Cutting edge: HLA-DM-mediated peptide exchange functions normally on MHC class II-peptide complexes that have been weakened by elimination of a conserved hydrogen bond

Journal of Immunology

Volumn 184, Issue 3, 2010, Pages 1153-1158

  Ferrante, Andrea ^a   Gorski, Jack ^a  

^a BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTIDINE; HLA DM ANTIGEN; HLA DR1 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; HLA D ANTIGEN; HLA DMB; HLA-DMB; INFLUENZA VIRUS HEMAGGLUTININ; LIGAND; MULTIPROTEIN COMPLEX; PEPTIDE FRAGMENT;

ARTICLE; BINDING SITE; COMPLEX FORMATION; ENERGY TRANSFER; HYDROGEN BOND; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; AMINO ACID SUBSTITUTION; BINDING COMPETITION; CELL LINE; GENETICS; HUMAN; IMMUNOLOGY; INFLUENZA VIRUS A; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; BINDING, COMPETITIVE; CELL LINE; CONSERVED SEQUENCE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HLA-D ANTIGENS; HLA-DR1 ANTIGEN; HUMANS; HYDROGEN BONDING; INFLUENZA A VIRUS; LIGANDS; MULTIPROTEIN COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY;

EID: 77949315137     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902878     Document Type: Article

References (12)

1. Watts, C., and S. Powis. 1999. Pathways of antigen processing and presentation. Rev. Immunogenet. 1: 60-74.
2. Brocke, P., N. Garbi, F. Momburg, and G. J. Hämmerling. 2002. HLA-DM, HLADO and tapasin: functional similarities and differences. Curr. Opin. Immunol. 14: 22-29.
3. Anderson, M. W., and J. Gorski. 2005. Cooperativity during the formation of peptide/MHC class II complexes. Biochemistry 44: 5617-5624.
4. Ferrante, A., and J. Gorski. 2007. Cooperativity of hydrophobic anchor interactions: evidence for epitope selection by MHC class II as a folding process. J. Immunol. 178: 7181-7189. (Pubitemid 46847444)
5. Stratikos, E., D. C. Wiley, and L. J. Stern. 2004. Enhanced catalytic action of HLADM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain. J. Immunol. 172: 1109-1117.
6. Ferrante, A., M. W. Anderson, C. S. Klug, and J. Gorski. 2008. HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available. PLoS One 3: e3722.
7. McFarland, B. J., C. Beeson, and A. J. Sant. 1999. Cutting edge: a single, essential hydrogen bond controls the stability of peptide-MHC class II complexes. J. Immunol. 163: 3567-3571.
8. Narayan, K., C. L. Chou, A. Kim, I. Z. Hartman, S. Dalai, S. Khoruzhenko, and S. Sadegh-Nasseri. 2007. HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes. Nat. Immunol. 8: 92-100.
9. Horovitz, A., and A. R. Fersht. 1990. Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins. J. Mol. Biol. 214: 613-617.
10. Horovitz, A., and A. R. Fersht. 1992. Co-operative interactions during protein folding. J. Mol. Biol. 224: 733-740.
11. Zhou, Z., K. A. Callaway, D. A. Weber, and P. E. Jensen. 2009. Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes. J. Immunol. 183: 4187-4191.
12. Painter, C. A., A. Cruz, G. E. López, L. J. Stern, and Z. Zavala-Ruiz. 2008. Model for the peptide-free conformation of class II MHC proteins. PLoS One 3: e2403.