Adenosine a2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell development

Journal of Leukocyte Biology

Volumn 85, Issue 3, 2009, Pages 438-444

  Katebi, Majid ^a   Soleimani, Mansooreh ^a   Cronstein, Bruce N ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD105; CD34; CD73

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 5' NUCLEOTIDASE; ADENOSINE A2A RECEPTOR; ADENOSINE RECEPTOR; CELL MARKER; ECTO 5' NUCLEOTIDASE; ENDOGLIN; PROCOLLAGEN; PROCOLLAGEN ALPHA 2 TYPE I; THY 1 ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL MATURATION; CELL PROLIFERATION; COLONY FORMING UNIT F; CONTROLLED STUDY; FEMALE; FLUOROGRAPHY; HEMATOPOIETIC STEM CELL; IMMUNOCYTOCHEMISTRY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BONE MARROW; CELL COUNT; CYTOLOGY; MOUSE MUTANT; PHYSIOLOGY;

MUS;

ANIMALS; BONE MARROW; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; MESENCHYMAL STEM CELLS; MICE; MICE, KNOCKOUT; RECEPTOR, ADENOSINE A2A;

EID: 61449152852     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0908520     Document Type: Article

References (71)

1. Ting, A. E., Mays, R. W., Frey, M. R., Hof, W. V., Medicetty, S., Deans, R. (2008) Therapeutic pathways of adult stem cell repair. Crit. Rev. Oncol. Hematol. 65, 81-93.
2. Togel, F., Westenfelder, C. (2007) Adult bone marrow-derived stem cells for organ regeneration and repair. Dev. Dyn. 236, 3321-3331.
3. Montesinos, M. C., Gadangi, P., Longaker, M., Sung, J., Levine, J., Nilsen, D., Reibman, J., Li, M., Jiang, C. K., Hirschhorn, R., Recht, P. A., Ostad, E., Levin, R. I., Cronstein, B. N. (1997) Wound healing is accelerated by agonists of adenosine A2 (G a s-linked) receptors. J. Exp. Med. 186, 1615-1620.
4. Victor-Vega, C., Desai, A., Montesinos, M., Cronstein, B. (2002) Adenosine A2A agonists promote more rapid wound healing than recombinant human platelet derived growth factor (PDGF). Inflammation 26, 19-24.
5. Montesinos, M. C., Desai, A. C., Chen, J. F., Yee, H., Schwarzschild, M. A., Fink, J. S., Cronstein, B. N. (2002) Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors. Am. J. Pathol. 160, 2009-2018.
6. Montesinos, M. C., Shaw, J. P., Yee, H., Shamamian, P., Cronstein, B. N. (2004) Adenosine A(2A) receptor activation promotes wound neovascu-larization by stimulating angiogenesis and vasculogenesis. Am. J. Pathol. 164, 1887-1892.
7. Desai, A., Victor-Vega, C., Gadangi, S., Montesinos, M. C., Chu, C. C., Cronstein, B. N. (2005) Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1. Mol. Pharmacol. 67, 1406-1413.
8. Chan, E. S., Fernandez, P., Merchant, A. A., Montesinos, M. C., Trzaska, S., Desai, A., Tung, C. F., Khoa, D. N., Pillinger, M. H., Reiss, A. B., Tomic-Canic, M., Chen, J. F., Schwarzschild, M. A., Cronstein, B. N. (2006) Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma. Arthritis Rheum. 54, 2632-2642.
9. Lennon, P. F., Taylor, C. T., Stahl, G. L., Colgan, S. P. (1998) Neutrophilderived 5'-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activation. J. Exp. Med. 188, 1433-1443.
10. Tompson, L. F., Eltzschig, H. K., Ibla, J. C., Van De Wiele, C. J., Resta, R., Morote-Garcia, J. C., Colgan, S. P. (2004) Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J. Exp. Med. 200, 1395-1405.
11. Eltzschig, H. K., Thompson, L. F., Karhausen, J., Cotta, R. J., Ibla, J. C., Robson, S. C., Colgan, S. P. (2004) Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood 104, 3986-3992.
12. Nemoto, E., Kunii, R., Tada, H., Tsubahara, T., Ishihata, H., Shimauchi, H. (2004) Expression of CD73/ecto-5'-nucleotidase on human gingival fibroblasts and contribution to the inhibition of interleukin-1a-induced granulocyte-macrophage colony stimulating factor production. J. Peri-odontal Res. 39, 10-19.
13. Zernecke, A., Bidzhekov, K., Ozuyaman, B., Fraemohs, L., Liehn, E. A., Luscher-Firzlaff, J. M., Luscher, B., Schrader, J., Weber, C. (2006) CD73/ecto-5′-nucleotidase protects against vascular inflammation and neointima formation. Circulation 113, 2120-2127.
14. Montesinos, M. C., Takedachi, M., Thompson, L. F., Wilder, T. F., Fernandez, P., Cronstein, B. N. (2007) The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleo-tides to adenosine by ecto-5′-nucleotidase: findings in a study of ecto-5′-nucleotidase gene-deficient mice. Arthritis Rheum. 56, 1440-1445.
15. Evans, B. A. J., Elford, C., Pexa, A., Francis, K., Hughes, A. C., Deussen, A., Ham, J. (2006) Human osteoblast precursors produce extracellular adenosine, which modulates their secretion of IL-6 and osteoprotegerin. J. Bone Miner. Res. 21, 228-236.
16. Volmer, J. B., Thompson, L. F., Blackburn, M. R. (2006) Ecto-5'-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury. J. Immunol. 176, 4449-4458.
17. Peng, Z., Fernandez-Ferri, P., Wilder, T., Yee, H., Chiriboga, L., Chan, E., Cronstein, B. (2008) Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis. FASEB J., 22, 2263-2272.
18. Deaglio, S., Dwyer, K. M., Gao, W., Friedman, D., Usheva, A., Erat, A., Chen, J. F., Enjyoji, K., Linden, J., Oukka, M., Kuchroo, V. K., Strom, T. B., Robson, S. C. (2007) Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204, 1257-1265.
19. Eckle, T., Krahn, T., Grenz, A., Kohler, D., Mittelbronn, M., Ledent, C., Jacobson, M. A., Osswald, H., Thompson, L. F., Unertl, K., Eltzschig,
20. H. K. (2007) Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation 115, 1581-1590.
21. Chen, J. F., Huang, Z., Ma, J., Zhu, J., Moratalla, R., Standaert, D., Moskowitz, M. A., Fink, J. S., Schwarzschild, M. A. (1999) A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. J. Neurosci. 19, 9192-9200.
22. Colvin, G. A., Lambert, J. F., Moore, B. E., Carlson, J. E., Dooner, M. S., Abedi, M., Cerny, J., Quesenberry, P. J. (2004) Intrinsic hematopoietic stem cell/progenitor plasticity: inversions. J. Cell. Physiol. 199, 20-31.
23. Brockbank, K. G., Ploemacher, R. E., van Peer, C. M. (1983) An in vitro analysis of murine hemopoietic fibroblastoid progenitors and fibroblastoid cell function during aging. Mech. Ageing Dev. 22, 11-21.
24. Brockbank, K. G., Ploemacher, R. E. (1983) Quantitation of stromal and hemopoietic progenitors in spleen and femoral marrow derived from Steel (Slj/+ and Sl/Sld) mice and their normal littermates. Exp. Hematol. 11, 467-474.
25. Napieralski, R., Kempkes, B., Gutensohn, W. (2003) Evidence for coordinated induction and repression of ecto-5′-nucleotidase (CD73) and the A2a adenosine receptor in a human B cell line. Biol. Chem. 384, 483-487.
26. Chan, E. S., Montesinos, M. C., Fernandez, P., Desai, A., Delano, D. L., Yee, H., Reiss, A. B., Pillinger, M. H., Chen, J. F., Schwarzschild, M. A., Friedman, S. L., Cronstein, B. N. (2006) Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. Br. J. Pharmacol. 148, 1144-1155.
27. Che, J., Chan, E. S., Cronstein, B. N. (2007) Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling cascade or p38 mitogen-activated protein kinase signaling pathway. Mol. Pharmacol. 72, 1626-1636.
28. Dubey, R. K., Gillespie, D. G., Jackson, E. K. (1998) Adenosine inhibits collagen and protein synthesis in cardiac fibroblasts: role of A2B receptors. Hypertension 31, 943-948.
29. Chen, Y., Epperson, S., Makhsudova, L., Ito, B., Suarez, J., Dillmann, W., Villarreal, F. (2004) Functional effects of enhancing or silencing adeno-sine A2b receptors in cardiac fibroblasts. Am. J. Physiol. Heart Circ. Physiol. 287, H2478-H2486.
30. Murakami, S., Hashikawa, T., Saho, T., Takedachi, M., Nozaki, T., Shima-bukuro, Y., Okada, H. (2001) Adenosine regulates the IL-1 β-induced cellular functions of human gingival fibroblasts. Int. Immunol. 13, 1533-1540.
31. Dubey, R. K., Gillespie, D. G., Zacharia, L. C., Mi, Z., Jackson, E. K. (2001) A(2b) receptors mediate the antimitogenic effects of adenosine in cardiac fibroblasts. Hypertension 37, 716-721.
32. Sitkovsky, M., Lukashev, D. (2005) Regulation of immune cells by local-tissue oxygen tension: HIF1 a and adenosine receptors. Nat. Rev. Immunol. 5, 712-721.
33. Meininger, C. J., Schelling, M. E., Granger, H. J. (1988) Adenosine and hypoxia stimulate proliferation and migration of endothelial cells. Am. J. Physiol. 255, H554-H562.
34. Ethier, M. F., Chander, V., Dobson Jr., J. G. (1993) Adenosine stimulates proliferation of human endothelial cells in culture. Am. J. Physiol. 265, H131-H138.
35. Sexl, V., Mancusi, G., Baumgartner-Parzer, S., Schutz, W., Freissmuth, M. (1995) Stimulation of human umbilical vein endothelial cell proliferation by A2-adenosine and β 2-adrenoceptors. Br. J. Pharmacol. 114, 1577-1586.
36. Sexl, V., Mancusi, G., Holler, C., Gloria-Maercker, E., Schutz, W., Fre-issmuth, M. (1997) Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells. J. Biol. Chem. 272, 5792-5799.
37. Sun, L. L., Xu, L. L., Nielsen, T. B., Rhee, P., Burris, D. (1999) Cyclopentyladenosine improves cell proliferation, wound healing, and hair growth. J. Surg. Res. 87, 14-24.
38. Shimegi, S. (1996) ATP and adenosine act as a mitogen for osteoblast-like cells (MC3T3-E1). Calcif. Tissue Int. 58, 109-113.
39. Shimegi, S. (1998) Mitogenic action of adenosine on osteoblast-like cells,
40. MC3T3-E1. Calcif. Tissue Int. 62, 418-425.
41. Walker, B. A., Rocchini, C., Boone, R. H., Ip, S., Jacobson, M. A. (1997)
42. Adenosine A2a receptor activation delays apoptosis in human neutrophils. J. Immunol. 158, 2926-2931.
43. Mayne, M., Fotheringham, J., Yan, H. J., Power, C., Del Bigio, M. R., Peeling, J., Geiger, J. D. (2001) Adenosine A2A receptor activation reduces proinflammatory events and decreases cell death following intra-cerebral hemorrhage. Ann. Neurol. 49, 727-735.
44. Zhao, Z. Q., Budde, J. M., Morris, C., Wang, N. P., Velez, D. A., Muraki, S., Guyton, R. A., Vinten-Johansen, J. (2001) Adenosine attenuates reper
45. fusion-induced apoptotic cell death by modulating expression of Bcl-2 and Bax proteins. J. Mol. Cell. Cardiol. 33, 57-68.
46. Apasov, S., Chen, J. F., Smith, P., Sitkovsky, M. (2000) A(2A) receptor dependent and A(2A) receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency. Blood 95, 3859-3867.
47. Morello, S., Ito, K., Yamamura, S., Lee, K. Y., Jazrawi, E., Desouza, P., Barnes, P., Cicala, C., Adcock, I. M. (2006) IL-1β and TNF-{α} regulation of the adenosine receptor (A2A) expression: differential requirement for NF-{κ}B binding to the proximal promoter. J. Immunol. 177, 7173-7183.
48. Murphree, L. J., Sullivan, G. W., Marshall, M. A., Linden, J. (2005) Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kB in A(2A) adenosine receptor induction. Biochem. J. 391, 575-580.
49. Khoa, N. D., Montesinos, M. C., Reiss, A. B., Delano, D., Awadallah, N., Cronstein, B. N. (2001) Inflammatory cytokines regulate function and expression of adenosine A2A receptors in human monocytic THP-1 cells. J. Immunol. 167, 4026-4032.
50. Nguyen, D. K., Montesinos, M. C., Williams, A. J., Kelly, M., Cronstein, B. N. (2003) Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells. J. Immunol. 171, 3991-3998.
51. Khoa, N. D., Postow, M., Danielsson, J., Cronstein, B. N. (2006) Tumor necrosis factor-{α} prevents desensitization of G{α}s-coupled receptors by regulating GRK2 association with the plasma membrane. Mol. Pharmacol. 69, 1311-1319.
52. Kiss, J., Yegutkin, G. G., Koskinen, K., Savunen, T., Jalkanen, S., Salmi, M. (2007) IFN-β protects from vascular leakage via up-regulation of CD73. Eur. J. Immunol. 37, 3334-3338.
53. Buffon, A., Wink, M. R., Ribeiro, B. V., Casali, E. A., Libermann, T. A., Zerbini, L. F., Robson, S. C., Sarkis, J. J. (2007) NTPDase and 5′ ecto-nucleotidase expression profiles and the pattern of extracellular ATP metabolism in the Walker 256 tumor. Biochim. Biophys. Acta 1770, 1259-1265.
54. Li, X., Zhou, T., Zhi, X., Zhao, F., Yin, L., Zhou, P. (2006) Effect of hypoxia/reoxygenation on CD73 (ecto-5′-nucleotidase) in mouse mi-crovessel endothelial cell lines. Microvasc. Res. 72, 48-53.
55. Tamajusuku, A. S., Carrillo-Sepulveda, M. A., Braganhol, E., Wink, M. R., Sarkis, J. J., Barreto-Chaves, M. L., Battastini, A. M. (2006) Activity and expression of ecto-5'-nucleotidase/CD73 are increased by thyroid hormones in vascular smooth muscle cells. Mol. Cell. Biochem. 289, 65-72.
56. Huang, D. Y., Vallon, V., Zimmermann, H., Koszalka, P., Schrader, J., Osswald, H. (2006) Ecto-5′-nucleotidase (cd73)-dependent and-independent generation of adenosine participates in the mediation of tubuloglo-merular feedback in vivo. Am. J. Physiol. Renal Physiol. 291, F282-F288.
57. Synnestvedt, K., Furuta, G. T., Comerford, K. M., Louis, N., Karhausen, J., Eltzschig, H. K., Hansen, K. R., Thompson, L. F., Colgan, S. P. (2002) Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J. Clin. Invest. 110, 993-1002.
58. Kalsi, K., Lawson, C., Dominguez, M., Taylor, P., Yacoub, M. H., Smo-lenski, R. T. (2002) Regulation of ecto-5′-nucleotidase by TNF-α in human endothelial cells. Mol. Cell. Biochem. 232, 113-119.
59. Narravula, S., Lennon, P. F., Mueller, B. U., Colgan, S. P. (2000) Regulation of endothelial CD73 by adenosine: paracrine pathway for enhanced endothelial barrier function. J. Immunol. 165, 5262-5268.
60. Airas, L., Niemela, J., Salmi, M., Puurunen, T., Smith, D. J., Jalkanen, S. (1997) Differential regulation and function of CD73, a glycosyl-phospha- tidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells. J. Cell Biol. 136, 421-431.
61. Niemela, J., Henttinen, T., Yegutkin, G. G., Airas, L., Kujari, A. M., Rajala, P., Jalkanen, S. (2004) IFN-α induced adenosine production on the endothelium: a mechanism mediated by CD73 (ecto-5′-nucleotidase) up-regulation. J. Immunol. 172, 1646-1653.
62. Ten Dijke, P., Goumans, M. J., Pardali, E. (2008) Endoglin in angiogen-esis and vascular diseases. Angiogenesis 11, 79-89.
63. Hofer, M., Pospisil, M., Znojil, V., Hola, J., Streitova, D., Vacek, A. (2008) Homeostatic action of adenosine A3 and A1 receptor agonists on proliferation of hematopoietic precursor cells. Exp. Biol. Med. (Maywood) 233, 897-900.
64. Hofer, M., Vacek, A., Pospfsil, M., Hola, J., Streitova, D., Znojil, V. (2008) Activation of adenosine A(3) receptors potentiates stimulatory effects of IL-3, SCF, and GM-CSF on mouse granulocyte-macrophage hematopoietic progenitor cells. Physiol Res., Epub ahead of print.
65. Hofer, M., Pospisil, M., Znojil, V., Hola, J., Vacek, A., Streitova, D. (2007) Adenosine A(3) receptor agonist acts as a homeostatic regulator of bone marrow hematopoiesis. Biomed. Pharmacother. 61, 356-359.
66. Pospisil, M., Hofer, M., Znojil, V., Vacha, J., Netikova, J., Hola, J. (1995) Synergistic effect of granulocyte colony-stimulating factor and drugs elevating extracellular adenosine on neutrophil production in mice. Blood 86, 3692-3697.
67. Pospisil, M., Hofer, M., Znojil, V., Vacha, J., Netikova, J., Hola, J. (1995) Radioprotection of mouse hemopoiesis by dipyridamole and adenosine monophosphate in fractionated treatment. Radiat. Res. 142, 16-22.
68. Hofer, M., Pospisil, M., Netikova, J., Znojil, V., Vacha, J., Hola, J. (1995) Radioprotective efficacy of dipyridamole and AMP combination in fractionated radiation regimen, and its dependence on the time of administration of the drugs prior to irradiation. Physiol. Res. 44, 93-98.
69. Bohacek, J., Hosek, B., Pospisil, M. (1993) Postirradiation administration of adenosine monophosphate combined with dipyridamole reduces early cellular damage in mice. Life Sci. 53, 1317-1324.
70. Hasko, G., Nemeth, Z. H., Vizi, E. S., Salzman, A. L., Szabo, C. (1998) An agonist of adenosine A3 receptors decreases interleukin-12 and interfer-on-γ production and prevents lethality in endotoxemic mice. Eur. J. Pharmacol. 358, 261-268.
71. Bar-Yehuda, S., Madi, L., Barak, D., Mittelman, M., Ardon, E., Ochaion, A., Cohn, S., Fishman, P. (2002) Agonists to the A3 adenosine receptor induce G-CSF production via NF-κB activation: a new class of myelopro-tective agents. Exp. Hematol. 30, 1390-1398.