New insight into the central benzodiazepine receptor-ligand interactions: Design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4 H -imidazo[1,5- a][1,4]benzodiazepines and related compounds

Journal of Medicinal Chemistry

Volumn 54, Issue 16, 2011, Pages 5694-5711

  Anzini, Maurizio ^a   Valenti, Salvatore ^a   Braile, Carlo ^a   Cappelli, Andrea ^a   Vomero, Salvatore ^a   Alcaro, Stefano ^b   Ortuso, Francesco ^b   Marinelli, Luciana ^c   Limongelli, Vittorio ^c   Novellino, Ettore ^c   Betti, Laura ^d   Giannaccini, Gino ^d   Lucacchini, Antonio ^d   Daniele, Simona ^d   Martini, Claudia ^d   Ghelardini, Carla ^e   Di Cesare Mannelli, Lorenzo ^e   Giorgi, Gianluca ^a   Mascia, Maria Paola ^f,g   Biggio, Giovanni ^f,g  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d UNIVERSITY OF PISA   (Italy)

^e UNIVERSITY OF FLORENCE   (Italy)

^f UNIVERSITY OF CAGLIARI   (Italy)

^g CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; CHLORINE 36; ETHYL 6 (4 CHLOROPHENYL) 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLATE; ETHYL 6 (4 METHYLPHENYL) 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLATE; ETHYL 8 FLUORO 6 (4 FLUOROPHENYL) 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLATE; FLUMAZENIL; FLUNITRAZEPAM; IMIDAZOLE DERIVATIVE; LIGAND; RECOMBINANT RECEPTOR; RO 229735; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; SIMULATION; STRUCTURE ACTIVITY RELATION; SYNAPSE; TRANQUILIZING ACTIVITY;

ANIMALS; BENZODIAZEPINES; BINDING SITES; BINDING, COMPETITIVE; CATTLE; CEREBRAL CORTEX; CHLORIDES; FLUMAZENIL; HEK293 CELLS; HUMANS; LIGANDS; MALE; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOTOR ACTIVITY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; SYNAPTOSOMES; TRITIUM; XENOPUS LAEVIS;

EID: 80051907594     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2001597     Document Type: Article

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