메뉴 건너뛰기




Volumn 92, Issue 9, 2011, Pages 2093-2104

The NS1 protein of influenza A virus suppresses interferon-regulated activation of antigenpresentation and immune-proteasome pathways

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; BETA 2 MICROGLOBULIN; BETA INTERFERON; CASPASE 10; CASPASE 5; COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C1S; COMPLEMENT COMPONENT C3; COMPLEMENT FACTOR H; COMPLEMENT FACTOR I; CXCL2 CHEMOKINE; DEAD BOX PROTEIN; GUANYLATE BINDING PROTEIN 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS KINASE EPSILON; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS 2; INTERFERON INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS 3; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1BETA CONVERTING ENZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MUCIN 1; NONSTRUCTURAL PROTEIN 1; NUCLEAR FACTOR IFN INDUCIBLE; PROTEASOME; PROTEIN; TRANSPORTER 1 ATP BINDING CASSETTE SUBFAMILY B; TRANSPORTER 2 ATP BINDING CASSETTE SUBFAMILY B; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 80051728300     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.032060-0     Document Type: Article
Times cited : (32)

References (46)
  • 1
    • 35448980010 scopus 로고    scopus 로고
    • Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus
    • other authors
    • Baskin, C. R., Bielefeldt-Ohmann, H., García-Sastre, A., Tumpey, T. M., Van Hoeven, N., Carter, V. S., Thomas, M. J., Proll, S., Solórzano, A. & other authors (2007). Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus. J Virol 81, 11817-11827.
    • (2007) J Virol , vol.81 , pp. 11817-11827
    • Baskin, C.R.1    Bielefeldt-Ohmann, H.2    García-Sastre, A.3    Tumpey, T.M.4    van Hoeven, N.5    Carter, V.S.6    Thomas, M.J.7    Proll, S.8    Solórzano, A.9
  • 2
    • 70349737879 scopus 로고    scopus 로고
    • The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways
    • other authors
    • Billharz, R., Zeng, H., Proll, S. C., Korth, M. J., Lederer, S., Albrecht, R., Goodman, A. G., Rosenzweig, E., Tumpey, T. M. & other authors (2009). The NS1 protein of the 1918 pandemic influenza virus blocks host interferon and lipid metabolism pathways. J Virol 83, 10557-10570.
    • (2009) J Virol , vol.83 , pp. 10557-10570
    • Billharz, R.1    Zeng, H.2    Proll, S.C.3    Korth, M.J.4    Lederer, S.5    Albrecht, R.6    Goodman, A.G.7    Rosenzweig, E.8    Tumpey, T.M.9
  • 4
    • 0032568809 scopus 로고    scopus 로고
    • Different requirements for signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 in the regulation of low molecular mass polypeptide 2 and transporter associated with antigen processing 1 gene expression
    • Chatterjee-Kishore, M., Kishore, R., Hicklin, D. J., Marincola, F. M. & Ferrone, S. (1998). Different requirements for signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 in the regulation of low molecular mass polypeptide 2 and transporter associated with antigen processing 1 gene expression. J Biol Chem 273, 16177-16183.
    • (1998) J Biol Chem , vol.273 , pp. 16177-16183
    • Chatterjee-Kishore, M.1    Kishore, R.2    Hicklin, D.J.3    Marincola, F.M.4    Ferrone, S.5
  • 5
    • 0034617294 scopus 로고    scopus 로고
    • Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1
    • Chatterjee-Kishore, M., van Den Akker, F. & Stark, G. R. (2000). Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1. J Biol Chem 275, 20406-20411.
    • (2000) J Biol Chem , vol.275 , pp. 20406-20411
    • Chatterjee-Kishore, M.1    van den Akker, F.2    Stark, G.R.3
  • 6
    • 0033560753 scopus 로고    scopus 로고
    • Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 39-end processing machinery
    • Chen, Z., Li, Y. & Krug, R. M. (1999). Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 39-end processing machinery. EMBO J 18, 2273-2283.
    • (1999) EMBO J , vol.18 , pp. 2273-2283
    • Chen, Z.1    Li, Y.2    Krug, R.M.3
  • 8
    • 1242307789 scopus 로고    scopus 로고
    • Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: Evidence for a novel RNA-binding mode
    • Chien, C. Y., Xu, Y., Xiao, R., Aramini, J. M., Sahasrabudhe, P. V., Krug, R. M. & Montelione, G. T. (2004). Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: evidence for a novel RNA-binding mode. Biochemistry 43, 1950-1962.
    • (2004) Biochemistry , vol.43 , pp. 1950-1962
    • Chien, C.Y.1    Xu, Y.2    Xiao, R.3    Aramini, J.M.4    Sahasrabudhe, P.V.5    Krug, R.M.6    Montelione, G.T.7
  • 9
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell, J. E., Jr, Kerr, I. M. & Stark, G. R. (1994). Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 10
    • 79953035505 scopus 로고    scopus 로고
    • PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo
    • de Graaf, N., van Helden, M. J., Textoris-Taube, K., Chiba, T., Topham, D. J., Kloetzel, P. M., Zaiss, D. M. & Sijts, A. J. (2011). PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo. Eur J Immunol 41, 926-935.
    • (2011) Eur J Immunol , vol.41 , pp. 926-935
    • de Graaf, N.1    van Helden, M.J.2    Textoris-Taube, K.3    Chiba, T.4    Topham, D.J.5    Kloetzel, P.M.6    Zaiss, D.M.7    Sijts, A.J.8
  • 12
    • 62649122865 scopus 로고    scopus 로고
    • A ChIPchip approach reveals a novel role for transcription factor IRF1 in the DNA damage response
    • Frontini, M., Vijayakumar, M., Garvin, A. & Clarke, N. (2009). A ChIPchip approach reveals a novel role for transcription factor IRF1 in the DNA damage response. Nucleic Acids Res 37, 1073-1085.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1073-1085
    • Frontini, M.1    Vijayakumar, M.2    Garvin, A.3    Clarke, N.4
  • 14
    • 0035864298 scopus 로고    scopus 로고
    • Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses
    • García-Sastre, A. (2001). Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses. Virology 279, 375-384.
    • (2001) Virology , vol.279 , pp. 375-384
    • García-Sastre, A.1
  • 15
    • 0026793719 scopus 로고
    • Translational control by influenza virus. Selective and cap-dependent translation of viral mRNAs in infected cells
    • Garfinkel, M. S. & Katze, M. G. (1992). Translational control by influenza virus. Selective and cap-dependent translation of viral mRNAs in infected cells. J Biol Chem 267, 9383-9390.
    • (1992) J Biol Chem , vol.267 , pp. 9383-9390
    • Garfinkel, M.S.1    Katze, M.G.2
  • 16
    • 0036678864 scopus 로고    scopus 로고
    • Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: The role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza
    • other authors
    • Geiss, G. K., Salvatore, M., Tumpey, T. M., Carter, V. S., Wang, X., Basler, C. F., Taubenberger, J. K., Bumgarner, R. E., Palese, P. & other authors (2002). Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. Proc Natl Acad Sci U S A 99, 10736-10741.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10736-10741
    • Geiss, G.K.1    Salvatore, M.2    Tumpey, T.M.3    Carter, V.S.4    Wang, X.5    Basler, C.F.6    Taubenberger, J.K.7    Bumgarner, R.E.8    Palese, P.9
  • 19
    • 77953784997 scopus 로고    scopus 로고
    • Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein
    • other authors
    • Hale, B. G., Steel, J., Medina, R.A., Manicassamy, B., Ye, J., Hickman, D., Hai, R., Schmolke, M., Lowen, A. C. & other authors (2010). Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein. J Virol 84, 6909-6922.
    • (2010) J Virol , vol.84 , pp. 6909-6922
    • Hale, B.G.1    Steel, J.2    Medina, R.A.3    Manicassamy, B.4    Ye, J.5    Hickman, D.6    Hai, R.7    Schmolke, M.8    Lowen, A.C.9
  • 20
    • 67449097020 scopus 로고    scopus 로고
    • The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory epithelial cells
    • Haye, K., Burmakina, S., Moran, T., García-Sastre, A. & Fernandez-Sesma, A. (2009). The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory epithelial cells. J Virol 83, 6849-6862.
    • (2009) J Virol , vol.83 , pp. 6849-6862
    • Haye, K.1    Burmakina, S.2    Moran, T.3    García-Sastre, A.4    Fernandez-Sesma, A.5
  • 21
    • 41949123710 scopus 로고    scopus 로고
    • A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity
    • Jackson, D., Hossain, M. J., Hickman, D., Perez, D. R. & Lamb, R. A. (2008). A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. Proc Natl Acad Sci U S A 105, 4381-4386.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 4381-4386
    • Jackson, D.1    Hossain, M.J.2    Hickman, D.3    Perez, D.R.4    Lamb, R.A.5
  • 22
    • 0025570286 scopus 로고
    • Translational control in influenza virus-infected cells
    • Katze, M. G. & Krug, R. M. (1990). Translational control in influenza virus-infected cells. Enzyme 44, 265-277.
    • (1990) Enzyme , vol.44 , pp. 265-277
    • Katze, M.G.1    Krug, R.M.2
  • 23
    • 0022617764 scopus 로고
    • Translational control by influenza virus: Suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs
    • Katze, M. G., Detjen, B. M., Safer, B. & Krug, R. M. (1986). Translational control by influenza virus: suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs. Mol Cell Biol 6, 1741-1750.
    • (1986) Mol Cell Biol , vol.6 , pp. 1741-1750
    • Katze, M.G.1    Detjen, B.M.2    Safer, B.3    Krug, R.M.4
  • 24
    • 0023708282 scopus 로고
    • Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase
    • Katze, M. G., Tomita, J., Black, T., Krug, R. M., Safer, B. & Hovanessian, A. (1988). Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase. J Virol 62, 3710-3717.
    • (1988) J Virol , vol.62 , pp. 3710-3717
    • Katze, M.G.1    Tomita, J.2    Black, T.3    Krug, R.M.4    Safer, B.5    Hovanessian, A.6
  • 25
    • 34250810666 scopus 로고    scopus 로고
    • Multiple anti-interferon actions of the influenza A virus NS1 protein
    • Kochs, G., García-Sastre, A. & Martínez-Sobrido, L. (2007). Multiple anti-interferon actions of the influenza A virus NS1 protein. J Virol 81, 7011-7021.
    • (2007) J Virol , vol.81 , pp. 7011-7021
    • Kochs, G.1    García-Sastre, A.2    Martínez-Sobrido, L.3
  • 26
    • 0030710459 scopus 로고    scopus 로고
    • Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein
    • Liu, J., Lynch, P. A., Chien, C. Y., Montelione, G. T., Krug, R. M. & Berman, H. M. (1997). Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein. Nat Struct Biol 4, 896-899.
    • (1997) Nat Struct Biol , vol.4 , pp. 896-899
    • Liu, J.1    Lynch, P.A.2    Chien, C.Y.3    Montelione, G.T.4    Krug, R.M.5    Berman, H.M.6
  • 27
    • 77957970275 scopus 로고    scopus 로고
    • The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble
    • Liu, H., Golebiewski, L., Dow, E. C., Krug, R. M., Javier, R. T. & Rice, A. P. (2010). The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble. J Virol 84, 11164-11174.
    • (2010) J Virol , vol.84 , pp. 11164-11174
    • Liu, H.1    Golebiewski, L.2    Dow, E.C.3    Krug, R.M.4    Javier, R.T.5    Rice, A.P.6
  • 28
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 22DDCt method
    • Livak, K. J. & Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 22DDCt method. Methods 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 29
    • 0028847292 scopus 로고
    • Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the eIF-2 translation initiation factor
    • Lu, Y., Wambach, M., Katze, M. G. & Krug, R. M. (1995). Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the eIF-2 translation initiation factor. Virology 214, 222-228.
    • (1995) Virology , vol.214 , pp. 222-228
    • Lu, Y.1    Wambach, M.2    Katze, M.G.3    Krug, R.M.4
  • 30
    • 33846061693 scopus 로고    scopus 로고
    • Inhibition of retinoic acidinducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus
    • Mibayashi, M., Martínez-Sobrido, L., Loo, Y. M., Cárdenas, W. B., Gale, M., Jr & García-Sastre, A. (2007). Inhibition of retinoic acidinducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus. J Virol 81, 514-524.
    • (2007) J Virol , vol.81 , pp. 514-524
    • Mibayashi, M.1    Martínez-Sobrido, L.2    Loo, Y.M.3    Cárdenas, W.B.4    Gale Jr., M.5    García-Sastre, A.6
  • 31
    • 0032086357 scopus 로고    scopus 로고
    • Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 39 end formation of cellular premRNAs
    • Nemeroff, M. E., Barabino, S. M., Li, Y., Keller, W. & Krug, R. M. (1998). Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 39 end formation of cellular premRNAs. Mol Cell 1, 991-1000.
    • (1998) Mol Cell , vol.1 , pp. 991-1000
    • Nemeroff, M.E.1    Barabino, S.M.2    Li, Y.3    Keller, W.4    Krug, R.M.5
  • 32
    • 0037444193 scopus 로고    scopus 로고
    • Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 39 end processing of cellular pre-mRNAS
    • Noah, D. L., Twu, K. Y. & Krug, R. M. (2003). Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 39 end processing of cellular pre-mRNAS. Virology 307, 386-395.
    • (2003) Virology , vol.307 , pp. 386-395
    • Noah, D.L.1    Twu, K.Y.2    Krug, R.M.3
  • 33
    • 23244457800 scopus 로고    scopus 로고
    • Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination
    • Nussbaum, A. K., Rodriguez-Carreno, M. P., Benning, N., Botten, J. & Whitton, J. L. (2005). Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination. J Immunol 175, 1153-1160.
    • (2005) J Immunol , vol.175 , pp. 1153-1160
    • Nussbaum, A.K.1    Rodriguez-Carreno, M.P.2    Benning, N.3    Botten, J.4    Whitton, J.L.5
  • 36
    • 0037223757 scopus 로고    scopus 로고
    • Newcastle disease virus (NDV)-based assay demonstrates interferonantagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins
    • Park, M. S., Shaw, M. L., Muñoz-Jordan, J., Cros, J. F., Nakaya, T., Bouvier, N., Palese, P., García-Sastre, A. & Basler, C. F. (2003). Newcastle disease virus (NDV)-based assay demonstrates interferonantagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins. J Virol 77, 1501-1511.
    • (2003) J Virol , vol.77 , pp. 1501-1511
    • Park, M.S.1    Shaw, M.L.2    Muñoz-Jordan, J.3    Cros, J.F.4    Nakaya, T.5    Bouvier, N.6    Palese, P.7    García-Sastre, A.8    Basler, C.F.9
  • 40
    • 19944419799 scopus 로고    scopus 로고
    • Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs
    • Solórzano, A., Webby, R. J., Lager, K. M., Janke, B. H., García-Sastre, A. & Richt, J. A. (2005). Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. J Virol 79, 7535-7543.
    • (2005) J Virol , vol.79 , pp. 7535-7543
    • Solórzano, A.1    Webby, R.J.2    Lager, K.M.3    Janke, B.H.4    García-Sastre, A.5    Richt, J.A.6
  • 42
    • 0029617947 scopus 로고
    • Virus induction of human IFN b gene expression requires the assembly of an enhanceosome
    • Thanos, D. & Maniatis, T. (1995). Virus induction of human IFN b gene expression requires the assembly of an enhanceosome. Cell 83, 1091-1100.
    • (1995) Cell , vol.83 , pp. 1091-1100
    • Thanos, D.1    Maniatis, T.2
  • 43
    • 0037425564 scopus 로고    scopus 로고
    • Mortality associated with influenza and respiratory syncytial virus in the United States
    • Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J. & Fukuda, K. (2003). Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 289, 179-186.
    • (2003) JAMA , vol.289 , pp. 179-186
    • Thompson, W.W.1    Shay, D.K.2    Weintraub, E.3    Brammer, L.4    Cox, N.5    Anderson, L.J.6    Fukuda, K.7
  • 45
    • 0034466776 scopus 로고    scopus 로고
    • Influenza A virus NS1 protein prevents activation of NF-kB and induction of alpha/beta interferon
    • Wang, X., Li, M., Zheng, H., Muster, T., Palese, P., Beg, A. A. & García-Sastre, A. (2000). Influenza A virus NS1 protein prevents activation of NF-kB and induction of alpha/beta interferon. J Virol 74, 11566-11573.
    • (2000) J Virol , vol.74 , pp. 11566-11573
    • Wang, X.1    Li, M.2    Zheng, H.3    Muster, T.4    Palese, P.5    Beg, A.A.6    García-Sastre, A.7
  • 46
    • 77957201252 scopus 로고    scopus 로고
    • Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: Role of the C-terminal ESEV motif in the viral NS1 protein
    • Zielecki, F., Semmler, I., Kalthoff, D., Voss, D., Mauel, S., Gruber, A. D., Beer, M. & Wolff, T. (2010). Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein. J Virol 84, 10708-10718.
    • (2010) J Virol , vol.84 , pp. 10708-10718
    • Zielecki, F.1    Semmler, I.2    Kalthoff, D.3    Voss, D.4    Mauel, S.5    Gruber, A.D.6    Beer, M.7    Wolff, T.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.