Dehydroepiandrosterone treatment of midlife dysthymia

Biological Psychiatry

Volumn 45, Issue 12, 1999, Pages 1533-1541

  Bloch, Miki ^b   Schmidt, Peter J ^a   Danaceau, Merry A ^a   Adams, Linda F ^a   Rubinow, David R ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b RAMBAM MEDICAL CENTER   (Israel)

Author keywords

Adrenal androgens; Dehydroepiandrosterone; Dysthymia; Midlife; Mood

Indexed keywords

PRASTERONE; PRASTERONE SULFATE;

ACNE; ADULT; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DYSTHYMIA; FEMALE; HORMONAL THERAPY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; SLEEP;

ADAPTATION, PSYCHOLOGICAL; ADJUVANTS, IMMUNOLOGIC; ADULT; AFFECT; COGNITION; CROSS-OVER STUDIES; CROSS-SECTIONAL STUDIES; DEHYDROEPIANDROSTERONE; DOUBLE-BLIND METHOD; DYSTHYMIC DISORDER; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PILOT PROJECTS; PSYCHIATRIC STATUS RATING SCALES;

EID: 0033564436     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00066-9     Document Type: Article

References (58)

1. Abadie J.M., Wright B., Correa G., Browne E.S., Porter J.R., Svec F. Effect of dehydroepiandrosterone on neurotransmitter levels and appetite regulation of the obese zucker rat The obesity research program . Diabetes. 42:1993;662-669.
2. Bahrke M.S., Yesalis C.E. III, Wright J.E. Psychological and behavioural effects of endogenous testosterone levels and anabolic-androgenic steroids among males A review . Sports Med. 10:1990;303-337.
3. Baulieu E.-E. Dehydroepiandrosterone (DHEA) A fountain of youth? J Clin Endocrinol Metab. 81:1996;3147-3151.
4. Baulieu E.-E., Robel P., Vatier O., Haug M., Le Goascogne C., Bourreau E. Neurosteroids Pregnenolone and dehydroepiandrosterone in the brain . Fuxe K., Agnati L.F. Receptor Interactions. 1987;89-104 Macmillan, Basingstoke, UK.
5. Beard G. Sexual Neurasthenia. 1884;E.B. Trent, New York.
6. Beck A.T., Ward C.H., Mendelson M., Mock J., Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 4:1961;561-571.
7. Belanger A., Candas B., Dupont A., et al. Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men. J Clin Endocrinol Metab. 79:1994;1086-1090.
8. Benton A.L., Hamsher K.D. Multilingual Aphasia Examination. 1989;AJA Associates, Iowa City, IA.
9. Benton A.L., Hamsher K.D., Varney N.R., Spreen O. Contributions to Neuropsychological Assessment. 1983;Oxford University Press, New York.
10. Berr C., Lafton S., Debuire B., Dartigues J.F., Baulieu E.E. Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality A French community-based study . Proc Natl Acad Sci USA. 93:1996;13410-13415.
11. Brown W.A. Placebo as a treatment for depression. Neuropsychopharmacology. 10:1994;265-269.
12. Cawood E.H., Bancroft J. Steroid hormones, the menopause, sexuality and well-being of women. Psychol Med. 26:1996;925-936.
13. 3 region of the rat dorsal hippocampus An effect mediated via sigma receptors . J Endocrinol. 150:(Suppl 3):1996;S33-S42.
14. Ditkoff E.C., Crary W.G., Cristo M., Lobo R.A. Estrogen improves psychological function in asymptomatic postmenopausal women. Obstet Gynecol. 78:1991;991-995.
15. Ebeling P., Kolvisto V.A. Physiological importance of dehydroepiandrosterone. Lancet. 343:1994;1479-1481.
16. Fava M., Littman A., Lamon-Fava S., et al. Psychological, behavioral and biochemical risk factors for coronary artery disease among American and Italian male corporate managers. Am J Cardiol. 70:1992;1412-1416.
17. Ferrari E, Locatelli M, Arcaini A, et al (1997): Chronobiological study of some neuroendocrine features of major depression in elderly people. Abstr 79th Annu Meeting Endocr Soc. Bethesda, MD: Endocrine Society Press.
18. Flood J.F., Morley J.E., Roberts E. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc Natl Acad Sci USA. 89:1992;1567-1571.
19. Friess E, Trachsel L, Guldner J, Schier T, Steiger A, Holsboer F (1995): DHEA administration increases rapid-eye-movement sleep and EEG power in the sigma frequency range. Am J Physiol 268:E107-E103.
20. George M.S., Guidotti A., Rubinow D.R., Pan B., Mikalauskas K., Post R.M. CSF neuroactive steroids in affective disorders Pregnenolone, progesterone and DBI . Biol Psychiatry. 35:1994;775-780.
21. Goodyer I.M., Herbert J., Atlham P.M.E., Pearson J., Secher S.M., Shiers H.M. Adrenal secretion during major depression in 8- to 16-year-olds, I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation. Psychol Med. 26:1996;245-256.
22. Gray A., Feldman H.A., McKinlay J.B., Longcope A. Age, disease and changing sex hormone levels in middle-aged men results of the Massachusetts male aging study . J Clin Endocrinol Metab. 73:1991;1016-1023.
23. Gronwall D.M.A. Paced auditory serial-addition task A measure of recovery from concussion . Percept Mot Skills. 44:1977;367-373.
24. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 23:1960;56-62.
25. Heuser I., Deuschle M., Luppa P., Schweiger U., Standhardt H., Weber B. Increased diurnal plasma concentrations of dehydroepiandrosterone in depressed patients. J Clin Endocrinol Metab. 83:1998;3130-3133.
26. Kampen D.L., Sherwin B.B. Estrogen use and verbal memory in healthy postmenopausal women. Obstet Gynecol. 83:1994;979-983.
27. Kudielka B.M., Hellhammer J., Hellhammer D.H., et al. Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandrosterone treatment. J Clin Endocrinol Metab. 83:1998;1756-1761.
28. Longcope C. The metabolism of dehydroepiandrosterone sulfate. Semin Repro Endocrinol. 13:1995;270-274.
29. A receptor: Mechanism of action and physiological significance . Prog Neurobiol. 38:1992;379-395.
30. A receptor. Brain Res. 526:1990;143-146.
31. Mason B.J., Kocsis J.H., Leon A.C., et al. Measurement of severity and treatment response in dysthymia. Psychiatr Ann. 23:1993;625-631.
32. McEwen B.S. What makes a steroid a neurosteroid? New Biol. 4:1992;212-216.
33. 3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus. Proc Natl Acad Sci U S A. 92:1995;3774-3778.
34. Morales A.J., Nolan J.J., Nelson J.C., Yen S.S.C. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab. 78:1994;1360-1367.
35. Mortola J.F., Yen S.S.C. The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J Clin Endocrinol Metab. 71:1990;696-704.
36. Orentreich N., Brind J.L., Rizer R.L., Vogelman J.H. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab. 59:1984;551-555.
37. Orentreich N., Brind J.L., Vogelman J.H., Andres R., Baldwin H. Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men. J Clin Endocrinol Metab. 75:1992;1002-1004.
38. Osran H., Reist C., Chen C.-C., Lifrak E.T., Chicz-DeMet A., Parker L.N. Adrenal androgens and cortisol in major depression. Am J Psychiatry. 150:1993;806-809.
39. Reitan R. Validity of the Trail Making Test as an indication of organic brain damage. Percept Mot Skills. 8:1958;271-276.
40. Reiter T. Testosterone implantation A clinical study of 240 implantations in aging males . J Am Geriatr Soc. 11:1963;540-550.
41. Robel P., Baulieu E.-E. Neurosteroids, biosynthesis and function. Trends Endocrinol Metab. 5:1994;1-8.
42. Rubinow D.R., Schmidt P.J. Androgens, brain and behavior. Am J Psychiatry. 153:1996;974-984.
43. Rubinow D.R., Su T.-P. Androgenic steroids Effects on brain and behavior . Biol Psychiatry. 35:1994;619.
44. Schmidt P.J., Rubinow D.R. Menopause-related affective disorders A justification for further study . Am J Psychiatry. 148:1991;844-852.
45. Shepard R.N., Metzler J. Mental rotation of three-dimensional objects. Science. 17:1972;701-703.
46. Sherwin B.B. Sex hormones and psychological functioning in postmenopausal women. Exp Gerontol. 29:1994;423-430.
47. Smith A. Symbol Digit Modalities Test (SDMT) Manual, revised. 1982;Western Psychological Services, Los Angeles.
48. Spitzer R.L., Endicott J. Schedule for Affective Disorders and Schizophrenia - Lifetime Version. 1975;Biometrics Research Department, New York State Psychiatric Institute, New York.
49. Spitzer R.L., Williams J.B., Gibbon M., First M.B. Structured Clinical Interview for DSM-III-R, patient edition. 1990;Biometrics Research Department, New York State Psychiatric Institute, New York.
50. Spreen O., Strauss E. A Compendium of Neuropsychological Tests. 1991;Oxford University Press, New York.
51. Tariot P.N., Sunderland T., Weingartner H., et al. Cognitive effects of L-deprenyl in Alzheimer's disease. Psychopharmacology. 91:1987;489-495.
52. Thase M.E., Fava M., Halbreich U., et al. A placebo-controlled, randomized clinical trial comparing sertraline and imipramine for the treatment of dysthymia. Arch Gen Psychiatry. 53:1996;777-784.
53. Vermeulen A. The male climacterium. Ann Med. 25:1993;531-534.
54. Versiani M., Amrein R., Stabl M. Moclobemide and imipramine in chronic depression (dysthymia) An international double-blind, placebo-controlled trial. International collaborative study group . Int Clin Psychopharmacol. 12:1997;183-193.
55. Wechsler D. Wechsler Adult Intelligence Scale, revised. 1981;The Psychological Corporation, Harcourt Brace Jovanovich, Inc, San Antonio.
56. Wolf O.T., Neumann O., Hellhammer D.H., et al. Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men. J Clin Endocrinol Metab. 82:1997;2263-2367.
57. Wolkowitz O.M., Reus V.I., Roberts E., et al. Antidepressant and cognition-enhancing effects of DHEA in major depression. Ann N Y Acad Sci. 774:1995;337-339.
58. Wolkowitz O.M., Reus V.I., Roberts E., et al. Dehydroepiandrosterone (DHEA) treatment of depression. Biol Psychiatry. 41:1997;311-318.