The genetics of autoimmune diseases: a networked perspective

Current Opinion in Immunology

Volumn 21, Issue 6, 2009, Pages 596-605

  Baranzini, Sergio E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CD6 ANTIGEN; CD69 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR6; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; EPIDERMAL GROWTH FACTOR RECEPTOR 3; HLA B ANTIGEN; HLA C ANTIGEN; HLA DQA1 ANTIGEN; HLA DR ANTIGEN; INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 21; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 27; LEUCINE RICH REPEAT KINASE 2; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MAJOR HISTOCOMPATIBILITY ANTIGEN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; STAT3 PROTEIN; STAT4 PROTEIN; TANKYRASE; TRANSCRIPTION FACTOR REL; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1;

ADDISON DISEASE; AUTOIMMUNE DISEASE; CELIAC DISEASE; CHROMOSOME 6P; CROHN DISEASE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GRAVES DISEASE; HUMAN; IMMUNOGENETICS; IMMUNOPATHOGENESIS; INSULIN DEPENDENT DIABETES MELLITUS; MULTIPLE SCLEROSIS; NUCLEOTIDE SEQUENCE; REVIEW; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; AUTOIMMUNE DISEASES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME; GENOME-WIDE ASSOCIATION STUDY; HUMANS;

EID: 70449470314     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2009.09.014     Document Type: Review

References (80)

1. Lin J.P., Cash J.M., Doyle S.Z., Peden S., Kanik K., Amos C.I., Bale S.J., and Wilder R.L. Familial clustering of rheumatoid arthritis with other autoimmune diseases. Hum Genet 103 (1998) 475-482
2. Tait K.F., Marshall T., Berman J., Carr-Smith J., Rowe B., Todd J.A., Bain S.C., Barnett A.H., and Gough S.C. Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository. Diabet Med 21 (2004) 358-362
3. Barcellos L.F., Kamdar B.B., Ramsay P.P., DeLoa C., Lincoln R.R., Caillier S., Schmidt S., Haines J.L., Pericak-Vance M.A., Oksenberg J.R., et al. Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study. Lancet Neurol 5 (2006) 924-931
4. IMSGC, The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes Immun 2009, 10:11-14.
5. Rzhetsky A., Wajngurt D., Park N., and Zheng T. Probing genetic overlap among complex human phenotypes. Proc Natl Acad Sci U S A 104 (2007) 11694-11699. Authors reviewed 1.5 million medical records and created models of co-morbidity among more than 160 diseases.
6. Hindorff L.A., Sethupathy P., Junkins H.A., Ramos E.M., Mehta J.P., Collins F.S., and Manolio T.A. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A 106 (2009) 9362-9367. This paper reports the creation of a searchable catalog of all published GWAS.
7. A Catalog of Published Genome-Wide Association Studies on World Wide Web URL, http://www.genome.gov/26525384.
8. Oksenberg J.R., Baranzini S.E., Sawcer S., and Hauser S.L. The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat Rev Genet 9 (2008) 516-526
9. Wellcome Trust Case Control Consortium 2 on World Wide Web URL, https://www.wtccc.org.uk/ccc2/index.shtml.
10. Torkamani A., Topol E.J., and Schork N.J. Pathway analysis of seven common diseases assessed by genome-wide association. Genomics 92 (2008) 265-272
11. Lesnick T.G., Papapetropoulos S., Mash D.C., Ffrench-Mullen J., Shehadeh L., de Andrade M., Henley J.R., Rocca W.A., Ahlskog J.E., and Maraganore D.M. A genomic pathway approach to a complex disease: axon guidance and Parkinson disease. PLoS Genet 3 (2007) e98
12. Wang K., Li M., and Bucan M. Pathway-based approaches for analysis of genomewide association studies. Am J Hum Genet (2007) 81
13. Baranzini S.E., Galwey N.W., Wang J., Khankhanian P., Lindberg R., Pelletier D., Wu W., Uitdehaag B.M., Kappos L., Polman C.H., et al. Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet 18 (2009) 2078-2090. In this article, authors overlap evidence of genetic association with evidence of physical interaction to identify new candidates involved in MS susceptibility.
14. Chen G.K., and Witte J.S. Enriching the analysis of genomewide association studies with hierarchical modeling. Am J Hum Genet 81 (2007) 397-404
15. Forabosco P., Bouzigon E., Ng M.Y., Hermanowski J., Fisher S.A., Criswell L.A., and Lewis C.M. Meta-analysis of genome-wide linkage studies across autoimmune diseases. Eur J Hum Genet 17 (2009) 236-243
16. De Jager P.L., Jia X., Wang J., de Bakker P.I., Ottoboni L., Aggarwal N.T., Piccio L., Raychaudhuri S., Tran D., Aubin C., et al. Meta-analysis of genome scans and replication identify CD6 IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 41 (2009) 776-782. In this article, authors describe a meta-analysis across genotyping platforms using linkage disequilibrium-based allele imputation. Novel candidates for MS are reported.
17. Johnson A.D., and O'Donnell C.J. An open access database of genome-wide association results. BMC Med Genet 10 (2009) 6. This article describes a compilation of P-values from 118 GWAS.
18. Fisher R.A. Combining independent tests of significance. American Statistician 2 (1948) 30
19. Goh K.I., Cusick M.E., Valle D., Childs B., Vidal M., and Barabasi A.L. The human disease network. Proc Natl Acad Sci U S A 104 (2007) 8685-8690. Authors create a network of genes and diseases using information from OMIM database.
20. Kumar V., Abbas A.K., Fausto N., Robbins S.L., and Cotran R.S. Robbins and Cotran pathologic basis of disease. 7th (2005), Elsevier Saunders, Philadelphia
21. Husebye E., and Lovas K. Pathogenesis of primary adrenal insufficiency. Best Pract Res Clin Endocrinol Metab 23 (2009) 147-157
22. Smyth D., Cooper J.D., Collins J.E., Heward J.M., Franklyn J.A., Howson J.M., Vella A., Nutland S., Rance H.E., Maier L., et al. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes 53 (2004) 3020-3023
23. Abraham C., and Cho J.H. IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease. Annu Rev Med 60 (2009) 97-110
24. Nelson B.H. IL-2, regulatory T cells, and tolerance. J Immunol 172 (2004) 3983-3988
25. Malek T.R., and Bayer A.L. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 4 (2004) 665-674
26. Jones J.L., Phuah C.L., Cox A.L., Thompson S.A., Ban M., Shawcross J., Walton A., Sawcer S.J., Compston A., and Coles A.J. IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). J Clin Invest 119 (2009) 2052-2061
27. Ettinger R., Kuchen S., and Lipsky P.E. The role of IL-21 in regulating B-cell function in health and disease. Immunol Rev 223 (2008) 60-86
28. Ettinger R., Kuchen S., and Lipsky P.E. Interleukin 21 as a target of intervention in autoimmune disease. Ann Rheum Dis 67 Suppl 3 (2008) iii83-iii86
29. Scalapino K.J., and Daikh D.I. CTLA-4: a key regulatory point in the control of autoimmune disease. Immunol Rev 223 (2008) 143-155
30. Maier L.M., Lowe C.E., Cooper J., Downes K., Anderson D.E., Severson C., Clark P.M., Healy B., Walker N., Aubin C., et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet 5 (2009) e1000322
31. Dendrou C.A., Plagnol V., Fung E., Yang J.H., Downes K., Cooper J.D., Nutland S., Coleman G., Himsworth M., Hardy M., et al. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet 41 (2009) 1011-1015
32. Gregersen P.K., Amos C.I., Lee A.T., Lu Y., Remmers E.F., Kastner D.L., Seldin M.F., Criswell L.A., Plenge R.M., Holers V.M., et al. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet 41 (2009) 820-823
33. Raychaudhuri S., Remmers E.F., Lee A.T., Hackett R., Guiducci C., Burtt N.P., Gianniny L., Korman B.D., Padyukov L., Kurreeman F.A., et al. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet 40 (2008) 1216-1223
34. Plenge R.M., Seielstad M., Padyukov L., Lee A.T., Remmers E.F., Ding B., Liew A., Khalili H., Chandrasekaran A., Davies L.R., et al. TRAF1-C5 as a risk locus for rheumatoid arthritis-a genomewide study. N Engl J Med 357 (2007) 1199-1209
35. WTCCC, Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007, 447:661-678.
36. Harley J.B., Alarcon-Riquelme M.E., Criswell L.A., Jacob C.O., Kimberly R.P., Moser K.L., Tsao B.P., Vyse T.J., Langefeld C.D., Nath S.K., et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 40 (2008) 204-210
37. Hom G., Graham R.R., Modrek B., Taylor K.E., Ortmann W., Garnier S., Lee A.T., Chung S.A., Ferreira R.C., Pant P.V., et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med 358 (2008) 900-909
38. Barrett J.C., Hansoul S., Nicolae D.L., Cho J.H., Duerr R.H., Rioux J.D., Brant S.R., Silverberg M.S., Taylor K.D., Barmada M.M., et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 40 (2008) 955-962
39. Nejentsev S., Walker N., Riches D., Egholm M., and Todd J.A. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 324 (2009) 387-389. This article describes the use of next generation sequencing to identify rare variants associated with type I diabetes
40. Hunt K.A., Zhernakova A., Turner G., Heap G.A., Franke L., Bruinenberg M., Romanos J., Dinesen L.C., Ryan A.W., Panesar D., et al. Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet 40 (2008) 395-402
41. van Heel D.A., Franke L., Hunt K.A., Gwilliam R., Zhernakova A., Inouye M., Wapenaar M.C., Barnardo M.C., Bethel G., Holmes G.K., et al. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet 39 (2007) 827-829
42. ANZgene. Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat Genet 41 (2009) 824-828
43. Comabella M., Craig D.W., Camina-Tato M., Morcillo C., Lopez C., Navarro A., Rio J., Montalban X., and Martin R. Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms. PLoS One 3 (2008) e3490
44. Hafler D.A., Compston A., Sawcer S., Lander E.S., Daly M.J., De Jager P.L., de Bakker P.I., Gabriel S.B., Mirel D.B., Ivinson A.J., et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 357 (2007) 851-862
45. Nair R.P., Duffin K.C., Helms C., Ding J., Stuart P.E., Goldgar D., Gudjonsson J.E., Li Y., Tejasvi T., Feng B.J., et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet 41 (2009) 199-204
46. Liu Y., Helms C., Liao W., Zaba L.C., Duan S., Gardner J., Wise C., Miner A., Malloy M.J., Pullinger C.R., et al. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet 4 (2008) e1000041
47. Capon F., Bijlmakers M.J., Wolf N., Quaranta M., Huffmeier U., Allen M., Timms K., Abkevich V., Gutin A., Smith R., et al. Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. Hum Mol Genet 17 (2008) 1938-1945
48. Zhang X.J., Huang W., Yang S., Sun L.D., Zhang F.Y., Zhu Q.X., Zhang F.R., Zhang C., Du W.H., Pu X.M., et al. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet 41 (2009) 205-210
49. Raelson J.V., Little R.D., Ruether A., Fournier H., Paquin B., Van Eerdewegh P., Bradley W.E., Croteau P., Nguyen-Huu Q., Segal J., et al. Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. Proc Natl Acad Sci U S A 104 (2007) 14747-14752
50. Rioux J.D., Xavier R.J., Taylor K.D., Silverberg M.S., Goyette P., Huett A., Green T., Kuballa P., Barmada M.M., Datta L.W., et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 39 (2007) 596-604
51. Libioulle C., Louis E., Hansoul S., Sandor C., Farnir F., Franchimont D., Vermeire S., Dewit O., de Vos M., Dixon A., et al. Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet 3 (2007) e58
52. Parkes M., Barrett J.C., Prescott N.J., Tremelling M., Anderson C.A., Fisher S.A., Roberts R.G., Nimmo E.R., Cummings F.R., Soars D., et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 39 (2007) 830-832
53. Plenge R.M., Cotsapas C., Davies L., Price A.L., de Bakker P.I., Maller J., Pe'er I., Burtt N.P., Blumenstiel B., DeFelice M., et al. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet 39 (2007) 1477-1482
54. Julia A., Ballina J., Canete J.D., Balsa A., Tornero-Molina J., Naranjo A., Alperi-Lopez M., Erra A., Pascual-Salcedo D., Barcelo P., et al. Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility. Arthritis Rheum 58 (2008) 2275-2286
55. Graham R.R., Cotsapas C., Davies L., Hackett R., Lessard C.J., Leon J.M., Burtt N.P., Guiducci C., Parkin M., Gates C., et al. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet 40 (2008) 1059-1061
56. Kozyrev S.V., Abelson A.K., Wojcik J., Zaghlool A., Linga Reddy M.V., Sanchez E., Gunnarsson I., Svenungsson E., Sturfelt G., Jonsen A., et al. Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus. Nat Genet 40 (2008) 211-216
57. Cooper J.D., Smyth D.J., Smiles A.M., Plagnol V., Walker N.M., Allen J.E., Downes K., Barrett J.C., Healy B.C., Mychaleckyj J.C., et al. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet 40 (2008) 1399-1401
58. Hakonarson H., Grant S.F., Bradfield J.P., Marchand L., Kim C.E., Glessner J.T., Grabs R., Casalunovo T., Taback S.P., Frackelton E.C., et al. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature 448 (2007) 591-594
59. Todd J.A., Walker N.M., Cooper J.D., Smyth D.J., Downes K., Plagnol V., Bailey R., Nejentsev S., Field S.F., Payne F., et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 39 (2007) 857-864
60. Hakonarson H., Qu H.Q., Bradfield J.P., Marchand L., Kim C.E., Glessner J.T., Grabs R., Casalunovo T., Taback S.P., Frackelton E.C., et al. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. Diabetes 57 (2008) 1143-1146
61. Grant S.F., Qu H.Q., Bradfield J.P., Marchand L., Kim C.E., Glessner J.T., Grabs R., Taback S.P., Frackelton E.C., Eckert A.W., et al. Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. Diabetes 58 (2009) 290-295
62. Franke A., Hampe J., Rosenstiel P., Becker C., Wagner F., Hasler R., Little R.D., Huse K., Ruether A., Balschun T., et al. Systematic association mapping identifies NELL1 as a novel IBD disease gene. PLoS One 2 (2007) e691
63. Duerr R.H., Taylor K.D., Brant S.R., Rioux J.D., Silverberg M.S., Daly M.J., Steinhart A.H., Abraham C., Regueiro M., Griffiths A., et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314 (2006) 1461-1463
64. Yamazaki K., McGovern D., Ragoussis J., Paolucci M., Butler H., Jewell D., Cardon L., Takazoe M., Tanaka T., Ichimori T., et al. Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum Mol Genet 14 (2005) 3499-3506
65. Baranzini S.E., Wang J., Gibson R.A., Galwey N., Naegelin Y., Barkhof F., Radue E.W., Lindberg R.L., Uitdehaag B.M., Johnson M.R., et al. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet 18 (2009) 767-778
66. Capon F., Di Meglio P., Szaub J., Prescott N.J., Dunster C., Baumber L., Timms K., Gutin A., Abkevic V., Burden A.D., et al. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet 122 (2007) 201-206
67. Steer S., Abkevich V., Gutin A., Cordell H.J., Gendall K.L., Merriman M.E., Rodger R.A., Rowley K.A., Chapman P., Gow P., et al. Genomic DNA pooling for whole-genome association scans in complex disease: empirical demonstration of efficacy in rheumatoid arthritis. Genes Immun 8 (2007) 57-68
68. Kamatani Y., Matsuda K., Ohishi T., Ohtsubo S., Yamazaki K., Iida A., Hosono N., Kubo M., Yumura W., Nitta K., et al. Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population. J Hum Genet 53 (2008) 64-73
69. Cervino A.C., Tsinoremas N.F., and Hoffman R.W. A genome-wide study of lupus: preliminary analysis and data release. Ann N Y Acad Sci 1110 (2007) 131-139
70. Saxena R., Voight B.F., Lyssenko V., Burtt N.P., de Bakker P.I., Chen H., Roix J.J., Kathiresan S., Hirschhorn J.N., Daly M.J., et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316 (2007) 1331-1336
71. Hanson R.L., Bogardus C., Duggan D., Kobes S., Knowlton M., Infante A.M., Marovich L., Benitez D., Baier L.J., and Knowler W.C. A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array. Diabetes 56 (2007) 3045-3052
72. Hayes M.G., Pluzhnikov A., Miyake K., Sun Y., Ng M.C., Roe C.A., Below J.E., Nicolae R.I., Konkashbaev A., Bell G.I., et al. Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies. Diabetes 56 (2007) 3033-3044
73. Rampersaud E., Damcott C.M., Fu M., Shen H., McArdle P., Shi X., Shelton J., Yin J., Chang Y.P., Ott S.H., et al. Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations. Diabetes 56 (2007) 3053-3062
74. Salonen J.T., Uimari P., Aalto J.M., Pirskanen M., Kaikkonen J., Todorova B., Hypponen J., Korhonen V.P., Asikainen J., Devine C., et al. Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. Am J Hum Genet 81 (2007) 338-345
75. Scott L.J., Mohlke K.L., Bonnycastle L.L., Willer C.J., Li Y., Duren W.L., Erdos M.R., Stringham H.M., Chines P.S., Jackson A.U., et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316 (2007) 1341-1345
76. Sladek R., Rocheleau G., Rung J., Dina C., Shen L., Serre D., Boutin P., Vincent D., Belisle A., Hadjadj S., et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445 (2007) 881-885
77. Steinthorsdottir V., Thorleifsson G., Reynisdottir I., Benediktsson R., Jonsdottir T., Walters G.B., Styrkarsdottir U., Gretarsdottir S., Emilsson V., Ghosh S., et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39 (2007) 770-775
78. Zeggini E., Weedon M.N., Lindgren C.M., Frayling T.M., Elliott K.S., Lango H., Timpson N.J., Perry J.R., Rayner N.W., Freathy R.M., et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316 (2007) 1336-1341
79. Florez J.C., Manning A.K., Dupuis J., McAteer J., Irenze K., Gianniny L., Mirel D.B., Fox C.S., Cupples L.A., and Meigs J.B. A 100 K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets. Diabetes 56 (2007) 3063-3074
80. Meigs J.B., Manning A.K., Fox C.S., Florez J.C., Liu C., Cupples L.A., and Dupuis J. Genome-wide association with diabetes-related traits in the Framingham Heart Study. BMC Med Genet 8 Suppl 1 (2007) S16