Cell surface receptors in lysophospholipid signaling

Seminars in Cell and Developmental Biology

Volumn 15, Issue 5, 2004, Pages 457-465

  Anliker, Brigitte ^a   Chun, Jerold ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

G protein coupled receptor; LPA; Lysophosphatidic acid; S1P; Sphingosine 1 phosphate

Indexed keywords

CELL SURFACE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHOLIPID; LYSOPHOSPHOLIPID RECEPTOR; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; BIRTH DEFECT; BRAIN NERVE CELL; CELL ACTIVATION; DEVELOPMENTAL BIOLOGY; EMBRYO DEVELOPMENT; FIBROBLAST; GENE DELETION; HUMAN; LIPID METABOLISM; MORPHOLOGICAL TRAIT; NERVE CELL EXCITABILITY; NONHUMAN; NULL ALLELE; PHENOTYPE; POSTNATAL DEVELOPMENT; PROTEIN ANALYSIS; PROTEIN LIPID INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 3242671309     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcdb.2004.05.005     Document Type: Article

References (80)

1. Pages C., Simon M.F., Valet P., Saulnier-Blache J.S. Lysophosphatidic acid synthesis and release. Prostaglandins Other Lipid Mediat. 64:2001;1-10
2. Tokumura A., Majima E., Kariya Y., Tominaga K., Kogure K., Yasuda K., et al. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J. Biol. Chem. 277:2002;39436-39442
3. Umezu-Goto M., Kishi Y., Taira A., Hama K., Dohmae N., Takio K., et al. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J. Cell Biol. 158:2002;227-233
4. Pilquil C., Singh I., Zhang Q.X., Ling Z.C., Buri K., Stromberg L.M., et al. Lipid phosphate phosphatase-1 dephosphorylates exogenous lysophosphatidate and thereby attenuates its effects on cell signalling. Prostaglandins Other Lipid Mediat. 64:2001;83-92
5. Luquain C., Sciorra V.A., Morris A.J. Lysophosphatidic acid signaling: how a small lipid does big things. Trends Biochem. Sci. 28:2003;377-383
6. Brauer A.U., Savaskan N.E., Kuhn H., Prehn S., Ninnemann O., Nitsch R. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Nat Neurosci. 6:2003;572-578
7. Smyth S.S., Sciorra V.A., Sigal Y.J., Pamuklar Z., Wang Z., Xu Y., et al. Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity. J. Biol. Chem. 278:2003;43214-43223
8. Tanyi J.L., Morris A.J., Wolf J.K., Fang X., Hasegawa Y., Lapushin R., et al. The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer. Cancer Res. 63:2003;1073-1082
9. Pyne S., Pyne N.J. Sphingosine 1-phosphate signalling in mammalian cells. Biochem. J. 349:2000;385-402
10. Spiegel S., Kolesnick R. Sphingosine 1-phosphate as a therapeutic agent. Leukemia. 16:2002;1596-1602
11. Kohama T., Olivera A., Edsall L., Nagiec M.M., Dickson R., Spiegel S. Molecular cloning and functional characterization of murine sphingosine kinase. J. Biol. Chem. 273:1998;23722-23728
12. Liu H., Sugiura M., Nava V.E., Edsall L.C., Kono K., Poulton S., et al. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J. Biol. Chem. 275:2000;19513-19520
13. Fukuda Y., Kihara A., Igarashi Y. Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1. Biochem. Biophys. Res. Commun. 309:2003;155-160
14. Mandala S.M., Thornton R., Galve-Roperh I., Poulton S., Peterson C., Olivera A., et al. Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. Proc. Natl. Acad Sci. USA. 97:2000;7859-7864
15. Ogawa C., Kihara A., Gokoh M., Igarashi Y. Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2. J. Biol. Chem. 278:2003;1268-1272
16. Li G., Foote C., Alexander S., Alexander H. Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. Development. 128:2001;3473-3483
17. Mendel J., Heinecke K., Fyrst H., Saba J.D. Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans. J. Biol. Chem. 278:2003;22341-22349
18. Herr D.R., Fyrst H., Phan V., Heinecke K., Georges R., Harris G.L., et al. Sply regulation of sphingolipid signaling molecules is essential for Drosophila development. Development. 130:2003;2443-2453
19. Sano T., Baker D., Virag T., Wada A., Yatomi Y., Kobayashi T., et al. Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood. J. Biol. Chem. 277:2002;21197-21206
20. Ancellin N., Colmont C., Su J., Li Q., Mittereder N., Chae S.S., et al. Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J. Biol. Chem. 277:2002;6667-6675
21. Clair T., Aoki J., Koh E., Bandle R.W., Nam S.W., Ptaszynska M.M., et al. Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. Cancer Res. 63:2003;5446-5453
22. Yatomi Y., Ozaki Y., Ohmori T., Igarashi Y. Sphingosine 1-phosphate: synthesis and release. Prostaglandins Other Lipid Mediat. 64:2001;107-122
23. Okajima F. Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator? Biochim Biophys Acta. 1582:2002;132-137
24. Baker D.L., Desiderio D.M., Miller D.D., Tolley B., Tigyi G.J. Direct quantitative analysis of lysophosphatidic acid molecular species by stable isotope dilution electrospray ionization liquid chromatography-mass spectrometry. Anal. Biochem. 292:2001;287-295
25. Weiner J.A., Fukushima N., Contos J.J., Scherer S.S., Chun J. Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling. J. Neurosci. 21:2001;7069-7078
26. Fukushima N., Weiner J.A., Chun J. Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology. Dev. Biol. 228:2000;6-18
27. Hecht J.H., Weiner J.A., Post S.R., Chun J. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J. Cell Biol. 135:1996;1071-1083
28. Fukushima N., Kimura Y., Chun J. A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc. Natl. Acad Sci. USA. 95:1998;6151-6156
29. Contos J.J., Ishii I., Chun J. Lysophosphatidic acid receptors. Mol. Pharmacol. 58:2000;1188-1196
30. Fukushima N., Ishii I., Contos J.J., Weiner J.A., Chun J. Lysophospholipid receptors. Annu. Rev. Pharmacol. Toxicol. 41:2001;507-534
31. An S., Dickens M.A., Bleu T., Hallmark O.G., Goetzl E.J. Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. Biochem. Biophys. Res. Commun. 231:1997;619-622
32. An S., Bleu T., Hallmark O.G., Goetzl E.J. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J. Biol. Chem. 273:1998;7906-7910
33. Bandoh K., Aoki J., Hosono H., Kobayashi S., Kobayashi T., Murakami-Murofushi K., et al. Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem. 274:1999;27776-27785
34. Im D.S., Heise C.E., Harding M.A., George S.R., O'Dowd B.F., Theodorescu D., et al. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. Mol. Pharmacol. 57:2000;753-759
35. Chun J., Goetzl E.J., Hla T., Igarashi Y., Lynch K.R., Moolenaar W., et al. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol. Rev. 54:2002;265-269
36. Noguchi K., Ishii S., Shimizu T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J. Biol. Chem. 278:2003;25600-25606
37. Kluk M.J., Hla T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim. Biophys. Acta. 1582:2002;72-80
38. Hla T., Maciag T. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. J. Biol. Chem. 265:1990;9308-9313
39. Lee M.J., Van Brocklyn J.R., Thangada S., Liu C.H., Hand A.R., Menzeleev R., et al. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science. 279:1998;1552-1555
40. Zondag G.C., Postma F.R., Etten I.V., Verlaan I., Moolenaar W.H. Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1. Biochem. J. 330(Pt 2):1998;605-609
41. Graler M.H., Bernhardt G., Lipp M. EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue. Genomics. 53:1998;164-169
42. Yamazaki Y., Kon J., Sato K., Tomura H., Sato M., Yoneya T., et al. Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway. Biochem. Biophys. Res. Commun. 268:2000;583-589
43. Van Brocklyn J.R., Graler M.H., Bernhardt G., Hobson J.P., Lipp M., Spiegel S. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. Blood. 95:2000;2624-2629
44. Candelore M.R., Wright M.J., Tota L.M., Milligan J., Shei G.J., Bergstrom J.D., et al. Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. Biochem. Biophys. Res. Commun. 297:2002;600-606
45. Glickman M., Malek R.L., Kwitek-Black A.E., Jacob H.J., Lee N.H. Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein- coupled receptor, nrg-1. Mol. Cell Neurosci. 14:1999;141-152
46. Im D.S., Heise C.E., Ancellin N., O'Dowd B.F., Shei G.J., Heavens R.P., et al. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. J. Biol. Chem. 275:2000;14281-14286
47. Macrae A.D., Premont R.T., Jaber M., Peterson A.S., Lefkowitz R.J. Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. Brain Res. Mol. Brain Res. 42:1996;245-254
48. Weiner J.A., Hecht J.H., Chun J. Lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J. Comp. Neurol. 398:1998;587-598
49. Weiner J.A., Chun J. Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid. Proc. Natl. Acad. Sci. USA. 96:1999;5233-5238
50. Contos J.J., Chun J. Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA. Genomics. 64:2000;155-169
51. Contos J.J., Chun J. The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern. Gene. 267:2001;243-253
52. Ishii I., Friedman B., Ye X., Kawamura S., McGiffert C., Contos J.J., et al. Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J Biol Chem. 276:2001;33697-33704
53. Zhang G., Contos J.J., Weiner J.A., Fukushima N., Chun J. Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene. 227:1999;89-99
54. Liu C.H., Hla T. The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. 43:1997;15-24
55. Okazaki H., Ishizaka N., Sakurai T., Kurokawa K., Goto K., Kumada M., et al. Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system. Biochem. Biophys. Res. Commun. 190:1993;1104-1109
56. MacLennan A.J., Browe C.S., Gaskin A.A., Lado D.C., Shaw G. Cloning and characterization of a putative G-protein coupled receptor potentially involved in development. Mol. Cell Neurosci. 5:1994;201-209
57. Yamaguchi F., Tokuda M., Hatase O., Brenner S. Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. Biochem. Biophys. Res. Commun. 227:1996;608-614
58. McGiffert C., Contos J.J., Friedman B., Chun J. Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis. FEBS Lett. 531:2002;103-108
59. Siehler S., Manning D.R. Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. Biochim. Biophys. Acta. 1582:2002;94-99
60. Graler M.H., Grosse R., Kusch A., Kremmer E., Gudermann T., Lipp M. The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13. J. Cell Biochem. 89:2003;507-519
61. Contos J.J., Ishii I., Fukushima N., Kingsbury M.A., Ye X., Kawamura S., et al. Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol Cell. Biol. 22:2002;6921-6929
62. Baudhuin L.M., Jiang Y., Zaslavsky A., Ishii I., Chun J., Xu Y. S1P3-mediated Akt activation and crosstalk with platelet-derived growth factor receptor (PDGFR). FASEB J. 18:2004;341-343
63. Takuwa Y. Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. Biochim. Biophys. Acta. 1582:2002;112-120
64. Payne S.G., Milstien S., Spiegel S. Sphingosine-1-phosphate: dual messenger functions. FEBS Lett. 531:2002;54-57
65. McIntyre T.M., Pontsler A.V., Silva A.R., St Hilaire A., Xu Y., Hinshaw J.C., et al. Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc. Natl. Acad. Sci. USA. 100:2003;131-136
66. Rosen E.D., Spiegelman B.M. PPARgamma: a nuclear regulator of metabolism, differentiation, and cell growth. J. Biol. Chem. 276:2001;37731-37734
67. Barak Y., Nelson M.C., Ong E.S., Jones Y.Z., Ruiz-Lozano P., Chien K.R., et al. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell. 4:1999;585-595
68. Rosen E.D., Sarraf P., Troy A.E., Bradwin G., Moore K., Milstone D.S., et al. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell. 4:1999;611-617
69. Hobson J.P., Rosenfeldt H.M., Barak L.S., Olivera A., Poulton S., Caron M.G., et al. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science. 291:2001;1800-1803
70. Alderton F., Rakhit S., Kong K.C., Palmer T., Sambi B., Pyne S., et al. Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells. J. Biol. Chem. 276:2001;28578-28585
71. Waters C., Sambi B., Kong K.C., Thompson D., Pitson S.M., Pyne S., et al. Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells. J. Biol. Chem. 278:2003;6282-6290
72. Liu Y., Wada R., Yamashita T., Mi Y., Deng C.X., Hobson J.P., et al. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J. Clin. Invest. 106:2000;951-961
73. Ishii I., Ye X., Friedman B., Kawamura S., Contos J.J., Kingsbury M.A., et al. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3,. J. Biol. Chem. 277:2002;25152-25159
74. Contos J.J., Fukushima N., Weiner J.A., Kaushal D., Chun J. Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc. Natl. Acad. Sci. USA. 97:2000;13384-13389
75. MacLennan A.J., Carney P.R., Zhu W.J., Chaves A.H., Garcia J., Grimes J.R., et al. An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability. Eur. J. Neurosci. 14:2001;203-209
76. Yang A.H., Ishii I., Chun J. In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice. Biochim. Biophys. Acta. 1582:2002;197-203
77. Li Y., Tennekoon G.I., Birnbaum M., Marchionni M.A., Rutkowski J.L. Neuregulin signaling through a PI3K/Akt/Bad pathway in Schwann cell survival. Mol. Cell Neurosci. 17:2001;761-767
78. Li Y., Gonzalez M.I., Meinkoth J.L., Field J., Kazanietz M.G., Tennekoon G.I. Lysophosphatidic acid promotes survival and differentiation of rat Schwann cells. J. Biol. Chem. 278:2003;9585-9591
79. Kingsbury M.A., Rehen S.K., Contos J.J., Higgins C.M., Chun J. Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding. Nat. Neurosci. 6:2003;1292-1299
80. Osborne N., Stainier D.Y. Lipid receptors in cardiovascular development. Annu. Rev. Physiol. 65:2003;23-43