Insights into the reaction mechanism of the prolyl - Acyl carrier protein oxidase involved in anatoxin-a and homoanatoxin-a biosynthesis

Biochemistry

Volumn 50, Issue 33, 2011, Pages 7184-7197

  Mann, Stéphane ^a,b   Lombard, Bérangère ^d   Loew, Damarys ^d   Méjean, Annick ^a,b,c   Ploux, Olivier ^a,b  

^a PSL RESEARCH UNIVERSITY   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACYL CARRIER PROTEINS; ACYL-COA; CATALYTIC CONSTANTS; CATALYTIC ROLE; CONJUGATED IMINE; DEUTERIUM LABELING; ENOLIZATION; EXPERIMENTAL EVIDENCE; GENE CLUSTERS; IN-VITRO; LC-MS/MS; LIQUID CHROMATOGRAPHY COUPLED TO TANDEM MASS SPECTROMETRY; REACTION MECHANISM; SEQUENCE ALIGNMENTS; SLOW OXIDATION; TWO-ELECTRON OXIDATION;

AMINO ACIDS; BIOSYNTHESIS; CATALYSIS; DEUTERIUM; GENES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NITROGEN COMPOUNDS; OXIDATION;

BIOCHEMISTRY;

ACYL CARRIER PROTEIN; ANATOXIN A; ANATOXIN B; DEHYDROPROLYL ANATOXIN D; DEUTERIUM; FLAVOPROTEIN; HOMOANATOXIN A; IMINE; OXYGEN; PROLINE; PROLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERIZATION; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REACTION ANALYSIS; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; TANDEM MASS SPECTROMETRY;

ACYL CARRIER PROTEIN; BACTERIAL TOXINS; BICYCLO COMPOUNDS, HETEROCYCLIC; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; CYANOBACTERIA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDATION-REDUCTION; PROLINE; TANDEM MASS SPECTROMETRY; TROPANES;

CYANOBACTERIA;

EID: 80051775847     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200892a     Document Type: Article

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