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Volumn 118, Issue 44, 1996, Pages 10684-10692

Specific recognition of substrate analogs by the DNA mismatch repair enzyme MutY

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DNA DAMAGE; DNA MODIFICATION; DNA REPAIR; ENZYME ACTIVITY; ENZYME BINDING; IN VITRO STUDY; MUTATION; STRUCTURE ACTIVITY RELATION;

EID: 0029836886     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9602206     Document Type: Article
Times cited : (82)

References (65)
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    • note
    • We are referring to the 2′-deoxynucleotides in the various base-pairs with a single- or two-letter abbreviation. For example, A = 2′-deoxyadenosine and Z = 2′-deoxyturbercidin.
  • 21
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    • 0021931926 scopus 로고
    • For some examples, see: (a) Henderson, J. F.; Paterson, A. R. P.; Caldwell, I. C.; Hori, M. Cancer Res. 1967, 27, 715-719. (b) Sarih, L.; Agoutin, B.; Lecoq, O.; Weill, D.; Jullien, P.; Heyman, T. Virology 1985, 145, 171-175.
    • (1985) Virology , vol.145 , pp. 171-175
    • Sarih, L.1    Agoutin, B.2    Lecoq, O.3    Weill, D.4    Jullien, P.5    Heyman, T.6
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    • note
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    • note
    • d. Additionally, the amount of cleavage at the A by MutY was not reported.
  • 37
    • 10544225091 scopus 로고    scopus 로고
    • note
    • d values of OG:A duplexes with long incubation times (1-2 h). This is presently under investigation.
  • 39
    • 0030570441 scopus 로고    scopus 로고
    • For examples, see: (a) Ramesh, V.; Nagaraja, V. J. Mol. Biol. 1996, 260, 22-33. (b) Oakley, M. G.; Mrksich, M.; Dervan, P .B. Biochemistry 1992, 31, 10969-10975.
    • (1996) J. Mol. Biol. , vol.260 , pp. 22-33
    • Ramesh, V.1    Nagaraja, V.2
  • 40
    • 0026495668 scopus 로고
    • For examples, see: (a) Ramesh, V.; Nagaraja, V. J. Mol. Biol. 1996, 260, 22-33. (b) Oakley, M. G.; Mrksich, M.; Dervan, P .B. Biochemistry 1992, 31, 10969-10975.
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    • Oakley, M.G.1    Mrksich, M.2    Dervan, P.B.3
  • 41
    • 0028898498 scopus 로고
    • (a) Footprinting experiments have been performed on T4-endonuclease V by trapping the intermediate formed after the glycosylase reaction by reduction with sodium borohydride. Latham, K. A.; Taylor, J.-S.; Lloyd, R. S. J. Biol. Chem. 1995, 270, 3765-3771.
    • (1995) J. Biol. Chem. , vol.270 , pp. 3765-3771
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  • 42
    • 0028924802 scopus 로고
    • (b) Footprinting experiments using oligonucleotides containing a reduced apyrimidinic site which are inhibitors of the β-lyase reaction at the AP site generated by the glycosylase reaction with endonuclease III and the FPG protein have also been reported. For endonuclease III see: O'Handley, S.; Scholes, C. P.; Cunningham, R. P. Biochemistry 1995, 34, 2528-2536. For the FPG protein, see: Castaing, B.; Boiteux, S.; Zelwar, C. Nucleic Acids. Res. 1992, 20, 389-394.
    • (1995) Biochemistry , vol.34 , pp. 2528-2536
    • O'Handley, S.1    Scholes, C.P.2    Cunningham, R.P.3
  • 43
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    • (b) Footprinting experiments using oligonucleotides containing a reduced apyrimidinic site which are inhibitors of the β-lyase reaction at the AP site generated by the glycosylase reaction with endonuclease III and the FPG protein have also been reported. For endonuclease III see: O'Handley, S.; Scholes, C. P.; Cunningham, R. P. Biochemistry 1995, 34, 2528-2536. For the FPG protein, see: Castaing, B.; Boiteux, S.; Zelwar, C. Nucleic Acids. Res. 1992, 20, 389-394.
    • (1992) Nucleic Acids. Res. , vol.20 , pp. 389-394
    • Castaing, B.1    Boiteux, S.2    Zelwar, C.3
  • 47
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    • note
    • We assume that the conditions of the hydroxyl radical footprinting provide the base for cleavage at the abasic site generated by MutY. The band with retarded mobility with respect to the position of the "A" results from incomplete base treatment, since these conditions are not as basic as used in the MutY assay to visualize the glycosylase activity.
  • 48
    • 10544245167 scopus 로고    scopus 로고
    • Unpublished results
    • In preliminary data with other footprinting reagents, we observe additional bands on the 5′ side of the "A". Porello, S. L.; David, S. S. Unpublished results.
    • Porello, S.L.1    David, S.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.