Antioxidant CR-6 protects against reperfusion injury after a transient episode of focal brain ischemia in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 30, Issue 3, 2010, Pages 638-652

  Pérez Asensio, Fernando J ^a   De La Rosa, Xavier ^a   Jiménez Altayó, Francesc ^b   Gorina, Roser ^a   Martínez, Emili ^a   Messeguer, Àngel ^c   Vila, Elisabet ^b   Chamorro, Àngel ^d,e   Planas, Anna M ^a  

^a CSIC   (Spain)

^b INSTITUT DE NEUROCIÈNCIES   (Spain)

^c INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^d HOSPITAL CLÍNIC   (Spain)

^e UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Antioxidants; Hyperemia; Ischemia; Middle cerebral artery; Reperfusion; Stroke

Indexed keywords

3,4 DIHYDRO 6 HYDROXY 7 METHOXY 2,2 DIMETHYL 1(2H) BENZOPYRAN; ALPHA TOCOPHEROL DERIVATIVE; ANTIOXIDANT; CR 6; CYCLOOXYGENASE 2; GLUTATHIONE; GLUTATHIONE DISULFIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MESSENGER RNA; MYELOPEROXIDASE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN PROTECTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; ENCEPHALITIS; HYPEREMIA; MEMBRANE PERMEABILITY; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC DISEASE; NEUTROPHIL CHEMOTAXIS; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN NITROTYROSINATION; RAT; REPERFUSION INJURY; TREATMENT OUTCOME;

EID: 77649273569     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.237     Document Type: Article

References (42)

1. Aronowski J, Strong R, Grotta JC (1997) Reperfusion injury: demonstration of brain damage produced by reperfusion alter transient focal ischemia in rats. J Cereb Blood Flow Metab 17:1048-1056
2. Baker MA, Cerniglia GJ, Zaman A (1990) Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal Biochem 190:360-365
3. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624
4. Candelario-Jalil E, González-Falcón A, García- Cabrera M, León OS, Fiebich BL (2007) Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats. J Neurochem 100:1108-1120
5. Casas J, Gorchs G, Sánchez-Baeza F, Teixidor P, Messeguer A (1992) Inhibition of rat liver microsomal lipid peroxidation elicited by simple 2,2-dimethylchromenes and chromans structurally related to precocenes. J Agric Food Chem 40:585-590
6. Chan PH (1996) Role of oxidants in ischemic brain damage. Stroke 27:1124-1129
7. Chong ZZ, Xu QP, Sun JN (2001) Effects and mechanism of triacetylshikimic acid on platelet adhesion to neutro-phil induced by thrombin and reperfusion after focal cerebral ischemia in rats. Acta Pharmacol Sin 22:679-684
8. D'Ambrosio AL, Pinsky DJ, Connolly ES (2001) The role of the complement cascade in ischemia/reperfusion injury: implications for neuroprotection. Mol Med 7:367-382
9. del Zoppo GJ, Mabuchi T (2003) Cerebral microvessel responses to focal ischemia. J Cereb Blood Flow Metab 23:879-894
10. del Zoppo GJ, Schmid-Schonbein GW, Mori E, Copeland BR, Chang CM (1991) Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 22: 1276-1283
11. Dietrich WD (1994) Morphological manifestations of reper-fusion injury in brain. Ann N Y Acad Sci 723:15-24
12. Doré S, Otsuka T, Mito T, Sugo N, Hand T, Wu L, Hurn PD, Traystman RJ, Andreasson K (2003) Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction. Ann Neurol 54:155-162
13. Gourley JK, Heistad DD (1984) Characteristics of reactive hyperemia in the cerebral circulation. Am J Physiol 246(1 Pt 2):H52-8
14. Humphreys SA, Koss MC (1998) Role of nitric oxide in post-ischemic cerebral hyperemia in anesthetized rats. Eur J Pharmacol 347:223-229
15. Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E, Morham S, Ross ME (2001) Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc Natl Acad Sci USA 98:1294-1299
16. Jiménez-Altayó F, Briones AM, Giraldo J, Planas AM, Salaices M, Vila E (2006) Increased superoxide anion production by interleukin-1b impairs nitric oxide-mediated relaxation in resistance arteries. J Pharmacol Exp Ther 316:42-52
17. Jiménez-Altayó F, Martín A, Rojas S, Justicia C, Briones AM, Giraldo J, Planas AM, Vila E (2007) Transient middle cerebral artery occlusion causes different structural, mechanical, and myogenic alterations in normo-tensive and hypertensive rats. Am J Physiol Heart Circ Physiol 293:H628-35
18. Justicia C, Martín A, Rojas S, Gironella M, Cervera A, Panés J, Chamorro A, Planas AM (2006) Anti-VCAM-1 antibodies did not protect against ischemic damage neither in rats nor in mice. J Cereb Blood Flow Metab 26:321-332
19. Kidwell CS, Saver JL, Mattiello J, Starkman S, Vinuela F, Duckwiler G, Gobin YP, Jahan R, Vespa P, Villablanca JP, Liebeskind DS, Woods RP, Alger JR (2001) Diffusion-perfusion MRI characterization of post recanalization hyperperfusion in humans. Neurology 57:2015-2021
20. Kim DJ, Kim DI, Lee SK, Suh SH, Lee YJ, Kim J, Chung TS, Lee JE (2006) Protective effect of agmatine on a reper-fusion model after transient cerebral ischemia: temporal evolution on perfusion MR imaging and histopathologic findings. AJNR Am J Neuroradiol 27:780-785
21. Kunz A, Anrather J, Zhou P, Orio M, Iadecola C (2007) Cyclooxygenase-2 does not contribute to postischemic production of reactive oxygen species. J Cereb Blood Flow Metab 27:545-551
22. Kutala VK, Khan M, Angelos MG, Kuppusamy P (2007) Role of oxygen in postischemic myocardial injury. Antioxid Redox Signal 9:1193-1206
23. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25: 402-408
24. Macfarlane R, Tasdemiroglu E, Moskowitz MA, Uemura Y, Wei EP, Kontos HA (1991) Chronic trigeminal gang-lionectomy or topical capsaicin application to pial vessels attenuates postocclusive cortical hyperemia but does not influence postischemic hypoperfusion. J Cereb Blood Flow Metab 11:261-271
25. Memezawa H, Smith ML, Siesjö BK (1992) Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke 23:552-559
26. Miranda M, Muriach M, Almansa I, Arnal E, Messeguer A, Díaz-Llopis M, Romero FJ, Bosch-Morell F (2007) CR-6 protects glutathione peroxidase activity in experimental diabetes. Free Radic Biol Med 43:1494-1498
27. Montoliu C, Llansola M, Sáez R, Yenes S, Messeguer A, Felipo V (1999) Prevention of glutamate neurotoxicity in cultured neurons by 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6), a scavenger of nitric oxide. Biochem Pharmacol 58:255-261
28. Moskowitz MA, Macfarlane R, Tasdemiroglu E, Wei EP, Kontos HA (1990) Neurogenic control of the cerebral circulation during global ischemia. Stroke 21(11 Suppl):III168-71
29. Pan J, Konstas A-A, Bateman B, Ortolano GA, Pile-Spell-man J (2007) Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies. Neuroradiology 49:93-102
30. Planas AM, Soriano MA, Justicia C, Rodŕiguez-Farré E (1999) Induction of cyclooxygenase-2 after a mild episode of focal cerebral ischemia without tissue inflammation or neural cell damage. Neuroscience Lett 273:1-4
31. Rogers DC, Campbell CA, Stretton JL, Mackay KB (1997) Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat. Stroke 28:2060-2065
32. Ruperez FJ, Mach M, Barbas C (2004) Direct liquid chromatography method for retinol, a-and g-tocopher-ols in rat plasma. J Chromatogr B 800:225-230
33. Sanvicens N, Gómez-Vicente V, Messeguer A, Cotter TG (2006) The radical scavenger CR-6 protects SH-SY5Y neuroblastoma cells from oxidative stress-induced apop-tosis: effect on survival pathways. J Neurochem 98:735-747
34. Tamura A, Asano T, Sano K (1980) Correlation between rCBF and histological changes following temporary middle cerebral artery occlusion. Stroke 11:487-493
35. Tasdemiroglu E, Christenberry PD, Ardell JL, Chronister RB, Taylor AE (1994) Effects of antioxidants on the blood-brain barrier and postischemic hyperemia. Acta Neurochir (Wien) 131:302-309
36. Todd NV, Picozzi P, Crockard HA (1986) Quantitative measurement of cerebral blood flow and cerebral blood volume alter cerebral ischaemia. J Cereb Blood Flow Metab 6:338-341
37. Traupe H, Kruse E, Heiss WD (1982) Reperfusion of focal ischemia of varying duration: postischemic hyper-and hypo-perfusion. Stroke 13:615-622
38. Tsuchidate R, He QP, Smith ML, Siesjö BK (1997) Regional cerebral blood flow during and after 2h of middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 17:1066-1073
39. Yamagami S, Miyamoto O, Nakamura T, Okada Y, Negi T, Hayashida Y, Nagao S, Itano T (1998) Suppression of hyperemia after brain ischemia by L-threo-3,4-dihydrox-yphenylserine. Neuroreport 9:2939-2943
40. Yang GY, Betz AL (1994) Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats. Stroke 25:1658-1664
41. Yenes S, Commandeur JN, Vermeulen NP, Messeguer A (2004) In vitro biotransformation of 3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)- benzopyran (CR-6), a potent lipid peroxidation inhibitor and nitric oxide scavenger, in rat liver microsomes. Chem Res Toxicol 17:904-913
42. Zhang RL, Chopp M, Chen H, Garcia JH (1994) Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat. J Neurol Sci 125:3-10