Diagnosis of anatoxin-a poisoning in dogs from North America

Journal of Veterinary Diagnostic Investigation

Volumn 20, Issue 1, 2008, Pages 89-92

  Puschner, Birgit ^a   Hoff, Brent ^b   Tor, Elizabeth R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

Anatoxin a; Blue green algae; Cyanobacteria; Dogs; Liquid chromatography mass spectrometry; Neurotoxic; Toxicosis

Indexed keywords

CANIS FAMILIARIS; CHLOROPHYTA; CYANOBACTERIA;

ANATOXIN A; NEUROTOXIN; TROPANE DERIVATIVE; WATER;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYANOBACTERIUM; DOG; DOG DISEASE; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; LIVER; MASS FRAGMENTOGRAPHY; METABOLISM; SEIZURE; STOMACH JUICE; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, LIQUID; CYANOBACTERIA; DOG DISEASES; DOGS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GASTROINTESTINAL CONTENTS; LIVER; NEUROTOXINS; SEIZURES; TANDEM MASS SPECTROMETRY; TROPANES; WATER;

EID: 54049131769     PISSN: 10406387     EISSN: None     Source Type: Journal    
DOI: 10.1177/104063870802000119     Document Type: Article

References (17)

1. Beltran EC, Neilan BA: 2000, Geographical segregation of the neurotoxin-producing cyanobacterium Anabaena circinalis. Appl Environ Microbiol 66:4468-4474.
2. Bogialli S, Bruno M, Curini R, et al.: 2006, Simple and rapid determination of anatoxin-a in lake water and fish muscle tissue by liquid-chromatography-tandem mass spectrometry. J Chromatogr A 1122:180-185.
3. Carmichael WW, Evans WR, Yin QQ, et al.: 1997, Evidence for paralytic shellfish poisons in the freshwater cyanobacterium Lyngbya wollei (Farlow ex Gomont) comb. nov. Appl Environ Microbiol 63:3104-3110.
4. Carmichael WW, Gorham PR, Biggs DF: 1977, Two laboratory case studies on oral toxicity to calves of freshwater cyanophyte (blue-green-alga) Anabaena flos-aquae Nrc-44-1. Can Vet J 18:71-75.
5. Edwards C, Beattie KA, Scrimgeour CM, Codd GA: 1992, Identification of anatoxin-A in benthic cyanobacteria (bluegreen algae) and in associated dog poisonings at Loch Insh, Scotland. Toxicon 30:1165-1175.
6. Fromme H, Kohler A, Krause R, Fuhrling D: 2000, Occurrence of cyanobacterial toxins - Microcystins and anatoxin-a - in Berlin water bodies with implications to human health and regulations. Environ Toxicol 15:120-130.
7. Furey A, Crowley J, Hamilton B, et al.: 2005, Strategies to avoid the mis-identification of anatoxin-a using mass spectrometry in the forensic investigation of acute neurotoxic poisoning. J Chromatogr A 1082:91-97.
8. Furey A, Crowley J, Lehane M, James KJ: 2003, Liquid chromatography with electrospray ion-trap mass spectrometry for the determination of anatoxins in cyanobacteria and drinking water. Rapid Commun Mass Spectrom 17:583-588.
9. Gugger M, Lenoir S, Berger C, et al.: 2005, First report in a river in France of the benthic cyanobacterium Phormidium favosum producing anatoxin-a associated with dog neurotoxicosis. Toxicon 45:919-928.
10. Gunn GJ, Rafferty AG, Rafferty GC, et al.: 1992, Fatal canine neurotoxicosis attributed to blue-green algae (cyanobacteria). Vet Rec 130:301-302.
11. James KJ, Crowley J, Hamilton B, et al.: 2005, Anatoxins and degradation products, determined using hybrid quadrupole time-of-flight and quadrupole ion-trap mass spectrometry: forensic investigations of cyanobacterial neurotoxin poisoning. Rapid Commun Mass Spectrom 19:1167-1175.
12. James KJ, Sherlock IR, Stack MA: 1997, Anatoxin-a in Irish freshwater and cyanobacteria, determined using a new fluorimetric liquid chromatographic method. Toxicon 35:963-971.
13. Krienitz L, Ballot A, Kotut K, et al.: 2003, Contribution of hot spring cyanobacteria to the mysterious deaths of Lesser Flamingos at Lake Bogoria, Kenya. FEMS Microbiol Ecol 43:141-148.
14. Tiwary AK, Puschner B, Charlton BR, Filigenzi MS: 2005, Diagnosis of zinc phosphide poisoning in chickens using a new analytical approach. Avian Dis 49:288-291.
15. Tor ER, Puschner B, Filigenzi MS, et al.: 2006, LC-MS/MS screen for penitrem A and roquefortine C in serum and urine samples. Anal Chem 78:4624-4629.
16. Wehr JD, Sheath RG: 2003. Freshwater algae of North America: ecology and classification. Academic Press, San Diego, CA.
17. Wood SA, Selwood AI, Rueckert A, et al.: 2007, First report of homoanatoxin-a and associated dog neurotoxicosis in New Zealand. Toxicon 50:292-301.