Insight into the functional consequences of inherited variants of the hMYH adenine glycosylase associated with colorectal cancer: Complementation assays with hMYH variants and pre-steady-state kinetics of the corresponding mutated E. coli enzymes

Journal of Molecular Biology

Volumn 327, Issue 2, 2003, Pages 431-443

  Chmiel, Nikolas H ^a   Livingston, Alison L ^a   David, Sheila S ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

7,8 dihydro 8 oxo 2 deoxyguanosine; Adenine glycosylase; Colon cancer; DNA repair; Familial adenomatous polyposis

Indexed keywords

2' DEOXY 2' FLUOROADENOSINE; ADENINE GLYCOSYLASE; ADENOSINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BINDING AFFINITY; BIOASSAY; COLORECTAL CARCINOMA; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE MUTATION; GENETIC COMPLEMENTATION; GENETIC VARIABILITY; HETEROZYGOSITY; KINETICS; MUTAGENESIS; MUTATION; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; REDUCTION; STEADY STATE;

ESCHERICHIA COLI;

EID: 0037459233     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00124-4     Document Type: Article

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