Arachidonic acid increases cerebral microvascular permeability by free radicals in single pial microvessels of the anaesthetized rat

Journal of Physiology

Volumn 507, Issue 2, 1998, Pages 541-547

  Easton, A S ^a   Fraser, P A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CATALASE; DEFEROXAMINE; FREE RADICAL; ICOSAPENTAENOIC ACID; INDOMETACIN; LIPID; LUCIFER YELLOW; NORDIHYDROGUAIARETIC ACID; SUPEROXIDE DISMUTASE; IRON CHELATING AGENT; LIPOXYGENASE INHIBITOR; POLYUNSATURATED FATTY ACID; PROSTAGLANDIN SYNTHASE; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; BRAIN MICROCIRCULATION; CAPILLARY; CONTROLLED STUDY; DOSE RESPONSE; LIPID PEROXIDATION; NONHUMAN; PIA MATER; PRIORITY JOURNAL; RAT; VENULE; ENZYME METABOLISM; FEMALE; IN VIVO STUDY; MALE; MEMBRANE PERMEABILITY; MICROVASCULARIZATION; MICROVASCULATURE; PIA ARTERY;

ANESTHESIA; ANIMALS; ANTIOXIDANTS; ARACHIDONIC ACID; BLOOD-BRAIN BARRIER; CAPILLARIES; CAPILLARY PERMEABILITY; CEREBRAL VEINS; CEREBROVASCULAR CIRCULATION; CYCLOOXYGENASE INHIBITORS; FATTY ACIDS; FEMALE; FLUORESCENT DYES; FREE RADICALS; IRON CHELATING AGENTS; ISOQUINOLINES; LIPOXYGENASE INHIBITORS; MALE; RATS; RATS, WISTAR;

EID: 0032030807     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.541bt.x     Document Type: Article

References (20)

1. ALEXANDER-NORTH, L. S., NORTH, J. A., KIMINYO, K. P., BUETTNER, G. R. & SPECTOR, A. A. (1994). Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells. Journal of Lipid Research 35, 1773-1785.
2. BLACK, K. L. & HOFF, J. T. (1985). Leukotrienes increase blood-brain barrier permeability following intraparenchymal injections in rats. Annals of Neurology 18, 349-351.
3. CARACENI, P., VANTHIEL, D. H. & BORLE, A. B. (1995). Dual effect of deferoxamine on free-radical formation and reoxygenation injury in isolated hepatocytes. American Journal of Physiology 32, G132-137.
4. CHAN, P. H. & FISHMAN, R. A. (1984). The role of arachidonic acid in vasogenic brain edema. Federation Proceedings 43, 210-213.
5. EASTON, A. S. & FRASER, P. A. (1994a). Variable restriction of albumin diffusion across inflamed cerebral microvessels of the anaesthetized rat. Journal of Physiology 475, 147-157.
6. EASTON, A. S. & FRASER, P. A. (1994a). Evidence that arachidonic acid disruption of blood-brain barrier is mediated by free radicals in the anaesthetized rat. Journal of Physiology 475.P, 71P.
7. EASTON, A. S., SARKER, M. H. & FRASER, P. A. (1997). Two components of blood-brain barrier disruption in the rat. Journal of Physiology 503, 613-623.
8. HENDERSON, W. R. JR (1994). The role of leukotrienes in inflammation. Annals of Internal Medicine 121, 684-697.
9. MAIER-HAUFF, K., LANGE, M., SCHÜRER, L., GUGGENBICHLER, C., VOGT, W., JACOB, K. & BAETHMANN, A. (1984). Glutamate and free fatty acid concentrations in extracellular vasogenic edema fluid. In Recent Progress in the Study and Therapy of Brain Edema, ed. Go, K. G. & BAETHMANN, A., pp. 183-192. Plenum Press, New York.
10. OHNISHI, T., POSNER, J. B. & SHAPIRO, W. R. (1992). Vasogenic brain edema induced by arachidonic acid: Role of extracellular arachidonic acid in blood-brain barrier dysfunction. Neurosurgery 30, 545-551.
11. OLESEN, S.-P. & CRONE, C. (1986). Substances that rapidly augment ionic conductance of endothelium in cerebral venules. Acta Physiologica Scandinavica 127, 233-241.
12. PALMER, C., ROBERTS, R. L. & BERO, C. (1994). Deferoxamine post treatment reduces ischemic brain injury in neonatal rats. Stroke 25, 1039-1045
13. RICE-EVANS, C. & BRUCKDORFER, K. R. (1992). Free radicals, lipoproteins and cardiovascular dysfunction. Molecular Aspects of Medicine 13, 1-111.
14. SALMON, J. A. & GARLAND, L. G. (1991). Leukotriene antagonists and inhibitors of leukotriene biosynthesis as potential therapeutic agents. Progress in Drug Research 37, 9-90.
15. SARDESAI, V. M. (1992). Biochemical and nutritional aspects of eicosanoids. Journal of Nutritional Biochemistry 3, 562-579
16. SHI, F., CAVITT, J. & AUDUS, K. L. (1995). 21-Aminosteroid and 2-(aminomethyl)chromans inhibiton of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers. Free Radical Biology and Medicine 19, 349-357.
17. SIMOPOULOS, A. P. (1991). Omega-3 fatty acids in health and disease and in growth and development. American Journal of Clinical Nutrition 54, 438-463.
18. SUZUKA, T., MABE, H. & ITO, E. (1994). Role of arachidonic acid metabolites on development of ischemic cerebral edema in rat middle cerebral artery occlusion. Brain and Nerve 46, 39-45.
19. UNTERBERG, A., SCHMIDT, W., WAHL, M., ELLIS, E. F., MARMAROU, A. & BAETHMANN, A. (1991). Evidence against leukotrienes as mediators of brain edema. Journal of Neurosurgery 74, 773-780.
20. 2 radicals in arachidonate-induced increased blood-brain barrier permeability to proteins. American Journal of Physiology 251, H693-699.