The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis

Cell Cycle

Volumn 10, Issue 16, 2011, Pages 2724-2736

  Yabuta, Norikazu ^a   Mukai, Satomi ^a   Okada, Nobuhiro ^a   Aylon, Yael ^b   Nojima, Hiroshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Aurora A; Aurora B; Lats1; Lats2; Phosphorylation

Indexed keywords

AURORA A KINASE; AURORA B KINASE; LATS1 PROTEIN; LATS2 PROTEIN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CHROMOSOME ABERRATION; CYTOKINESIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MITOSIS; MUTANT; NONHUMAN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

EID: 80051770191     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.16.16873     Document Type: Article

References (50)

1. Nigg EA Mitotic kinases as regulators of cell division and its checkpoints Nat Rev Mol Cell Biol 2001; 2:21- 32; PMID: 11413462; DOI: 10.1038/35048096.
2. Salaun P., Rannou Y., Prigent C Cdk1, Plks, Auroras and Neks: the mitotic bodyguards Adv Exp Med Biol 2008; 617:41-56; PMID: 18497029; DOI: 10.1007/978-0-387-69080-3-4.
3. Storchova Z., Pellman D From polyploidy to aneuploidy, genome instability and cancer Nat Rev Mol Cell Biol 2004; 5:45-54; PMID: 14708009; DOI: 10.1038/nrm1276.
4. Musacchio A., Salmon ED The spindle-assembly checkpoint in space and time Nat Rev Mol Cell Biol 2007; 8:379-93; PMID: 17426725; DOI: 10.1038/ nrm2163.
5. King RW When 2 + 2 = 5: the origins and fates of aneuploid and tetraploid cells Biochim Biophys Acta 2008; 1786:4-14; PMID: 18703117; DOI:10.1016/j. bbcan.2008.07.007.
6. Marumoto T., Zhang D., Saya H Aurora A - a guardian of poles Nat Rev Cancer 2005; 5:42-50; PMID: 15630414; DOI: 10.1038/nrc1526.
7. Barr A.R., Gergely F Aurora A: the maker and breaker of spindle poles J Cell Sci 2007; 120:2987-96; PMID: 17715155; DOI: 10.1242/jcs.013136.
8. Karthigeyan D., Prasad S.B., Shandilya J., Agrawal S., Kundu T.K. Biology of Aurora A kinase: Implications in cancer manifestation and therapy. Med Res Rev 2010; 31: In press; PMID: 20196102.
9. Ruchaud S., Carmena M., Earnshaw WC Chromosomal passengers: conducting cell division Nat Rev Mol Cell Biol 2007; 8:798-812; PMID: 17848966; DOI: 10.1038/nrm2257.
10. Carmena M., Ruchaud S., Earnshaw WC Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins Curr Opin Cell Biol 2009; 21:796-805; PMID: 19836940; DOI: 10.1016/j.ceb.2009.09.008.
11. Slattery S.D., Mancini M.A., Brinkley B.R., Hall RM Aurora-C kinase supports mitotic progression in the absence of Aurora B Cell Cycle 2009; 8:2984-94; PMID: 19713763; DOI: 10.4161/cc.8.18.9591.
12. Marumoto T., Honda S., Hara T., Nitta M., Hirota T., Kohmura E., et al. Aurora A kinase maintains the fidelity of early and late mitotic events in HeLa cells. J Biol Chem 2003; 278:51786-95; PMID: 14523000; DOI: 10.1074/jbc. M306275200.
13. -/- cells. EMBO J 2002; 21:483-92; PMID: 11847097; DOI: 10.1093/emboj/21.4.483.
14. Hoar K., Chakravarty A., Rabino C., Wysong D., Bowman D., Roy N., et al. MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy. Mol Cell Biol 2007; 27:4513-25; PMID: 17438137; DOI: 10.1128/MCB.02364-06.
15. Kaestner P., Stolz A., Bastians H Determinants for the efficiency of anticancer drugs targeting either Aurora A or Aurora B kinases in human colon carcinoma cells Mol Cancer Ther 2009; 8:2046-56; PMID: 19584233; DOI: 10.1158/1535-7163.MCT-09-0323.
16. Visser S., Yang X LATS tumor suppressor: a new governor of cellular homeostasis Cell Cycle 2010; 9:3892- 903; PMID: 20935475; DOI: 10.4161/cc.9.19.13386.
17. Yabuta N., Fujii T., Copeland N.G., Gilbert D.J., Jenkins N.A., Nishiguchi H., et al. Structure, expression and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/ warts. Genomics 2000; 63:263-70; PMID: 10673337; DOI: 10.1006/geno.1999.6065.
18. Hergovich A., Hemmings BA Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling Biofactors 2009; 35:338-45; PMID: 19484742; DOI: 10.1002/biof.47.
19. Aylon Y., Michael D., Shmueli A., Yabuta N., Nojima H., Oren M A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization Genes Dev 2006; 20:2687-700; PMID: 17015431; DOI: 10.1101/gad.1447006.
20. Aylon Y., Yabuta N., Besserglick H., Buganim Y., Rotter V., Nojima H., et al. Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation. Oncogene 2009; 28:4469-79; PMID: 19855428; DOI: 10.1038/onc.2009.270.
21. Aylon Y., Ofir-Rosenfeld Y., Yabuta N., Lapi E., Nojima H., Lu X., et al. The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1. Genes Dev 2010; 24:2420-9; PMID: 21041410; DOI: 10.1101/ gad.1954410.
22. Toji S., Yabuta N., Hosomi T., Nishihara S., Kobayashi T., Suzuki S., et al. The centrosomal protein Lats2 is a phosphorylation target of Aurora A kinase. Genes Cells 2004; 9:383-97; PMID: 15147269; DOI: 10.1111/j.1356-9597. 2004.00732.x.
23. McPherson J.P., Tamblyn L., Elia A., Migon E., Shehabeldin A., Matysiak-Zablocki E., et al. Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J 2004; 23:3677-88; PMID: 15343267; DOI: 10.1038/ sj.emboj.7600371.
24. Yabuta N., Okada N., Ito A., Hosomi T., Nishihara S., Sasayama Y., et al. Lats2 is an essential mitotic regulator required for the coordination of cell division. J Biol Chem 2007; 282:19259-71; PMID: 17478426; DOI: 10.1074/jbc.M608562200.
25. Okada N., Yabuta N., Suzuki H., Aylon Y., Oren M., Nojima H A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage J Cell Sci 2011; 124:57-67; PMID: 21118956; DOI: 10.1242/jcs.072918.
26. Chan E.H., Nousiainen M., Chalamalasetty R.B., Schäfer A., Nigg E.A., Silljé HH The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1 Oncogene 2005; 24:2076-86; PMID: 15688006; DOI: 10.1038/sj.onc.1208445.
27. Tao W., Zhang S., Turenchalk G.S., Stewart R.A., St. John M.A., Chen W., et al. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet 1999; 21:177-81; PMID: 9988268; DOI: 10.1038/5960.
28. Hirota T., Morisaki T., Nishiyama Y., Marumoto T., Tada K., Hara T., et al. Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J Cell Biol 2000; 149:1073-86; PMID: 10831611; DOI: 10.1083/jcb.149.5.1073.
29. Morisaki T., Hirota T., Iida S., Marumoto T., Hara T., Nishiyama Y., et al. WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis. FEBS Lett 2002; 529:319-24; PMID: 12372621; DOI: 10.1016/S0014-5793(02)03360-4.
30. Humbert N., Navaratnam N., Augert A., Da Costa M., Martien S., Wang J., et al. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J 2010; 29:376-86; PMID: 19927127; DOI: 10.1038/emboj.2009.342.
31. Tyler R.K., Shpiro N., Marquez R., Eyers PA VX-680 inhibits Aurora A and Aurora B kinase activity in human cells Cell Cycle 2007; 6:2846-54; PMID: 18032922; DOI: 10.4161/cc.6.22.4940.
32. Bothos J., Tuttle R.L., Ottey M., Luca F.C., Halazonetis TD Human LATS1 is a mitotic exit network kinase Cancer Res 2005; 65:6568-75; PMID: 16061636; DOI: 10.1158/0008-5472.CAN-05-0862.
33. Ota T., Suto S., Katayama H., Han Z.B., Suzuki F., Maeda M., et al. Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora B overexpression contributes to chromosome number instability. Cancer Res 2002; 62:5168-5177; PMID: 12234980.
34. Hauf S., Cole R.W., LaTerra S., Zimmer C., Schnapp G., Walter R., et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochoremicrotubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol 2003; 161:281-94; PMID: 12707311; DOI: 10.1083/jcb.200208092.
35. Cimini D., Wan X., Hirel C.B., Salmon ED Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors Curr Biol 2006; 16:1711-8; PMID: 16950108; DOI: 10.1016/j.cub.2006.07.022.
36. Bardin A.J., Amon A Men and sin: what's the difference? Nat Rev Mol Cell Biol 2001; 2:815-26; PMID: 11715048; DOI: 10.1038/35099020.
37. Doxsey S., McCollum D., Theurkauf W Centrosomes in cellular regulation Annu Rev Cell Dev Biol 2005; 21:411-34; PMID: 16212501; DOI: 10.1146/annurev. cellbio.21.122303.120418.
38. Stoepel J., Ottey M.A., Kurischko C., Hieter P., Luca FC The mitotic exit network Mob1p-Dbf2p kinase complex localizes to the nucleus and regulates passenger protein localization Mol Biol Cell 2005; 16:5465-79; PMID: 16176976; DOI: 10.1091/mbc.E05-04-0337.
39. Zhao B., Wei X., Li W., Udan R.S., Yang Q., Kim J., et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 2007; 21:2747-61; PMID: 17974916; DOI: 10.1101/gad.1602907.
40. Lei Q.Y., Zhang H., Zhao B., Zha Z.Y., Bai F., Pei X.H., et al. TAZ promotes cell proliferation and epithelialmesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol 2008; 28:2426-36; PMID: 18227151; DOI: 10.1128/MCB.01874-07.
41. Harvey K., Tapon N The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network Nat Rev Cancer 2007; 7:182-91; PMID: 17318211; DOI: 10.1038/nrc2070.
42. Saucedo L.J., Edgar BA Filling out the Hippo pathway Nat Rev Mol Cell Biol 2007; 8:613-21; PMID: 17622252; DOI: 10.1038/nrm2221.
43. Yu J., Zheng Y., Dong J., Klusza S., Deng W.M., Pan D Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded Dev Cell 2010; 18:288-99; PMID: 20159598; DOI: 10.1016/j.devcel.2009.12.012.
44. Das Thakur M., Feng Y., Jagannathan R., Seppa M.J., Skeath J.B., Longmore GD Ajuba LIM proteins are negative regulators of the Hippo signaling pathway Curr Biol 2010; 20:657-62; PMID: 20303269; DOI: 10.1016/j.cub.2010.02.035.
45. Hirota T., Kunitoku N., Sasayama T., Marumoto T., Zhang D., Nitta M., et al. Aurora A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 2003; 114:585-98; PMID: 13678582; DOI: 10.1016/ S0092-8674(03)00642-1.
46. Abe Y., Ohsugi M., Haraguchi K., Fujimoto J., Yamamoto T LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis FEBS Lett 2006; 580:782-8; PMID: 16413547; DOI: 10.1016/j.febslet.2005.12.096.
47. Wilmeth L.J., Shrestha S., Montaño G., Rashe J., Shuster CB Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis Mol Biol Cell 2010; 21:380-92; PMID: 19955215; DOI: 10.1091/mbc.E09-06-0471.
48. Praskova M., Xia F., Avruch J MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation Curr Biol 2008; 18:311-21; PMID: 18328708; DOI: 10.1016/j.cub.2008.02.006.
49. Oh H.J., Kim M.J., Song S.J., Kim T., Lee D., Kwon S.H., et al. MST1 limits the kinase activity of aurora B to promote stable kinetochore-microtubule attachment. Curr Biol 2010; 20:416-22; PMID: 20171103; DOI: 10.1016/j.cub.2009.12.054.
50. Chen J., Jin S., Tahir S.K., Zhang H., Liu X., Sarthy A.V., et al. Survivin enhances Aurora B kinase activity and localizes Aurora B in human cells. J Biol Chem 2003; 278:486-90; PMID: 12419797; DOI: 10.1074/jbc. M211119200.