Amelioration of impaired cerebral metabolism after severe acidotic ischemia by tirilazad posttreatment in dogs

Stroke

Volumn 27, Issue 1, 1996, Pages 114-121

  Kim, Hotaek ^a   Koehler, Raymond C ^a   Hurn, Patricia D ^a   Hall, Edward D ^b   Traystman, Richard J ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b PFIZER INC   (United States)

Author keywords

acidosis; dogs; free radicals; lipid peroxidation; metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; CREATINE PHOSPHATE; FREE RADICAL; GLUTATHIONE; RADIOACTIVE MICROSPHERE; TIRILAZAD;

ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN OXYGEN CONSUMPTION; CONTROLLED STUDY; DOG; DOSE RESPONSE; INTRAVENOUS DRUG ADMINISTRATION; LACTIC ACIDOSIS; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0030049467     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.27.1.114     Document Type: Article

References (32)

1. Ginsberg MD, Welsh FA, Budd WW. Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia in the cat, I: local cerebral blood flow and glucose utilization. Stroke. 1980;11: 347-354.
2. Kalimo H, Rehncrona S, Söderfeldt B, Olsson Y, Siesjö BK. Brain lactic acidosis and ischemic cell damage, II: histopathology. J Cereb Blood Flow Metab. 1981;1:313-327.
3. Paljärvi L. Brain lactic acidosis and ischemic cell damage: a topographic study with high-resolution light microscopy of early recovery in a rat model of severe incomplete ischemia. Acta Neuropathol (Berl). 1984;64:89-98.
4. Pulsinelli WA, Waldman S, Rawlinson D, Plum F. Moderate hyperglycemia augments ischemic brain damage: a neuropathologic study in the rat. Neurology. 1982;32:1239-1246.
5. 2. J Cereb Blood Flow Metab. 1989;9:65-70.
6. Hurn PD, Koehler RC, Blizzard KK, Traystman RJ. Deferoxamine reduces early metabolic failure associated with severe cerebral ischemic acidosis in dogs. Stroke. 1995;26:688-695.
7. Hurn PD, Koehler RC, Norris SE, Blizzard KK, Traystman RJ. Dependence of cerebral energy phosphate and evoked potential recovery on end-ischemic pH. Am J Physiol. 1991;260:H532-H541.
8. Maruki Y, Koehler RC, Kirsch JR, Blizzard KK, Traystman RJ. Tirilazad pretreatment improves early cerebral metabolic and blood flow recovery from hyperglycemic ischemia. J Cereb Blood Flow Metab. 1995;15:88-96.
9. Braughler JM, Pregenzer JF. The 21-aminosteroid inhibitors of lipid peroxidation: reactions with lipid peroxyl and phenoxy radicals. Free Radic Biol Med. 1989;7:125-130.
10. Braughler JM, Pregenzer JF, Chase RL, Duncan LA, Jacobsen EJ, McCall JM. Novel 21-aminosteroids as potent inhibitors of iron-dependent lipid peroxidation. J Biol Chem. 1987;262:10438-10440.
11. Hall ED, McCall JM, Means FD. Therapeutic potential of the lazaroids (21-aminosteroids) in CNS injury, ischemia and subarachnoid hemorrhage. Adv Pharmacol. 1994;28:221-268.
12. Nishijima M, Koehler RC, Hurn PD, Eleff SM, Norris S, Jacobus WE, Traystman RJ. Postischemic recovery rate of cerebral ATP, phosphocreatine, pH, and evoked potentials. Am J Physiol. 1989; 257:H1860-H1870.
13. Hurn PD, Koehler RC, Norris SE, Schwentker AE, Traystman RJ. Bicarbonate conservation during incomplete cerebral ischemia with superimposed hypercapnia. Am J Physiol. 1991;261:H853-H859.
14. Neuschwander-Tetri BA, Roll FJ. Glutathione measurement by high-performance liquid chromatography separation and fluorimetric detection of the glutathione-ortho-pthalaldehyde adduct. Anal Biochem. 1989;179:236-241.
15. Zhang J-R, Andrus PK, Hall ED. Age-related changes in hydroxyl radical stress and antioxidants in gerbil brain. J Neurochem. 1993; 61:1640-1647.
16. Maruki Y, Koehler RC, Kirsch JR, Blizzard KK, Traystman RJ. Effect of the 21-aminosteroid tirilazad on cerebral pH and somatosensory evoked potentials after incomplete ischemia. Stroke. 1993; 24:724-730.
17. Sieber FE, Koehler RC, Brown PR, Eleff SM, Traystman RJ. Diabetic chronic hyperglycemia and cerebral pH recovery following global ischemia. Stroke. 1994;25:1449-1455.
18. Haraldseth O, Grønås T, Unsgård G. Quicker metabolic recovery after forebrain ischemia in rats treated with the antioxidant U74006F. Stroke. 1991;22:1188-1192.
19. Hall ED, Andrus PK, Yonkers PA. Brain hydroxyl radical generation in acute experimental head injury. J Neurochem. 1993;60:588-594.
20. Hall ED, Pazara KE, Braughler JM. Effects of tirilazad mesylate on postischemic brain lipid peroxidation and recovery of extracellular calcium in gerbils. Stroke. 1991;22:361-366.
21. Sato PH, Hall ED. Tirilazad mesylate protects vitamins C and E in brain ischemia-reperfusion injury. J Neurochem. 1992;58:2263-2268.
22. Lundgren J, Zhang H, Agardh C-D, Smith M-L, Evans PJ, Halliwell B, Siesjö BK. Acidosis-induced ischemic brain damage: are free radicals involved? J Cereb Blood Flow Metab. 1991;11:587-596.
23. Kontos CD, Wei EP, Williams JI, Kontos HA, Povlishock JT. Cytochemical detection of superoxide in cerebral inflammation and ischemia in vivo. Am J Physiol. 1992;263:H1234-H1242.
24. Audus KL, Guillot FL, Braughler JM. Evidence for 21-aminosteroid association with the hydrophobic domains of brain microvessel endothelial cells. Free Radic Biol Med. 1991;11:361-371.
25. Paljärvi L, Rehncrona S, Söderfeldt B, Olsson Y, Kalimo H. Brain lactic acidosis and ischemic cell damage: quantitative ultrastructural changes in capillaries of rat cerebral cortex. Acta Neuropathol (Berl). 1983;60:232-240.
26. Dietrich WD, Alonso O, Busto R. Moderate hyperglycemia worsens acute blood-brain injury after forebrain ischemia in rats. Stroke. 1993;24:111-116.
27. Hall ED, Pazara KE, Braughler JM. 21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils. Stroke. 1988;19:997-1002.
28. Lesiuk H, Sutherland G, Peeling J, Butler K, Saunders J. Effect of U74006F on forebrain ischemia in rats. Stroke. 1991;22:896-901.
29. Natale JE, Schott RJ, Hall ED, Braughler JM, D'Alecy LG. Effect of the aminosteroid U74006F after cardiopulmonary arrest in dogs. Stroke. 1988;19:1371-1378.
30. Perkins WJ, Milde LN, Milde JH, Michenfelder JD. Pretreatment with U74006F improves neurologic outcome following complete cerebral ischemia in dogs. Stroke. 1991;22:902-909.
31. Buchan AM, Bruederlin B, Heinicke E, Li H. Failure of the lipid peroxidation inhibitor, U74006F, to prevent postischemic selective neuronal injury. J Cereb Blood Flow Metab. 1992;12:250-256.
32. Park CK, Hall ED. Dose-response analysis of the effect of 21-aminosteroid tirilazad mesylate (U-74006F) upon neurological outcome and ischemic brain damage in permanent focal cerebral ischemia. Brain Res. 1994;645:157-163.