and Heidingsfelder SA (1969) Effect of adrenergic receptor blockade on nicotinic acid-induced plasma FFA rebound. Metabolism 18:226-233.
-
(1969)
Metabolism
, vol.18
, pp. 226-233
-
-
Blackard, W.G.1
Heidingsfelder, S.A.2
-
5
-
-
0034813837
-
Obesity, free fatty acids and insulin resistance
-
Boden G (2001) Obesity, free fatty acids and insulin resistance. Curr Opin Endocrinol Diab 8:235-239.
-
(2001)
Curr Opin Endocrinol Diab
, vol.8
, pp. 235-239
-
-
Boden, G.1
-
6
-
-
29044447292
-
Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-{kappa}B pathway in rat liver
-
Boden G, She P, Mozzoli M, Cheung P, Gumireddy K, Reddy P, Xiang X, Luo Z, and Ruderman N (2005) Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-{kappa}B pathway in rat liver. Diabetes 54:3458-3465.
-
(2005)
Diabetes
, vol.54
, pp. 3458-3465
-
-
Boden, G.1
She, P.2
Mozzoli, M.3
Cheung, P.4
Gumireddy, K.5
Reddy, P.6
Xiang, X.7
Luo, Z.8
Ruderman, N.9
-
7
-
-
0021676512
-
Reversal of dietary-induced insulin resistance in muscle of the rat by adenosine deaminase and an adenosine-receptor antagonist
-
Budohoski L, Challiss RA, Cooney GJ, McManus B, and Newsholme EA (1984) Reversal of dietary-induced insulin resistance in muscle of the rat by adenosine deaminase and an adenosine-receptor antagonist. Biochem J 224:327-330.
-
(1984)
Biochem J
, vol.224
, pp. 327-330
-
-
Budohoski, L.1
Challiss, R.A.2
Cooney, G.J.3
McManus, B.4
Newsholme, E.A.5
-
8
-
-
22644437126
-
Nicotinic acid: The broad-spectrum lipid drug: a 50th anniversary review
-
Carlson LA (2005) Nicotinic acid: the broad-spectrum lipid drug: a 50th anniversary review. J Intern Med 258:94-114.
-
(2005)
J Intern Med
, vol.258
, pp. 94-114
-
-
Carlson, L.A.1
-
9
-
-
0000242585
-
The effect of nicotinic acid on the plasma free fatty acid; demonstration of a metabolic type of sympathicolysis
-
Carlson LA and Oro L (1962) The effect of nicotinic acid on the plasma free fatty acid; demonstration of a metabolic type of sympathicolysis. Acta Med Scand 172:641-645.
-
(1962)
Acta Med Scand
, vol.172
, pp. 641-645
-
-
Carlson, L.A.1
Oro, L.2
-
10
-
-
0023153344
-
Resistance to insulin suppression of plasma free fatty acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus
-
Chen YD, Golay A, Swislocki AL, and Reaven GM (1987) Resistance to insulin suppression of plasma free fatty acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 64:17-21.
-
(1987)
J Clin Endocrinol Metab
, vol.64
, pp. 17-21
-
-
Chen, Y.D.1
Golay, A.2
Swislocki, A.L.3
Reaven, G.M.4
-
12
-
-
33947384716
-
-
1 adenosine receptor agonists. U.S. patent application number 20060009417. 2006 Jan 12
-
1 adenosine receptor agonists. U.S. patent application number 20060009417. 2006 Jan 12.
-
-
-
-
13
-
-
33947416790
-
-
1 adenosine receptors. U.S. patent application number 20060052330. 2006 Mar 9
-
1 adenosine receptors. U.S. patent application number 20060052330. 2006 Mar 9.
-
-
-
-
14
-
-
0015502039
-
Effects of adenosine nucleosides on adenylate cyclase, phosphodiesterase, cyclic adenosine monophosphate accumulation, and lipolysis in fat cells
-
Fain JN, Pointer RH, and Ward WF (1972) Effects of adenosine nucleosides on adenylate cyclase, phosphodiesterase, cyclic adenosine monophosphate accumulation, and lipolysis in fat cells. J Biol Chem 247:6866-6872.
-
(1972)
J Biol Chem
, vol.247
, pp. 6866-6872
-
-
Fain, J.N.1
Pointer, R.H.2
Ward, W.F.3
-
15
-
-
33645875608
-
A novel partial agonist of the A1-adenosine receptor and evidence of receptor homogeneity in adipocytes
-
Fatholahi M, Xiang Y, Wu Y, Li Y, Wu L, Dhalla AK, Belardinelli L, and Shryock JC (2006) A novel partial agonist of the A1-adenosine receptor and evidence of receptor homogeneity in adipocytes. J Pharmacol Exp Ther 317:676-684.
-
(2006)
J Pharmacol Exp Ther
, vol.317
, pp. 676-684
-
-
Fatholahi, M.1
Xiang, Y.2
Wu, Y.3
Li, Y.4
Wu, L.5
Dhalla, A.K.6
Belardinelli, L.7
Shryock, J.C.8
-
16
-
-
0037382360
-
1 adenosine receptor agonist, antagonizes catecholamine-induced lipolysis without cardiovascular effects in awake rats
-
1 adenosine receptor agonist, antagonizes catecholamine-induced lipolysis without cardiovascular effects in awake rats. J Pharmacol Exp Ther 305:225-231.
-
(2003)
J Pharmacol Exp Ther
, vol.305
, pp. 225-231
-
-
Fraser, H.1
Gao, Z.2
Ozeck, M.J.3
Belardinelli, L.4
-
17
-
-
0033559337
-
1 adenosine receptor-G-protein complexes: Effects of receptor down-regulation and phosphorylation on coupling
-
1 adenosine receptor-G-protein complexes: effects of receptor down-regulation and phosphorylation on coupling. Biochem J 338:729-736.
-
(1999)
Biochem J
, vol.338
, pp. 729-736
-
-
Gao, Z.1
Robeva, A.S.2
Linden, J.3
-
18
-
-
0028239364
-
The effects of GR79236 on plasma fatty acid concentrations, heart rate and blood pressure in the conscious rat
-
Gardner CJ, Twissell DJ, Coates J, and Strong P (1994) The effects of GR79236 on plasma fatty acid concentrations, heart rate and blood pressure in the conscious rat. Eur J Pharmacol 257:117-121.
-
(1994)
Eur J Pharmacol
, vol.257
, pp. 117-121
-
-
Gardner, C.J.1
Twissell, D.J.2
Coates, J.3
Strong, P.4
-
19
-
-
0037158150
-
Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: Results of the assessment of diabetes control and evaluation of the efficacy of Niaspan Trial
-
Grundy SM, Vega GL, McGovern ME, Tulloch BR, Kendall DM, Fitz-Patrick D, Ganda OP, Rosenson RS, Buse JB, Robertson DD, et al. (2002) Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of Niaspan Trial. Arch Intern Med 162:1568-1576.
-
(2002)
Arch Intern Med
, vol.162
, pp. 1568-1576
-
-
Grundy, S.M.1
Vega, G.L.2
McGovern, M.E.3
Tulloch, B.R.4
Kendall, D.M.5
Fitz-Patrick, D.6
Ganda, O.P.7
Rosenson, R.S.8
Buse, J.B.9
Robertson, D.D.10
-
20
-
-
0022483288
-
Desensitization of adenosine receptor-mediated inhibition of lipolysis: The mechanism involves the development of enhanced cyclic adenosine monophosphate accumulation in tolerant adipocytes
-
Hoffman BB, Chang H, Dall'Aglio E, and Reaven GM (1986a) Desensitization of adenosine receptor-mediated inhibition of lipolysis: the mechanism involves the development of enhanced cyclic adenosine monophosphate accumulation in tolerant adipocytes. J Clin Investig 78:185-190.
-
(1986)
J Clin Investig
, vol.78
, pp. 185-190
-
-
Hoffman, B.B.1
Chang, H.2
Dall'Aglio, E.3
Reaven, G.M.4
-
21
-
-
0022908516
-
Suppression of free fatty acids and triglycerides in normal and hypertriglyceridemic rats by the adenosine receptor agonist phenylisopropyladenosine
-
Hoffman BB, Dall'Aglio E, Hollenbeck C, Chang H, and Reaven GM (1986b) Suppression of free fatty acids and triglycerides in normal and hypertriglyceridemic rats by the adenosine receptor agonist phenylisopropyladenosine. J Pharmacol Exp Ther 239:715-718.
-
(1986)
J Pharmacol Exp Ther
, vol.239
, pp. 715-718
-
-
Hoffman, B.B.1
Dall'Aglio, E.2
Hollenbeck, C.3
Chang, H.4
Reaven, G.M.5
-
22
-
-
0036300538
-
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
-
Itani SI, Ruderman NB, Schmieder F, and Boden G (2002) Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 51:2005-2011.
-
(2002)
Diabetes
, vol.51
, pp. 2005-2011
-
-
Itani, S.I.1
Ruderman, N.B.2
Schmieder, F.3
Boden, G.4
-
23
-
-
0033812857
-
Effects of nicotinic acid on insulin sensitivity and blood pressure in healthy subjects
-
Kelly JJ, Lawson JA, Campbell LV, Storlien LH, Jenkins AB, Whitworth JA, and O'Sullivan AJ (2000) Effects of nicotinic acid on insulin sensitivity and blood pressure in healthy subjects. J Hum Hypertens 14:567-572.
-
(2000)
J Hum Hypertens
, vol.14
, pp. 567-572
-
-
Kelly, J.J.1
Lawson, J.A.2
Campbell, L.V.3
Storlien, L.H.4
Jenkins, A.B.5
Whitworth, J.A.6
O'Sullivan, A.J.7
-
24
-
-
0031726194
-
Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy
-
Kovoor A, Celver JP, Wu A, and Chavkin C (1998) Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy. Mol Pharmacol 54:704-711.
-
(1998)
Mol Pharmacol
, vol.54
, pp. 704-711
-
-
Kovoor, A.1
Celver, J.P.2
Wu, A.3
Chavkin, C.4
-
26
-
-
0028057319
-
A comparison of the efficacy and toxic effects of sustained vs immediate-release niacin in hypercholesterolemic patients
-
McKenny J, Proctor J, Harris S, and Chinchili V (1994) A comparison of the efficacy and toxic effects of sustained vs immediate-release niacin in hypercholesterolemic patients. J Am Med Assoc 271:672-710.
-
(1994)
J Am Med Assoc
, vol.271
, pp. 672-710
-
-
McKenny, J.1
Proctor, J.2
Harris, S.3
Chinchili, V.4
-
27
-
-
0014086435
-
The plasma free fatty acid rebound induced by nicotinic acid
-
Pereira JN (1967) The plasma free fatty acid rebound induced by nicotinic acid. J Lipid Res 8:239-244.
-
(1967)
J Lipid Res
, vol.8
, pp. 239-244
-
-
Pereira, J.N.1
-
28
-
-
0041312408
-
Nicotinic acid-induced insulin resistance is related to increased circulating fatty acids and fat oxidation but not muscle lipid content
-
Poynten AM, Gan SK, Kriketos AD, O'Sullivan A, Kelly JJ, Ellis BA, Chisholm DJ, and Campbell LV (2003) Nicotinic acid-induced insulin resistance is related to increased circulating fatty acids and fat oxidation but not muscle lipid content. Metabolism 52:699-704.
-
(2003)
Metabolism
, vol.52
, pp. 699-704
-
-
Poynten, A.M.1
Gan, S.K.2
Kriketos, A.D.3
O'Sullivan, A.4
Kelly, J.J.5
Ellis, B.A.6
Chisholm, D.J.7
Campbell, L.V.8
-
29
-
-
0028947949
-
The fourth musketeer: From Alexandre Dumas to Claude Bernard
-
Reaven GM (1995) The fourth musketeer: from Alexandre Dumas to Claude Bernard. Diabetologia 38:3-13.
-
(1995)
Diabetologia
, vol.38
, pp. 3-13
-
-
Reaven, G.M.1
-
30
-
-
0029948212
-
Mechanism of free fatty acid-induced insulin resistance in humans
-
Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, and Shulman GI (1996) Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Investig 97:2859-2865.
-
(1996)
J Clin Investig
, vol.97
, pp. 2859-2865
-
-
Roden, M.1
Price, T.B.2
Perseghin, G.3
Petersen, K.F.4
Rothman, D.L.5
Cline, G.W.6
Shulman, G.I.7
-
31
-
-
0024990107
-
Effects of age and adenosine in the modulation of insulin action on rat adipocyte metabolism
-
Rolband GC, Furth ED, Staddon JM, Rogus EM, and Goldberg AP (1990) Effects of age and adenosine in the modulation of insulin action on rat adipocyte metabolism. J Gerontol 45:B174-B178.
-
(1990)
J Gerontol
, vol.45
-
-
Rolband, G.C.1
Furth, E.D.2
Staddon, J.M.3
Rogus, E.M.4
Goldberg, A.P.5
-
32
-
-
0024995157
-
A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation
-
Sako Y and Grill VE (1990) A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127:1580-1589.
-
(1990)
Endocrinology
, vol.127
, pp. 1580-1589
-
-
Sako, Y.1
Grill, V.E.2
-
33
-
-
3042745158
-
Characterization of adenosine-A1 receptor-mediated antilipolysis in rats by tissue microdialysis, 1H-spectroscopy, and glucose clamp studies
-
Schoelch C, Kuhlmann J, Gossel M, Mueller G, Neumann-Haefelin C, Belz U, Kalisch J, Biemer-Daub G, Kramer W, Juretschke HP, et al. (2004) Characterization of adenosine-A1 receptor-mediated antilipolysis in rats by tissue microdialysis, 1H-spectroscopy, and glucose clamp studies. Diabetes 53:1920-1926.
-
(2004)
Diabetes
, vol.53
, pp. 1920-1926
-
-
Schoelch, C.1
Kuhlmann, J.2
Gossel, M.3
Mueller, G.4
Neumann-Haefelin, C.5
Belz, U.6
Kalisch, J.7
Biemer-Daub, G.8
Kramer, W.9
Juretschke, H.P.10
-
34
-
-
0016237090
-
Facilitation by adenosine of the action of insulin on the accumulation of adenosine 3′:5′- monophosphate, lipolysis, and glucose oxidation in isolated fat cells
-
Schwabe U, Schonhofer PS, and Ebert R (1974) Facilitation by adenosine of the action of insulin on the accumulation of adenosine 3′:5′- monophosphate, lipolysis, and glucose oxidation in isolated fat cells. Eur J Biochem 46:537-545.
-
(1974)
Eur J Biochem
, vol.46
, pp. 537-545
-
-
Schwabe, U.1
Schonhofer, P.S.2
Ebert, R.3
-
35
-
-
0031777856
-
Inverse agonists and neutral antagonists of recombinant human A1 adenosine receptors stably expressed in Chinese hamster ovary cells
-
Shryock JC, Ozeck MJ, and Belardinelli L (1998) Inverse agonists and neutral antagonists of recombinant human A1 adenosine receptors stably expressed in Chinese hamster ovary cells. Mol Pharmacol 53:886-893.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 886-893
-
-
Shryock, J.C.1
Ozeck, M.J.2
Belardinelli, L.3
-
36
-
-
0033538526
-
Enhancement by adenosine of insulin-induced activation of phosphoinositide 3-kinase and protein kinase B in rat adipocytes
-
Takasuga S, Katada T, Ui M, and Hazeki O (1999) Enhancement by adenosine of insulin-induced activation of phosphoinositide 3-kinase and protein kinase B in rat adipocytes. J Biol Chem 274:19545-19550.
-
(1999)
J Biol Chem
, vol.274
, pp. 19545-19550
-
-
Takasuga, S.1
Katada, T.2
Ui, M.3
Hazeki, O.4
-
37
-
-
0032588293
-
1 adenosine receptor of human and mouse adipose tissues: Cloning, expression, and characterization
-
1 adenosine receptor of human and mouse adipose tissues: cloning, expression, and characterization. Biochem Pharmacol 58:1269-1277.
-
(1999)
Biochem Pharmacol
, vol.58
, pp. 1269-1277
-
-
Tatsis-Kotsidis, I.1
Erlanger, B.F.2
-
38
-
-
0037352280
-
PUMA-G and HM74 are receptors for nicotinic acid and mediate its antilipolytic effect
-
Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, and Offermanns S (2003) PUMA-G and HM74 are receptors for nicotinic acid and mediate its antilipolytic effect. Nat Med 9:352-355.
-
(2003)
Nat Med
, vol.9
, pp. 352-355
-
-
Tunaru, S.1
Kero, J.2
Schaub, A.3
Wufka, C.4
Blaukat, A.5
Pfeffer, K.6
Offermanns, S.7
-
39
-
-
0023616250
-
Opioid receptor desensitization in NG 108-15 cells: Differential effects of a full and a partial agonist on the opioid-dependent GTPase
-
Vachon L, Costa T, and Herz A (1987) Opioid receptor desensitization in NG 108-15 cells: differential effects of a full and a partial agonist on the opioid-dependent GTPase. Biochem Pharmacol 36:2889-2897.
-
(1987)
Biochem Pharmacol
, vol.36
, pp. 2889-2897
-
-
Vachon, L.1
Costa, T.2
Herz, A.3
-
40
-
-
0031801494
-
Selectivity of action of 8-alkylamino analogues of N6-cyclopentyladenosine in vivo: Haemodynamic versus anti-lipolytic responses in rats
-
van Schaick EA, Tukker HE, Roelen HCPF, IJzerman AP, and Danhof M (1998) Selectivity of action of 8-alkylamino analogues of N6-cyclopentyladenosine in vivo: haemodynamic versus anti-lipolytic responses in rats. British J Pharm 124:607-618.
-
(1998)
British J Pharm
, vol.124
, pp. 607-618
-
-
van Schaick, E.A.1
Tukker, H.E.2
Roelen, H.C.P.F.3
IJzerman, A.P.4
Danhof, M.5
-
41
-
-
19344370665
-
Influence of extended-release nicotinic acid on nonesterified fatty acid flux in the metabolic syndrome with atherogenic dyslipidemia
-
Vega GL, Cater NB, Meguro S, and Grundy SM (2005) Influence of extended-release nicotinic acid on nonesterified fatty acid flux in the metabolic syndrome with atherogenic dyslipidemia. Am J Cardiol 95:1309-1313.
-
(2005)
Am J Cardiol
, vol.95
, pp. 1309-1313
-
-
Vega, G.L.1
Cater, N.B.2
Meguro, S.3
Grundy, S.M.4
-
42
-
-
0035002026
-
A partial agonist of the A(1)-adenosine receptor selectively slows AV conduction in guinea pig hearts
-
Wu L, Belardinelli L, Zablocki JA, Palle V, and Shryock JC (2001) A partial agonist of the A(1)-adenosine receptor selectively slows AV conduction in guinea pig hearts. Am J Physiol 280:H334-H343.
-
(2001)
Am J Physiol
, vol.280
-
-
Wu, L.1
Belardinelli, L.2
Zablocki, J.A.3
Palle, V.4
Shryock, J.C.5
|