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Volumn 22, Issue 3, 2011, Pages 285-294

Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer's disease

Author keywords

Alzheimer's disease; amyloid precursor protein; amyloid ; calcium; memantine; NMDA receptors

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; APP PROTEIN, HUMAN;

EID: 80051927442     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/RNS.2011.029     Document Type: Review
Times cited : (69)

References (81)
  • 2
    • 78649417803 scopus 로고    scopus 로고
    • Activation of extrasynaptic, but not synaptic NMDA receptors modifi es amyloid precursor protein expression pattern and increases amyloid- βproduction
    • Bordji, K., Becerril-Ortega, J., Nicole, O., and Buisson A. (2010). Activation of extrasynaptic, but not synaptic NMDA receptors modifi es amyloid precursor protein expression pattern and increases amyloid-βproduction. J. Neurosci. 30, 15927-15942.
    • (2010) J. Neurosci. , vol.30 , pp. 15927-15942
    • Bordji, K.1    Becerril-Ortega, J.2    Nicole, O.3    Buisson, A.4
  • 4
    • 33344458827 scopus 로고    scopus 로고
    • M1 receptors play a central role in modulating AD-like pathology in transgenic mice
    • DOI 10.1016/j.neuron.2006.01.020, PII S0896627306000730
    • Caccamo, A., Oddo, S., Billings, L.M., Green, K.N., Martinez-Coria, H., Fisher, A., and LaFerla F.M. (2006). M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron 49, 671-682. (Pubitemid 43290127)
    • (2006) Neuron , vol.49 , Issue.5 , pp. 671-682
    • Caccamo, A.1    Oddo, S.2    Billings, L.M.3    Green, K.N.4    Martinez-Coria, H.5    Fisher, A.6    LaFerla, F.M.7
  • 5
    • 0035816661 scopus 로고    scopus 로고
    • A transcriptivety active complex of APP with Fe65 and histone acetyltransferase Tip60
    • DOI 10.1126/science.1058783
    • Cao, X. and Sudhof, T.C. (2001). A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293, 115-120. (Pubitemid 32625507)
    • (2001) Science , vol.293 , Issue.5527 , pp. 115-120
    • Cao, X.1    Sudhof, T.C.2
  • 6
    • 0030921730 scopus 로고    scopus 로고
    • Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C
    • Caputi, A., Barindelli, S., Pastorino, L., Cimino, M., Buxbaum, J.D., Cattabeni, F., and Di Luca M. (1997). Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C. J. Neurochem. 68, 2523-2529. (Pubitemid 27218175)
    • (1997) Journal of Neurochemistry , vol.68 , Issue.6 , pp. 2523-2529
    • Caputi, A.1    Barindelli, S.2    Pastorino, L.3    Cimino, M.4    Buxbaum, J.D.5    Cattabeni, F.6    Di Luca, M.7
  • 7
    • 33745034018 scopus 로고    scopus 로고
    • The chemical biology of clinically tolerated NMDA receptor antagonists
    • DOI 10.1111/j.1471-4159.2006.03991.x
    • Chen, H.S. and Lipton, S.A. (2006). The chemical biology of clinically tolerated NMDA receptor antagonists. J. Neurochem. 97, 1611-1626. (Pubitemid 43873656)
    • (2006) Journal of Neurochemistry , vol.97 , Issue.6 , pp. 1611-1626
    • Chen, H.-S.V.1    Lipton, S.A.2
  • 8
    • 0026564448 scopus 로고
    • Open-channel block of N-methyl-d-aspartate (NMDA) responses by memantine: Therapeutic advantage against NMDA receptor-mediated neurotoxicity
    • Chen, H.S., Pellegrini, J.W., Aggarwal, S.K., Lei, S.Z., Warach, S., Jensen, F.E., and Lipton S.A. (1992). Open-channel block of N-methyl-d-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J. Neurosci. 12, 4427-4436.
    • (1992) J. Neurosci , vol.12 , pp. 4427-4436
    • Chen, H.S.1    Pellegrini, J.W.2    Aggarwal, S.K.3    Lei, S.Z.4    Warach, S.5    Jensen, F.E.6    Lipton, S.A.7
  • 9
    • 0028799654 scopus 로고
    • Calcium: Still in the central stage in hypoxicischemic neuronal death
    • Choi, D.W. (1995). Calcium: still in the central stage in hypoxicischemic neuronal death. Trends Neurosci. 18, 58-60.
    • (1995) Trends Neurosci , vol.18 , pp. 58-60
    • Choi, D.W.1
  • 10
    • 0023870521 scopus 로고
    • Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists
    • Choi, D.W., Koh, J.Y., and Peters S. (1988). Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J. Neurosci. 8, 185-196. (Pubitemid 18038308)
    • (1988) Journal of Neuroscience , vol.8 , Issue.1 , pp. 185-196
    • Choi, D.W.1    Koh, J.-Y.2    Peters, S.3
  • 12
    • 41549155927 scopus 로고    scopus 로고
    • Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo
    • DOI 10.1016/j.neuron.2008.02.003, PII S0896627308001244
    • Cirrito, J.R., Kang, J.E., Lee, J., Stewart, F.R., Verges, D.K., Silverio, L.M., Bu, G., Mennerick, S., and Holtzman D.M. (2008). Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron 58, 42-51. (Pubitemid 351467029)
    • (2008) Neuron , vol.58 , Issue.1 , pp. 42-51
    • Cirrito, J.R.1    Kang, J.-E.2    Lee, J.3    Stewart, F.R.4    Verges, D.K.5    Silverio, L.M.6    Bu, G.7    Mennerick, S.8    Holtzman, D.M.9
  • 13
    • 4344580888 scopus 로고    scopus 로고
    • Strategies for disease modification in Alzheimer?s disease
    • Citron, M. (2004). Strategies for disease modification in Alzheimer?s disease. Nat. Rev. Neurosci. 5, 677-685.
    • (2004) Nat. Rev. Neurosci , vol.5 , pp. 677-685
    • Citron, M.1
  • 15
    • 63449094785 scopus 로고    scopus 로고
    • Amyloid beta mediates memory formation
    • Garcia-Osta, A. and Alberini, C.M. (2009). Amyloid beta mediates memory formation. Learn. Mem. 16, 267-272.
    • (2009) Learn. Mem , vol.16 , pp. 267-272
    • Garcia-Osta, A.1    Alberini, C.M.2
  • 16
    • 1442264828 scopus 로고    scopus 로고
    • Take five - BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generation
    • DOI 10.1038/sj.emboj.7600061
    • Haass, C. (2004). Take fi ve-BACE and the gamma-secretase quartet conduct Alzheimer?s amyloid beta peptide generation. EMBO J. 23, 483-488. (Pubitemid 38282380)
    • (2004) EMBO Journal , vol.23 , Issue.3 , pp. 483-488
    • Haass, C.1
  • 17
    • 33751268411 scopus 로고    scopus 로고
    • Pro-survival signalling from the NMDA receptor
    • DOI 10.1042/BST0340936
    • Hardingham, G.E. (2006). Pro-survival signalling from the NMDA receptor. Biochem. Soc. Trans. 34, 936-938. (Pubitemid 44796454)
    • (2006) Biochemical Society Transactions , vol.34 , Issue.5 , pp. 936-938
    • Hardingham, G.E.1
  • 18
    • 77956917231 scopus 로고    scopus 로고
    • Synaptic versus extrasynaptic NMDA receptor signalling: Implications for neurodegenerative disorders
    • Hardingham, G.E. and Bading, H. (2010). Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat. Rev. Neurosci. 11, 682-696.
    • (2010) Nat. Rev. Neurosci. , Issue.11 , pp. 682-696
    • Hardingham, G.E.1    Bading, H.2
  • 19
    • 0036241207 scopus 로고    scopus 로고
    • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
    • DOI 10.1038/nn835
    • Hardingham, G.E., Fukunaga, Y., and Bading H. (2002). Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shutoff and cell death pathways. Nat. Neurosci. 5, 405-414. (Pubitemid 34454245)
    • (2002) Nature Neuroscience , vol.5 , Issue.5 , pp. 405-414
    • Hardingham, G.E.1    Fukunaga, Y.2    Bading, H.3
  • 20
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer?s disease
    • Hardy, J. and Allsop, D. (1991). Amyloid deposition as the central event in the aetiology of Alzheimer?s disease. Trends Pharmacol. Sci. 12, 383-388.
    • (1991) Trends Pharmacol. Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 21
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy, J. and Selkoe, D.J. (2002). The amyloid hypothesis of Alzheimer?s disease: progress and problems on the road to therapeutics. Science 297, 353-356. (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 22
    • 33646576836 scopus 로고    scopus 로고
    • Survival signalling pathways activated by NMDA receptors
    • Hetman, M. and Kharebava, G. (2006). Survival signalling pathways activated by NMDA receptors. Curr. Top. Med. Chem. 6, 787-799.
    • (2006) Curr. Top. Med. Chem , vol.6 , pp. 787-799
    • Hetman, M.1    Kharebava, G.2
  • 23
    • 65549119787 scopus 로고    scopus 로고
    • Synaptic NMDA receptor activation stimulates secretase amyloid precursor protein processing and inhibits amyloid-βproduction
    • Hoey, S.E., Williams, R.J., and Perkinton M.S. (2009). Synaptic NMDA receptor activation stimulates secretase amyloid precursor protein processing and inhibits amyloid-βproduction. J. Neurosci. 29, 4442-4460.
    • (2009) J. Neurosci , vol.29 , pp. 4442-4460
    • Hoey, S.E.1    Williams, R.J.2    Perkinton, M.S.3
  • 25
    • 0141676771 scopus 로고    scopus 로고
    • Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
    • DOI 10.1016/S1474-4422(02)00164-3
    • Ikonomidou, C. and Turski, L. (2002). Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury ? Lancet 1, 383-386. (Pubitemid 37159164)
    • (2002) Lancet Neurology , vol.1 , Issue.6 , pp. 383-386
    • Ikonomidou, C.1    Turski, L.2
  • 26
    • 33645837486 scopus 로고    scopus 로고
    • Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons
    • Ivanov, A., Pellegrino, C., Rama, S., Dumalska, I., Salyha, Y., Ben-Ari, Y., and Medina I. (2006). Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons. J. Physiol. 572, 789-798.
    • (2006) J. Physiol , vol.572 , pp. 789-798
    • Ivanov, A.1    Pellegrino, C.2    Rama, S.3    Dumalska, I.4    Salyha, Y.5    Ben-Ari, Y.6    Medina, I.7
  • 27
    • 30844460987 scopus 로고    scopus 로고
    • Mechanism of action of memantine
    • DOI 10.1016/j.coph.2005.09.007, PII S1471489205001876
    • Johnson, J.W. and Kotermanski, S.E. (2006). Mechanism of action of memantine. Curr. Opin. Pharmacol. 6, 61-67. (Pubitemid 43103820)
    • (2006) Current Opinion in Pharmacology , vol.6 , Issue.1 SPEC. ISS. , pp. 61-67
    • Johnson, J.W.1    Kotermanski, S.E.2
  • 28
    • 0033636136 scopus 로고    scopus 로고
    • Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I
    • Kamal, A., Stokin, G.B., Yang, Z., Xia, C.H., and Goldstein L.S. (2000). Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron 28, 449-459.
    • (2000) Neuron , vol.28 , pp. 449-459
    • Kamal, A.1    Stokin, G.B.2    Yang, Z.3    Xia, C.H.4    Goldstein, L.S.5
  • 30
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • DOI 10.1038/325733a0
    • Kang, J., Lemaire, H.G., Unterbeck, A., Salbaum, J.M., Masters, C.L., Grzeschik, K.H., Multhaup, G., Beyreuther, K., and Müller-Hill B. (1987). The precursor of Alzheimer?s disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736. (Pubitemid 17054046)
    • (1987) Nature , vol.325 , Issue.6106 , pp. 733-736
    • Kang, J.1    Lemaire, H.-G.2    Unterbeck, A.3
  • 32
    • 0023369739 scopus 로고
    • Hypothesis on the regulation of cytosol calcium concentration and the aging brain
    • Khachaturian, Z.S. (1987). Hypothesis on the regulation of cytosol calcium concentration and the aging brain. Neurobiol. Aging 8, 345-346.
    • (1987) Neurobiol. Aging , vol.8 , pp. 345-346
    • Khachaturian, Z.S.1
  • 34
    • 0028651951 scopus 로고
    • Calcium hypothesis of Alzheimer?s disease and brain aging
    • Khachaturian, Z.S. (1994). Calcium hypothesis of Alzheimer?s disease and brain aging. Ann. NY Acad. Sci. 747, 1-11.
    • (1994) Ann. NY Acad. Sci , vol.747 , pp. 1-11
    • Khachaturian, Z.S.1
  • 36
    • 0031765270 scopus 로고    scopus 로고
    • Glutamate toxicity in chronic neurodegenerative disease
    • Lancelot, E. and Beal, M.F. (1998). Glutamate toxicity in chronic neurodegenerative diseases. Prog. Brain Res. 116, 331-347. (Pubitemid 28526944)
    • (1998) Progress in Brain Research , vol.116 , pp. 331-347
    • Lancelot, E.1    Beal, M.F.2
  • 40
    • 57349135887 scopus 로고    scopus 로고
    • Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors
    • Lé veillé , F., El Gaamouch, F., Gouix, E., Lecocq, M., Lobner, D., Nicole, O., and Buisson A. (2008). Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J. 22, 4258-4271.
    • (2008) FASEB J , vol.22 , pp. 4258-4271
    • Léveillé, F.1    El Gaamouch, F.2    Gouix, E.3    Lecocq, M.4    Lobner, D.5    Nicole, O.6    Buisson, A.7
  • 41
    • 67249087641 scopus 로고    scopus 로고
    • Soluble oligomers of amyloid-beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake
    • Li, S., Hong, S., Shepardson, N.E., Walsh, D.M., Shankar, G.M., and Selkoe D. (2009). Soluble oligomers of amyloid-beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron 62, 788-801.
    • (2009) Neuron , vol.62 , pp. 788-801
    • Li, S.1    Hong, S.2    Shepardson, N.E.3    Walsh, D.M.4    Shankar, G.M.5    Selkoe, D.6
  • 42
    • 33645095476 scopus 로고    scopus 로고
    • Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
    • Lipton, S.A. (2006). Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat. Rev. Neurosci. 5, 160-170.
    • (2006) Nat. Rev. Neurosci , vol.5 , pp. 160-170
    • Lipton, S.A.1
  • 43
    • 34648843243 scopus 로고    scopus 로고
    • Pathologically activated therapeutics for neuroprotection
    • DOI 10.1038/nrn2229, PII NRN2229
    • Lipton, S.A. (2007). Pathologically activated therapeutics for neuroprotection. Nat. Rev. Neurosci. 8, 803-808. (Pubitemid 47462118)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.10 , pp. 803-808
    • Lipton, S.A.1
  • 44
    • 0028762647 scopus 로고
    • Mechanisms of disease: Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton, S.A. and Rosenberg, P.A. (1994). Mechanisms of disease: excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613-622.
    • (1994) N. Engl. J. Med , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 45
    • 0028260083 scopus 로고
    • Senile plaques in temporal lobe epilepsy
    • DOI 10.1007/s004010050116
    • Mackenzie, I.R. and Miller, L.A. (1994). Senile plaques in temporal lobe epilepsy. Acta Neuropathol. 87, 504-510. (Pubitemid 24128978)
    • (1994) Acta Neuropathologica , vol.87 , Issue.5 , pp. 504-510
    • Mackenzie, I.R.A.1    Miller, L.A.2
  • 47
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • DOI 10.1038/nature02621
    • Mattson, M.P. (2004). Pathways towards and away from Alzheimer?s disease. Nature 430, 631-639. (Pubitemid 39061671)
    • (2004) Nature , vol.430 , Issue.7000 , pp. 631-639
    • Mattson, M.P.1
  • 48
    • 0027478347 scopus 로고
    • Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein
    • DOI 10.1016/0896-6273(93)90315-I
    • Mattson, M.P., Cheng, B., Culwell, A.R., Esch, F.S., Lieberburg, I., and Rydel R.E. (1993). Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the betaamyloid precursor protein. Neuron 10, 243-254. (Pubitemid 23079546)
    • (1993) Neuron , vol.10 , Issue.2 , pp. 243-254
    • Mattson, M.P.1    Cheng, B.2    Culwell, A.R.3    Esch, F.S.4    Lieberburg, I.5    Rydel, R.E.6
  • 49
    • 0037036463 scopus 로고    scopus 로고
    • Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway
    • DOI 10.1074/jbc.M107948200
    • Mbebi, C., Sé e, V., Mercken, L., Pradier, L., Müller, U., and Loeffl er J.P. (2002). Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway. J. Biol. Chem. 277, 20979-20990. (Pubitemid 34967409)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.23 , pp. 20979-20990
    • Mbebi, C.1    See, V.2    Mercken, L.3    Pradier, L.4    Muller, U.5    Loeffler, J.-P.6
  • 51
    • 0027447656 scopus 로고
    • Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)
    • DOI 10.1038/362075a0
    • Nishimoto, I., Okamoto, T., Matsuura, Y., Takahashi, S., Okamoto, T., Murayama, Y., and Ogata E. (1993). Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o). Nature 362, 75-79. (Pubitemid 23087295)
    • (1993) Nature , vol.362 , Issue.6415 , pp. 75-79
    • Nishimoto, I.1    Okamoto, T.2    Matsuura, Y.3    Takahashi, S.4    Okamoto, T.5    Murayama, Y.6    Ogata, E.7
  • 52
    • 0033663907 scopus 로고    scopus 로고
    • The selective muscarinic M1 agonist AF102B decreases levels of total Aβin cerebrospinal fluid of patients with Alzheimer?s disease
    • Nitsch, R.M., Deng, M., Tennis, M., Schoenfeld, D., and Growdon J.H. (2000). The selective muscarinic M1 agonist AF102B decreases levels of total Aβin cerebrospinal fluid of patients with Alzheimer?s disease. Ann. Neurol. 48, 913-918.
    • (2000) Ann. Neurol , vol.48 , pp. 913-918
    • Nitsch, R.M.1    Deng, M.2    Tennis, M.3    Schoenfeld, D.4    Growdon, J.H.5
  • 53
    • 71549143207 scopus 로고    scopus 로고
    • Balance between synaptic versus extrasynaptic NMDA receptor activity Influences inclusions and neurotoxicity of mutant huntingtin
    • Okamoto, S., Pouladi, M.A., Talantova, M., Yao, D., Xia, P., Ehrnhoefer, D.E., Zaidi, R., Clemente, A., Kaul, M., Graham, R.K., et al. (2009). Balance between synaptic versus extrasynaptic NMDA receptor activity Influences inclusions and neurotoxicity of mutant huntingtin. Nat. Med. 15, 1407-1413.
    • (2009) Nat. Med , vol.15 , pp. 1407-1413
    • Okamoto, S.1    Pouladi, M.A.2    Talantova, M.3    Yao, D.4    Xia, P.5    Ehrnhoefer, D.E.6    Zaidi, R.7    Clemente, A.8    Kaul, M.9    Graham, R.K.10
  • 54
    • 34548264782 scopus 로고    scopus 로고
    • Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
    • DOI 10.1016/j.neuron.2007.07.025, PII S0896627307005703
    • Palop, J.J., Chin, J., Roberson, E.D., Wang, J., Thwin, M.T., Bien-Ly, N., Yoo, J., Ho, K.O., Yu, G.Q., Kreitzer, A., et al. (2007). Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer?s disease. Neuron 55, 697-711. (Pubitemid 47321079)
    • (2007) Neuron , vol.55 , Issue.5 , pp. 697-711
    • Palop, J.J.1    Chin, J.2    Roberson, E.D.3    Wang, J.4    Thwin, M.T.5    Bien-Ly, N.6    Yoo, J.7    Ho, K.O.8    Yu, G.-Q.9    Kreitzer, A.10    Finkbeiner, S.11    Noebels, J.L.12    Mucke, L.13
  • 56
    • 34948842904 scopus 로고    scopus 로고
    • Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse
    • DOI 10.1016/j.neuropharm.2007.07.013, PII S0028390807002298
    • Parsons, C.G., Stöffl er, A., and Danysz W. (2007). Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system-too little activation is bad, too much is even worse. Neuropharmacology 53, 699-723. (Pubitemid 47532143)
    • (2007) Neuropharmacology , vol.53 , Issue.6 , pp. 699-723
    • Parsons, C.G.1    Stoffler, A.2    Danysz, W.3
  • 57
    • 58149385218 scopus 로고    scopus 로고
    • Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus
    • Puzzo, D., Privitera, L., Leznik, E., Fa, M., Staniszewski, A., Palmeri, A., and Arancio O. (2008). Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J. Neurosci. 28, 14537-14545.
    • (2008) J. Neurosci , vol.28 , pp. 14537-14545
    • Puzzo, D.1    Privitera, L.2    Leznik, E.3    Fa, M.4    Staniszewski, A.5    Palmeri, A.6    Arancio, O.7
  • 58
    • 0029257190 scopus 로고
    • Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner
    • Qiu, W.Q., Ferreira, A., Miller, C., Koo, E.H., and Selkoe D.J. (1995). Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J. Neurosci. 15, 2157-2167.
    • (1995) J. Neurosci , vol.15 , pp. 2157-2167
    • Qiu, W.Q.1    Ferreira, A.2    Miller, C.3    Koo, E.H.4    Selkoe, D.J.5
  • 59
    • 0028204224 scopus 로고
    • Calcium ionophore increases amyloid β peptide production by cultured cells
    • Querfurth, H.W. and Selkoe, D.J. (1994). Calcium ionophore increases amyloid beta peptide production by cultured cells. Biochemistry 33, 4550-4561. (Pubitemid 24145103)
    • (1994) Biochemistry , vol.33 , Issue.15 , pp. 4550-4561
    • Querfurth, H.W.1    Selkoe, D.J.2
  • 60
    • 0028872674 scopus 로고
    • Excitotoxicity and the NMDA receptor-still lethal after eight years
    • Rothman, S.M. and Olney, J.W. (1995). Excitotoxicity and the NMDA receptor-still lethal after eight years. Trends Neurosci. 18, 57-58.
    • (1995) Trends Neurosci , vol.18 , pp. 57-58
    • Rothman, S.M.1    Olney, J.W.2
  • 61
    • 0024395366 scopus 로고
    • Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts
    • DOI 10.1016/0092-8674(89)90096-2
    • Saitoh, T., Sundsmo, M., Roch, J.M., Kimura, N., Cole, G., Schubert, D., Oltersdorf, T., and Schenk D.B. (1989). Secreted form of amyloid beta protein precursor is involved in the growth regulation of fi broblasts. Cell 58, 615-622. (Pubitemid 19210955)
    • (1989) Cell , vol.58 , Issue.4 , pp. 615-622
    • Saitoh, T.1    Sundsmo, M.2    Roch, J.-M.3    Kimura, N.4    Cole, G.5    Schubert, D.6    Oltersdorf, T.7    Schenk, D.B.8
  • 62
    • 0031792791 scopus 로고    scopus 로고
    • Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity
    • Sattler, R., Charlton, M.P., Hafner, M., and Tymianski M. (1998). Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity. J. Neurochem. 71, 2349-2364. (Pubitemid 28531245)
    • (1998) Journal of Neurochemistry , vol.71 , Issue.6 , pp. 2349-2364
    • Sattler, R.1    Charlton, M.P.2    Hafner, M.3    Tymianski, M.4
  • 63
    • 57049085109 scopus 로고    scopus 로고
    • Memantine leads to behavioral improvement and amyloid reduction in Alzheimer?s-disease-model transgenic mice shown as by micromagnetic resonance imaging
    • Scholtzova, H., Wadghiri, Y.Z., Douadi, M., Sigurdsson, E.M., Li, Y.S., Quartermain, D., Banerjee, P., and Wisniewski T. (2008). Memantine leads to behavioral improvement and amyloid reduction in Alzheimer?s-disease-model transgenic mice shown as by micromagnetic resonance imaging. J. Neurosci. Res. 86, 2784-2791.
    • (2008) J. Neurosci. Res , vol.86 , pp. 2784-2791
    • Scholtzova, H.1    Wadghiri, Y.Z.2    Douadi, M.3    Sigurdsson, E.M.4    Li, Y.S.5    Quartermain, D.6    Banerjee, P.7    Wisniewski, T.8
  • 64
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer?s disease: Genes, proteins, and therapy
    • Selkoe, D.J. (2001). Alzheimer?s disease: genes, proteins, and therapy. Physiol. Rev. 81, 741-766.
    • (2001) Physiol. Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 65
    • 0001181116 scopus 로고    scopus 로고
    • Alzheimer's disease: Molecular understanding predicts amyloid-based therapeutics
    • DOI 10.1146/annurev.pharmtox.43.100901.140248
    • Selkoe, D.J. and Shenk, D. (2003). Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu. Rev. Pharmacol. Toxicol. 43, 545-584. (Pubitemid 37372653)
    • (2003) Annual Review of Pharmacology and Toxicology , vol.43 , pp. 545-584
    • Selkoe, D.J.1    Schenk, D.2
  • 66
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • DOI 10.1523/JNEUROSCI.4970-06.2007
    • Shankar, G.M., Bloodgood, B.L., Townsend, M., Walsh, D.M., Selkoe, D.J., and Sabatini B.L. (2007). Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signalling pathway. J. Neurosci. 27, 2866-2875. (Pubitemid 46438992)
    • (2007) Journal of Neuroscience , vol.27 , Issue.11 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3    Walsh, D.M.4    Selkoe, D.J.5    Sabatini, B.L.6
  • 67
    • 0034723418 scopus 로고    scopus 로고
    • Protein kinase C-dependent α-secretase competes with β-secretase for cleavage of amyloid-β precursor protein in the trans-Golgi network
    • DOI 10.1074/jbc.275.4.2568
    • Skovronsky, D.M., Moore, D.B., Milla, M.E., Doms, R.W., and Lee V.M. (2000). Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-Golgi network. J. Biol. Chem. 275, 2568-2575. (Pubitemid 30082022)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.4 , pp. 2568-2575
    • Skovronsky, D.M.1    Moore, D.B.2    Milla, M.E.3    Doms, R.W.4    Lee, V.M.-Y.5
  • 68
    • 24644456470 scopus 로고    scopus 로고
    • Calcium dysregulation in Alzheimer's disease: Recent advances gained from genetically modified animals
    • DOI 10.1016/j.ceca.2005.06.021, PII S0143416005001089
    • Smith, I.F., Green, K.N., and LaFerla F.M. (2005). Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modifi ed animals. Cell Calcium 38, 427-437. (Pubitemid 41283281)
    • (2005) Cell Calcium , vol.38 , Issue.SPEC. ISS. , pp. 427-437
    • Smith, I.F.1    Green, K.N.2    LaFerla, F.M.3
  • 69
    • 55949126654 scopus 로고    scopus 로고
    • Memantine protects rat cortical cultured neurons against beta-amyloidinduced toxicity by attenuating tau phosphorylation
    • Song, M.S., Rauw, G., Baker, G.B., and Kar S. (2008). Memantine protects rat cortical cultured neurons against beta-amyloidinduced toxicity by attenuating tau phosphorylation. Eur. J. Neurosci. 28, 1989-2002.
    • (2008) Eur. J. Neurosci , vol.28 , pp. 1989-2002
    • Song, M.S.1    Rauw, G.2    Baker, G.B.3    Kar, S.4
  • 71
    • 0034568802 scopus 로고    scopus 로고
    • Intramembrane proteolysis by presenilins
    • Steiner, H. and Haass, C. (2000). Intramembrane proteolysis by presenilins. Nat. Rev. Mol. Cell Biol. 1, 217-224.
    • (2000) Nat. Rev. Mol. Cell Biol , vol.1 , pp. 217-224
    • Steiner, H.1    Haass, C.2
  • 72
    • 33748096584 scopus 로고    scopus 로고
    • Cognitive reserve and Alzheimer disease
    • DOI 10.1097/00002093-200607001-00010, PII 0000209320060700100010
    • Stern, Y. (2006). Cognitive reserve and Alzheimer disease. Alzheimer's Dis. Assoc. Disord. 20, S69-S74. (Pubitemid 44265854)
    • (2006) Alzheimer Disease and Associated Disorders , vol.20 , Issue.SUPPL. 2
    • Stern, Y.1
  • 73
    • 33746355958 scopus 로고    scopus 로고
    • Axonal transport and Alzheimer's disease
    • Stokin, G.B. and Goldstein, L.S. (2006). Axonal transport and Alzheimer?s disease. Annu. Rev. Biochem. 75, 607-627.
    • (2006) Annu. Rev. Biochem , vol.75 , pp. 607-627
    • Stokin, G.B.1    Goldstein, L.S.2
  • 74
    • 15244352734 scopus 로고    scopus 로고
    • Calcium dysregulation, IP3 signaling, and Alzheimer's disease
    • Stutzmann, G.E. (2005). Calcium dysregulation, IP3 signaling, and Alzheimer's disease. Neuroscientist 11, 110-115.
    • (2005) Neuroscientist , vol.11 , pp. 110-115
    • Stutzmann, G.E.1
  • 75
    • 84885915876 scopus 로고    scopus 로고
    • Synapses, synaptic activity and intraneuronal Aβin Alzheimer's disease
    • Tampellini, D. and Gouras, G.K. (2010). Synapses, synaptic activity and intraneuronal Aβin Alzheimer's disease. Front. Aging Neurosci. 2, 1-5.
    • (2010) Front. Aging Neurosci. , vol.2 , pp. 1-5
    • Tampellini, D.1    Gouras, G.K.2
  • 76
    • 68549127183 scopus 로고    scopus 로고
    • Synaptic activity reduces intraneuronal Aβ, promotes APP transport to synapses, and protects against Aβ-related synaptic alterations
    • Tampellini, D., Rahman, N., Gallo, E.F., Huang, Z., Dumont, M., Capetillo-Zarate, E., Ma, T., Zheng, R., Lu, B., Nanus, D.M., et al. (2009). Synaptic activity reduces intraneuronal Aβ, promotes APP transport to synapses, and protects against Aβ-related synaptic alterations. J. Neurosci. 29, 9704-9713.
    • (2009) J. Neurosci , vol.29 , pp. 9704-9713
    • Tampellini, D.1    Rahman, N.2    Gallo, E.F.3    Huang, Z.4    Dumont, M.5    Capetillo-Zarate, E.6    Ma, T.7    Zheng, R.8    Lu, B.9    Nanus, D.M.10
  • 77
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
    • DOI 10.1016/j.cell.2005.02.008
    • Tanzi, R.E. and Bertram, L. (2005). Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 120, 545-555. (Pubitemid 40269768)
    • (2005) Cell , vol.120 , Issue.4 , pp. 545-555
    • Tanzi, R.E.1    Bertram, L.2
  • 78
    • 0027497936 scopus 로고
    • Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
    • Tymianski, M., Charlton, M.P., Carlen, P.L., and Tator C.H. (1993). Source Specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. J. Neurosci. 13, 2085-2104. (Pubitemid 23113418)
    • (1993) Journal of Neuroscience , vol.13 , Issue.5 , pp. 2085-2104
    • Tymianski, M.1    Charlton, M.P.2    Carlen, P.L.3    Tator, C.H.4
  • 79
    • 34248190279 scopus 로고    scopus 로고
    • Aβoligomers-a decade of discovery
    • Walsh, D.M. and Selkoe, D.J. (2007). Aβoligomers-a decade of discovery. J. Neurochem. 101, 1172-1184.
    • (2007) J. Neurochem , vol.101 , pp. 1172-1184
    • Walsh, D.M.1    Selkoe, D.J.2
  • 80
    • 13544268511 scopus 로고    scopus 로고
    • N-methyl-D-aspartate receptor subtypes: Multiple roles in excitotoxicity and neurological disease
    • DOI 10.1177/1073858404269012
    • Waxman, E.A. and Lynch, D.R. (2005). N-methyl-D-aspartate receptors subtypes: multiple roles in excitotoxicity and neurological disease. Neuroscientist 11, 37-49. (Pubitemid 40223089)
    • (2005) Neuroscientist , vol.11 , Issue.1 , pp. 37-49
    • Waxman, E.A.1    Lynch, D.R.2
  • 81
    • 77955855654 scopus 로고    scopus 로고
    • Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses
    • Xia, P., Chen, H.S., Zhang, D., and Lipton S.A. (2010). Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses. J. Neurosci. 30, 11246-11250.
    • (2010) J. Neurosci. , vol.30 , pp. 11246-11250
    • Xia, P.1    Chen, H.S.2    Zhang, D.3    Lipton, S.A.4


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