메뉴 건너뛰기




Volumn 81, Issue 4, 2007, Pages 316-326

Adenosine inhibition of lipopolysaccharide-induced interleukin-6 secretion by the osteoblastic cell line MG-63

Author keywords

Adenosine; Inflammation; Interleukin 6; Osteoblast; Purine receptor

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE;

EID: 34848824403     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-007-9060-y     Document Type: Article
Times cited : (17)

References (78)
  • 1
    • 84940815279 scopus 로고
    • The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart
    • Drury AN, Szent-Györgyi A (1929) The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. J Physiol 68:213-237
    • (1929) J Physiol , vol.68 , pp. 213-237
    • Drury, A.N.1    Szent-Györgyi, A.2
  • 3
    • 0035209620 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
    • Fredholm BB, Ijzerman AP, Jacobson KA, Klotz K-N, Linden J (2001) International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53:527-552
    • (2001) Pharmacol Rev , vol.53 , pp. 527-552
    • Fredholm, B.B.1    Ijzerman, A.P.2    Jacobson, K.A.3    Klotz, K.-N.4    Linden, J.5
  • 4
    • 17844371308 scopus 로고    scopus 로고
    • Adenosine in tissue protection and tissue regeneration
    • Linden J (2005) Adenosine in tissue protection and tissue regeneration. Mol Pharmacol 67:1385-1387
    • (2005) Mol Pharmacol , vol.67 , pp. 1385-1387
    • Linden, J.1
  • 5
    • 0038771191 scopus 로고    scopus 로고
    • Signalling from adenosine receptors to mitogen-activated protein kinases
    • Schulte G, Fredholm BB (2003) Signalling from adenosine receptors to mitogen-activated protein kinases. Cell Signal 15:813
    • (2003) Cell Signal , vol.15 , pp. 813
    • Schulte, G.1    Fredholm, B.B.2
  • 6
    • 0036371001 scopus 로고    scopus 로고
    • Potential therapeutic targets in the rapidly expanding field of purinergic signalling
    • Burnstock G (2002) Potential therapeutic targets in the rapidly expanding field of purinergic signalling. Clin Med J R Coll Physicians 2:45-53
    • (2002) Clin Med J R Coll Physicians , vol.2 , pp. 45-53
    • Burnstock, G.1
  • 8
    • 0037678324 scopus 로고    scopus 로고
    • Adenosine modulation: A novel approach to analgesia and inflammation
    • Kowaluk EA (1998) Adenosine modulation: a novel approach to analgesia and inflammation. Expert Opin Investig Drugs 7:535-543
    • (1998) Expert Opin Investig Drugs , vol.7 , pp. 535-543
    • Kowaluk, E.A.1
  • 9
    • 23144453122 scopus 로고    scopus 로고
    • Clinical application of adenosine and ATP for pain control
    • Hayashida M, Fukuda K-i, Fukunaga A (2005) Clinical application of adenosine and ATP for pain control. J Anesthesia 19:225
    • (2005) J Anesthesia , vol.19 , pp. 225
    • Hayashida, M.1    K-I, F.2    Fukunaga, A.3
  • 12
    • 0031754497 scopus 로고    scopus 로고
    • Receptors for purines and pyrimidines
    • Ralevic V, Burnstock G (1998) Receptors for purines and pyrimidines. Pharmacol Rev 50:413-492
    • (1998) Pharmacol Rev , vol.50 , pp. 413-492
    • Ralevic, V.1    Burnstock, G.2
  • 13
    • 0030044335 scopus 로고    scopus 로고
    • ATP and adenosine act as a mitogen for osteoblast-like cells (MC3T3-E1)
    • Shimegi S (1996) ATP and adenosine act as a mitogen for osteoblast-like cells (MC3T3-E1). Calcif Tissue Int 58:109-113
    • (1996) Calcif Tissue Int , vol.58 , pp. 109-113
    • Shimegi, S.1
  • 14
    • 0025569752 scopus 로고
    • Overview. Purinergic mechanisms
    • Burnstock G (1990) Overview. Purinergic mechanisms. Ann N Y Acad Sci 603:1b-17
    • (1990) Ann N Y Acad Sci , vol.603
    • Burnstock, G.1
  • 15
    • 0028946706 scopus 로고
    • Adenosine receptor subtypes: Characterization and therapeutic regulation
    • Olah M, Stiles G (1995) Adenosine receptor subtypes: characterization and therapeutic regulation. Annu Rev Pharmacol Toxicol 35:581-606
    • (1995) Annu Rev Pharmacol Toxicol , vol.35 , pp. 581-606
    • Olah, M.1    Stiles, G.2
  • 19
    • 0034105650 scopus 로고    scopus 로고
    • Molecular identification and pharmacological characterization of adenosine receptors in the guinea-pig colon
    • Kadowaki M, Takeda M, Tokita K, Hanaoka K, Tomoi M (2000) Molecular identification and pharmacological characterization of adenosine receptors in the guinea-pig colon. Br J Pharmacol 129:871-876
    • (2000) Br J Pharmacol , vol.129 , pp. 871-876
    • Kadowaki, M.1    Takeda, M.2    Tokita, K.3    Hanaoka, K.4    Tomoi, M.5
  • 21
    • 0028169223 scopus 로고
    • Cloned adenosine A3 receptors: Pharmacological properties, species differences and receptor functions
    • Linden J (1994) Cloned adenosine A3 receptors: pharmacological properties, species differences and receptor functions. Trends Pharmacol Sci 15:298-306
    • (1994) Trends Pharmacol Sci , vol.15 , pp. 298-306
    • Linden, J.1
  • 23
    • 0036847461 scopus 로고    scopus 로고
    • Effects of an adenosine kinase inhibitor and an adenosine deaminase inhibitor on accumulation of extracellular adenosine by equine articular chondrocytes
    • Tesch AM, MacDonald MH, Kollias-Baker C, Benton HP (2002) Effects of an adenosine kinase inhibitor and an adenosine deaminase inhibitor on accumulation of extracellular adenosine by equine articular chondrocytes. Am J Vet Res 63:1512-1519
    • (2002) Am J Vet Res , vol.63 , pp. 1512-1519
    • Tesch, A.M.1    MacDonald, M.H.2    Kollias-Baker, C.3    Benton, H.P.4
  • 24
    • 2342533099 scopus 로고    scopus 로고
    • Endogenously produced adenosine regulates articular cartilage matrix homeostasis: Enzymatic depletion of adenosine stimulates matrix degradation
    • Tesch AM, MacDonald MH, Kollias-Baker C, Benton HP (2004) Endogenously produced adenosine regulates articular cartilage matrix homeostasis: enzymatic depletion of adenosine stimulates matrix degradation. Osteoarthritis Cartilage 12:349
    • (2004) Osteoarthritis Cartilage , vol.12 , pp. 349
    • Tesch, A.M.1    MacDonald, M.H.2    Kollias-Baker, C.3    Benton, H.P.4
  • 26
  • 29
    • 0032836645 scopus 로고    scopus 로고
    • 2b adenosine receptors: Radioligand binding, Western blotting, and coupling to Gq in human embryonic kidney 293 cells and HMC-1 mast cells
    • 2b adenosine receptors: radioligand binding, Western blotting, and coupling to Gq in human embryonic kidney 293 cells and HMC-1 mast cells. Mol Pharmacol 56:705-713
    • (1999) Mol Pharmacol , vol.56 , pp. 705-713
    • Linden, J.1    Thai, T.2    Figler, H.3    Jin, X.4    Robeva, A.S.5
  • 30
    • 21644466461 scopus 로고    scopus 로고
    • Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts
    • Genetos D, Geist D, Liu D, Donahue H, Duncan R (2005) Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. J Bone Miner Res 20:41-49
    • (2005) J Bone Miner Res , vol.20 , pp. 41-49
    • Genetos, D.1    Geist, D.2    Liu, D.3    Donahue, H.4    Duncan, R.5
  • 31
    • 30044443068 scopus 로고    scopus 로고
    • The P2X7 nucleotide receptor mediates skeletal mechanotransduction
    • Li J, Liu D, Ke HZ, Duncan RL, Turner CH (2005) The P2X7 nucleotide receptor mediates skeletal mechanotransduction. J Biol Chem 280:42952-42959
    • (2005) J Biol Chem , vol.280 , pp. 42952-42959
    • Li, J.1    Liu, D.2    Ke, H.Z.3    Duncan, R.L.4    Turner, C.H.5
  • 32
    • 2242489133 scopus 로고    scopus 로고
    • P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells
    • You J, Jacobs CR, Steinberg TH, Donahue HJ (2002) P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells. J Biol Chem 277:48724-48729
    • (2002) J Biol Chem , vol.277 , pp. 48724-48729
    • You, J.1    Jacobs, C.R.2    Steinberg, T.H.3    Donahue, H.J.4
  • 35
    • 0035211501 scopus 로고    scopus 로고
    • Autocrine up-regulation of glucocorticoid receptors by interleukin-6 in human osteoblast-like cells
    • Dovio A, Masera RG, Sartori ML, Racca S, Angeli A (2001) Autocrine up-regulation of glucocorticoid receptors by interleukin-6 in human osteoblast-like cells. Calcif Tissue Int 69:299-304
    • (2001) Calcif Tissue Int , vol.69 , pp. 299-304
    • Dovio, A.1    Masera, R.G.2    Sartori, M.L.3    Racca, S.4    Angeli, A.5
  • 37
    • 31044449633 scopus 로고    scopus 로고
    • Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis
    • Wong P, Quinn J, Sims N, Nieuwenhuijze A, Campbell I, Wicks I (2006) Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis. Arthritis Rheum 54:158-168
    • (2006) Arthritis Rheum , vol.54 , pp. 158-168
    • Wong, P.1    Quinn, J.2    Sims, N.3    Nieuwenhuijze, A.4    Campbell, I.5    Wicks, I.6
  • 38
    • 0026437455 scopus 로고
    • Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone
    • Ohsaki Y, Takahashi S, Scarcez T, Demulder A, Nishihara T, Williams R, Roodman GD (1992) Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone. Endocrinology 131:2229-2234
    • (1992) Endocrinology , vol.131 , pp. 2229-2234
    • Ohsaki, Y.1    Takahashi, S.2    Scarcez, T.3    Demulder, A.4    Nishihara, T.5    Williams, R.6    Roodman, G.D.7
  • 39
    • 0028322948 scopus 로고
    • Interleukin-6 antisense deoxyoligonucleotides inhibit bone resorption by giant cells from human giant cell tumors of bone
    • Reddy S, Takahashi S, Dallas M, Williams R, Neckers L, Roodman GD (1994) Interleukin-6 antisense deoxyoligonucleotides inhibit bone resorption by giant cells from human giant cell tumors of bone. J Bone Miner Res 9:753-757
    • (1994) J Bone Miner Res , vol.9 , pp. 753-757
    • Reddy, S.1    Takahashi, S.2    Dallas, M.3    Williams, R.4    Neckers, L.5    Roodman, G.D.6
  • 41
    • 0025313227 scopus 로고
    • IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release
    • Kurihara N, Bertolini D, Suda T, Akiyama Y, Roodman GD (1990) IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J Immunol 144:4226-4230
    • (1990) J Immunol , vol.144 , pp. 4226-4230
    • Kurihara, N.1    Bertolini, D.2    Suda, T.3    Akiyama, Y.4    Roodman, G.D.5
  • 42
    • 0032077461 scopus 로고    scopus 로고
    • The role of IL-6 type cytokines and their receptors in bone
    • Manolagas SC (1998) The role of IL-6 type cytokines and their receptors in bone. Ann N Y Acad Sci 840:194-204
    • (1998) Ann N Y Acad Sci , vol.840 , pp. 194-204
    • Manolagas, S.C.1
  • 44
    • 33646396235 scopus 로고    scopus 로고
    • Estrogen deficiency and bone loss: An inflammatory tale
    • Weitzmann MN, Pacifici R (2006) Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest 116:1186-1194
    • (2006) J Clin Invest , vol.116 , pp. 1186-1194
    • Weitzmann, M.N.1    Pacifici, R.2
  • 45
    • 0029147741 scopus 로고
    • Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta
    • Stein B, Yang MX (1995) Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol Cell Biol 15:4971-4979
    • (1995) Mol Cell Biol , vol.15 , pp. 4971-4979
    • Stein, B.1    Yang, M.X.2
  • 46
    • 33749326391 scopus 로고    scopus 로고
    • Cytokine-induced osteoclastic bone resorption in charcot arthropathy: An immunohistochemical study
    • Baumhauer J, O'Keefe R, Schon L, Pinzur M (2006) Cytokine-induced osteoclastic bone resorption in charcot arthropathy: an immunohistochemical study. Foot Ankle Int 27:797-800
    • (2006) Foot Ankle Int , vol.27 , pp. 797-800
    • Baumhauer, J.1    O'Keefe, R.2    Schon, L.3    Pinzur, M.4
  • 47
    • 29244465497 scopus 로고    scopus 로고
    • Myeloma bone disease
    • Sezer O (2005) Myeloma bone disease. Hematology 10:19-24
    • (2005) Hematology , vol.10 , pp. 19-24
    • Sezer, O.1
  • 48
    • 2342533995 scopus 로고    scopus 로고
    • Increased bone resorption with decreased activity and increased recruitment of osteoblasts in osteogenesis imperfecta type I
    • Iwamoto J, Takeda T, Ichimura S (2002) Increased bone resorption with decreased activity and increased recruitment of osteoblasts in osteogenesis imperfecta type I. J Bone Miner Metab 20:174-179
    • (2002) J Bone Miner Metab , vol.20 , pp. 174-179
    • Iwamoto, J.1    Takeda, T.2    Ichimura, S.3
  • 50
    • 33144490116 scopus 로고    scopus 로고
    • Human osteoblast precursors produce extracellular adenosine, which modulates their secretion of IL-6 and osteoprotegerin
    • Evans BAJ, Elford C, Pexa A, Francis K, Hughes AC, Deussen A, Ham J (2006) Human osteoblast precursors produce extracellular adenosine, which modulates their secretion of IL-6 and osteoprotegerin. J Bone Miner Res 21:228-236
    • (2006) J Bone Miner Res , vol.21 , pp. 228-236
    • Evans, B.A.J.1    Elford, C.2    Pexa, A.3    Francis, K.4    Hughes, A.C.5    Deussen, A.6    Ham, J.7
  • 51
    • 85074914953 scopus 로고    scopus 로고
    • A PCR primer bank for quantitative gene expression analysis
    • Wang X, Seed B (2003) A PCR primer bank for quantitative gene expression analysis. Nucl Acids Res 31:e154
    • (2003) Nucl Acids Res , vol.31 , pp. 154
    • Wang, X.1    Seed, B.2
  • 53
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 54
    • 0032708707 scopus 로고    scopus 로고
    • Staphylococcus aureus infection of mouse or human osteoblasts induces high levels of interleukin-6 and interleukin-12 production
    • Bost KL, Ramp WK, Nicholson NC, Bento JL, Marriott I, Hudson MC (1999) Staphylococcus aureus infection of mouse or human osteoblasts induces high levels of interleukin-6 and interleukin-12 production. J Infect Dis 180:1912-1920
    • (1999) J Infect Dis , vol.180 , pp. 1912-1920
    • Bost, K.L.1    Ramp, W.K.2    Nicholson, N.C.3    Bento, J.L.4    Marriott, I.5    Hudson, M.C.6
  • 57
    • 0017142811 scopus 로고
    • Adenosine-mediated stimulation of bone cell adenylate cyclase activity
    • Peck W, Carpenter J, Shuster R (1976) Adenosine-mediated stimulation of bone cell adenylate cyclase activity. Endocrinology 99:901-909
    • (1976) Endocrinology , vol.99 , pp. 901-909
    • Peck, W.1    Carpenter, J.2    Shuster, R.3
  • 58
    • 0036025166 scopus 로고    scopus 로고
    • Inhibition of the NF-kB transcriptional activity by protein kinase a
    • Takahashi N, Tetsuka T, Uranishi H, Okamoto T (2002) Inhibition of the NF-kB transcriptional activity by protein kinase A. Eur J Biochem 269:4559-4565
    • (2002) Eur J Biochem , vol.269 , pp. 4559-4565
    • Takahashi, N.1    Tetsuka, T.2    Uranishi, H.3    Okamoto, T.4
  • 59
    • 0141727577 scopus 로고    scopus 로고
    • 2 inhibits TNF production in murine bone marrow-derived dendritic cells
    • 2 inhibits TNF production in murine bone marrow-derived dendritic cells. Cell Immunol 223:120-132
    • (2003) Cell Immunol , vol.223 , pp. 120-132
    • Vassiliou, E.1    Jing, H.2    Ganea, D.3
  • 60
    • 9644272333 scopus 로고    scopus 로고
    • Modulation of endotoxin stimulated interleukin-6 production in monocytes and Kupffer cells by S-adenosylmethionine (SAMe)
    • Song Z, Chen T, Deaciuc IV, Uriarte S, Hill D, Barve S, McClain CJ (2004) Modulation of endotoxin stimulated interleukin-6 production in monocytes and Kupffer cells by S-adenosylmethionine (SAMe). Cytokine 28:214-223
    • (2004) Cytokine , vol.28 , pp. 214-223
    • Song, Z.1    Chen, T.2    Deaciuc, I.V.3    Uriarte, S.4    Hill, D.5    Barve, S.6    McClain, C.J.7
  • 61
    • 33645883843 scopus 로고    scopus 로고
    • Characterization of adenosine receptors in the human bladder carcinoma T24 cell line
    • Phelps PT, Anthes JC, Correll CC (2006) Characterization of adenosine receptors in the human bladder carcinoma T24 cell line. Eur J Pharmacol 536:28-37
    • (2006) Eur J Pharmacol , vol.536 , pp. 28-37
    • Phelps, P.T.1    Anthes, J.C.2    Correll, C.C.3
  • 62
    • 0030614454 scopus 로고    scopus 로고
    • 2a adenosine receptors
    • 2a adenosine receptors. J Biol Chem 272:337-344
    • (1997) J Biol Chem , vol.272 , pp. 337-344
    • Olah, M.E.1
  • 64
    • 0141569161 scopus 로고    scopus 로고
    • 2b receptor recruits divergent pathways to regulate ERK1/2 and p38
    • 2b receptor recruits divergent pathways to regulate ERK1/2 and p38. Exp Cell Res 290:168-176
    • (2003) Exp Cell Res , vol.290 , pp. 168-176
    • Schulte, G.1    Fredholm, B.B.2
  • 68
    • 0035824548 scopus 로고    scopus 로고
    • Critical role of cAMP-GEFII.Rim2 complex in incretin-potentiated insulin secretion
    • Kashima Y, Miki T, Shibasaki T, Ozaki N, Miyazaki M, Yano H, Seino S (2001) Critical role of cAMP-GEFII.Rim2 complex in incretin-potentiated insulin secretion. J Biol Chem 276:46046-46053
    • (2001) J Biol Chem , vol.276 , pp. 46046-46053
    • Kashima, Y.1    Miki, T.2    Shibasaki, T.3    Ozaki, N.4    Miyazaki, M.5    Yano, H.6    Seino, S.7
  • 70
    • 2642576793 scopus 로고    scopus 로고
    • Presynaptic mechanism underlying cAMP-dependent synaptic potentiation
    • Kaneko M, Takahashi T (2004) Presynaptic mechanism underlying cAMP-dependent synaptic potentiation. J Neurosci 24:5202-5208
    • (2004) J Neurosci , vol.24 , pp. 5202-5208
    • Kaneko, M.1    Takahashi, T.2
  • 71
    • 0041465883 scopus 로고    scopus 로고
    • Direct modulation of synaptic vesicle priming by GABAB receptor activation at a glutamatergic synapse
    • Sakaba T, Neher E (2003) Direct modulation of synaptic vesicle priming by GABAB receptor activation at a glutamatergic synapse. Nature 424:775-778
    • (2003) Nature , vol.424 , pp. 775-778
    • Sakaba, T.1    Neher, E.2
  • 72
    • 33746214770 scopus 로고    scopus 로고
    • The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn
    • Levy O, Coughlin M, Cronstein BN, Roy RM, Desai A, Wessels MR (2006) The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn. J Immunol 177:1956-1966
    • (2006) J Immunol , vol.177 , pp. 1956-1966
    • Levy, O.1    Coughlin, M.2    Cronstein, B.N.3    Roy, R.M.4    Desai, A.5    Wessels, M.R.6
  • 73
    • 29244490904 scopus 로고    scopus 로고
    • 3 receptor in RAW 264.7 cells inhibits lipopolysaccharide-stimulated tumor necrosis factor-alpha release by reducing calcium-dependent activation of nuclear factor-kappaB and extracellular signal-regulated kinase 1/2
    • 3 receptor in RAW 264.7 cells inhibits lipopolysaccharide-stimulated tumor necrosis factor-alpha release by reducing calcium-dependent activation of nuclear factor-kappaB and extracellular signal-regulated kinase 1/2. J Pharmacol Exp Ther 316:71-78
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 71-78
    • Martin, L.1    Pingle, S.C.2    Hallam, D.M.3    Rybak, L.P.4    Ramkumar, V.5
  • 75
    • 33846083132 scopus 로고    scopus 로고
    • 2a receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter
    • 2a receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter. Mol Biol Cell 18:14-23
    • (2007) Mol Biol Cell , vol.18 , pp. 14-23
    • Ramanathan, M.1    Pinhal-Enfield, G.2    Hao, I.3    Leibovich, S.J.4
  • 78
    • 0036130068 scopus 로고    scopus 로고
    • 2a receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (becaplermin gel)
    • 2a receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (becaplermin gel). Inflammation 26:19-24
    • (2002) Inflammation , vol.26 , pp. 19-24
    • Victor-Vega, C.1    Desai, A.2    Montesinos, M.3    Cronstein, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.