메뉴 건너뛰기




Volumn 48, Issue 15-16, 2011, Pages 1735-1743

Small molecule modulators of MHC class II antigen presentation: Mechanistic insights and implications for therapeutic application

Author keywords

Antigen presentation; HLA DM; MHC class II; Peptides; Small molecules

Indexed keywords

ADAMANTANE; ADAMANTANE DERIVATIVE; ALCOHOL; CARBOPLATIN; CISPLATIN; HLA DM ANTIGEN; HLA DR1 ANTIGEN; HLA DR2 ANTIGEN; HLA DR4 ANTIGEN; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; METAL COMPLEX; PEPTIDE; PHENYLALANINE;

EID: 80051918929     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.05.022     Document Type: Review
Times cited : (16)

References (62)
  • 2
    • 0033571092 scopus 로고    scopus 로고
    • Phosphorylation of the invariant chain by protein kinase C regulates MHC class II trafficking to antigen-processing compartments
    • Anderson H.A., Bergstralh D.T., Kawamura T., Blauvelt A., Roche P.A. Phosphorylation of the invariant chain by protein kinase C regulates MHC class II trafficking to antigen-processing compartments. J. Immunol. 1999, 163:5435-5443.
    • (1999) J. Immunol. , vol.163 , pp. 5435-5443
    • Anderson, H.A.1    Bergstralh, D.T.2    Kawamura, T.3    Blauvelt, A.4    Roche, P.A.5
  • 3
    • 70449470314 scopus 로고    scopus 로고
    • The genetics of autoimmune diseases: a networked perspective
    • Baranzini S.E. The genetics of autoimmune diseases: a networked perspective. Curr. Opin. Immunol. 2009, 21:596-605.
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 596-605
    • Baranzini, S.E.1
  • 6
    • 0030052495 scopus 로고    scopus 로고
    • Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum
    • Busch R., Cloutier I., Sekaly R.P., Hammerling G.J. Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum. EMBO J. 1996, 15:418-428.
    • (1996) EMBO J. , vol.15 , pp. 418-428
    • Busch, R.1    Cloutier, I.2    Sekaly, R.P.3    Hammerling, G.J.4
  • 7
    • 0025107356 scopus 로고
    • Detection of peptide-MHC class II complexes on the surface of intact cells
    • Busch R., Rothbard J.B. Detection of peptide-MHC class II complexes on the surface of intact cells. J. Immunol. Methods 1990, 134:1-22.
    • (1990) J. Immunol. Methods , vol.134 , pp. 1-22
    • Busch, R.1    Rothbard, J.B.2
  • 9
    • 0032532038 scopus 로고    scopus 로고
    • Large protein fragments as substrates for endocytic antigen capture by MHC class II molecules
    • Castellino F., Zappacosta F., Coligan J.E., Germain R.N. Large protein fragments as substrates for endocytic antigen capture by MHC class II molecules. J. Immunol. 1998, 161:4048-4057.
    • (1998) J. Immunol. , vol.161 , pp. 4048-4057
    • Castellino, F.1    Zappacosta, F.2    Coligan, J.E.3    Germain, R.N.4
  • 10
    • 0032005330 scopus 로고    scopus 로고
    • Endosomal proteolysis and MHC class II function
    • Chapman H.A. Endosomal proteolysis and MHC class II function. Curr. Opin. Immunol. 1998, 10:93-102.
    • (1998) Curr. Opin. Immunol. , vol.10 , pp. 93-102
    • Chapman, H.A.1
  • 11
    • 0027515609 scopus 로고
    • Enhancement of peptide antigen presentation by a second peptide
    • de Kroon A.I., McConnell H.M. Enhancement of peptide antigen presentation by a second peptide. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:8797-8801.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 8797-8801
    • de Kroon, A.I.1    McConnell, H.M.2
  • 13
    • 33748475526 scopus 로고    scopus 로고
    • Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis
    • Delamarre L., Couture R., Mellman I., Trombetta E.S. Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis. J. Exp. Med. 2006, 203:2049-2055.
    • (2006) J. Exp. Med. , vol.203 , pp. 2049-2055
    • Delamarre, L.1    Couture, R.2    Mellman, I.3    Trombetta, E.S.4
  • 14
    • 0028981178 scopus 로고
    • HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading
    • Denzin L.K., Cresswell P. HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading. Cell 1995, 82:155-165.
    • (1995) Cell , vol.82 , pp. 155-165
    • Denzin, L.K.1    Cresswell, P.2
  • 15
    • 0030458137 scopus 로고    scopus 로고
    • HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules
    • Denzin L.K., Hammond C., Cresswell P. HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules. J. Exp. Med. 1996, 184:2153-2165.
    • (1996) J. Exp. Med. , vol.184 , pp. 2153-2165
    • Denzin, L.K.1    Hammond, C.2    Cresswell, P.3
  • 17
    • 0033713296 scopus 로고    scopus 로고
    • Determination of the HLA-DM interaction site on HLA-DR molecules
    • Doebele R.C., Busch R., Scott H.M., Pashine A., Mellins E.D. Determination of the HLA-DM interaction site on HLA-DR molecules. Immunity 2000, 13:517-527.
    • (2000) Immunity , vol.13 , pp. 517-527
    • Doebele, R.C.1    Busch, R.2    Scott, H.M.3    Pashine, A.4    Mellins, E.D.5
  • 18
    • 0037169536 scopus 로고    scopus 로고
    • Ligand exchange of major histocompatibility complex class II proteins is triggered by H-bond donor groups of small molecules
    • Falk K., Lau J.M., Santambrogio L., Esteban V.M., Puentes F., Rotzschke O., Strominger J.L. Ligand exchange of major histocompatibility complex class II proteins is triggered by H-bond donor groups of small molecules. J. Biol. Chem. 2002, 277:2709-2715.
    • (2002) J. Biol. Chem. , vol.277 , pp. 2709-2715
    • Falk, K.1    Lau, J.M.2    Santambrogio, L.3    Esteban, V.M.4    Puentes, F.5    Rotzschke, O.6    Strominger, J.L.7
  • 19
    • 56649109618 scopus 로고    scopus 로고
    • HLA-DM mediates epitope selection by a " compare-exchange" mechanism when a potential peptide pool is available
    • Ferrante A., Anderson M.W., Klug C.S., Gorski J. HLA-DM mediates epitope selection by a " compare-exchange" mechanism when a potential peptide pool is available. PLoS One 2008, 3:e3722.
    • (2008) PLoS One , vol.3
    • Ferrante, A.1    Anderson, M.W.2    Klug, C.S.3    Gorski, J.4
  • 20
    • 77949315137 scopus 로고    scopus 로고
    • Cutting edge: HLA-DM-mediated peptide exchange functions normally on MHC class II-peptide complexes that have been weakened by elimination of a conserved hydrogen bond
    • Ferrante A., Gorski J. Cutting edge: HLA-DM-mediated peptide exchange functions normally on MHC class II-peptide complexes that have been weakened by elimination of a conserved hydrogen bond. J. Immunol. 2010, 184:1153-1158.
    • (2010) J. Immunol. , vol.184 , pp. 1153-1158
    • Ferrante, A.1    Gorski, J.2
  • 21
    • 0029782111 scopus 로고    scopus 로고
    • Structures of an MHC class II molecule with covalently bound single peptides
    • Fremont D.H., Hendrickson W.A., Marrack P., Kappler J. Structures of an MHC class II molecule with covalently bound single peptides. Science 1996, 272:1001-1004.
    • (1996) Science , vol.272 , pp. 1001-1004
    • Fremont, D.H.1    Hendrickson, W.A.2    Marrack, P.3    Kappler, J.4
  • 25
    • 0029853195 scopus 로고    scopus 로고
    • Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules
    • Katz J.F., Stebbins C., Appella E., Sant A.J. Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules. J. Exp. Med. 1996, 184:1747-1753.
    • (1996) J. Exp. Med. , vol.184 , pp. 1747-1753
    • Katz, J.F.1    Stebbins, C.2    Appella, E.3    Sant, A.J.4
  • 26
    • 0030978530 scopus 로고    scopus 로고
    • HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH
    • Kropshofer H., Arndt S.O., Moldenhauer G., Hammerling G.J., Vogt A.B. HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH. Immunity 1997, 6:293-302.
    • (1997) Immunity , vol.6 , pp. 293-302
    • Kropshofer, H.1    Arndt, S.O.2    Moldenhauer, G.3    Hammerling, G.J.4    Vogt, A.B.5
  • 28
    • 0028880008 scopus 로고
    • Self-release of CLIP in peptide loading of HLA-DR molecules
    • Kropshofer H., Vogt A.B., Stern L.J., Hammerling G.J. Self-release of CLIP in peptide loading of HLA-DR molecules. Science 1995, 270:1357-1359.
    • (1995) Science , vol.270 , pp. 1357-1359
    • Kropshofer, H.1    Vogt, A.B.2    Stern, L.J.3    Hammerling, G.J.4
  • 29
    • 0026505030 scopus 로고
    • Irreversible association of peptides with class II MHC molecules in living cells
    • Lanzavecchia A., Reid P.A., Watts C. Irreversible association of peptides with class II MHC molecules in living cells. Nature 1992, 357:249-252.
    • (1992) Nature , vol.357 , pp. 249-252
    • Lanzavecchia, A.1    Reid, P.A.2    Watts, C.3
  • 30
    • 0029131499 scopus 로고
    • Kinetics of the reactions between the invariant chain (85-99) peptide and proteins of the murine class II MHC
    • Liang M.N., Beeson C., Mason K., McConnell H.M. Kinetics of the reactions between the invariant chain (85-99) peptide and proteins of the murine class II MHC. Int. Immunol. 1995, 7:1397-1404.
    • (1995) Int. Immunol. , vol.7 , pp. 1397-1404
    • Liang, M.N.1    Beeson, C.2    Mason, K.3    McConnell, H.M.4
  • 31
    • 0037321893 scopus 로고    scopus 로고
    • Small-molecular compounds enhance the loading of APC with encephalitogenic MBP protein
    • Marin-Esteban V., Falk K., Rotzschke O. Small-molecular compounds enhance the loading of APC with encephalitogenic MBP protein. J. Autoimmun. 2003, 20:63-69.
    • (2003) J. Autoimmun. , vol.20 , pp. 63-69
    • Marin-Esteban, V.1    Falk, K.2    Rotzschke, O.3
  • 32
    • 10944263783 scopus 로고    scopus 로고
    • " Chemical analogues" of HLA-DM can induce a peptide-receptive state in HLA-DR molecules
    • Marin-Esteban V., Falk K., Rotzschke O. " Chemical analogues" of HLA-DM can induce a peptide-receptive state in HLA-DR molecules. J. Biol. Chem. 2004, 279:50684-50690.
    • (2004) J. Biol. Chem. , vol.279 , pp. 50684-50690
    • Marin-Esteban, V.1    Falk, K.2    Rotzschke, O.3
  • 33
    • 20444422540 scopus 로고    scopus 로고
    • Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein
    • McFarland B.J., Katz J.F., Sant A.J., Beeson C. Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein. J. Mol. Biol. 2005, 350:170-183.
    • (2005) J. Mol. Biol. , vol.350 , pp. 170-183
    • McFarland, B.J.1    Katz, J.F.2    Sant, A.J.3    Beeson, C.4
  • 34
    • 0024415067 scopus 로고
    • Molecular sieving, receptor processing and peptidolysis as major determinants of peptide pharmacokinetics in vivo
    • McMartin C. Molecular sieving, receptor processing and peptidolysis as major determinants of peptide pharmacokinetics in vivo. Biochem. Soc. Trans. 1989, 17:931-934.
    • (1989) Biochem. Soc. Trans. , vol.17 , pp. 931-934
    • McMartin, C.1
  • 35
    • 0025056497 scopus 로고
    • Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes
    • Mellins E., Smith L., Arp B., Cotner T., Celis E., Pious D. Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes. Nature 1990, 343:71-74.
    • (1990) Nature , vol.343 , pp. 71-74
    • Mellins, E.1    Smith, L.2    Arp, B.3    Cotner, T.4    Celis, E.5    Pious, D.6
  • 36
    • 40749104640 scopus 로고    scopus 로고
    • An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice
    • Menges P.R., Jenks S.A., Bikoff E.K., Friedmann D.R., Knowlden Z.A., Sant A.J. An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice. J. Immunol. 2008, 180:1619-1633.
    • (2008) J. Immunol. , vol.180 , pp. 1619-1633
    • Menges, P.R.1    Jenks, S.A.2    Bikoff, E.K.3    Friedmann, D.R.4    Knowlden, Z.A.5    Sant, A.J.6
  • 37
    • 0033807322 scopus 로고    scopus 로고
    • DM determines the cryptic and immunodominant fate of T cell epitopes
    • Nanda N.K., Sant A.J. DM determines the cryptic and immunodominant fate of T cell epitopes. J. Exp. Med. 2000, 192:781-788.
    • (2000) J. Exp. Med. , vol.192 , pp. 781-788
    • Nanda, N.K.1    Sant, A.J.2
  • 38
    • 33846952190 scopus 로고    scopus 로고
    • HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes
    • Narayan K., Chou C.L., Kim A., Hartman I.Z., Dalai S., Khoruzhenko S., Sadegh-Nasseri S. HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes. Nat. Immunol. 2007, 8:92-100.
    • (2007) Nat. Immunol. , vol.8 , pp. 92-100
    • Narayan, K.1    Chou, C.L.2    Kim, A.3    Hartman, I.Z.4    Dalai, S.5    Khoruzhenko, S.6    Sadegh-Nasseri, S.7
  • 39
    • 0031030323 scopus 로고    scopus 로고
    • Amino-terminal trimming of peptides for presentation on major histocompatibility complex class II molecules
    • Nelson C.A., Vidavsky I., Viner N.J., Gross M.L., Unanue E.R. Amino-terminal trimming of peptides for presentation on major histocompatibility complex class II molecules. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:628-633.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 628-633
    • Nelson, C.A.1    Vidavsky, I.2    Viner, N.J.3    Gross, M.L.4    Unanue, E.R.5
  • 43
    • 0025909318 scopus 로고
    • Free ligand-induced dissociation of MHC-antigen complexes
    • Pedrazzini T., Sette A., Albertson M., Grey H.M. Free ligand-induced dissociation of MHC-antigen complexes. J. Immunol. 1991, 146:3496-3501.
    • (1991) J. Immunol. , vol.146 , pp. 3496-3501
    • Pedrazzini, T.1    Sette, A.2    Albertson, M.3    Grey, H.M.4
  • 44
    • 0031881533 scopus 로고    scopus 로고
    • Peptide loading onto recycling HLA-DR molecules occurs in early endosomes
    • Pinet V.M., Long E.O. Peptide loading onto recycling HLA-DR molecules occurs in early endosomes. Eur. J. Immunol. 1998, 28:799-804.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 799-804
    • Pinet, V.M.1    Long, E.O.2
  • 46
    • 0028518986 scopus 로고
    • Intracellular assembly and transport of endogenous peptide-MHC class II complexes
    • Rudensky A.Y., Maric M., Eastman S., Shoemaker L., DeRoos P.C., Blum J.S. Intracellular assembly and transport of endogenous peptide-MHC class II complexes. Immunity 1994, 1:585-594.
    • (1994) Immunity , vol.1 , pp. 585-594
    • Rudensky, A.Y.1    Maric, M.2    Eastman, S.3    Shoemaker, L.4    DeRoos, P.C.5    Blum, J.S.6
  • 48
    • 0028921633 scopus 로고
    • Binding of major histocompatibility complex class II to the invariant chain-derived peptide CLIP, is regulated by allelic polymorphism in class II
    • Sette A., Southwood S., Miller J., Appella E. Binding of major histocompatibility complex class II to the invariant chain-derived peptide CLIP, is regulated by allelic polymorphism in class II. J. Exp. Med. 1995, 181:677-683.
    • (1995) J. Exp. Med. , vol.181 , pp. 677-683
    • Sette, A.1    Southwood, S.2    Miller, J.3    Appella, E.4
  • 49
    • 0029084023 scopus 로고
    • DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide
    • Sherman M.A., Weber D.A., Jensen P.E. DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide. Immunity 1995, 3:197-205.
    • (1995) Immunity , vol.3 , pp. 197-205
    • Sherman, M.A.1    Weber, D.A.2    Jensen, P.E.3
  • 51
    • 0028899617 scopus 로고
    • The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent
    • Stebbins C.C., Loss G.E., Elias C.G., Chervonsky A., Sant A.J. The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent. J. Exp. Med. 1995, 181:223-234.
    • (1995) J. Exp. Med. , vol.181 , pp. 223-234
    • Stebbins, C.C.1    Loss, G.E.2    Elias, C.G.3    Chervonsky, A.4    Sant, A.J.5
  • 52
    • 0028348369 scopus 로고
    • Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
    • Stern L.J., Brown J.H., Jardetzky T.S., Gorga J.C., Urban R.G., Strominger J.L., Wiley D.C. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 1994, 368:215-221.
    • (1994) Nature , vol.368 , pp. 215-221
    • Stern, L.J.1    Brown, J.H.2    Jardetzky, T.S.3    Gorga, J.C.4    Urban, R.G.5    Strominger, J.L.6    Wiley, D.C.7
  • 53
    • 1642495746 scopus 로고    scopus 로고
    • Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain
    • Stratikos E., Wiley D.C., Stern L.J. Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain. J. Immunol. 2004, 172:1109-1117.
    • (2004) J. Immunol. , vol.172 , pp. 1109-1117
    • Stratikos, E.1    Wiley, D.C.2    Stern, L.J.3
  • 54
    • 27744498868 scopus 로고    scopus 로고
    • Follicular B helper T cells in antibody responses and autoimmunity
    • Vinuesa C.G., Tangye S.G., Moser B., Mackay C.R. Follicular B helper T cells in antibody responses and autoimmunity. Nat. Rev. Immunol. 2005, 5:853-865.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 853-865
    • Vinuesa, C.G.1    Tangye, S.G.2    Moser, B.3    Mackay, C.R.4
  • 57
    • 0029824101 scopus 로고    scopus 로고
    • Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
    • Weber D.A., Evavold B.D., Jensen P.E. Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM. Science 1996, 274:618-620.
    • (1996) Science , vol.274 , pp. 618-620
    • Weber, D.A.1    Evavold, B.D.2    Jensen, P.E.3
  • 58
    • 0032882684 scopus 로고    scopus 로고
    • Studies on activities of invariant chain peptides on releasing or exchanging of antigenic peptides at human leukocyte antigen-DR1
    • Xu M., Jackson R., Adams S., Humphreys R.E. Studies on activities of invariant chain peptides on releasing or exchanging of antigenic peptides at human leukocyte antigen-DR1. Arzneimittelforschung 1999, 49:791-799.
    • (1999) Arzneimittelforschung , vol.49 , pp. 791-799
    • Xu, M.1    Jackson, R.2    Adams, S.3    Humphreys, R.E.4
  • 59
    • 78651242465 scopus 로고    scopus 로고
    • Molecular and structural determinants of adamantyl susceptibility to HLA-DRs allelic variants: an in silico approach to understand the mechanism of MLEs
    • Zaheer ul H., Khan W. Molecular and structural determinants of adamantyl susceptibility to HLA-DRs allelic variants: an in silico approach to understand the mechanism of MLEs. J. Comput. Aided Mol. Des. 2011, 25:81-101.
    • (2011) J. Comput. Aided Mol. Des. , vol.25 , pp. 81-101
    • Zaheer ul, H.1    Khan, W.2
  • 61
    • 70449711381 scopus 로고    scopus 로고
    • Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes
    • Zhou Z., Callaway K.A., Weber D.A., Jensen P.E. Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes. J. Immunol. 2009, 183:4187-4191.
    • (2009) J. Immunol. , vol.183 , pp. 4187-4191
    • Zhou, Z.1    Callaway, K.A.2    Weber, D.A.3    Jensen, P.E.4
  • 62
    • 52649167708 scopus 로고    scopus 로고
    • CD4 T cells: fates, functions, and faults
    • Zhu J., Paul W.E. CD4 T cells: fates, functions, and faults. Blood 2008, 112:1557-1569.
    • (2008) Blood , vol.112 , pp. 1557-1569
    • Zhu, J.1    Paul, W.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.