1,2,3-Triazolo[1,5-a]quinoxalines: Synthesis and binding to benzodiazepine and adenosine receptors

European Journal of Medicinal Chemistry

Volumn 33, Issue 2, 1998, Pages 113-122

  Bertelli, Lucia ^a   Biagi, Giuliana ^a   Giorgi, Irene ^a   Manera, Clementina ^a   Livi, Oreste ^a   Scartoni, Valerio ^a   Betti, Laura ^a   Giannaccini, Gino ^a   Trincavelli, Letizia ^a   Barili, Pier Luigi ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

1,2,3 triazolol 12,5 a quinoxalines; Adenosine receptor binding; Benzodiazepine receptor binding

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; 1,2,3 TRIAZOLO[1,5 A]QUINOXALINE DERIVATIVE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 AMINOBUTYRIC ACID; ADENOSINE RECEPTOR; BENZODIAZEPINE RECEPTOR; CYCLOHEXYLADENOSINE; FLUMAZENIL; QUINOXALINE DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; BRAIN REGION; CATTLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROMETRY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0032006456     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(98)80036-6     Document Type: Article

References (27)

1. [1] Biagi G., Giorgi I., Scartoni V., Velo S., De Santis B., Martinelli A., Martini C., Senatore G., Il Farmaco 51 (1996) 13-18.
2. [2] Biagi G., Giorgi I., Scartoni V., Velo S., De Santis B., Martinelli A., Lucacchini A., Senatore G., Il Farmaco 51 (1996) 131-136.
3. [3] Toman J., Mindl J., Lycha A., Klicnar J., Srovnalova I., Konicek M., Collect. Czech. Chem. Commun. 59 (1994) 2493-2500.
4. [4] Vogel M., Lippmann E., J. Prakt. Chem. 331 (1989) 75-81.
5. [5] Vogel M., Lippmann E., J. Prakt. Chem. 331 (1989) 69-74.
6. [6] Vogel M., Lippmann E., J. Prakt. Chem. 329 (1987) 101-107.
7. [7] Andreichikov Y.S., Pitirimova S.G., USSR 721,441, 1980.
8. [8] Dyall L.K., Aust. J. Chem. 39 (1986) 89-101.
9. [9] Zhang W., Koehler K.F., Zhang P., Cook J.M., Drug Des. Discov. 12 (1995) 193-248.
10. [10] Biagi G., Giorgi I., Livi O., Lucacchini A., Martini C., Scartoni V., Tacchi P., Il Farmaco 49 (1994) 183-186.
11. [11] Biagi G., Giorgi I., Livi O., Lucacchini A., Martini C., Scartoni V., Tacchi P., Il Farmaco 49 (1994) 187-191.
12. [12] Biagi G., Giorgi I., Livi O., Scartoni V., Lucacchini A., Martini C., Tacchi P., Il Farmaco 50 (1995) 13-19.
13. [13] Biagi G., Breschi C., Giorgi I., Livi O., Martini C., Scartoni V., Scatizzi R., Il Farmaco 50 (1995) 659-667.
14. [14] Biagi G., Giorgi I., Livi O., Lucacchini A., Scartoni V., Il Farmaco 51 (1996) 395-399.
15. [15] Biagi G., Giorgi I., Livi O., Scartoni V., Martini C., Tacchi P., Merlino S., Pasero M., Il Farmaco 49 (1994) 175-181.
16. [16] Biagi G., Giorgi I., Livi O., Scartoni V., Lucacchini A., Senatore G., Barili P.L., Il Farmaco 49 (1994) 357-362.
17. [17] Biagi G., Giorgi I., Livi O., Scartoni V., Velo S., Martini C., Senatore G., Barili P.L., Il Farmaco 50 (1995) 99-105.
18. [18] Biagi G., Giorgi I., Livi O., Manera C., Scartoni V., Lucacchini A., Senatore G., Il Farmaco 51 (1996) 601-608.
19. [19] Dudley M.W., Norton N., Peet P., David D., Demeter A., Herschel H., Weintraub J.R., Ijzerman A.P., Nordvall G., van Galen P.J.M., Jacobson K.A., Drug Dev. Res. 28 (1993) 237-243.
20. [20] Smith P.A.S., Boyer J.K., Benzofurazane oxide. In: Schreiber R.S. (Ed.), Organic Syntheses, Wiley, New York, 1951, pp. 14-16.
21. [21] Tanaka Y., Velen S.R., Miller S.I., Tetrahedron 29 (1973) 3271-3283.
22. [22] Dyall L.K., Kemp J.E., Aust. J. Chem. 20 (1967) 1395-1402.
23. [23] Martini C., Lucacchini A., Ronca G., Hrelia S., Rossi C.A., J. Neurochem. 38 (1982) 15-19.
24. [24] Martini C., Rigacci T., Lucacchini A., J. Neurochem. 41 (1983) 1183-1185.
25. [25] Lowry D.H., Roserbrough N.J., Fair A.L., Randall R.J., J. Biol. Chem. 193 (1951) 265-275.
26. [26] Cheng Y.C., Prusoff W.H., Biochem. Pharmacol. 22 (1973) 3099-3108.
27. [27] Martini C., Poli M.G., Lucacchini A., Bull. Mol. Biol. Med. 11 (1986) 1-10.