Dendritic cells in oral tolerance in the gut

Cellular Microbiology

Volumn 13, Issue 9, 2011, Pages 1312-1318

  Rescigno, Maria ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; CD11B ANTIGEN; CD209 ANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR1; FOOD ALLERGEN; GLYCOPROTEIN P 15095; INTERLEUKIN 10; PROGRAMMED DEATH 1 LIGAND 1; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; CD8+ T LYMPHOCYTE; CELL FUNCTION; CLONAL ANERGY; DENDRITIC CELL; HUMAN; IMMUNOLOGICAL TOLERANCE; INTESTINE; LAMINA PROPRIA; LIVER; LYMPHOCYTE PROLIFERATION; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; SHORT SURVEY;

ANIMALS; ANTIGEN-PRESENTING CELLS; DENDRITIC CELLS; FOOD HYPERSENSITIVITY; HUMANS; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL;

EID: 80051814222     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2011.01626.x     Document Type: Short Survey

References (55)

1. Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., and Onoue, M., etal. (2008) ATP drives lamina propria T(H)17 cell differentiation. Nature 455: 808-812.
2. Ballesteros-Tato, A., Leon, B., Lund, F.E., and Randall, T.D. (2010) Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza. Nat Immunol 11: 216-224.
3. Bedoui, S., Whitney, P.G., Waithman, J., Eidsmo, L., Wakim, L., and Caminschi, I., etal. (2009) Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nat Immunol 10: 488-495.
4. Belladonna, M.L., Volpi, C., Bianchi, R., Vacca, C., Orabona, C., and Pallotta, M.T. etal. (2008) Cutting edge: autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells. J Immunol 181: 5194-5198.
5. Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T.B., and Oukka, M., etal. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238.
6. Bogunovic, M., Ginhoux, F., Helft, J., Shang, L., Hashimoto, D., and Greter, M., etal. (2009) Origin of the lamina propria dendritic cell network. Immunity 31: 513-525.
7. Brandtzaeg, P. (2010) Food allergy: separating the science from the mythology. Nat Rev Gastroenterol Hepatol 7: 380-400.
8. Braun, D., Longman, R.S., and Albert, M.L. (2005) A two-step induction of indoleamine 2, 3 dioxygenase (IDO) activity during dendritic-cell maturation. Blood 106: 2375-2381.
9. Chen, W., Jin, W., Hardegen, N., Lei, K.J., Li, L., Marinos, N., etal. (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198: 1875-1886.
10. Cisse, B., Caton, M.L., Lehner, M., Maeda, T., Scheu, S., Locksley, R., etal. (2008) Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell 135: 37-48.
11. Coombes, J.L., Siddiqui, K.R., Arancibia-Carcamo, C.V., Hall, J., Sun, C.M., Belkaid, Y., and Powrie, F. (2007) A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-{beta} and retinoic acid dependent mechanism. J Exp Med 204: 1757-1764.
12. Denning, T.L., Wang, Y.C., Patel, S.R., Williams, I.R., and Pulendran, B. (2007) Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8: 1086-1094.
13. DePaolo, R.W., Abadie, V., Tang, F., Fehlner-Peach, H., Hall, J.A., Wang, W., etal. (2011) Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature 471: 220-224.
14. Fallarino, F., Grohmann, U., You, S., McGrath, B.C., Cavener, D.R., Vacca, C., etal. (2006) The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol 176: 6752-6761.
15. Faria, A.M., and Weiner, H.L. (2005) Oral tolerance. Immunol Rev 206: 232-259.
16. Fortin, G., Raymond, M., Van, V.Q., Rubio, M., Gautier, P., Sarfati, M., and Franchimont, D. (2009) A role for CD47 in the development of experimental colitis mediated by SIRPalpha+CD103- dendritic cells. J Exp Med 206: 1995-2011.
17. Fukaya, T., Takagi, H., Sato, Y., Sato, K., Eizumi, K., Taya, H., etal. (2010) Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance. Blood 116: 2266-2276.
18. Goubier, A., Dubois, B., Gheit, H., Joubert, G., Villard-Truc, F., Asselin-Paturel, C., etal. (2008) Plasmacytoid dendritic cells mediate oral tolerance. Immunity 29: 464-475.
19. Hadis, U., Wahl, B., Schulz, O., Hardtke-Wolenski, M., Schippers, A., Wagner, N., etal. (2011) Intestinal tolerance requires gut homing and expansion of FoxP3(+) regulatory T cells in the lamina propria. Immunity 34: 237-246.
20. Hammerschmidt, S.I., Ahrendt, M., Bode, U., Wahl, B., Kremmer, E., Forster, R., and Pabst, O. (2008) Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo. J Exp Med 205: 2483-2490.
21. Iliev, I.D., Mileti, E., Matteoli, G., Chieppa, M., and Rescigno, M. (2009a) Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning. Mucosal Immunol 2: 340-350.
22. Iliev, I.D., Spadoni, I., Mileti, E., Matteoli, G., Sonzogni, A., Sampietro, G.M., etal. (2009b) Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells. Gut 58: 1481-1489.
23. Jaensson, E., Uronen-Hansson, H., Pabst, O., Eksteen, B., Tian, J., Coombes, J.L., etal. (2008) Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med 205: 2139-2149.
24. Jaensson-Gyllenback, E., Kotarsky, K., Zapata, F., Persson, E.K., Gundersen, T.E., Blomhoff, R., and Agace, W.W. (2011) Bile retinoids imprint intestinal CD103(+) dendritic cells with the ability to generate gut-tropic T cells. Mucosal Immunol, in press.
25. Johansson-Lindbom, B., Svensson, M., Pabst, O., Palmqvist, C., Marquez, G., Forster, R., and Agace, W.W. (2005) Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med 202: 1063-1073.
26. Laffont, S., Siddiqui, K.R., and Powrie, F. (2010) Intestinal inflammation abrogates the tolerogenic properties of mln cd103(+) dendritic cells. Eur J Immunol 40: 1877-1883.
27. Li, W., Chou, S.T., Wang, C., Kuhr, C.S., and Perkins, J.D. (2004) Role of the liver in peripheral tolerance: induction through oral antigen feeding. Am J Transplant 4: 1574-1582.
28. Manicassamy, S., Reizis, B., Ravindran, R., Nakaya, H., Salazar-Gonzalez, R.M., Wang, Y.C., and Pulendran, B. (2010) Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science 329: 849-853.
29. Matteoli, G., Mazzini, E., Iliev, I.D., Mileti, E., Fallarino, F., Puccetti, P., etal. (2010) Gut CD103+ dendritic cells express indoleamine 2, 3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction. Gut 59: 595-604.
30. Molenaar, R., Greuter, M., van der Marel, A.P., Roozendaal, R., Martin, S.F., Edele, F., etal. (2009) Lymph node stromal cells support dendritic cell-induced gut-homing of T cells. J Immunol 183: 6395-6402.
31. Molenaar, R., Knippenberg, M., Goverse, G., Olivier, B.J., de Vos, A.F., O'Toole, T., and Mebius, R.E. (2011) Expression of retinaldehyde dehydrogenase enzymes in mucosal dendritic cells and gut-draining lymph node stromal cells is controlled by dietary vitamin A. J Immunol 186: 1934-1942.
32. Munn, D.H., and Mellor, A.L. (2007) Indoleamine 2, 3-dioxygenase and tumor-induced tolerance. J Clin Invest 117: 1147-1154.
33. Newberry, R.D., Stenson, W.F., and Lorenz, R.G. (1999) Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen. Nat Med 5: 900-906.
34. Newberry, R.D., McDonough, J.S., Stenson, W.F., and Lorenz, R.G. (2001) Spontaneous and continuous cyclooxygenase-2-dependent prostaglandin E2 production by stromal cells in the murine small intestine lamina propria: directing the tone of the intestinal immune response. J Immunol 166: 4465-4472.
35. Niess, J.H., and Adler, G. (2010) Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions. J Immunol 184: 2026-2037.
36. Nudel, I., Elnekave, M., Furmanov, K., Arizon, M., Clausen, B.E., Wilensky, A., and Hovav, A.H. (2011) Dendritic cells in distinct oral mucosal tissues engage different mechanisms to prime CD8+ T cells. J Immunol 186: 891-900.
37. Pabst, O., and Bernhardt, G. (2010) The puzzle of intestinal lamina propria dendritic cells and macrophages. Eur J Immunol 40: 2107-2111.
38. Rescigno, M. (2010a) Dendritic cells in tolerance induction for the treatment of autoimmune diseases. Eur J Immunol 40: 2119-2123.
39. Rescigno, M. (2010b) Intestinal dendritic cells. Adv Immunol 107: 109-138.
40. Rescigno, M., and Di Sabatino, A. (2009) Dendritic cells in intestinal homeostasis and disease. J Clin Invest 119: 2441-2450.
41. Rimoldi, M., Chieppa, M., Salucci, V., Avogadri, F., Sonzogni, A., Sampietro, G.M., etal. (2005) Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol 6: 507-514.
42. Schulz, O., Jaensson, E., Persson, E.K., Liu, X., Worbs, T., Agace, W.W., and Pabst, O. (2009) Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med 206: 3101-3114.
43. Sharma, M.D., Baban, B., Chandler, P., Hou, D.Y., Singh, N., Yagita, H., etal. (2007) Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2, 3-dioxygenase. J Clin Invest 117: 2570-2582.
44. Shevach, E.M., Davidson, T.S., Huter, E.N., Dipaolo, R.A., and Andersson, J. (2008) Role of TGF-beta in the induction of Foxp3 expression and T regulatory cell function. J Clin Immunol 28: 640-646.
45. Spahn, T.W., Fontana, A., Faria, A.M., Slavin, A.J., Eugster, H.P., Zhang, X., etal. (2001) Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches. Eur J Immunol 31: 1278-1287.
46. Steinman, R.M., Hawiger, D., and Nussenzweig, M.C. (2003) Tolerogenic dendritic cells. Annu Rev Immunol 21: 685-711.
47. Stock, A., Booth, S., and Cerundolo, V. (2011) Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans. J Exp Med 208: 761-773.
48. Sun, C.M., Hall, J.A., Blank, R.B., Bouladoux, N., Oukka, M., Mora, J.R., and Belkaid, Y. (2007) Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 204: 1775-1785.
49. Uematsu, S., Fujimoto, K., Jang, M.H., Yang, B.G., Jung, Y.J., Nishiyama, M., etal. (2008) Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol 9: 769-776.
50. Ueno, H., Klechevsky, E., Morita, R., Aspord, C., Cao, T., Matsui, T., etal. (2007) Dendritic cell subsets in health and disease. Immunol Rev 219: 118-142.
51. Varol, C., Vallon-Eberhard, A., Elinav, E., Aychek, T., Shapira, Y., Luche, H., etal. (2009) Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31: 502-512.
52. Worbs, T., Bode, U., Yan, S., Hoffmann, M.W., Hintzen, G., Bernhardt, G., etal. (2006) Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med 203: 519-527.
53. Xiao, S., Jin, H., Korn, T., Liu, S.M., Oukka, M., Lim, B., and Kuchroo, V.K. (2008) Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol 181: 2277-2284.
54. Yokota, A., Takeuchi, H., Maeda, N., Ohoka, Y., Kato, C., Song, S.Y., and Iwata, M. (2009) GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity. Int Immunol 21: 361-377.
55. Zhou, Y., Kawasaki, H., Hsu, S.C., Lee, R.T., Yao, X., Plunkett, B., etal. (2010) Oral tolerance to food-induced systemic anaphylaxis mediated by the C-type lectin SIGNR1. Nat Med 16: 1128-1133.