Redesigning the active-site of an acyl-CoA dehydrogenase: New evidence supporting a one-base mechanism

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 12, 1997, Pages 2157-2164

  Dakoji, Srikanth ^a   Shin, Injae ^a   Battaile, Kevin P ^b   Vockley, Jerry ^c   Liu, Hung Wen ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DEHYDROGENASE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME MODIFICATION; ENZYME STRUCTURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ACYL-COA DEHYDROGENASES; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RATS; SEQUENCE ALIGNMENT; STEREOISOMERISM;

EID: 0031438569     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)00159-4     Document Type: Article

References (32)

1. Thorpe, C.; Matthews, R. G.; Williams, C. H. Biochemistry 1979, 18, 331.
2. Ghisla, S.; Thorpe, C.; Massey, V. Biochemistry 1984, 23, 3154.
3. Pohl, B.; Raichle, T.; Ghisla, S. Eur. J. Biochem. 1986,160, 109.
4. Ghisla, S. In Flavins and Flavoproteins; Bray, R. C.; Engel, P. C.; Mayhew, S. G., Eds.; Walter de Gruyter: Berlin, 1984; pp 385-401.
5. Bienert, H. In Enzymes; Boyer, P. C.; Lardy, H.; Myrbäck, K., Eds.; Academic: New York and London, 1963; Vol. 7, pp 447-466.
6. Engel, P. C. In Chemistry and Biochemistry of Flavoenzymes; Müller, F., Ed.; CRC: New York, 1991; pp 597-655.
7. Schulz, H. In Fatty Acid Oxidation: Clinical, Biochemical, and Molecular Aspects; Tanaka, K.; Coates, P. M., Eds.; Alan R. Liss: New York, 1991; pp 23-36.
8. Powell, P. J.; Thorpe, C. Biochemistry 1988, 27, 8022.
9. Freund, K.; Mizzer, J. P.; Dick, W.; Thorpe, C. Biochemistry 1985, 25, 5996.
10. Lundberg, N. N.; Thorpe, C. Archives. Biochem. Biophys. 1993, 305, 454.
11. Kim, J. P.; Wang, M.; Paschke, R. Proc. Natl. Acad. Sci. U.SA. 1993, 90, 7523.
12. Djordjevic, S.; Pace, C. P.; Stankovich, M. T.; Kim, J.-J. P. Biochemistry 1995, 34, 2163.
13. Bross, P.; Engst, S.; Strauss, A.W.; Kelly, D. P.; Rasched, I.; Ghisla, S. J. Biol. Chem. 1990, 265, 7116.
14. Becker, D. F.; Fuchs, J. A.; Banfield, D. K.; Walter, F. D.; MacGillivray, R. T. A.; Stankovich, M. T. Biochemistry 1993, 32, 10736.
15. Matsubara, Y.; Ito, M.; Ito, M.; Glassberg, R.; Satyabhama, S.; Ikeda, Y.; Tanaka, K. J. Clin. Invest 1990, 85, 1058.
16. Matsubara, Y.; Indo, Y.; Naito, E.; Ozasa, H.; Glassberg, R.; Vockley, J.; Ikeda, Y.; Kraus, J.; Tanaka, K. J. Biol. Chem. 1989, 264, 16321.
17. Djordjeric, S.; Dong, Y.; Paschke, R.; Frerman, F. E.; Strauss, A. W.; Kim, J.-J. P. Biochemistry 1994, 34, 4258.
18. Mohsen, A.-W.; Vockley, J. Biochemistry 1995, 34, 10146.
19. Kim, J.-J. P.; Wang, M.; Paschke, R.; Djordjevic, S.; Bennett, D. W.; Vockley, J. In Flavins and Flavoproteins 1993; Yagi, K., Ed.; Walter de Gruyter: New York, 1994; pp 273-282.
20. Battaile, K. P.; Mohsen, A.-W. A.; Vockley, J. Biochemistry 1996, 35, 15356.
21. Biellmann, J. F.; Hirth, C. G. FEBS Lett. 1970, 8, 55.
22. Biellmann, J. F.; Hirth, C. G. FEBS Lett. 1970, 9, 335.
23. Fendrich, G.; Abeles, R. H. Biochemistry 1970, 21, 6685.
24. Nandy, A.; Kieweg, V.; Krutle, F.-G.; Vock, P.; Burkhard, K.; Bross, P.; Kim, J.-J. P.; Rasched, I.; Ghisla, S. Biochemistry 1996, 35, 12402.
25. Lee, H.-J. K.; Wang, M.; Paschke, R.; Nandy, A.; Ghisla, S.; Kim, J.-J. P. Biochemistry 1996, 35, 12412.
26. Cummings, J. G.; Thorpe, C. Biochemistry 1994, 33, 788.
27. Dakoji, S.; Shin, I.; Becker, D.; Stankovich, M. T.; Liu, H.-w. J. Am. Chem. Soc. 1996, 118, 10971.
28. Gomes, B.; Fendrich, G.; Abeles, R. H. Biochemistry 1981, 20, 1481.
29. Lai, M.-t.; Oh, E.; Shih, Y.; Liu, H.-w. J. Org. Chem. 1992, 57, 2471.
30. Herr, R. W.; Wieland, D. M.; Johnson, C. R. J. Am. Chem. Soc. 1970, 92, 3813.
31. Lai, M.-t.; Liu, L.-d.; Liu, H.-w. J. Am. Chem. Soc. 1991, 773, 7388.
32. D'Ordine, R. L.; Tonge, P. J.; Carey, P. R.; Anderson, V. E. Biochemistry 1994, 33, 14733.