MST1 Limits the Kinase Activity of Aurora B to Promote Stable Kinetochore-Microtubule Attachment

Current Biology

Volumn 20, Issue 5, 2010, Pages 416-422

  Oh, Hyun Jung ^a   Kim, Mi Ju ^a   Song, Su Jung ^a   Kim, Tackhoon ^a   Lee, Dongjun ^a   Kwon, Seung Hae ^b   Choi, Eui Ju ^c   Lim, Dae Sik ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

^c Korea University   (South Korea)

Author keywords

CELLBIO

Indexed keywords

AURORA KINASE; MACROPHAGE STIMULATING PROTEIN; NDR1 PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; SCATTER FACTOR;

ARTICLE; CELL CYCLE; CENTROMERE; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; HELA CELL; HUMAN; METABOLISM; MICROTUBULE; PHOSPHORYLATION; PHYSIOLOGY;

CELL CYCLE; GENE EXPRESSION REGULATION; HELA CELLS; HEPATOCYTE GROWTH FACTOR; HUMANS; KINETOCHORES; MICROTUBULES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS;

MAMMALIA;

EID: 77649183891     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2009.12.054     Document Type: Article

References (30)

1. Radu M., and Chernoff J. The DeMSTification of mammalian Ste20 kinases. Curr. Biol. 19 (2009) R421-R425
2. Tanaka T.U., Rachidi N., Janke C., Pereira G., Galova M., Schiebel E., Stark M.J., and Nasmyth K. Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell 108 (2002) 317-329
3. Lampson M.A., Renduchitala K., Khodjakov A., and Kapoor T.M. Correcting improper chromosome-spindle attachments during cell division. Nat. Cell Biol. 6 (2004) 232-237
4. Cimini D., Wan X., Hirel C.B., and Salmon E.D. Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors. Curr. Biol. 16 (2006) 1711-1718
5. Saucedo L.J., and Edgar B.A. Filling out the Hippo pathway. Nat. Rev. Mol. Cell Biol. 8 (2007) 613-621
6. Wu S., Huang J., Dong J., and Pan D. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114 (2003) 445-456
7. Chan E.H., Nousiainen M., Chalamalasetty R.B., Schäfer A., Nigg E.A., and Silljé H.H. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene 24 (2005) 2076-2086
8. Emoto K., Parrish J.Z., Jan L.Y., and Jan Y.N. The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. Nature 443 (2006) 210-213
9. Vichalkovski A., Gresko E., Cornils H., Hergovich A., Schmitz D., and Hemmings B.A. NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis. Curr. Biol. 18 (2008) 1889-1895
10. Lai Z.C., Wei X., Shimizu T., Ramos E., Rohrbaugh M., Nikolaidis N., Ho L.L., and Li Y. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 120 (2005) 675-685
11. Wei X., Shimizu T., and Lai Z.C. Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila. EMBO J. 26 (2007) 1772-1781
12. Praskova M., Xia F., and Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr. Biol. 18 (2008) 311-321
13. Musacchio A., and Salmon E.D. The spindle-assembly checkpoint in space and time. Nat. Rev. Mol. Cell Biol. 8 (2007) 379-393
14. Meraldi P., Draviam V.M., and Sorger P.K. Timing and checkpoints in the regulation of mitotic progression. Dev. Cell 7 (2004) 45-60
15. Chiba S., Ikeda M., Katsunuma K., Ohashi K., and Mizuno K. MST2- and Furry-mediated activation of NDR1 kinase is critical for precise alignment of mitotic chromosomes. Curr. Biol. 19 (2009) 675-681
16. Mayer T.U., Kapoor T.M., Haggarty S.J., King R.W., Schreiber S.L., and Mitchison T.J. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286 (1999) 971-974
17. Kapoor T.M., Mayer T.U., Coughlin M.L., and Mitchison T.J. Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J. Cell Biol. 150 (2000) 975-988
18. Yasui Y., Urano T., Kawajiri A., Nagata K., Tatsuka M., Saya H., Furukawa K., Takahashi T., Izawa I., and Inagaki M. Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. J. Biol. Chem. 279 (2004) 12997-13003
19. Ditchfield C., Johnson V.L., Tighe A., Ellston R., Haworth C., Johnson T., Mortlock A., Keen N., and Taylor S.S. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. 161 (2003) 267-280
20. Lampson M.A., and Kapoor T.M. The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments. Nat. Cell Biol. 7 (2005) 93-98
21. Oh S., Lee D., Kim T., Kim T.S., Oh H.J., Hwang C.Y., Kong Y.Y., Kwon K.S., and Lim D.S. Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol. Cell. Biol. 29 (2009) 6309-6320
22. DeLuca J.G., Gall W.E., Ciferri C., Cimini D., Musacchio A., and Salmon E.D. Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell 127 (2006) 969-982
23. Andrews P.D., Ovechkina Y., Morrice N., Wagenbach M., Duncan K., Wordeman L., and Swedlow J.R. Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6 (2004) 253-268
24. Bakhoum S.F., Thompson S.L., Manning A.L., and Compton D.A. Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nat. Cell Biol. 11 (2009) 27-35
25. Vader G., Medema R.H., and Lens S.M. The chromosomal passenger complex: Guiding Aurora-B through mitosis. J. Cell Biol. 173 (2006) 833-837
26. Sugiyama K., Sugiura K., Hara T., Sugimoto K., Shima H., Honda K., Furukawa K., Yamashita S., and Urano T. Aurora-B associated protein phosphatases as negative regulators of kinase activation. Oncogene 21 (2002) 3103-3111
27. Liu D., Vader G., Vromans M.J., Lampson M.A., and Lens S.M. Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science 323 (2009) 1350-1353
28. Katayama H., Brinkley W.R., and Sen S. The Aurora kinases: Role in cell transformation and tumorigenesis. Cancer Metastasis Rev. 22 (2003) 451-464
29. Seidel C., Schagdarsurengin U., Blümke K., Würl P., Pfeifer G.P., Hauptmann S., Taubert H., and Dammann R. Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma. Mol. Carcinog. 46 (2007) 865-871
30. Minoo P., Zlobec I., Baker K., Tornillo L., Terracciano L., Jass J.R., and Lugli A. Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer. Mod. Pathol. 20 (2007) 331-338