Efficient recognition of substrates and substrate analogs by the adenine glycosylase MutY requires the C-terminal domain

Nucleic Acids Research

Volumn 29, Issue 2, 2001, Pages 553-564

  Chmiel, Nikolas H ^a   Golinelli, Marie Pierre ^a,b   Francis, Anthony W ^a   David, Sheila S ^a  

^a UNIVERSITY OF UTAH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; ADENINE; DEOXYADENOSINE; DIMETHYL SULFATE; DNA GLYCOSYLTRANSFERASE; DOUBLE STRANDED DNA; GENE PRODUCT; HYDROXYL RADICAL;

AMINO TERMINAL SEQUENCE; ARTICLE; ASSAY; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA FOOTPRINTING; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SUBSTRATE; GENE MUTATION; IN VIVO STUDY; KINETICS; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN METABOLISM;

ESCHERICHIA COLI;

EID: 0035863770     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.2.553     Document Type: Article

References (55)

1. Oxidative damage to DNA: Formation, measurement and biological significance
2. Formation, prevention and repair of DNA damage by iron/hydrogen peroxide
3. Endogenous mutagens and the causes of aging and cancer
4. BRCA1 required for transcription-coupled repair of oxidative DNA damage
5. A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer
6. 8-Hydroxy-2′-deoxyguanosine as a biological marker of in vivo oxidative damage
7. Hydroxy radicals and DNA base damage
8. Oxidative decay of DNA
9. Genetic effects of oxidative DNA damage-comparative mutagenesis of 7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine in E.coli
10. Insertion of specific bases during DNA synthesis past the oxidation damaged base 8-oxodG
11. Chemistry of glycosylases and endonucleases involved in base-excision repair
12. A repair system for 8-oxo-7,8-dihydrodeoxyguanosine
13. Mutagenesis by 8-oxoguanine: An enemy within
14. MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis
15. Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA
16. Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs
17. Some mismatch repair activities in Escherichia coli
18. DNA determinants and substrate specificities of Escherichia coli MutY
19. Recognition of substrate analogs by the DNA mismatch repair enzyme MutY
20. Substrate recognition by Escherichia coli MutY using substrate analogs
21. Unusually strong binding of a designed transition-state analog to a base-excision DNA repair protein
22. Substrate specificity of Escherichia coli MutY protein
23. Recognition of the nonpolar base 4-methylindole in DNA by the DNA repair adenine glycosylase MutY
24. Single-turnover and pre-steady-state kinetics of the reaction of the adenine glycosylase MutY with mismatch-containing DNA substrates
25. MutY, an adenine glycosylase active on G-A mispairs, has homology to endonuclease III
26. Characterization of the Escherichia coli X-ray endonuclease, endonuclease III
27. New substrates for old enzymes
28. DNA glycosylase activities for thymine residues damaged by ring saturation, fragmentation or ring contraction are functions of endonuclease III in Escherichia coli
29. Identification of the structural and functional domains of MutY, an Escherichia coli DNA mismatch repair enzyme
30. Specific recognition of A/G and A/7,8-dihydro-8-oxoguanine (8-oxoG) mismatches by Escherichia coli MutY: Removal of the C-terminal domain preferentially affects A/8-oxo-G recognition
31. MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily
32. Cloning, overexpression and biochemical characterization of the catalytic domain of MutY
33. The C-terminal domain of the adenine-DNA glycosylase MutY confers specificity of 8-oxoguanine-adenine mispairs and may have evolved from MutT, an 8-oxo-dGTPase
34. The C-terminal domain of MutY glycosylase determines the 7,8-dihydro-8-oxo-guanine specificity and is crucial for mutation avoidance
35. Structural similarities between MutT and the C-Terminal domain of MutY
36. Positively charged residues within the iron-sulfur cluster loop of E. coli MutY participate in damage recognition and removal
37. A single engineered point mutation in the adenine glycosylase MutY confers bifunctional glycosylase/AP lyase activity
38. A set of LacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions
39. Site-directed mutagenesis of the cysteine ligands to the [4Fe-4S] cluster of Escherichia coli MutY
40. Gel retardation
41. Specific binding of a designed pyrrolidine abasic site analog to multiple DNA glycosylases
42. MutY DNA glycosylase: Base release and intermediate complex formation
43. Measurements of binding kinetics using the gel electrophoresis mobility shift assay
44. Kinetic mechanism of damage site recognition and uracil flipping by Escherichia coli uracil DNA glycosylase
45. The structural basis of specific base-excision repair by uracil-DNA glycosylase
46. Crystal structure and mutational analysis of human uracil-DNA glycosylase: Structural basis for specificity and catalysis
47. Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure
48. Structure of a duplex DNA containing a thymine glycol residue in solution
49. Crystal structure of a DNA duplex containing 8-hydroxydeoxyguanine-adenine base pairs
50. Reference points for comparisons of two-dimensional maps of proteins from different human cell types defined in a pH scale where isoelectric points correlate with polypeptide compositions
51. Protein identification and analysis tools in the ExPASy Server
52. Mechanism-based DNA-protein cross-linking of MutY via oxidation of 8-oxoguanosine
53. NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn)-dA(anti) alignment at lesion site